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Rapid-onset antidepressant efficacy of glutamatergic system modulators:The neural plasticity hypothesis of depression

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Neuroscience Bulletin 2015年第1期31卷 75-86页

作者： Jing Wang Liang Jing juan-carlos Toledo-Salas Lin Xu Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of Zoology KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of Sciences Kunming College of Life Science University of the Chinese Academy of Sciences

Depression is a devastating psychiatric disorder widely attributed to defi cient monoaminergic signaling in the central nervous system. However,most clinical antidepressants enhance monoaminergic neurotransmission with little delay but require 4-8 weeks to reach therapeutic efficacy,a paradox suggesting that the monoaminergic hypothesis of depression is an oversimplifi cation. In contrast to the antidepressants targeting the monoaminergic system,a single dose of the N-methyl-D-aspartate receptor（NMDAR） antagonist ketamine produces rapid（within 2 h） and sustained（over 7 days） antidepressant effi cacy in treatment-resistant patients. Glutamatergic transmission mediated by NMDARs is critical for experience-dependent synaptic plasticity and learning,processes that can be modifi ed indirectly by the monoaminergic system. To better understand the mechanisms of action of the new antidepressants like ketamine,we review and compare the monoaminergic and glutamatergic antidepressants,with emphasis on neural plasticity. The pathogenesis of depression may involve maladaptive neural plasticity in glutamatergic circuits that may serve as a new class of targets to produce rapid antidepressant effects.

关键词： depression stress neural plasticity glutamatergic transmission monoamine-based antidepressant ketamine

Effect of genistein supplementation of thawing medium on characteristics of frozen human spermatozoa

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Asian Journal of Andrology 2010年第3期12卷 431-441,I0012页

作者： juan carlos Martinez-Soto juan de DiosHourcade Alfonso Gutierrez-Adan Jose Lorenzo Landeras Joaquin Gadea Department of Physiology School of Veterinary Murcia University Murcia 30100 Spain IVI- MURCIA Murcia 30007 Spain Department of Animal Reproduction INIA Madrid 28040 Spain

In this study, we evaluated the effects of genistein supplementation of the thawing extender on frozen-thawed human semen parameters. We analyzed the effect of supplementation on sperm motility, capacitation （membrane lipid disorder）, reactive oxygen species （ROS） generation, chromatin condensation and DNA damage. Using this preliminary information, it maybe possible to improve the cryopreservation process and reduce the cellular damage. We have confirmed that the isoflavone genistein （10 μmol L-1） has antioxidant properties on the frozen-thawed spermatozoa. This results in a decreased ROS production that shows a slight improvement in the sperm motility, and decreases the membrane lipid disorder and DNA damage caused by cryopreservation. These results suggest an effect of genistein on sperm functionality that could be of interest for assisted reproduction treatments using frozen- thawed human spermatozoa, but further studies will be necessary to confirm our findings and to evaluate the possible clinical applications.

关键词： antioxidants cryopreservation DNA damage genistein isoflavones sperm motility

Age and sex differences in niche use at molt and its effect on plumage coloration characteristics in a bird

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Current Zoology 2019年第3期65卷 251-260页

作者： Emilio PAGANI-NUNEZ Craig R.A.BARNETT juan carlos SENAR State Key Laboratory of Biocontrol Department of Ecology/School of Life Sciences Sun Yat-sen University Guangzhou China Department of Zoology Graduate School of Science University of Kyoto Kitashirakawaoiwake-cho Sakio-ku Kyoto Japan Natural History Museum of Barcelona Barcelona Spain

Bird plumage is often very colorful and can communicate the quality of the bearer to conspecifics. These plumage-based signals of quality are composed of multiple pigments (e.g., melanin and carote no ids). Therefore, sex and age classes, which often show marked differe nces in plumage coloration, may have different dietary needs for the different plumage components and this might promote pref ere nces for differe nt dietary niches at different molting stages. However, no study has addressed the role that changes in niche use play in the expression of multiple component plumage signals in birds. We used stable isotope analysis to test the hypothesis that niche use is related to age and sex and to differently cultured plumage patches, yellow carotenoid-based and black melanin-based, in great tits Parus major. We recorded high niche overlap between plumage patches, although δ15N was higher in black than yellow plumage. Niche overlap was relatively low for age classes and relatively high for sex classes, and age classes showed a contrasting pattern of niche overlap between carotenoid- and melanin-based plumages. Moreover,δ13C, but not δ15N, had a significant negative relationship with carotenoid-based plumage, which was only apparent in juveniles. Take n together, our results demonstrate that n iche use had a moderate in fluence on plumage coloration characteristics of great tit individuals, mostly associated with δ13C rather than with δ15N and with age rather than with sex. Therefore, our study is significant because it confirms the releva nee of n iche use duri ng orn ame nt production in free-livi ng birds.

关键词： carotenoids great tits melanin multiple ornaments niche overlap stable isotopes

Topological Minors in Bipartite Graphs

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Acta Mathematica Sinica,English Series 2011年第11期27卷 2085-2100页

作者： Camino BALBUENA Martin CERA Pedro GARCIA-VAZQUEZ juan carlos VALENZUELA Departament de Matematica Aplicada III Universitat Politecnica de Catalunya C/ Jordi Girona 1-3 （ Edifici C2 Despatx 302） 08034 Barcelona Spain Departamento de Matemdtica Aplicada I Universidad de SeviUa EUIT Agrlcola Ctra. Utrera Kin. 1 41013 Sevilla Spain Departamento de Matemdtica Aplicada I Universidad de Sevilla ETS Arquitectura Avda. Reina Mercedes 2 41012 Sevilla Spain Departamento de Matemdticas Universidad de Cddiz EPS Algeciras Avda. Ramdn Puyol s/n 11202 Algeciras Spain

For a bipartite graph G on m and n vertices, respectively, in its vertices classes, and for integers s andt such that 2≤ s ≤ t, 0≤ m-s ≤ n-t, andre＋n≤ 2s＋t-1, we prove that if G has at least mn- （2（m - s）＋ n - t） edges then it contains a subdivision of the complete bipartite K（s,t） with s vertices in the m-class and t vertices in the n-class. Furthermore, we characterize the corresponding extremal bipartite graphs with mn- （2（m - s）＋ n - t ＋ 1） edges for this topological Turan type problem.

关键词： Bipartite graphs extremal graph theory topological minor

Adenine base editing disease mutations in to mimic or correcl rodents

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Protein & Cell 2018年第9期9卷 752-753页

作者： Ruotong Ren juan carlos Izpisua Belmonte Guang-Hui Liu Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric Disorders Xuanwu Hospital of Capital Medical University Beijing 100053 China National Laboratory of Biomacromolecules CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China Gene Expression Laboratory Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla California 92037 USA Institute of Stem cell and Regeneration Chinese Academy of Sciences Beijing 100101 China

Cytidine base editors （CBEs, rAPOBECI-nCas9-UGI） and adenine base editors （ABEs, TadA-TadA＊-nCas9） are newly developed genome-editing tools that have enabled highly efficient base conversions （CoG to T·A or A·T to G·C） at designated target sites （Komor et al., 2016; Gaudelli et al., 2017）. Both types of base editors enzymatically catalyze deamination of target bases and respectively replace C with U or A with I.

关键词： Basic Editing Adenine Base GSD II Hereditary Tyrosinemia Type Target Site Identification

Denitrification-nitrification process in permeable coastal sediments: An investigation on the effect of salinity and nitrate availability using flow-through reactors

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Acta Oceanologica Sinica 2021年第9期40卷 1-12页

作者： Shan Jiang Mark Kavanagh juan Severino Pino Ibánhez carlos Rocha State Key Laboratory of Estuarine and Coastal Research East China Normal University School of Natural Sciences Trinity College Dublin Trinity Centre for the Environment School of Natural Sciences Trinity College Dublin Instituto de Investigacións Mari?as Consejo Superior de Investigaciones Científicas

Permeable coastal sediments act as a reactive node in the littoral zone,transforming nutrients via a wide range of biogeochemical *** rates are controlled by abiotic factors,e.g.,salinity,temperature or solute ***,a series of incubation experiments,using flow-through reactors,were conducted to simulate the biogeochemical cycling of nitrate (NO3~?) and phosphorus (P) in permeable sediments under differentNO3~?availability conditions (factor I) along a salinity gradient (admixture of river and seawater,factor II).In an oligotrophic scenario,i.e.,unamendedNO3~?concentrations in both river and seawater,sediments acted as a permanent net source ofNO3~?to the water *** peak production rate occurred at an intermediate salinity(20).IncreasingNO3~?availability in river water significantly enhanced netNO3~?removal rates within the salinity range of 0 to 30,likely via the denitrification pathway based on the sediment microbiota *** this scenario,the most active removal was obtained at salinity of *** both river and seawater were spiked with NO3~?,the highest removal rate switched to the highest salinity (36).It suggests the salinity preference of theNO3~?removal pathway by local denitrifiers (e.g.,Bacillus and Paracoccus) and thatNO3~?removal in coastal sediments can be significantly constrained by the dilution relatedNO3~?*** with the obtained variation forNO3~?reactions,permeable sediments acted as a sink of soluble reactive P in all treatments,regardless of salinity andNO3~?input concentrations,indicating a possibility of P-deficiency for coastal water from the intensive cycling in permeable ***,the net production of dissolved organic carbon (DOC) in all treatments was positively correlated with the measuredNO3~?reaction rates,indicating that the DOC supply may not be the key factor forNO3~?removal rates due to the consumption by intensive aerobic *** the intensive pr

关键词： NO − 3 production and removal flow-through reactors salinity stable isotopes permeable sediments

A Non-Destructive Time Series Model for the Estimation of Cherry Coffee Production

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Computers, Materials & Continua 2022年第3期70卷 4725-4743页

作者： Jhonn Pablo Rodríguez David Griol Zoraida Callejas juan carlos Corrales Telematics Engineering Group University of CaucaPopayán190002Colombia INRAE University of ToulouseUMR 1248 AGIRF-31326Castanet TolosanFrance Department of Software Engineering University of GranadaGranada18071Spain

Coffee plays a key role in the generation of rural employment in *** than 785,000 workers are directly employed in this activity,which represents the 26%of all jobs in the agricultural *** coffee growers estimate the production of cherry coffee with the main aim of planning the required activities,and resources(number of workers,required infrastructures),anticipating negotiations,estimating,price,and foreseeing losses of coffee production in a specific *** important processes can be affected by several factors that are not easy to predict(e.g.,weather variability,diseases,or plagues.).In this paper,we propose a non-destructive time series model,based on weather and crop management information,that estimate coffee production allowing coffee growers to improve their management of agricultural activities such as flowering calendars,harvesting seasons,definition of irrigation methods,nutrition calendars,and programming the times of concentration of production to define the amount of personnel needed for *** combination of time series and machine learning algorithms based on regression trees(XGBOOST,TR and RF)provides very positive results for the test dataset collected in real conditions for more than a *** best results were obtained by the XGBOOST model(MAE=0.03;RMSE=0.01),and a difference of approximately 0.57%absolute to the main harvest of 2018.

关键词： Cherry coffee production estimation learner approaches time series weather data crop management data

Virtual Conductance Based Cascade Voltage Controller for VSCs in Islanded Operation Mode

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Journal of Modern Power Systems and Clean Energy 2022年第6期10卷 1704-1713页

作者： Francisco Jesús Matas-Díaz Manuel Barragán-Villarejo juan carlos Olives-Camps juan Manuel Mauricio JoséMaría Maza-Ortega Department of Elec‐trical Engineering Universidad de SevillaSeville 41092Spain

Voltage source converters have become the main enabler for the integration of distributed energy resources in *** the case of islanded operation,these devices normally set the amplitude and frequency of the network voltage by means of a cascade controller composed of an outer voltage control loop and an inner current control *** strategies to compute the gains of both control loops have been proposed in the literature in order to obtain a fast and decoupled response of the voltages at the point of common *** paper proposes an alternative and simple methodology based on the introduction of a virtual conductance in the classic cascade *** strategy allows to design each control loop independently,obtaining a closed-loop response of a first-order *** this way,the gains of each control loop are easily derived from the parameters of the LC coupling filter and the desired closed-loop time ***,a state observer is included in the controller to estimate the inductor current of the LC filter in order to reduce the number of required measurements.A laboratory testbed is used to validate and compare the proposed *** experimental results demonstrate the effectiveness of the proposal both in steady-state and transient regimes.

关键词： Voltage source converter microgrid cascade controller virtual conductance

Unravelling host-mediated effects on hemiparasitic Mexican mistletoe Psittacanthus calyculatus(DC.)*** traits linked to mutualisms with pollinators and seed dispersers

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Journal of Plant Ecology 2018年第6期11卷 827-842页

作者： Sandra Rodríguez-Mendieta carlos Lara juan Francisco Ornelas Centro de Investigación en Ciencias Biológicas Universidad Autónoma de Tlaxcalakm 10.5 Carretera San Martín Texmelucan-TolucaSan Felipe IxtacuixtlaTlaxcala 90120Mexico Departamento de Biología Evolutiva Instituto de EcologíaA.C.(INECOL)Carretera antigua a Coatepec 351XalapaVeracruz 91080Mexico

Aims While the influence of mistletoe-host interactions on each other’s evolution is well-recognized,the role of interactions between mis-tletoes and its mutualistic pollinators and seed dispersers mediated by host species is relatively *** Here,we examine the effects of host species(Mexican hawthorn Crataegus mexicana DC,black cherry Prunus serotina Ehrh.,leather-leaf Mexican oak Quercus crassipes Bonpl.)on flower morphology,nectar production,pollinator visitation rate and female reproduct-ive fitness in hemiparasitic Mexican mistletoe Psittacanthus caly-culatus(DC.)***(Loranthaceae)populations at three different *** first measured the lengths of corolla,style,stamen,exerted stamen and anther,the length and width of the ovary and nectar availability for mistletoe flowers in natural ***,we evaluated flower visitation and measured(length and width)and weighed the fruits and its seeds of mistletoes growing on each of the three host ***,we evaluated the effects of host species,location and flower traits on fruit or seed size variation(both as proxies of reproductive fitness).Important Findings We found mistletoes growing on natural hosts *** and *** produced larger flowers,fruits and seeds than mistle-toes on cultivated ***,these differences varied across *** amount of available nectar and hummingbird vis-itation rates in flowers of mistletoes on *** was higher at the three sites than in flowers of mistletoes on *** or *** effects of host species,study site and floral trait covariates affected significantly all fitness measures,indicating that mistletoes’reproductive fitness is affected differently depending on the host species and their site of *** host-associated differ-ences in reproduction might have implications for interactions with mutualistic vectors.

关键词： floral and fruit traits hosts hummingbirds local host adaptation mistletoes nectar parasitic plants pollination Psittacanthus