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Genome and clonal hematopoiesis stability contrasts with immune,cfDNA,mitochondrial,and telomere length changes during short duration spaceflight

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Precision Clinical Medicine 2024年第1期7卷 1-13页

作者： J.Sebastian Garcia-Medina Karolina Sienkiewicz S.Anand Narayanan Eliah G.Overbey Kirill Grigorev Krista A.Ryon Marissa Burke Jacqueline Proszynski Braden Tierney Caleb M.Schmidt Nuria Mencia-Trinchant Remi Klotz Veronica Ortiz Jonathan Foox Christopher Chin Deena Najjar Irina Matei Irenaeus Chan carlos Cruchaga Ashley Kleinman JangKeun Kim Alexander Lucaci Conor Loy Omary Mzava Iwijn De Vlaminck Anvita Singaraju Lynn E.Taylor Julian C.Schmidt Michael A.Schmidt Kelly Blease juan Moreno Andrew Boddicker Junhua Zhao Bryan Lajoie Andrew Altomare Semyon Kruglyak Shawn Levy Min Yu Duane C.Hassane Susan M.Bailey Kelly Bolton Jaime Mateus Christopher E.Mason Department of Physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Department of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Department of Stem Cell Biology and Regenerative Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Space Exploration Technologies Corporation HawthomeCA 90250USA Sovaris Aerospace BoulderCO 80302USA Advanced Pattern Analysis&Human Performance Group BoulderCO 80302USA Children's Cancer and Blood Foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Meyer Cancer Center Weill Cornell MedicineNew YorkNY 10065USA Department of Nutrition and Integrative Physiology Florida State UniversityTallahasseeFL 32306USA Department of Systems Engineering Colorado State UniversityFort CollinsCO 80523USA Element Biosciences San DiegoCA 10055USA Department of Environmental and Radiological Health Sciences Colorado State UniversityFort CollinsCO 80523USA Cell and Molecular Biology Program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University St Louis Oncology Division St.LouisMO 63100USA Meinig School of Biomedical Engineering Cornell UniversityIthacaNY 14853USA The Feil Family Brain and Mind Research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)mission,the first all-civilian orbital flight mission,investigated the physiological effects of short-duration spaceflight through a multi-omic *** advances,there remains much to learn about human adaptation to spaceflight's unique challenges,including microgravity,immune system perturbations,and radiation *** To provide a detailed genetics analysis of the mission,we collected dried blood spots pre-,during,and post-flight for DNA *** length was measured by quantitative PCR,while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations.A robust bioinformatic pipeline was used for data analysis,including variant calling to assess mutational *** Telomere elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased immune cell signatures *** significant clonal hematopoiesis of indeterminate potential(CHIP)or whole-genome instability was *** long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early development of CHIP in astronauts,an understudied phenomenon as previous studies have focused on career *** study will serve as a reference point for future commercial and non-commercial spaceflight,low Earth orbit(LEO)missions,and deep-space exploration.

关键词： genomes clonal hematopoiesis stability immune mitochondria ribosomes spaceflight

A Note on Extreme Points in Dual Spaces

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Acta Mathematica Sinica,English Series 2013年第3期29卷 471-476页

作者： juan Francisco MENA-JURADO juan carlos NAVARRO-PASCUAL Departamento de Análisis Matemático Facultad de Ciencias Universidad de Granada Departamento de lgebra y Análisis Matemático Universidad de Almería

Given a normed space X it can be easily proven that every extreme point in Bx＊, the unit ball of X＊, is the restriction of an extreme point in Bx Our purpose is to study when the restrictions of extreme points in B... 详细信息

关键词： Extreme point Ll-predual M-ideal

Ligation or Occlusion of the Internal Iliac Arteries for the Treatment of Placenta Accreta Spectrum:Why Is This Technique Still Performed?

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Maternal-Fetal Medicine 2023年第3期5卷 131-136页

作者： Albaro José Nieto-Calvache José M.Palacios-Jaraquemada Rozi Aditya Aryananda Nicolas Basanta juan Manuel Burgos-Luna Fernando Rodriguez carlos Ordonez Daniela Sarria-Ortiz Laura Munoz-Cordoba juan carlos Quintero Valentina Galindo-Velasco Adriana Messa-Bryon Fundación Valle del Lili Departamento de Ginecología y ObstetriciaClínica de Espectro de Acretismo PlacentarioCali 760032Colombia Latin American Group for the Study of Placenta Accreta Spectrum Departamento de Ginecología y Obstetricia Hospital Universitario CEMICBuenos Aires C1431FWOArgentina Department of Obstetrics and Gynecology Dr.Soetomo Academic General HospitalUniversitas AirlanggaSurabaya 60131Indonesia Departamento de Ginecología y Obstetricia Hospital General de Agudos Juan A FernándezBuenos Aires 7011Argentina Fundación Valle del Lili Centro de Investigaciones ClínicasCali 760032Colombia Unidad de diagnóstico prenatal Clínica ImbanacoGrupo Quirón SaludCali 760042Colombia Departamento de ginecología y obstetricia Universidad del ValleCali 760042Colombia Universidad Icesi Facultad de Ciencias de la SaludCali 760031Colombia

Introduction The major complication of placenta accreta spectrum(PAS)disorder is massive bleeding;therefore,multiple vascular interventions have been described to prevent or treat pelvic *** of the internal iliac arteries(IIAs)was published more than 130 years ago,and although research relating to the physiology of this procedure has demonstrated poor vascular control over the last few decades,2-this technique has evolved into an established technique known as endovascular IIA balloon occlusion.

关键词： balloon Internal bleeding

The effects of patch richness on con-specific interference in the parasitoid Ibalia leucospoides （Hymenoptera： Ibaliidae）

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Insect Science 2010年第4期17卷 379-385页

作者： Valeria Fernandez-Arhex juan carlos Corley Lab. Ecologia de tnsectos INTA EEA-Bariloche Bariloche Rio Negro Argentina

We experimentally studied con-specific interference in Ibalia leucospoides, a parasitoid of the woodwasp Sirex noctilio, on pine logs containing variable numbers of woodwasp larvae. Competiton occurred when two different-sized female parasitoids foraged on a host patch, and consequently the small female always abandoned the patch. Regardless of host density, con-specific presence did not affect the attack rate, the number of hosts attacked, nor patch residence time by the winner, when compared to a control female that foraged alone. In contrast, con-specific presence reduced patch time and the number of hosts attacked by the loser. Finally patch time （by both） as well as number of hosts attacked （by the winner only） increased with host density per patch. Our results suggest that con-specific presence has different consequences for different-sized females during patch exploitation.

关键词： aggregation direct competition host-parasitoid interactions parasitoid com-petition patch quality Sirex noctilio

Nanotechnology in aquaculture: Applications, perspectives and regulatory challenges

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Aquaculture and Fisheries 2022年第2期7卷 185-200页

作者： carlos Fajardo Gonzalo Martinez-Rodriguez Julian Blasco juan Miguel Mancera Bolaji Thomas Marcos De Donato School of Tourism and Maritime Technology Polytechnic of Leiria(MARE-IPLeiria)Santuario de Nossa Senhora dos RemediosCampus 4Peniche2520-641Portugal Department of Biology Faculty of Marine and Environmental SciencesInstituto Universitario de Investi-gaci´on Marina(INMAR)Campus de Excelencia Internacional del Mar(CEI⋅MAR)University of Cadiz(UCA)Puerto Real11519Spain Institute of Marine Sciences of Andalusia(ICMAN) Department of Marine Biology and AquacultureSpanish National Research Council(CSIC)Puerto Real11519Spain Department of Biomedical Sciences Rochester Institute of TechnologyRochester14623USA Tecnologico de Monterrey Escuela de Ingenieria y CienciasQueretaro76130Mexico

Aquaculture is considered one of the most important food production systems both in terms of economic impact and food security,and the ongoing development of this industry is a key factor in the strategy to guarantee global nutritional ***,different types of nanotechnology-based systems have been employed to increase its production,efficiency and *** efforts have been made in the fields of health management,enhancement of fish and shellfish development by dietary supplementation with nutraceuticals,but also in the processing and preservation of seafood and water treatment,among ***,nanotechnology has a significant role to play in the improvement of the efficiency and the environmental impact of this *** this perspective,we propose to review the current situation of nanotechnology in the field of aquaculture and fisheries,emphasizing not only in current applications,and future prospects,but also in the ethical and governance aspects associated with this topic.

关键词： Health management Nano-regulation Nutraceuticals Preservation of seafood Risk assessment

Experimental analysis of infragravity waves in two eroded microtidal beaches

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Acta Oceanologica Sinica 2017年第5期36卷 31-43页

作者： MARIO Conde-Frias LUIS Otero juan Camilo Restrepo juan carlos Ortiz Geosciences Research Group GE04 Department of PhysicsUniversidad del NorteBarranquilla 081007Colombia

This work aims to contribute to the characterization and understanding ofinfragravity waves on two beaches with erosion problems. For this reason, we have used an array of ADCP and a pressure sensor to measure wave parameters and pressure inside and outside of the surf zone during the dry and rainy period in the beaches of Galerazamba and Manzanillo del Mar （both dissipative and eroded beaches） located in the Colombian Caribbean coast. Based on these measurements, we have carried out a spectral analysis in order to identify the frequency components that characterize the wave and its energy; thus, we identified the characteristic frequencies of iufragravity waves to finally filter the infragravity signal on each beach in different seasonal periods. Among the results of the Welch spectrum applied to surface elevation time series, we found that, the frequencies＇ energy of the sea-swell band decreases due to bottom friction and wave breaking as the wave approaches the shore, while the frequencies＇ energy of the infragravity band increases significantly. In addition, for the wavelet analysis, we could observe how the energy of the infragravity band, especially the lowest frequencies gain energy as the waves approaches the coast. Furthermore, based on the infragravity wave obtained from the extreme wave event registered during the field campaign we can conclude that the contribution of this signal is important in the erosion problems presented in the beaches of Galerazamba and Manzanillo del Mar. Finally, these results show the need to realize other studies that allow us to understand deeply, the role of infragravity waves on the morphological changes that occurs in these beaches.

关键词： infragravity waves long waves experimental analysis fourier analysis wavelet transform

An Intelligent Transportation System Application for Smartphones Based on Vehicle Position Advertising and Route Sharing in Vehicular Ad-Hoc Networks

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Journal of Computer Science & Technology 2018年第2期33卷 249-262页

作者： Seilendria A. Hadiwardoyo Subhadeep Patra carlos T. Calafate juan-carlos Cano Pietro Manzoni Deptartment of Computer Engineering Universitat Politecnica de Valencia Valencia 46022 Spain

Alerting drivers about incoming emergency vehicles and their routes can greatly improve their travel time in congested cities, while reducing the risk of accidents due to distractions. This paper contributes to this goal by proposing Messiah, an Android application capable of informing regular vehicles about incoming emergency vehicles like ambulances, police cars and fire brigades. This is made possible by creating a network of vehicles capable of directly communicating between them. The user can, therefore, take driving decisions in a timely manner by considering incoming alerts. Using the support of our GRCBox hardware, the application can rely on vehicular ad-hoc network communications in the 5 GHz band, being V2V （vehicle-to-vehicle） communication provided through a combination of Android-based smartphone and our GRCBox device. The application was tested in three different scenarios with different levels of obstruction, showing that it is capable of providing alerts up to 300 meters, and notifying vehicles within less than one second.

关键词： intelligent transportation systems (ITS) vehicular ad-hoc network (VANET) mobile application Android,navigation ad-hoc network

Site Characterization Index for Continuous Power Quality Monitoring Based on Higher-order Statistics

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Journal of Modern Power Systems and Clean Energy 2022年第1期10卷 222-231页

作者： Olivia Florencias-Oliveros juan-José González-de-la-Rosa Jose-María Sierra-Fernández Agustín Agüera-Pérez Manuel-Jesús Espinosa-Gavira José-carlos Palomares-Salas Department of Automation Engineering ElectronicsArchitecture and Computers NetworksResearch Group TIC168Higher Polytechnic SchoolUniversity of CádizAlgeciras 11202Spain

The high penetration of distributed generation(DG)has set up a challenge for energy management and consequently for the monitoring and assessment of power quality(PQ).Besides,there are new types of disturbances owing to the uncontrolled connections of non-linear *** stochastic behaviour triggers the need for new holistic indicators which also deal with big data of PQ in terms of compression and scalability so as to extract the useful information regarding different network states and the prevailing PQ disturbances for future risk assessment and energy management *** and continuous monitoring would guarantee the report to claim for damages and to assess the risk of PQ *** this context,we propose a measurement method that postulates the use of two-dimensional(2D)diagrams based on higher-order statistics(HOSs)and a previous voltage quality index that assesses the voltage supply waveform in a continous monitoring *** suitable for both PQ and reliability applications,the results conclude that the inclusion of HOS measurements in the industrial metrological reports helps characterize the deviations of the voltage supply waveform,extracting the individual customers’pattern fingerprint,and compressing the data from both time and spatial *** method allows a continuous and robust performance needed in the SG ***,the method can be used by an average consumer as a probabilistic method to assess the risk of PQ deviations in site characterization.

关键词： Continuous statistical monitoring big data data compression higher-order statistics(HOSs) power quality(PQ)

Understanding root-zone soil moisture in agricultural regions of Central Mexico using the ensemble Kalman filter,satellite-derived information,and the THEXMEX-18 dataset

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International Journal of Digital Earth 2022年第1期15卷 52-78页

作者： Héctor Ernesto Huerta-Bátiz Daniel Enrique Constantino-Recillas Alejandro Monsiváis-Huertero juan carlos Hernández-Sánchez Jasmeet Judge Ramón Sidonio Aparicio-García Escuela Superior de Ingeniería Mecánica y Eléctrica Unidad Ticomán Instituto Politécnico NacionalMexico CityMexico Escuela Superior de Ingeniería Mecánica y Eléctrica Unidad Zacatenco Instituto Politécnico NacionalMexico CityMexico Tecnológico Nacional de México-TESE EcatepecMexico Department of Agricultural and Biological Engineering University of FloridaGainesvilleFLUSA

An Ensemble Kalman Filter(EnKF)-based assimilation algorithm was implemented to estimate root-zone soil moisture(RZSM)using a Soil-Vegetation-Atmosphere Transfer(SVAT)model during a complete growing season of corn in Central *** and field soil moisture(SM)observations and NASA SMAP SM retrievals were used to understand the effect of vertically spatial updates and uncertainties in meteorological forcings on RZSM *** of RZSM every 3 days using SM observations at 4 depths lowered the averaged standard deviation(ASD)and the root mean square error(RMSE)by 60%and 50%,respectively,compared to the open-loop *** assimilation of synthetic SM at the top 0-5 cm obtained RZSM closer to observations compared to THEXMEX-18 SM measurements and SMAP SM *** between EnKF estimates and SM observations and SMAP SM retrievals are mainly due to misrepresentation of vegetation *** results improved SM estimates up to 10-cm depth using SMAP SM retrievals;however,additional studies are needed to improve SM at deeper *** implemented methodology can estimate SM at the top 10 cm of the soil every 3 days to mitigate the impact of the climate change on agricultural production over rainfed areas,particularly in developing countries.

关键词： Root-zone soil moisture SVAT model ensemble kalman filter soil moisture active-Passive(SMAP)mission agricultural region THEXMEX-18 central Mexico