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Dendritic nanoarchitecture imparts ZSM-5 zeolite with enhanced adsorption and catalytic performance in energy applications

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Journal of Energy Chemistry 2023年第5期80卷 77-88,I0003页

作者： María del Mar Alonso-Doncel Cristina Ochoa-Hernández Gema Gómez-Pozuelo Adriana Oliveira JoséGonzález-Aguilar ángel Peral Raúl Sanz David P.Serrano Thermochemical Processes Unit IMDEA Energy InstituteAvda.Ramon de la Sagra3E28935MostolesMadridSpain Department of Heterogeneous Catalysis Max-Planck-Institut für KohlenforschungKaiser-Wilhem-Platz14540Muheim an der RuhGermay Department of Chemical and Environmental Technology Rey Juan Carlos UniversityC/Tulipan s/nE28933MostolesMadridSpain High Temperature Processes Unit IMDEA Energy InstituteAvda.Ramon de la Sagra3E28935MostolesMadridSpain Department of Chemical Energy and Mechanical TechnologyRey Juan Carlos UniversityC/Tulipan s/n28933MostolesMadridSpain

The development of zeolites possessing dendritic features represents a great opportunity for the design of novel materials with applications in a large variety of fields and,in particular,in the energy sector to afford its transition towards a low carbon *** the current work,ZSM-5 zeolite showing a dendritic3D nanoarchitecture has been synthesized by the functionalization of protozeolitic nanounits with an amphiphilic organosilane,which provokes the branched aggregative growth of zeolite *** ZSM-5 exhibits outstanding accessibility arising from a highly interconnected network of radially-oriented mesopores(3-10 nm)and large cavities(20-80 nm),which add to the zeolitic micropores,thus showing a well-defined trimodal pore size *** singular features provide dendritic ZSM-5 with sharply enhanced performance in comparison with nano-and hierarchical reference materials when tested in a number of energy related applications,such as VOCs(toluene)adsorption(improved capacity),plastics(low-density polyethylene)catalytic cracking(boosted activity)and hydrogen production by methane catalytic decomposition(higher activity and deactivation resistance).

关键词： Dendritic ZSM-5 VOCs adsorption Plastics cracking Methane decomposition Hydrogen production

Latitudinal pattern of the thermal sensitivity of running speed in the endemic lizard Liolaemus multimaculatus

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Integrative Zoology 2022年第4期17卷 619-637页

作者： Oscar Aníbal STELLATELLI Laura EVEGA Carolina BLOCK Camila ROCCA Patricio BELLAGAMBA juan Esteban DAJIL Félix Benjamín CRUZ Instituto de Investigaciones Marinas y Costeras(IIMyC) Universidad Nacional de Mar del Plata-CONICETFacultad de Ciencias Exactas y NaturalesMar del PlataArgentina Municipalidad de General Pueyrredón Mar del PlataArgentina Instituto de Investigaciones en Biodiversidad y Medioambiente(INIBIOMA) Universidad Nacional del Comahue-CONICETSan Carlos de BarilocheArgentina

Physiological performance in lizards may be affected by climate across latitudinal or altitudinal *** the coastal dune barriers in central-eastern Argentina,the annual maximum environmental temperature decreases up to 2℃ from low to high latitudes,while the mean relative humidity of the air decreases from 50%to 25%.Liolaemus multimaculatus,a lizard in the family Liolaemidae,is restricted to these coastal *** investigated the locomotor performance of the species at 6 different sites distributed throughout its range in these dune *** inquired whether locomotor performance metrics were sensitive to the thermal regime attributable to *** thermal performance breadth increased from 7%to 82%with latitude,due to a decrease in its critical thermal minimum of up to 5℃ at higher *** from high latitude sites showed a thermal optimum,that is,the body temperature at which maximum speed is achieved,up to 4℃lower than that of lizards from the low *** relatively low temperatures,the maximum running speed of high-latitude individuals was faster than that of low-latitude *** parameters of locomotor performance were labile,decreasing as a function of *** results show populations of *** adjust thermal physiology to cope with local climatic *** suggests that thermal sensitivity responds to the magnitude of latitudinal fluctuations in environmental temperature.

关键词： latitude Liolaemus reptile running speed temperature thermal sensitivity

Vicious cycle of lipid peroxidation and iron accumulation in neurodegeneration

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Neural Regeneration Research 2023年第6期18卷 1196-1202页

作者： Instituto de Salud carlos III Irene Villalón-García Suleva Povea-Cabello MónicaÁlvarez-Córdoba Marta Talaverón-Rey juan MSuárez-Rivero Alejandra Suárez-Carrillo Manuel Munuera-Cabeza Diana Reche-López Paula Cilleros-Holgado Rocío Piñero-Pérez JoséA.Sánchez-Alcázar Centro Andaluz de Biología del Desarrollo(CABD-CSIC-Universidad Pablo de Olavide de Sevilla) and Centro de Investigación Biomédica en Red:Enfermedades RarasInstituto de Salud Carlos IIISevillaSpain

Lipid peroxidation and iron accumulation are closely associated with neurodegenerative diseases,such as Alzheimer’s,Parkinson’s,and Huntington’s diseases,or neurodegeneration with brain iron accumulation *** dysfunction,lipofuscin accumulation,autophagy disruption,and ferroptosis have been implicated as the critical pathomechanisms of lipid peroxidation and iron accumulation in these ***,the connection between lipid peroxidation and iron accumulation and the initial cause or consequence in neurodegeneration processes is *** this review,we have compiled the known mechanisms by which lipid peroxidation triggers iron accumulation and lipofuscin formation,and the effect of iron overload on lipid peroxidation and cellular *** vicious cycle established between both pathological alterations may lead to the development of ***,the investigation of these mechanisms is essential for exploring therapeutic strategies to restrict *** addition,we discuss the interplay between lipid peroxidation and iron accumulation in neurodegeneration,particularly in PLA2G6-associated neurodegeneration,a rare neurodegenerative disease with autosomal recessive inheritance,which belongs to the group of neurodegeneration with brain iron accumulation disorders.

关键词： 4-hidroxynonenal ferroptosis iron lipid peroxidation lipofuscin neurodegeneration neurodegeneration with brain iron accumulation oxidative stress PLA2G6-associated neurodegeneration

Assessing methods for multiple imputation of systematic missing data in marine fisheries time series with a new validation algorithm

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Aquaculture and Fisheries 2023年第5期8卷 587-599页

作者： Ivan F.Benavides Marlon Santacruz Jhoana P.Romero-Leiton carlos Barreto John Josephraj Selvaraj Instituto de Estudios del Pacífico Universidad Nacional de ColombiaTumaco CampusKilometro 30-31CajapíVía Nacional Tumaco-PastoTumacoNarino522020Colombia Ingeniería en Produccion Acuícola Universidad de NarinoCra.22#30-63Torre 4 apto.703San Juan de PastoNarino520004Colombia Facultad de ingeniería Universidad CesmagPasto520004Colombia Datambiente 520001Colombia Autoridad Nacional de Pesca y Acuicultura(AUNAP) 520001Colombia

Time series from fisheries often contain multiple missing *** is a severe limitation that prevents using the data for research on population dynamics,stock assessment,forecasting,and,hence,decision-making around marine *** methods have been proposed to impute missing data in univariate time ***,their performances depend not only on the amount of missing data but also on the data *** study compares the performance of twelve imputation methods on the time series of marine fishery landings for six species in the Colombian Pacific *** other studies,we validate the precision of the imputations in the same target time series that include missing data,using the Known Sub-Sequence Algorithm(KSSA),a novelty validation approach that simulates missing data in known sub-sequences of the target time *** results showed that the best methods for imputation are Seasonal Decomposition with Kalman filters and Structural Models with Kalman filters fitted by maximum *** also show that validating the imputation methods with other time series different to the target time series,leads to wrong imputation methods *** is noteworthy that these methods and also the validation framework are mainly suited to time series with non-random distribution of missing data,this is,missing data produced systematically in chunks or clusters with predictable frequency,which are common in marine sciences.

关键词： Data gaps Fish populations Artisanal fishing Time series imputation

Novel Tandem Three Consecutive Reactions: Aza-Wittig, Imine Condensation and Electrophilic Aromatic Substitution Strategy to Indolizine Synthesis

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International Journal of Organic Chemistry 2021年第2期11卷 55-71页

作者： Julio C. González-Rodríguez carlos González-Romero Erick Cuevas-Yáñez juan J. Mejía Vega Christopher K. Jankowski David Corona-Becerril Centro Conjunto de Investigación en Química Sustentable (CCIQS) UAEM-UNAM Universidad Autónoma del Estado de México Unidad San Cayetano Toluca de Lerdo México Departamento de Química Orgánica Facultad de Química Universidad Autónoma del Estado de México Paseo Colón/Paseo Tollocan s/n Toluca Estado de México México Department de Chimie et Biochimie Université de Moncton Moncton Canadá

Reaction of ethyl (Z)-3-(heteroaryl/aryl)-2-((triphenyl-λ5-phosphaneylidene) amino) acrylates intermediates with 2,3-thiophenedicarboxaldehyde was used in novel Tandem three consecutive reactions: aza-Wittig, imine condensation and electrophilic heteroaromatic cyclization to obtain a series of indolizines. A tentative mechanism of this reaction is proposed.

关键词： Iminophosphorane Tandem Reaction Indolizine Synthesis

Fibrinogen-thrombin collagen patch reinforcement of highrisk colonic anastomoses in rats

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World Journal of Gastrointestinal Surgery 2016年第9期8卷 627-633页

作者： juan Manuel Suárez-Grau carlos Bernardos García Carmen Cepeda Franco Cristina Mendez García Salud García Ruiz Fernando Docobo Durantez Salvador Morales-Conde Javier Padillo Ruiz Department of General and Digestive Surgery Riotinto Hospital 21660 Huelva Spain Division of General and Laparoscopic Surgery Clinic Quiron Sagrado Corazón 41013 Seville Spain Institute of Biomedicine of Seville Research center University Hospital Virgen del Rocio 41013 Seville Spain Division of General Surgery Hospital of San Juan de Dios 41930 Bormujos Spain Department of General and Digestive Surgery University Hospital Virgen del Rocio 41013 Seville Spain Department of General surgery Hospital of Jerez 11407 Jerez de la Frontera Cadiz Spain Division of Surgery Clinic Quiron Donostia 20012 Donostia Spain Clinic Quiron Sagrado Corazón 41013 Seville Spain

AIMTo evaluate the effectiveness of human fibrinogen-thrombin collagen patch (TachoSil®) in the reinforcement of high-risk colon *** quasi-experimental study was conducted in Wistar rats (n = 56) that all underwent high-risk anastomoses (anastomosis with only two sutures) after colectomies. The rats were divided into two randomized groups: Control group (24 rats) and treatment group (24 rats). In the treatment group, high-risk anastomosis was reinforced with TachoSil® (a piece of TachoSil® was applied over this high-risk anastomosis, covering the gap). Leak incidence, overall survival, intra-abdominal adhesions, and histologic healing of anastomoses were analyzed. Survivors were divided into two subgroups and euthanized at 15 and 30 d after intervention in order to analyze the adhesions and histologic *** survival was 71.4% and 57.14% in the TachoSil® group and control group, respectively (P = 0.29); four rats died from other causes and six rats in the treatment group and 10 in the control group experienced colonic leakage (P > 0.05). The intra-abdominal adhesion score was similar in both groups, with no differences between subgroups. We found non-significant differences in the healing process according to the histologic score used in both groups (P = 0.066).CONCLUSIONIn our study, the use of TachoSil® was associated with a non-statistically significant reduction in the rate of leakage in high-risk anastomoses. TachoSil® has been shown to be a safe product because it does not affect the histologic healing process or increase intra-abdominal adhesions.

关键词： Colon Rats Anastomosis Leak TachoSil® Surgery

Arrhythmogenic cardiomyopathy with left ventricular involvement versus ischemic heart disease: lessons learned from the family study and the reviewed autopsy of a young male

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Forensic Sciences Research 2019年第3期4卷 274-279页

作者： Pilar Molina Jorge Sanz-Sánchez Manuel Fenollosa Marina Martínez-Matilla juan Giner Esther Zorio Servicio de Patología Instituto de Medicina Legal y Ciencias Forenses de ValenciaValenciaEspana Unidad de Valoración del Riesgo de Muerte Súbita Familiar and Unidad de Cardiopatías Familiares Muerte Súbita y Mecanismos de Enfermedad(CaFaMuSMe)Instituto de Investigación Sanitaria La FeValenciaEspana Servicio de Cardiología Hospital Universitario y Politécnico La FeValenciaEspana Unidad Genómica Instituto de Investigación Sanitaria La FeValenciaEspana

Ischemic heart disease (IHD) is the leading cause of sudden cardiac death (SCD) and often non-thrombosed severe coronary stenoses with or without myocardial scars are *** dominant arrhythmogenic cardiomyopathy (LDAC) is a life-threating rare disease which has been more thoroughly studied in the last *** macroscopic study of an SCD victim was conducted and re-evaluated 9years *** cardiological work-up in his firstdegree relatives initially comprised an electrocardiogram (ECG) and an *** they were re-evaluted 9years later,a cardiac magnetic resonance,an ECG-monitoring,an exercise testing and a genetic study were performed and the pedigree was extended *** 2008,an IHD was suspected in the sports-triggered SCD of a 37-year-old man upon the postmortem (75% stenosis of the left main and circumflex coronary arteries;the subepicardial left ventricular fibrofatty infiltration with mild myocardial degeneration was assumed to be a past myocardial infarction).No cardiomyopathy was identified in any of the two proband's *** years thereafter,distant relatives were diagnosed with LDAC due to a pathogenic desmoplakin *** reanalysis of the two sisters showed ventricular arrhythmias in one of them without structural heart involvement and the reviewed postmortem of the proband was reclassified as LDAC based on the fibrofatty infiltration;both were mutation *** completion of the family study on 19 family members yielded one SCD due to LDAC (the proband),three living patients diagnosed with LDAC (two with a defibrillator),one mutation carrier without structural ventricular involvement,and 14 healthy relatives (who were discharged) with a very good co-segregation of the *** rare,LDAC exists and sometimes its differential diagnosis with iHD has to be *** previous postmortem misdiagnoses can help family screening to further prevent SCDs.

关键词： Forensic sciences forensic pathology ischemic heart disease arrhythmogenic cardiomyopathy family study

Prevalence of Primary Open Angle Glaucoma among Patients with Diagnosis of Systemic Hypertension and Diabetes Mellitus: The Colombian Glaucoma Study

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Open Journal of Ophthalmology 2020年第2期10卷 99-114页

作者： carlos E. Rivera Erika Cantor Andres Castillo Alexander Martinez Lyle Newball juan C. Rueda Alejandro Valencia Sandra Belalcazar Tulio Cabal Oscar Albis-Donado Fabian Mendez Fundación Oftalmológica del Valle Cali Colombia Institute of Statistics Universidad de Valparaiso Valparaiso Chile Department of Biology Faculty of Natural & Exact Sciences Universidad del Valle Cali Colombia Ophthalmology Residency Program Universidad del Valle Centro Médico Imbanaco Cali Colombia Clínica Lynd Newball San Andrés Islas Colombia FOSCAL Internacional Bucaramanga Colombia Glaucoma Unit Medellin Colombia Fundación Oftalmológica Nacional Bogotá Colombia Clínica Visión Cabal Buga Colombia Visual Sense Private Practice Mexico City Mexico School of Public Health GESP Group Universidad del Valle Cali Colombia

Objective: To establish the prevalence and risk factors of Primary Open Angle Glaucoma (POAG) among patients with Systemic Hypertension (SH) and Diabetes Mellitus (DM) in six cities of Colombia. Methods: A cross-sectional study among hypertensive and diabetic patients was conducted in Colombia. This study included 2067 subjects older than 50 years of age diagnosed with SH and/or DM. Participants underwent a complete ophthalmic examination including intraocular pressure (IOP) measurement by Goldmann tonometry and blood pressure measurement. The glaucoma diagnosis was confirmed by structural and functional evidence. Interviews and standardized questionnaires were used to evaluate participants’ lifestyle and other health conditions. Results: Among participants with DM/SH, 142 cases of POAG were confirmed for a prevalence of 5.6% [95% CI: 4.6 - 6.6], while 9.1% were glaucoma suspects [95% CI: 7.8% - 10.4%]. The majority of confirmed cases (77.5%) were undiagnosed. The prevalence of POAG was significantly higher with male gender, greater age, and diastolic blood pressure > 90 mmHg as risk factors. Conclusion: We found a high prevalence of POAG in patients with adequate SH and DM care in a novel Latino population. We also found great unawareness of the disease in this population. Our results have potentially enormous public health implications for Colombia and other Latino populations.

关键词： Open Angle-Glaucoma Glaucoma Systemic Hypertension Diabetes Mellitus

New horizons for uncommon mutations in non-small cell lung cancer: BRAF, KRAS, RET, MET, NTRK, HER2

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World Journal of Clinical Oncology 2022年第4期13卷 276-286页

作者： Maria Eugenia Olmedo Raquel Cervera Luis Cabezon-Gutierrez Yolanda Lage Elena Corral de la Fuente Ana Gomez Rueda1,Xabier Mielgo-Rubio juan carlos Trujillo Felipe Counago Department of Medical Oncology Ramon y Cajal University HospitalMadrid 28034Spain Department of Medical Oncology Del Henares University HospitalCoslada 28822MadridSpain Medical Oncology Hospital Universitario de TorrejonTorrejon de Ardoz 28850MadridSpain Medical Oncology Department Hospital Universitario Ramon y CajalMadrid 28034Spain Department of Medical Oncology Foundation Alcorcon University HospitalAlcorcón 28922MadridSpain Department Thoracic Surgery Hospital de la Santa Creu I Sant PauBarcelona 08029CataloniaSpain Department of Surgery Universitat Autonoma de BarcelonaBarcelona 08029CataloniaSpain Department of Radiation Oncology Hospital Universitario Quironsalud MadridPozuelo 28223MadridSpain Department of Radiation Oncology Hospital La LuzMadrid 28003Spain Medicine Department School of Biomedical SciencesUniversidad Europea de MadridMadrid 28670Spain

The 2004 discovery of EGFR mutations,followed by ALK rearrangements,ushered in a targeted therapy era for advanced non-small cell lung cancer(NSCLC).Tyrosine kinase inhibitors targeting gene alterations have substantially improved survival and quality of life for patients with *** the last decade,rearrangements of the ROS1 oncogene have been incorporated into healthcare practice that are applicable to another small subgroup of patients who benefit from similar targeted *** genome studies of lung adenocarcinoma have identified other possible therapeutic targets,including RET,NTRK fusions,c-MET alterations,and activating mutations in KRAS,BRAF,and HER2,all with frequencies greater than 1%.Lung cancers harbouring these genome changes can potentially be treated with agents approved for other indications or under clinical *** review updates the therapeutic arsenal that especially targets those genes.

关键词： BRAF NTRK KRAS MET RET HER2 Non-small cell lung cancer Targeted therapy Uncommon mutations