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Effects of improved amino acid balance diet on lysine mammary utilization, whole body protein turnover and muscle protein breakdown on lactating sows

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Journal of Animal Science and Biotechnology 2024年第5期15卷 2031-2043页

作者： Sai Zhang juan c.marini Vengai Mavangira Andrew claude Julie Moore Mahmoud A.Mohammad Nathalie L.Trottier Department of Animal Science Michigan State UniversityEast Lansing 48824USA State Key Laboratory of Swine and Poultry Breeding Industry Key Laboratory of Animal Nutrition and Feed Science in South ChinaMinistry of Agriculture and Rural AffairsGuangdong Provincial Key Laboratory of Animal Breeding and NutritionInstitute of Animal ScienceGuangdong Academy of Agricultural SciencesGuangzhou 510640PR China USDA/ARS children’s Nutrition Research center and Pediatric critical care Medicine Department of PediatricsBaylor College of MedicineHoustonTX 77030USA Department of Large Animal clinical Sciences Michigan State UniversityEast LansingMI 48824USA Present address:Department of Animal Science Cornell UniversityFrank Morrison Hall507 Tower RoadIthacaNY 14853‑4801USA

Background The study objective was to test the hypothesis that low crude protein(cP)diet with crystalline amino acids(cAA)supplementation improves Lys utilization efficiency for milk production and reduces protein turnover and muscle protein *** lactating multiparous Yorkshire sows were allotted to 1 of 2 isocaloric diets(10.80 MJ/kg net energy):control(cON;19.24%cP)and reduced cP with“optimal”AA profile(OPT;14.00%cP).Sow body weight and backfat were recorded on d 1 and 21 of lactation and piglets were weighed on d 1,14,18,and 21 of *** d 14 and 18,a subset of 9 sows(cON=4,OPT=5)was infused with a mixed solution of 3-[methyl-2H3]histidine(bolus injection)and[13c]bicarbonate(priming dose)first,then a constant 2-h[13c]bicarbonate infusion followed by a 6-h primed constant[1-13c]lysine *** blood and milk sampling were performed to determine plasma and milk Lys enrichment,Lys oxidation rate,whole body protein turnover,and muscle protein *** Over the 21-d lactation period,compared to cON,sows fed OPT had greater litter growth rate(Pcompared to cON,sows fed OPT had greater efficiency of Lys(Pciency(Pcompared to cON,sows fed OPT tended to have lower whole body protein breakdown rate(P=0.069).Muscle protein breakdown rate did not differ between OPT and cON(P=0.197).conclusion Feeding an improved AA balance diet increased efficiency of Lys and reduced whole-body protein turnover and protein *** results imply that the lower maternal N retention observed in lactating sows fed improved AA balance diets in previous studies may be a result of greater partitioning of AA towards milk rather than greater body protein breakdown.

关键词： Amino acid Efficiency Lactating sows Protein breakdown Protein turnover Reduced protein diet

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Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi juan Pablo de Rivero Vaccari Jennifer c.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang J.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric critical care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

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ON THE cAUcHY PROBLEM FOR AW-RAScLE SYSTEM WITH LINEAR DAMPING

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Acta Mathematica Scientia 2021年第1期41卷 311-318页

作者： juan c.JUAJIBIOY Escuela de Matemdticas y Estadistica Universidad Pedagogica y Tecnològica de ColombiaTunja 15001BoyacaColombia

The existence of global BV solutions for the Aw-Rascle system with linear damping is *** order to get approximate solutions we consider the system in Lagrangian coordinates,then by using the wave front tracking method coupling with and suitable splitting algorithm and the ideas of[1]we get a sequence of approximate *** we show the convergence of this approximate sequence to the weak entropic solution.

关键词： wave front tracking global weak entropy solutions linear damping

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APPLYING PROcESS MINING APPROAcH TO SUPPORT THE VERIFIcATION OF A MULTI-AGENT SYSTEM

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Journal of Systems Science and Systems Engineering 2010年第2期19卷 131-149页

作者： c.OU-YANG Yeh-chun juan Depart.of Industrial Management National Taiwan University of Science and Technology Depart.of Industrial Engineering and Management Ming Chi University of Technology

Using agent development tools to construct an agent-based system is a well applied approach. However, the development tools usually do not have the function to check the feasibility about the workflow of the agent system during it implementation stage. Therefore, to develop an evaluation approach to analyze the feasibility of a developing agent system such that the improper workflow of an agent system can be found in the early design stage is a necessary task to reduce the risk of implementation. In this research, a Petri Net （PN） based three-stage evaluation approach was developed. In the conceptual stage, the pitfall of the current agent system developing process was examined and an improvement analysis process was specified. Then, in the system design stage, an evaluation approach which extracted the process log file from a developing agent system into a PN model in terms of a process mining approach-or algorithm was proposed. This model was simulated in a PN simulation package. The agent system performance was evaluated in terms of analyzing the deadlock phenomena of the PN model. Finally, in the implementation stage, the proposed concept was implemented by using an agent developing tool JADE and a PN simulation tool cPN. An agent-based robotic assembly system was used to examine the possible deadlock of the agent system.

关键词： Agent-based systems workflow feasibility process mining Petri Nets

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Design and optimization of cSP power plants for Pakistan:a comparative study

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clean Energy 2023年第3期7卷 690-704页

作者： Kashif Liaqat juan c.Ordonez Department of Mechanical Engineering FAMU-FSU College of EngineeringEnergy and Sustainability Centerand Center for Advanced Power SystemsFlorida State UniversityTallahasseeFL 32310USA

Despite having very high solar irradiance,Pakistan still does not have any installed concentrated solar power(cSP)*** studies have shown that multiple locations within the country are suitable for cSP plants,but there is limited availability of comprehensive comparative ***,this article presents a comparative analysis of different cSP technologies in Pakistan,focusing on their potential to address the country’s energy *** study evaluates the pros and cons of different cSP technologies at various locations through site assessment,modelling,optimization and economic analysis using the System Advisor *** and Nawabshah were selected as the locations for modelling multiple scenarios of 100-MW plants,using central receiver systems,parabolic trough collectors and linear Fresnel *** plants were integrated with thermal energy storage and the storage capacity was optimized using parametric *** results showed that a central receiver system for the location of Quetta was the most favourable option,with an annual energy yield of 622 GWh at 7.44 cents/kWh,followed by a central receiver system for Nawabshah(608 GWh,9.03 cents/kWh).This study is the first to show that switching between line-concentrated and point-concentrated cSP technologies can open new opportunities for sites in Pakistan with relatively high solar resources,resulting in a 21.3%reduction in the levelized cost.

关键词： concentrated solar power parabolic trough collector linear Fresnel reflector central receiver System Advisor Model Pakistan

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Flexible foraging decisions made by workers of the social wasp Vespula germanica (Hymenoptera: Vespidae) in response to different resources: influence of ontogenetic shifts and colony feedback

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Insect Science 2022年第2期29卷 581-594页

作者： Analía Mattiacci MaitéMasciocchi juan c.corley Grupo de Ecología de Poblaciones de Insectos IFAB(CONICETINTA EEA Bariloche)BarilocheArgentina Departamento de Ecología Centro Regional Universitario BarilocheUniversidad Nacional Del ComahueBarilocheArgentina

Decisions made by foraging animals conform a complex process based on the integration of information from multiple external environmental stimuli and internal physiological signals,which in turn are modulated by individual experience and a detection threshold of each *** social insects in which foraging is limited to given age subcastes,individual foraging decisions may also be affected by ontogenetic shifts and colony *** studied the short-term changes in foraging preferences of the generalist wasp Vespula germanica,focusing on whether the individual response to different resources could be influenced by the ontogenetic shifts and/or by social interaction with *** carried both laboratory and field experiments to confront worker wasps to a short-term resource switch between either protein or carbohydrate-based *** tested the response of(1)Preforager workers(no foraging experience nor interaction with other wasps),(2)Forager workers(experience in foraging and no colony feedback),and(3)Wild forager workers(foraging naturally and exposed to free interactions with nestmates).We evaluated the maxilla-labium extension response(MaLER)for laboratory assays or the landing response for field *** observed that for wasps deprived of colony feedback(either preforagers or foragers),the protein-rich foods acceptance threshold increased(and thus a lower level of foraging on that item was observed)if they had foraged on carbohydrates previously,whereas carbohydrates were accepted in all ***,wasps immersed in a natural foraging context did accept protein foods regardless of their first foraging experience and reduced the carbohydrates collected when trained on protein *** provide evidence that short-term changes in foraging preferences depend on the type of resource foraged and on the social interactions,but not on ontogenetic shifts.

关键词： German wasp invasive species plastic insect behavior response thresholds modulation social insect yellowjackets

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大中小学思政课区域一体化的价值意蕴、驱动要素与推进策略

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东北师大学报（哲学社会科学版） 2025年第1期 10-18页

作者：李爱琴师海娟东北林业大学马克思主义学院黑龙江哈尔滨150040

大中小学思政课区域一体化是大中小学思政课一体化的重要组成部分和重点建设方向,其核心要义在于区域教育主体突破学段和校际壁垒,以共同体成员的协作互动促进思想政治教育资源在区域间的有序流动和优化配置,实现大中小学思政课区域一... 详细信息

大中小学思政课区域一体化是大中小学思政课一体化的重要组成部分和重点建设方向,其核心要义在于区域教育主体突破学段和校际壁垒,以共同体成员的协作互动促进思想政治教育资源在区域间的有序流动和优化配置,实现大中小学思政课区域一体化的整体内涵式发展。新时代持续推进大中小学思政课区域一体化走深走实,可广泛凝聚区域多主体人才协同共培的价值共识,形成多模态纵横连贯式的区域教育网络生态系统,全面提升大中小学思想政治教育区域一体化的建设质量。学校思想政治教育政策要求、新时代思政课改革创新发展诉求和学生个人成长发展需求对大中小学思政课区域一体化具有正向驱动作用,牵动着大中小学思政课区域一体化建设的“时”和“序”、“质”和“量”、“道”和“术”。深化大中小学思政课区域一体化建设,要健全常态长效运行机制,畅通区域管理行动经络;补足协同推进短板弱项,统筹区域格局协调发展;建立多元主题合作网络,深化区域合作互联互通;优化教育资源服务供给,实现区域资源无界共享。

关键词：大中小学思政课区域一体化立德树人思想政治教育

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Feedback control for Ecosystem Management:The case of Wolf-Elk-Hunting Dynamics in the US Mountain West

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Journal of Mountain Science 2014年第4期11卷 850-865页

作者： Kevin MAcKSAMIE Jeffrey WAGNER juan c.cOcKBURN Black River Systems company Inc. 162 Genesee Street Utica New York 13507 USA Department of Economics Rochester Institute of Technology 92 Lomb Memorial Drive Rochester NY 14623 USA Department of computer Engineering Rochester Institute of Technology 83 Lomb Memorial Drive Rochester NY 14623USA

The purpose of this paper is to explore the promise of utilizing some relatively new feedback control techniques in ecosystem management. First, we set forth a basic ecological-economic model of a predator-prey-hunting system in which both the predator and prey have use(flow) and non-use(stock) value and when the predator can inflict transboundary damages. We then use new data from the US Mountain West to show how a particular feedback approach—linear parameter-varying(LPV) control—can be utilized in this context. Our LPV model is able to quantify the cost of managing disturbances that inevitably arise as a manager tries to keep the actual path of the system "close" to its optimum. The results suggest management strategies in mountain ecosystems that feature large, mammalian carnivores.

关键词： Feedback control Linear parameter Optimal vontrol Robust control Predator-prey Recreational hunting

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Mechanical and natural ventilation systems in a greenhouse designed using computational fluid dynamics

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International Journal of Agricultural and Biological Engineering 2014年第1期7卷 1-16页

作者： Jorge Flores-Velazquez juan I.Montero Esteban J.Baeza juan c.Lopez Mexican Institute of Water Technology.Paseo cuauhnáhuac 8532 Col.ProgresoC.P.62550JiutepecMor.Mexico Institut de Recerca i Tecnologia Agroalimentàries 08348Cabrils(Barcelona)Spain IFAPA centro La Mojonera(Junta de Andalucía) Camino San Nicolás 104745 La MojoneraAlmeríaSpain Fundación cajamar.Estación Experimental“Las Palmerillas”Autovía del Mediterráneo Km 416 704710El EjidoAlmeríaSpain

The aim of this study was to analyse air exchange and temperature distribution in a greenhouse with combined mechanical and natural ventilation and to design more efficient mechanical ventilation *** this purpose,a computational fluid dynamics(cFD)model of the greenhouse was *** configurations were considered:configuration 1(mechanical ventilation and closed roof ventilators),configurations 2 and 3(mechanical ventilation and roof ventilators open 30%and 100%,respectively).After validation,the cFD model was used to improve the design of the greenhouse mechanical ventilation system in each of the three configurations *** greenhouse lengths,28 m,50 m,75 m and 100 m,were used in the *** to fan ventilation only,roof ventilation improved the climate of fan-ventilated greenhouses in terms of the air exchange rate(22%)and climate uniformity because the internal air was mixed better than with mechanical ventilation *** the greenhouse length increased,more advantages were achieved with natural ventilation compared to mechanical *** most configurations,there was a strong linear correlation between temperature gradient and greenhouse *** greenhouse whose regression line had the steepest slope was the one with closed roof *** the fan capacity produced a general reduction in temperature,but the effect was less intense for the greenhouses with open roof *** to box inlet ventilators,an enlarged continuous inlet in the wall opposite the fans increased overall system performance because it eliminated backflow recirculation zones,which are prone to produce high temperatures.

关键词： greenhouse cooling fan ventilation roof ventilators combined ventilation

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Ultrasound-Mediated Drug Delivery:Sonoporation Mechanisms,Biophysics,and critical Factors

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Biomedical Engineering Frontiers 2022年第1期3卷 14-30页

作者： juan Tu Alfred c.H.Yu Key Laboratory of Modern Acoustics(MOE) Department of PhysicsCollaborative Innovation Center of Advanced MicrostructureNanjing UniversityNanjingChina Schlegel Research Institute for Aging University of WaterlooWaterlooONCanada

Sonoporation,or the use of ultrasound in the presence of cavitation nuclei to induce plasma membrane perforation,is well considered as an emerging physical approach to facilitate the delivery of drugs and genes to living ***,this emerging drug delivery paradigm has not yet reached widespread clinical use,because the efficiency of sonoporation is often deemed to be mediocre due to the lack of detailed understanding of the pertinent scientific ***,we summarize the current observational evidence available on the notion of sonoporation,and we discuss the prevailing understanding of the physical and biological processes related to *** facilitate systematic understanding,we also present how the extent of sonoporation is dependent on a multitude of factors related to acoustic excitation parameters(ultrasound frequency,pressure,cavitation dose,exposure time),microbubble parameters(size,concentration,bubble-to-cell distance,shell composition),and cellular properties(cell type,cell cycle,biochemical contents).By adopting a science-backed approach to the realization of sonoporation,ultrasound-mediated drug delivery can be more controllably achieved to viably enhance drug uptake into living cells with high sonoporation *** drug delivery approach,when coupled with concurrent advances in ultrasound imaging,has potential to become an effective therapeutic paradigm.

关键词： cavitation bubble realization

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