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Toll-like receptor 4 polymorphisms and bacterial infections in patients with cirrhosis and ascites

World Journal of Hepatology 2018年第1期10卷 124-133页

作者： Edilmar Alvarado-Tapias carlos Guarner-Argente Elida Oblitas Elisabet Sánchez Silvia Vidal Eva Román Mar Concepción Maria Poca Cristina Gely Oana Pavel juan Camilo Nieto Cándido Juárez carlos Guarner Germán Soriano Department of Gastroenterology Hospital de la Santa Creu i Sant PauBarcelona 08025Spain Instituto de Salud carlos III Institut de Recerca IIBSant PauUniversitat Autònoma de BarcelonaBellaterra(Cerdanyola del Vallès)08193Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBERehd) Instituto de Salud Carlos IIIMadrid 28029Spain Department of Immunology Hospital de la Santa Creu i Sant PauBarcelona 08025Spain Escola Universitària d’Infermeria EUI-Sant Pau Hospital de la Santa Creu i Sant PauBarcelona 08025Spain

AIM To assess the relationship between the presence of toll-like receptor 4(TLR4) polymorphisms and bacterial infections in cirrhotic patients with ascites. METHODS We prospectively included consecutive patients with cirrhosis and ascites hospitalized during a 6-year period. Patients with human immunodeficiency virus(HIV) infection or any other immunodeficiency, patients with advanced hepatocellular carcinoma(beyond Milan's criteria) or any other condition determining poor short-term prognosis, and patients with a permanent urinary catheter were excluded. The presence of D299 G and/or T399 I TLR4 polymorphisms was determined by sequencing and related to the incidence and probability of bacterial infections, other complications of cirrhosis, hepatocellular carcinoma, and mortality during follow-up. A multivariate analysis to identify predictive variables of mortality in the whole series was performed. RESULTS We included 258 patients: 28(10.8%) were carriers of D299G and/or T399I TLR4 polymorphisms(polymorphism group) and 230 patients were not(wildtype group). The probability of developing any bacterial infection at one-year follow-up was 78% in the polymorphism group and 69% in the wild-type group(P = 0.54). The one-year probability of presenting infections caused by gram-negative bacilli(51% vs 44%, P = 0.68), infections caused by gram-positive cocci(49% vs 40%, P = 0.53), and spontaneous bacterial peritonitis(29% vs 34%, respectively, P = 0.99) did not differ between the two groups. The oneyear probability of transplant-free survival was 55% in the polymorphism group and 66% in the wild-type group(P = 0.15). Multivariate analysis confirmed that age, Child-Pugh score, active alcohol intake, previous hepatic encephalopathy, hepatocellular carcinoma and serum creatinine were associated with a higher risk of death during follow-up. CONCLUSION Genetic polymorphisms D299 G and/or T399 I of TLR4 do not seem to play a relevant role in the predisposition of cirrhotic patie

关键词： Cirrhosis Genetic polymorphisms Toll-like receptor 4 Bacterial infections Ascites

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Risk Factors and Gender Differences for Depression in Chilean Older Adults:A Cross-Sectional Analysis from the National Health Survey 2016–2017

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International Journal of Mental Health Promotion 2022年第5期24卷 679-697页

作者： Gabriela Nazar carlos-María Alcover Yeny Concha-Cisternas Igor Cigarroa Ximena Díaz-Martínez Mariela Gatica-Saavedra Fabián Lanuza Ana María Leiva-Ordónez María Adela Martínez-Sanguinetti Miquel Martorell Fanny Petermann-Rocha Claudia Troncoso-Pantoja carlos Celis-Morales Departamento de Psicología Facultad de Ciencias SocialesUniversidad de ConcepciónConcepciónChile Centro de Vida Saludable Universidad de ConcepciónConcepciónChile Departamento de Psicología Facultad de Ciencias de la SaludUniversidad Rey Juan CarlosMadridEspaña Pedagogía en Educación Física Facultad de EducaciónUniversidad AutónomaTalcaChile Escuela de Kinesiología Facultad de SaludUniversidad Santo TomásLosÁngelesChile Grupo de Investigación Calidad de Vida Departamento de Ciencias de la EducaciónUniversidad del BiobíoChillánChile Depto de Psiquiatría y Salud Mental Facultad de MedicinaUniversidad de ConcepciónConcepciónChile Centro de Epidemiología Cardiovascular y Nutricional(EPICYN) Facultad de MedicinaUniversidad de La FronteraTemucoChile Biomarkers and Nutrimetabolomics Laboratory Department of NutritionFood Sciences and GastronomyFood Technology Reference Net(XIA)Nutrition and Food Safety Research Institute(INSA)Faculty of Pharmacy and Food SciencesUniversity of BarcelonaBarcelona08028Spain Instituto de Anatomía Histología y PatologíaFacultad de MedicinaUniversidad Austral de ChileValdiviaChile Instituto de Farmacia Facultad de CienciasUniversidad Austral de ChileValdiviaChile Departamento de Nutrición y Dietética Facultad de Farmacia.Universidad de ConcepciónConcepciónChile Facultad de Medicina Universidad Diego PortalesSantiagoChile BHF Glasgow Cardiovascular Research Centre Institute of Cardiovascular and Medical SciencesUniversity of GlasgowGlasgowUK Centro de Investigación en Educación y Desarrollo(CIEDE-UCSC).Departamento de Salud Pública Facultad de MedicinaUniversidad Católica de la Santísima ConcepciónConcepciónChile Laboratorio de Rendimiento Humano Grupo de Estudio en EducaciónActividad Física y Salud(GEEAFyS)Universidad Católica del MauleTalcaChile

Depressive disorders are recognized as one of the most common mental health conditions across different age ***,the risk factors associated with depression among older people from low-and middle-income countries remains *** study aims to identify socio-demographic,health and psychosocial-related factors associated with depression in Chilean older adults.A cross-sectional study was carried out in a representative sample of 1,765 adults aged≥60 years participants from the Chilean National Health Survey 2016–***-sion was assessed with the Composite International Diagnostic Interview(CIDI-SF).Associations between the exposure variables and depression were investigated using Poisson regression *** mainﬁndings indi-cated that women showed higher likelihood of depression than men(Prevalence Ratio(PR)=2.6[95%CI:1.40;4.89]).An increased likelihood of depression was found in older adults with chronic pain,multimorbidity(≥2 diseases),previous diagnose of depression,high perception of stress,ﬁnancial stress,and difﬁculties for social *** women,higher likelihood of depression was found for those with the frailty phenotype(PR:8.53[95%CI:1.68;43.32]),rheumatoid arthritis(PR:2.41[95%CI:1.34;4.34]),insomnia(PR:2.99[95%CI:1.74;5.12])and low self-rated well-being(PR:4.94[95%CI:2.26;10.79]).Men who were divorced(PR:7.10[95%CI:1.44;34.90])or widowed(PR:10.83[95%CI:3.71;31.58]),obese(PR:5.08[95%CI:1.48;17.42])and who had asthma(PR:7.60[95%CI:2.31;24.99])were associated with higher odds of *** currentﬁndings may have clinical implications for the early identiﬁcation of older adults more susceptible to depression and also suggest the need to implement cultural and age-sensitive strategies to promote mental health in late life.

关键词： Depression older adults aging late-life depression risk factors

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Simulation Model to the Zika Virus Considering Asymptomatic Population

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Open Journal of Modelling and Simulation 2018年第1期6卷 1-12页

作者： juan carlos Jamboos Dalia Marcela Munoz Anibal Munoz Oscar Andres Manrique Steven Raigosa Grupo de Modelacion Matematica en Epidemiologia(GMME) Facultad de EducacionUniversidad del QuindioArmeniaColombia

A simulation model based on nonlinear ordinary differential equations to interpret the transmission dynamics of Zika Virus (ZIKV), is formulated and analyzed, integrating the asymptomatic human population and coupled to the Aedes aegypti dynamics, the epidemic threshold Basic Reproduction Number R0 is determined, as the spectral radius of Next-Generation Matrix and the system is simulated with MAPLE computing program taking the parameter values from literature.

关键词： Simulation Models Zika Virus(ZIKV) Basic Reproductive Number R_(0) Spectral Radius Asymptomatic Next-Generation Matrix

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Determinants of percutaneous coronary intervention success in repeat chronic total occlusion procedures following an initial failed attempt

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World Journal of Cardiology 2017年第4期9卷 355-362页

作者： Cecilia Cuevas Nicola Ryan Alicia Quirós juan Gustavo del Angel Nieves Gonzalo Pablo Salinas Pilar Jiménez-Quevedo Luis Nombela-Franco Ivan Nunez-Gil Antonio Fernandez-Ortiz carlos Macaya Javier Escaned Cardiovascular Institute Hospital Clinico San Carlos28040 MadridSpain

AIM To investigate the rates and determinants of success of repeat percutaneous coronary intervention(PCI) following an initial failed attempt at recanalising the chronic total occlusions(CTO) *** In 445 consecutive first attempt CTO-PCI procedures in our institution,procedural failure occurred in 149(33.5%). Sixty-four re-PCI procedures were performed in 58 patients(39%) all had a single CTO. Procedural and outcome data in the re-PCI population was entered into the institutional database. A retrospective analysis of clinical,angiographic and procedural data was performed. RESULTS Procedural success was achieved in 41(64%) procedures. Univariate analysis of clinical and angiographic characteristics showed that re-PCI success was associated with intravascular ultrasound(IVUS) guidance(19.5% vs 0%,P = 0.042),while failure was associated with severecalcification(30.4% vs 9.7%,P = 0.047) and a JCTO score > 3(56.5% vs 17.1% P = 0.003). Following multiple regression analysis the degree of lesion complexity(J-CTO score > 3),IVUS use,involvement of an experienced CTO operator and LAD CTO location were significant predictors of successful re-PCI. Overall the complication rate was low,with the only MACCE two periprocedural MI's neither of which required intervention. CONCLUSION Re-PCI substantially increases the overall success rate of CTO revascularization. Predictors of re-PCI success included the use of IVUS,the involvement of an experienced CTO operator in the repeat attempt and the location of the CTO.

关键词： Repeat percutaneous coronary intervention Chronic total occlusion

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Pleistocene history of Iberomys,an endangered endemic rodent from southwestern Europe

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Integrative Zoology 2014年第4期9卷 481-497页

作者： Gloria CUENCA-BESCÓS juan Manuel LÓPEZ-GARCÍA María Angeles GALINDO-PELLICENA Rosa GARCÍA-PEREA Julio GISBERT juan ROFES Jacint VENTURA Research Group Aragosaurus-IUCA PaleontologyEarth Sciences DepartmentUniversity of ZaragozaZaragozaSpain Research Group of Paleobiology and Prehistory Human Studies DepartmentUniversity of FerraraFerraraItaly Research Institute of Evolution and Human Behavior UCM-ISCIIIMadridSpain GALEMIA Conservation and Study of Forgotten VertebratesMadridSpain Department of Stratigraphy and Paleontology Faculty of Sciences and TechnologyUniversity of the Basque CountryGipuzkoaGuipúzcoaSpain Department of Animal Biology Plant Biology and EcologyFaculty of BiosciencesUniversity Autonoma de BarcelonaBarcelonaSpain

The extant Cabrera’s vole,Microtus cabrerae,differs in morphology and evolutionary history from the other species of *** arvicoline has unique derived features in the cranium,mandible and ***bly its most conspicuous features are its large size,the high skull in lateral view,the long and distally broad nasals,and the triangle shape of the anteroconid complex,with a marked labio-lingual asymmetry of the occlusal surface of the first lower *** this study,we propose a phylogenetic lineage that includes Cabrera’s vole in what until now has been the Microtus subgenus *** information and several life history traits support the elevation of Iberomys to the rank of *** Iberomys comprises species that have appeared in succession during the Quaternary:in the Early Pleistocene,the extinct *** in the Middle Pleistocene,the extinct *** and in the Late Pleistocene,the extant ***,the extant species shows several biological singularities,such as multiple polymorphic copies of the SRY male-specific gene in both males and females,and the lowest basal metabolic rate in relation to weight among arvicoline ***,its habitat requirement is unique among the Iberian ***,the biological and paleontological data that we present in this work support the elevation of its taxonomic rank to that of ge*** study also suggests a modification of nomenclature:Microtus(Iberomys)brecciensis is replaced with *** and the common name of the extant M.(I.)cabrerae changed from‘topillo’to‘iberon’to improve conservation and protection actions.

关键词： Cabrera’s vole conservation Iberoccitanian endemism Iberomys origin

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Need for infliximab dose intensification in Crohn's disease and ulcerative colitis

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World Journal of Gastroenterology 2014年第27期20卷 9170-9177页

作者： carlos Taxonera David Olivares juan L Mendoza Manuel Díaz-Rubio Enrique Rey Inflammatory Bowel Disease Unit Department of Gastroenterology Hospital Clínico San Carlos Instituto de Investigación del Hospital Clínico San carlos (IdISSC) Department of Gastroenterology Hospital Clínico San Carlos

AIM: To compare the need for infliximab dose intensification in two cohorts of patients with Crohn's disease(CD) or ulcerative colitis(UC).METHODS: Single centre, uncontrolled, observational study. Consecutive patients with CD and UC who responded to infliximab induction doses were included. Data collected in a prospectively maintained database were retrospectively analysed. Differences in the rates of dose intensification per patient-month and the intensification-free survival time were compared. We also evaluated the interval between the first infliximab induction dose and the first infliximab escalated dose. The weight-adjusted infliximab administration costs were also ***: Fifty nine patients with CD and 38 patients with UC were enrolled. The rate of intensification per patient-month was 3.9% for UC and 1.4% for CD(P = 0.005). The median time from baseline to intensification was significantly shorter in UC compared to CD [6.6 mo(IQR: 4.2-9.5 mo) vs 10.7 mo(IQR: 8.9-11.7 mo), P = 0.005]. In the survival analysis, the cumulative probability of avoiding infliximab dose intensification was significantly higher in CD(P = 0.002). In the multivariate analysis, disease(UC vs CD) was the only factor significantly associated with dose intensification. The infiximab administration costs during the first year were significantly higher for UC compared to CD(mean ± SD 234.9 ± 53.3 Euros/kg vs 212.3 ± 15.1 Euros/kg, P = 0.03).CONCLUSION: The rate of infliximab dose intensification per patient-month is significantly higher in UC patients. The infliximab administration costs are also significantly higher in patients with UC.

关键词： Crohn’s disease Ulcerative colitis Infliximab Dose

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Clinicopathological differences,risk factors and prognostic scores for western patients with intestinal and diffuse-type gastric cancer

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World Journal of Gastrointestinal Oncology 2022年第6期14卷 1162-1174页

作者： Cristina Díaz del Arco Lourdes Estrada Muñoz Luis Ortega Medina Elena Molina Roldán MÁngeles Cerón Nieto Soledad García Gómez de las Heras M Jesús Fernández Aceñero Department of Surgical Pathology Hospital Clínico San CarlosMadrid 28040Spain Department of Legal Medicine Psychiatry and PathologyComplutense University of MadridMadrid 28040Spain Department of Surgical Pathology Hospital Rey Juan CarlosMadrid 28933Spain Department of Basic Medical Sciences Rey Juan Carlos UniversityMadrid 28933Spain

BACKGROUND In the molecular era,the Laurén system is still a cost-effective and widely implemented classification for gastric cancer(GC)and it has been recently associated with clinical,histological and molecular features of these *** recent advances in the understanding of the molecular biology of GC,there is a need to develop new prognostic tools for patient stratification in clinical ***,the identification of easily available prognostic factors in patients with intestinal and diffuse-type tumors can significantly improve risk assessment and patient stratification in *** To identify clinicopathological differences,risk factors,and to develop costeffective prognostic scores for patients with intestinal and diffuse-type *** Retrospective study of all patients undergoing surgery for GC at a tertiary referral center from 2001 to 2019.286 cases met inclusion criteria(intestinal:190,diffuse:96).Clinical data and gross findings were *** specimens were reviewed by two independent pathologists and a detailed protocol for histologic evaluation was *** tissue microarrays(TMAs)were constructed and sections of the TMA block were immunostained for HERCEPTEST,MSH2,MSH6,MLH1 and *** analyses were performed and prognostic scores were developed based on hazard *** Intestinal and diffuse-type GC showed different epidemiological,clinicopathological and prognostic *** tumors were significantly associated with younger age,less symptomatology,flat morphology,deeper invasion,perineural infiltration,advanced stage at diagnosis,administration of adjuvant therapy and poorer *** lesions were fungoid or polypoid,showed necrosis,desmoplasia,microsatellite instability and HERCEPTEST positivity and were diagnosed at earlier *** depth,desmoplasia,macroscopic type and lymph node involvement were independently related to the Laurén ***,intestinal and diffuse GC were asso

关键词： Gastric cancer Clinicopathological Score Prognosis Laurén Molecular

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Vector-valued operators, optimal weighted estimates and the C_p condition

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Science China Mathematics 2020年第7期63卷 1339-1368页

作者： María Eugenia Cejas Kangwei Li carlos Pérez Israel Pablo Rivera-Ríos BCAM—Basque Center for Applied Mathematics Bilbao 48009Spain CONICET Departamento de MatematicaFacultad de Ciencias ExactasUniversidad Nacional de La PlataLa Plata 1900Argentina Department of Mathematics University of the Basque CountryBilbao 48080Spain Ikerbasque Basque Foundation of ScienceBilbao 48013Spain INMABB CONICETDepartamento de MatematicaUniversidad Nacional del SurBahia Blanca 8000Argentina

In this paper some new results concerning the C_p classes introduced by Muckenhoupt(1981)and later extended by Sawyer(1983),are *** particular,we extend the result to the full expected range p>0,to the weak norm,to other operators and to their vector-valued *** of those results rely upon sparse domination,which in the vector-valued case are provided as *** will also provide sharp weighted estimates for vector-valued extensions relying on those sparse domination results.

关键词： A_p weights quantitative estimates C_p estimates vector-valued extensions sparse domination maximal functions Calderon-Zygmund operators commutators

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一个由干湿交替极端气候事件主导的内陆湖盆:来自鄂尔多斯盆地上三叠统延长组露头剖面的沉积学证据

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地球科学 2023年第1期48卷 293-316页

作者：李相博刘化清杨伟伟张艳 carlos Zavala 吉利民杨占龙郝彬黄军平王菁中国石油勘探开发研究院西北分院甘肃兰州730020 中国石油集团油藏描述重点实验室甘肃兰州730020 中国石油长庆油田分公司勘探开发研究院陕西西安710018 GCS Argentina Molina Campos 150Bahía Blanca 8000 Departamento de Geología Universidad Nacional del SurSan Juan 670Bahía Blanca 8000 中国科学院西北生态环境资源研究院甘肃兰州730000

鄂尔多斯盆地是我国陆上最主要的油气盆地之一,三叠系延长组是该盆地的主要含油层位.通过对延长组典型露头的考察与研究,结合古生物及岩性岩相资料,取得了3点新认识:(1)恢复了延长组沉积时期的古气候环境,认为其具有三分性,其中早期拉... 详细信息

鄂尔多斯盆地是我国陆上最主要的油气盆地之一,三叠系延长组是该盆地的主要含油层位.通过对延长组典型露头的考察与研究,结合古生物及岩性岩相资料,取得了3点新认识:(1)恢复了延长组沉积时期的古气候环境,认为其具有三分性,其中早期拉丁期为干旱环境;中期受卡尼期梅雨事件(CPE)影响气候发生突变,转变为温暖潮湿气候环境;晚期诺利-瑞替期再次转变为半干旱-半湿润气候环境.(2)CPE事件改变了延长组沉积物搬运与沉积方式,其中CPE事件之前与事件之后的干旱环境时期,主要发育暴雨洪水引发的季节性河流、决口扇、决口河道沉积;CPE事件当中及卡尼中期,陆源碎屑物质主要通过异重流、浊流及砂质碎屑流等多种途径搬运至水下环境,形成富砂质重力流事件沉积,同时受CPE事件控制,在深水环境还发育了黑色富有机质页岩事件沉积.(3)建立了延长组干旱与潮湿两种环境沉积模式,干旱环境湖泊水域面积较小,主要沉积单元为洪泛平原、季节性河道及决口扇,主要沉积方式为填平补齐、加积式沉积,不发育前积沉积现象;潮湿环境湖泊水域面积较大,发育完整的陆相河流-三角洲-湖泊-重力流沉积体系,由于具有稳定的长流水,河道相对固定,加之受湖平面变化控制,其沉积方式以前积作用为主.该认识不仅对于深入探讨鄂尔多斯延长组大型坳陷湖盆形成演化机理、沉积层序充填演化及指导油气勘探实践有积极意义,而且对揭示晚三叠世全球极端气候事件在内陆湖盆的沉积学记录有积极意义,可以填补CPE事件在古特提斯东缘泛大陆内部沉积响应研究的空白.

关键词：干湿气候交替洪水事件梅雨事件沉积模式延长组晚三叠世鄂尔多斯盆地石油地质学

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痤疮并非HIV感染的标志:36例患者回顾

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世界核心医学期刊文摘（皮肤病学分册） 2005年第11期1卷 43-44页

作者： Almagro M. del pozo J. Garca-Silva J. 焦婷 Dr. Servicio de Dermatologa Hospital Juan Canalejo Xubias de Arriba 84 ES-15006 La Corǖna Spain

Introduction: Several diseases with follicular occlusion have been described in HIV-infected patients and can appear isolated or associated with each other in an independent disease named ‘HIV-associated follicular syndrome’. Worsening of cutaneous lesions during the course of infection in patients with previous acne vulgaris, late onset or severe forms of acne have been reported in HIV-infected patients. Patients and Methods: A prospective study of 335 HIV-infected patients was performed in our hospital. A meticulous dermatological exploration in all patients was made, and multiple data were stored into a Microsoft Access 97 program. Patients diagnosed as having acne were considered separately, and we studied their characteristics. A statistical analysis with SPSS 9.0 (Statistical Package for the Social Sciences) was performed. Results: Thirty-six patients (10.8%)were diagnosed as having acne. Papulopustular lesions were themost frequent clinical presentation. Most lesions were localized on the face or on the back, and 80%of patients had mild to moderate acne; 40%of them required no treatment and the remainderwas treated with topical measures,oral antibiotics and isotretinoin. 85%of cases reported the onset of acne during adolescence or before HIV infection and without any relationship with this disease. No relation between acne intensity and stage of HIV infection was observed. A multivariate analysis showed that the most important variable was age. Discussion: In contrast to previous reports, no greater intensity or modifications in acne lesions were observed in our HIV-infected patients during the course of the disease. In the majority of cases, cutaneous lesions started before HIV infection, during adolescence, and the most important factor for suffering from acnewas young age. In contrast to data reported in the literature, no relation of acne lesions to CD4 lymphocyte count or AIDS case criteria was found in our patients. Conclusions: Acne in HIV-infected pat

关键词： HIV感染中度痤疮寻常型痤疮痤疮患者淋巴细胞总数统计学分析皮损形态丘疱疹前瞻性调查迟发型

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