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钢纤维类型对超高性能混凝土高温爆裂性能的影响

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复合材料学报 2018年第6期35卷 1599-1608页

作者：杨娟朋改非北京交通大学土木建筑工程学院北京100044

为了探寻可以有效改善超高性能混凝土(Ultra-high-performance concrete,UHPC)抗火性能的钢纤维类型,本文试验测定了不同类型钢纤维(3种普通钢纤维和2种来自于废旧轮胎的再生钢纤维)增韧UHPC及空白组混凝土的从常温至800℃高温爆裂行为... 详细信息

为了探寻可以有效改善超高性能混凝土(Ultra-high-performance concrete,UHPC)抗火性能的钢纤维类型,本文试验测定了不同类型钢纤维(3种普通钢纤维和2种来自于废旧轮胎的再生钢纤维)增韧UHPC及空白组混凝土的从常温至800℃高温爆裂行为和断裂能。结果显示,未掺入任何钢纤维的空白组UHPC试件全都发生了严重高温爆裂,钢纤维可以显著减轻其高温爆裂但却不能避免爆裂的发生,而掺入端钩型普通工业钢纤维(长度为35mm,直径为0.55mm)的UHPC呈现出最优的抗高温爆裂性能,其次是掺入未附着橡胶颗粒(RSF)的再生钢纤维(RSFR)增韧UHPC。可见,钢纤维自身性能特征显著影响了钢纤维增韧UHPC的高温爆裂,相同掺量情况下混凝土单位体积内分布密度较大的钢纤维或者分布密度较小但可以显著增加混凝土断裂韧性(断裂能)的钢纤维比较适合应用于具有较高抗火要求的UHPC结构中。

关键词：超高性能混凝土普通钢纤维再生钢纤维高温爆裂断裂能

Poly(p-coumaric acid)nanoparticles alleviate temporomandibular joint osteoarthritis by inhibiting chondrocyte ferroptosis

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Bioactive Materials 2024年第10期40卷 212-226页

作者： Jiaxin Guo Kai Su Liying Wang Bingyu Feng Xinru You Miao Deng Wei Seong Toh Jun Wu Bin Cheng juan Xia Hospital of Stomatology Sun Yat-sen UniversityGuangzhou510055PR China Guangdong Provincial Key Laboratory of Stomatology Guangzhou510055PR China Department of Hematology The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen518107PR China Center for Nanomedicine and Department of Anesthesiology Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA Department of Orthopaedic Surgery Yong Loo Lin School of MedicineNational University of Singapore119228Singapore Faculty of Dentistry National University of Singapore119085Singapore Bioscience and Biomedical Engineering Thrust The Hong Kong University of Science and Technology(Guangzhou)NanshaGuangzhou511455PR China Division of Life Science The Hong Kong University of Science and TechnologyHong KongChina

Oxidative stress and inflammation are key drivers of osteoarthritis(OA)pathogenesis and disease *** we report the synthesis of poly(p-coumaric)nanoparticles(PCA NPs)from p-courmaic acid(p-CA),a naturally occurring phytophenolic acid,to be a multifunctional and drug-free therapeutic for temporomandibular joint osteoarthritis(TMJOA).Compared to hyaluronic acid(HA)that is clinically given as viscosupplementation,PCA NPs exhibited long-term efficacy,superior anti-oxidant and anti-inflammatory properties in alleviating TMJOA and repairing the TMJ cartilage and subchondral bone in a rat model of ***,TMJ repair mediated by PCA NPs could be attributed to their anti-oxidant and anti-inflammatory properties in enhancing cell proliferation and matrix synthesis,while reducing inflammation,oxidative stress,matrix degradation,and chondrocyte ***,our study demonstrates a multifunctional nanoparticle,synthesized from natural p-coumaric acid,that is stable and possess potent antioxidant,anti-inflammatory properties and ferroptosis inhibition,beneficial for treatment of TMJOA.

关键词： Temporomandibular joint osteoarthritis Poly(p-coumaric acid)nanoparticles Ferroptosis Oxidative pressure Cartilage

Determination of Residues and Safety Analysis of Metal Impurities in Platinum-based Antitumor Drugs

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贵金属 2012年第A1期33卷 258-262页

作者： PENG juan PU Shaoping LI Guangli HE Jian ZHANG Zhirong LIAO Yunxing Guiyan Phamaceuitical Co Ltd.Kunming 650106China Kunming University of Science and Technology Kunming 650093China Sino-Platinum Metals Co.Ltd. Kunming 650106China

The residual metal impurities in cisplatin, carboplatin and oxaliplatin were determined by ICP-AES. The samples were ignited and dissolved with HCl:HNO 3 (3:1). The method is simple and accurate. By the determination of the metal residues in the samples, the calculated actual daily exposure and concentration of the metal Pd, Ir, Rh, Ru, Mo, Ni, Cr, V, Cu, Mn, Fe and Zn that were less than the permitted daily exposures (PDE) and the limited concentration permitted in the EMEA guideline on the specification limits for residues of metal catalysts or metal reagents [1] . The metal residues can de adequately removed from the active pharmaceutical ingredients and the corresponding drugs. The trace metal residues will not affect human health and lead to the safety hazard by the intravenous injection.

关键词： ICP-AES platinum-based antitumor drug metal reagent residue safety

四吡啶基卟啉质子化结构变化研究Ⅱ.m-甲基吡啶基的取代基效应

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化学学报 2001年第2期59卷 195-200页

作者：马思渝王娟北京师范大学化学系北京100875

卟啉衍生物对嵌入并堆积在DNA螺旋中具有高选择性 .为考察m -甲基吡啶取代基对质子化卟啉结构的影响 ,在m -四吡啶基卟啉研究的基础上 ,用半经验的AM1MO方法 ,并进行合理的对称性限制 ,计算了m -四甲基吡啶卟啉 (TmPyPH2 4 +)及其质子... 详细信息

卟啉衍生物对嵌入并堆积在DNA螺旋中具有高选择性 .为考察m -甲基吡啶取代基对质子化卟啉结构的影响 ,在m -四吡啶基卟啉研究的基础上 ,用半经验的AM1MO方法 ,并进行合理的对称性限制 ,计算了m -四甲基吡啶卟啉 (TmPyPH2 4 +)及其质子化二酸 (TmPyPH4 6 +)的几种可能的构型 .结果表明 ,由于m -甲基吡啶的影响 ,在质子化过程中结构和键电荷布居有明显变化 ;前沿分子轨道具有与四吡啶基情形相反的变化趋势。

关键词： M-四甲基吡啶卟啉 N-质子化二酸构型变化 AM1MO方法分子堆积取代基效应构型

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益生菌功能开发及其应用性能强化

科学通报 2019年第3期64卷 246-259页

作者：张娟陈坚江南大学工业生物技术教育部重点实验室无锡214122 江南大学生物工程学院无锡214122 江南大学粮食发酵工艺与技术国家工程实验室无锡214122

随着人们居住环境、饮食习惯和生活节奏的改变,许多新型疾病开始出现并严重威胁着人类健康.在"大健康"理念及其产业化背景下,人们的健康意识逐渐提升,而益生菌凭借其优良的益生性能受到了越来越广泛的关注.益生菌(probiotics)指可有效... 详细信息

随着人们居住环境、饮食习惯和生活节奏的改变,许多新型疾病开始出现并严重威胁着人类健康.在"大健康"理念及其产业化背景下,人们的健康意识逐渐提升,而益生菌凭借其优良的益生性能受到了越来越广泛的关注.益生菌(probiotics)指可有效增强食用者身体健康水平的活菌制剂及其代谢产物,具有改善便秘、缓解腹泻、降胆固醇、增强免疫力、预防和治疗自闭及抑郁症,抗肿瘤和保护口腔健康等功效,其主要产品益生菌膳食补充剂和益生菌非处方药等已在医药领域得到广泛应用.随着对益生菌与疾病关系研究的不断深入,益生菌在新型及重大疾病防治领域的新功能不断刷新着人类的认知.因此,学术界需进一步加强益生菌的基础研究,开发益生菌在疾病防治领域的新功能.同时,在益生菌产品的制备和应用过程中,多种严峻的环境胁迫会影响菌株正常的代谢和存活能力,抑制其益生作用的发挥.因此,利用多种手段,对其应用性能进行强化显得尤为重要.本文综述了益生菌功能开发和性能强化的主要方法和原理,概括了其在多种疾病防治过程中的应用效果,为加深对益生菌功能的认识,进一步促进益生菌产业升级提供了可借鉴的思路.

关键词：益生菌大健康菌株筛选性能强化疾病防治

The Herbicidal Activity of Mutant Isolates from Botrytis cinerea

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Agricultural Sciences in China 2006年第8期5卷 622-628页

作者： ZHANG Jin-lin ZHANG Li-hui LIU Ying-chao MA juan LI Chuan DONG Jin-gao Mycotoxin Laboratory Hebei Agricultural University Baoding 071001 P.R.China

Fifteen mutant isolates were obtained by ultraviolet mutation from parent isolate Botrytis cinerea BC-4. Among them three mutant isolates, BC4-1, BC4-2, and BC4-15, showed strong herbicidal activity. BC4-1 showed maximum herbicidal activity for inhibition of germination and growth of Digitaria sanguinalis L. and Arnaranthus retroflexus L. The results also showed that herbicidal activity was influenced by differing pH of PD media, with pH value of 4.0 being the optimum. The crude toxin was extracted using chloroform, petroleum ether, and ethyl acetate, respectively, and the ethyl acetate extracts showed the strongest inhibitory activity on the germination and growth of D. sanguinalis L. and A. retroflexus L. Using HPLC, one fraction with an absorption peak at 271 nm was separated from the crude toxin. This fraction could strongly inhibit the growth of D. sanguinalis L. at a concentration of 100 mg L^-1 and could completely inhibit the seed germination of D. sanguinalis L. and A. retroflexus L. at a concentration of 50 mg L^-1 .

关键词： Botrytis cinerea toxin ultraviolet mutation herbicide activity separation and purification

Relational coordination and healthcare management in lung cancer

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World Journal of Clinical Cases 2014年第12期2卷 757-768页

作者： José Antonio Vinagre Romero juan Del Llano Se?arís Carmen De Pablos Heredero Mark Nuijten Clinical Management Business Organization Entrepreneurship Health Administration Business Organization Universidad Rey Juan Carlos Respiratory Unit at La Paz University Hospital28046 Madrid Spain Community Health Gaspar Casal Foundation Universidad Pompeu Fabra-CRES 28006 Madrid Spain Economics Rey Juan Carlos University School of Social Sciences Doctoral Program in Business Organization and Entrepreneurship 28032 Madrid Spain Rotterdam School of Management Erasmus University University of Maastricht the University of Groningen 3062 PA Rotterdam The Netherlands

In the current socio-economic scenario characterized by a growing shortage of resources and progressive budget constraints, the need to better coordinate processes in health institutions appears as a relevant aspect to ensure the future sustainability of system. In this sense, Relational Coordination(RC) provides a valuable opportunity for the reconfiguration of clinical guidelines concerning isolated single-level considerations. In this research the RC model has been applied to explain best results in the process of diagnosing and offering clinical treatments for lung cancer. Lung cancer presents the higher rates of tumor's mortality worldwide. Through unstructured and informal interviews with clinicians at both levels(Primary/Specialist Care), a diagnosis of the situation in relation to joint management of lung cancer is provided. Solutions of continuity in terms of coordination are explained due to the observation of lack of effective knowledge transfer between the two levels. It is this disconnection which justifies the introduction of a modified model of RC for the study and implementation of transfer relations between the knowledge holders, in order to structure consolidated and cooperative evidence-based models that lead to a substantial shortening in the response times with a marked outcomes improvement. To our knowledge, the application of this model to a Public Health problem bringing together both levels of care, hasn't been made till now.

关键词： Relational Coordination Lung cancer Clinical pathway Dialogic practices High performance work systems Healthcare performance

A review and comparison of common maternal positions during the second-stage of labor

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International Journal of Nursing Sciences 2019年第4期6卷 460-467页

作者： Jing Huang Yu Zang Li-Hua Ren Feng-juan Li Hong Lu School of Nursing Peking University Beijing China Maternal and Child Health Hospital of Xinjiang Uyghur Autonomous Region Uyghur China

The second-stage of labor is the most stressful part of childbirth process and the proper maternal position during this period is paramount for women's safe vaginal *** play a pivotal role in managing maternal positions during the second-stage of ***,there is limited evidence to support an ideal maternal position during the second-stage of ***,the difference between different maternal positions might not be *** paper aims to review and compare the benefits and risks of common maternal positions during the second-stage of labor,thereby to provide midwives evidence-based practical guidelines.

关键词： Second labor stage Parturition Posture Review

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直接零件标志条码区域定位算法

计算机辅助设计与图形学学报 2014年第7期26卷 1159-1166页

作者：王娟王萍天津大学电气与自动化工程学院模式识别实验室天津300072

针对受工况、光照的限制,现场采集的含有直接零件标志(DPM)条码的图像经常亮度不一,并伴有变形等情况,导致因定位不准确而识别DPM条码困难,提出一种改进的SUSAN角点检测和半监督机制下的近邻传播聚类相结合的DPM条码定位算法.首先针对DP... 详细信息

针对受工况、光照的限制,现场采集的含有直接零件标志(DPM)条码的图像经常亮度不一,并伴有变形等情况,导致因定位不准确而识别DPM条码困难,提出一种改进的SUSAN角点检测和半监督机制下的近邻传播聚类相结合的DPM条码定位算法.首先针对DPM条码图像区域多直角的特点对检测角点的SUSAN算法进行改进,使其适应由于光照问题导致灰度不均的DPM条码区域,具有检出变形角点的能力,同时极大程度地抑制背景上及条码区域中的伪角点;以此为基础,使用近邻传播聚类算法对角点进行聚类,并将DPM条码区域中角点的聚集特点转化为监督规则,形成半监督机制下的角点近邻传播聚类.实验结果表明,该算法检测出的角点对DPM条码区域的示意性强、效率高,基于角点聚类结果的DPM条码定位比其他算法精准、快速.

关键词： DPM条码角点检测半监督近邻传播聚类算法条码定位