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CCS Chemistry 2024年第10期6卷 2439-2451页

作者： Wei Fu Valentina Pelliccioli Raquel Casares-l.pez juan M.Cuerva Martin Simon Christopher Golz Manuel Alcarazo Institut für Organische und Biomolekulare Chemie Georg-August-Universität Göttingen37077 Göttingen departamento de Química Orgánica Universidad de GranadaUnidad de Excelencia Química Aplicada a Biomedicina y MedioambienteE-18071 Granada

An expedient synthesis of a series of configurationally stable oxa[5]helicenes,oxa[6]helicenes,and dioxa[6]helicenes has been developed using an intramolecular,highly enantioselective,Au-catalyzed,alkyne hydroarylation *** absolute configuration of the newly prepared structures has been established by crystallography,their inversion barriers have been determined theoretically and experimentally,and their chiroptical properties have been *** of these data with those reported for thia-or carbohelicenes sharing an otherwise identical helical framework enables the establishment of comprehensive correlations between the nature of the embedded(hetero)atom(s)and the magnitude of these *** studies on the postsynthetic functionalization of the oxahelicenes obtained are also ***,siteselective bromination at the 15-position in oxa[5]helicene 5d allows its subsequent manipulation into pyridine-containing aza-oxa[7]helicene 13d;while the two termini of oxa[6]helicene 7d have been intramolecularly cyclised into the pleiadeno[1,12,11-bcde]benzofuran derivative 15d by acidic *** transformations take place without erosion of the enantiopurity.

关键词： Au-catalysis enantioselective synthesis oxa[n]helicenes racemization dynamics postsynthetic functionalization

Toxicity and feeding response of adult corn earworm (lepidoptera: Noctuidae) to an organic spinosad formulation in sucrose solution

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Advances in Entomology 2014年第1期2卷 33-41页

作者： juan d. l.pez Mohamed A. latheef Wesley C. Hoffmann USdA-ARS Aerial Application Technology Research Unit College Station USA

Adult corn earworm, Helicoverpa zea (Boddie), feeds on plant exudates soon after emergence from pupa in their natural habitat, and thereafter disperses to suitable host plants for reproduction. The intent of this study was to determine if EntrustTM, an organic formulation of spinosad, could be used in a behavioral-based pest management strategy to control H. zea in organic farming systems. In the laboratory, we evaluated the response of the corn earworm to Entrust mixed with sugar solution relative to ingestion, toxicity and proboscis extension. The sucrose solution served as a feeding stimulant and simulated the plant exudate. lethal concentration of Entrust (lC50 with 95% Cls) for male corn earworm captured in pheromone-baited traps was 0.48 (0.43 - 0.53) mgl-1 for 24 h response. Mean lethal time was 2.56 ± 0.13 h with ingestion of Entrust at 50 mg·l-1. A lethal dose of Entrust at 1000 mg·l-1 inhibited neither ingestion nor proboscis extension response of the insect. A detailed study of the adult corn earworm in the laboratory relative to toxicity after ingestion of Entrust indicates that the pesticide has potential to control the insect when used in an insecticidal bait formulation as part of an attract-and- kill system. Field studies are needed to support the conclusion.

关键词： Entrust Attract-and-Kill Helicoverpa zea Adult Control Bioinsecticide

Metabolic complications in liver transplant recipients

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World Journal of Gastroenterology 2016年第28期22卷 6416-6423页

作者： Miguel Jiménez-Pérez Rocío González-Grande Edith Omonte Guzmán Víctor Amo Trillo juan Miguel Rodrigo l.pez UGC de Aparato digestivo Unidad de Hepatología-Trasplante Hepático Hospital Universitario Regional de Málaga

The metabolic syndrome(MS), which includes obesity,dyslipidaemia, hypertension and hyperglycaemia according to the most widely accepted definitions now used, is one of the most common post-transplant complications, with a prevalence of 44%-58%. The MS, together with the immunosuppression, is considered the main risk factor for the development of cardiovascular disease(CVd) in transplant recipients, which in turn accounts for 19%-42% of all deaths unrelated to the graft. The presence of MS represents a relative risk for the development of CVd and death of 1.78. On the other hand, non-alcoholic fatty liver disease(NAFld), considered as the manifestation of the MS in the liver, is now the second leading reason for liver transplantation in the United States after hepatitis C and alcohol. NAFld has a high rate of recurrence in the liver graft and a direct relation with the worsening of other metabolic disorders, such as insulin resistance or diabetes mellitus. Consequently, it is vitally important to identify and treat as soon as possible such modifiable factors as hypertension, overweight, hyperlipidaemia or diabetes in transplanted patients to thus minimise the impact on patient survival. Additionally, steroid-free regimens are favoured, with minimal immunosuppression to limit the possible effects on the development of the MS.

关键词： Metabolic syndrome liver transplantation Immunosuppressions Risk factors Non-alcoholic fatty liver disease

Need for infliximab dose intensification in Crohn's disease and ulcerative colitis

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World Journal of Gastroenterology 2014年第27期20卷 9170-9177页

作者： Carlos Taxonera david Olivares juan l Mendoza Manuel díaz-Rubio Enrique Rey Inflammatory Bowel disease Unit Department of Gastroenterology Hospital Clínico San Carlos Instituto de Investigación del Hospital Clínico San Carlos (IdISSC) department of Gastroenterology Hospital Clínico San Carlos

AIM: To compare the need for infliximab dose intensification in two cohorts of patients with Crohn’s disease (Cd) or ulcerative colitis (UC).

关键词： Crohn's disease Ulcerative colitis Infliximab dose intensification Costs

Three-dimensional acoustic propagation model for shallow waters based on an indirect boundary element method

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Chinese Physics B 2023年第5期32卷 485-495页

作者： Edmundo F.lavia juan d.Gonzalez Silvia Blanc Acoustic Propagation department Argentinian Navy Research Office(DIIV)Buenos Aires 1638Argentina UNIdEF(National Council of Scientific and Technical Research/Ministry of defense) Buenos AiresArgentina

This work has a two-fold *** the one hand,the theoretical formulation of a three-dimensional(3d)acoustic propagation model for shallow waters with a constant sound speed is presented,based on the boundary element method(BEM),which uses a half-space Green function instead of the more conventional free-space Green *** the other hand,a numerical implementation is illustrated to explore the formulation in simple idealized cases,controlled by a few parameters,which provides necessary tests for the accuracy and performance of the *** half-space Green's function,which has been previously used in scattering and diffraction,adds terms to the usual expressions of the integral operators without altering their continuity *** against the wavenumber integration solution of the Pekeris waveguide suggest that the model allows an adequate prediction for the acoustic ***,numerical experiments in relation to the necessary mesh size for the description of the water-marine sediment interface lead to the conclusion that a transmission loss prediction with acceptable accuracy can be obtained with the use of a limited mesh around the desired evaluation region.

关键词： three-dimensional acoustic propagation boundary element method half-space Green function

Preparation of sulfur hydrophobized plasmonic photocatalyst towards durable superhydrophobic coating material

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Journal of Materials Science & Technology 2020年第6期41卷 159-167页

作者： Emese lantos lászlóMérai ágota deák juan Gómez-Pérez dániel Sebo?k Imre dékány Zoltán Kónya lászlóJanovák University of Szeged Interdisciplinary Excellence CentreDepartment of Physical Chemistry and Materials ScienceH-6720Rerrich Béla tér 1SzegedHungary University of Szeged Interdisciplinary Excellence CentreDepartment of Applied and Environmental ChemistryH-6720Rerrich Béla tér 1SzegedHungary

The widely used photocatalytic self-cleaning coating materials are often made of polymers and polymer based composites,where the photocatalyst immobilization occurs with ***,these organic polymers are often unstable under exposure to UV irradiation and easily degraded by reactive radicals produced in the photocatalytic *** order to solve this problem,in this paper,we present the facile preparation of a multifunctional coating with dual superhydrophobic and photocatalytic properties,where the fixation and the hydrophobization of the plasmonic Ag-TiO2 photocatalyst particles with visible light activity was performed with non-water soluble sulfur,which is a cheap and easily available *** resulted novel nanocomposite with rough and nano-tructured surface roughness(1.25–2.45 nm determined by small-angle X-ray scattering)has sufficient low surface energy(3.3 mJ/m2)for superhydrophobic(θ=151.1°v)***,in contrast of the organic and expensive fluoropolymer based composites,this non-wetting nature was durable,because the measured was higher than 150°during the long-term lEd(λmax=405 nm)light irradiation.

关键词： Nanocomposite Coating materials Wetting lotus-type structure Visible light photocatalyst

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi juan Pablo de Rivero Vaccari Jennifer C.Munoz Pareja Andrew Reisner laura Blackwell Yehia Mechref Kevin K.Wang J.Adrian Tyndall Binu Tharakan Firas Kobeissy department of Surgery Morehouse School of MedicineAtlantaGAUSA department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA department of Neurological Surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA department of Pediatrics Emory UniversityAtlantaGAUSA department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOd-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOd-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOd-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NlRP1 NlRP3 pyroptosis tauopathy traumatic brain injury

Nonlinear numerical assessment of the seismic response of hillside RC buildings

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Earthquake Engineering and Engineering Vibration 2021年第2期20卷 423-440页

作者： Miguel A.Gómez Edgar Giovanny díaz-Segura juan Carlos Vielma Civil Engineering School Pontificia Universidad Católica de ValparaísoValparaíso 2340000Chile

Major damage has been reported in hilly areas after major earthquakes,primarily because of two special conditions:the variation in the seismic ground motion due to the inclined ground surface and the irregularities caused by a stepped base level in the *** aim of this study is to evaluate possible differences in the responses of Chilean hillside buildings through numerical linear-elastic and nonlinear *** the first step,a set of response-spectrum analyses were performed on four simplified 2d structures with mean base inclination angles of 0°,15°,30°,and 45°.The structures were designed to comply with Chilean seismic codes and standards,and the primary response parameters were *** assess the seismic performance of the buildings,nonlinear static(pushover)and dynamic(time-history)analyses were performed with SeismoStruct *** analyses were used to compare the nonlinear response at the maximum roof displacement and the damage ***-history analyses were performed to assess the nonlinear dynamic response of the structures subjected to seismic ground motions modified by topographic *** consider the topographic modification,acceleration records were obtained from numerical models of soil,which were calculated using the rock acceleration record of the Mw 8.01985 Chilean *** differences in the structure responses(roof displacements and maximum element forces and moments)were caused by the topographic effects in the seismic input motion,with the highly predominant ones being the differences caused by the step-back configuration at the base of the *** concentrations of shear forces in short walls were observed,corresponding to the walls located in the upper zone of the foundation *** response of the structures with higher angles was observed to be more prone to fragile failures due to the accumulation of shear *** though hillside buildings gain stiffness in the lower stories,resulting

关键词： topographic effect hillside buildings nonlinear analyses shear-wall buildings

Virtual Conductance Based Cascade Voltage Controller for VSCs in Islanded Operation Mode

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Journal of Modern Power Systems and Clean Energy 2022年第6期10卷 1704-1713页

作者： Francisco Jesús Matas-díaz Manuel Barragán-Villarejo juan Carlos Olives-Camps juan Manuel Mauricio JoséMaría Maza-Ortega department of Elec‐trical Engineering Universidad de SevillaSeville 41092Spain

Voltage source converters have become the main enabler for the integration of distributed energy resources in *** the case of islanded operation,these devices normally set the amplitude and frequency of the network voltage by means of a cascade controller composed of an outer voltage control loop and an inner current control *** strategies to compute the gains of both control loops have been proposed in the literature in order to obtain a fast and decoupled response of the voltages at the point of common *** paper proposes an alternative and simple methodology based on the introduction of a virtual conductance in the classic cascade *** strategy allows to design each control loop independently,obtaining a closed-loop response of a first-order *** this way,the gains of each control loop are easily derived from the parameters of the lC coupling filter and the desired closed-loop time ***,a state observer is included in the controller to estimate the inductor current of the lC filter in order to reduce the number of required measurements.A laboratory testbed is used to validate and compare the proposed *** experimental results demonstrate the effectiveness of the proposal both in steady-state and transient regimes.

关键词： Voltage source converter microgrid cascade controller virtual conductance

Beta-blocker therapy in elderly patients with renal dysfunction and heart failure

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Journal of Geriatric Cardiology 2021年第1期18卷 20-29页

作者： juan Martínez-Milla Marcelino Cortés García Julia Anna Palfy Mikel Taibo Urquía Marta l.pez Castillo Ana devesa Arbiol Ana lucía Rivero Monteagudo María luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero juan Antonio Franco-Pelaéz JoséTuñón department of Cardiology Hospital Universitario Fundación Jiménez Díaz-Quirónsalud Centro Nacional de Investigaciones Cardiovasculares MadridSpain department of Cardiology Hospital Central de Asturias department of Cardiology Hospital Universitario Ruber-Quirónsalud department of Cardiology Hospital Universitario Infanta Leonor department of Endocrinology Hospital Clínico San Carlos Universidad Autónoma de Madrid CIBERCV MadridSpain

OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKd)aged≥75 *** ANd RESUlTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m l/min per 1.73 m^*** analyzed the relationship between treatment with BB and mortality or cardiovascular *** mean age of our population was 82.6±4.1 *** ejection fraction was 27.9%±6.5%.GFR was 60-45 m l/min per 1.73 m^2 in 50.3%of patients,45-30 m l/min per 1.73 m^2 in 37.4%,andl/min per 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving *** median follow-up was28.04(IR:19.41-36.67)*** the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;Ply showed a reduced risk of death across the different stages of CKd:stage IIIa(GFR=30-45 m l/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,Pl/min per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFRl/min per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).CONClUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better *** of BB should be encouraged when possible.

关键词： CKd GFR Beta-blocker therapy in elderly patients with renal dysfunction and heart failure