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Effects of maternal dietary omega-3 polyunsaturated fatty acids and methionine during late gestation on fetal growth,DNA methylation,and mRNA relative expression of genes associated with the inflammatory response,lipid metabolism and DNA methylation in placenta and offspring’s liver in sheep

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Journal of Animal Science and Biotechnology 2021年第2期12卷 611-625页

作者： Milca Rosa velazquez Fernanda Batistel juan Manuel Pinos rodriguez Alejandro Enrique Relling Facultad de Medicina Veterinaria y Zootecnia Universidad Veracruzana91710 VeracruzMexico Department of Animal Science Ohio Agricultural Research and Development Center(OARDC)The Ohio State University114 Gerlaugh Hall1680 Madison AveWoosterOH 44691USA Department of Animal Dairy and Veterinary SciencesUtah State UniversityLoganUT 84322USA

Background:Omega-3 PUFA or methionine(Met)supply during gestation alters offspring ***,the effect of both nutrients on fetal development has not been *** objective was to determine the effects of supplementation of these two nutrients during late gestation on fetal growth,DNA methylation,and mRNA expression of genes associated with the inflammatory response,and DNA ***(n=5/treatment)were fed from day 100 to 145 of gestation one of the following treatments:1)basal diet(NS)without fatty acids(FS)or methionine(MS)supplementation;2)FS(10 g/kg Ca salts,source omega-3 PUFA);3)MS(1 g/kg rumen protected methionine);and 4)FS and MS(FS-MS).On day 145,ewes were euthanized,and data from dams and fetus was ***(cotyledon),fetal liver,and blood samples were ***:A treatments interaction on fetal liver weight,ewe body weight and body condition score(BCS)was observed;FS-MS were heavier(P<0.01)than FS and MS,and FS-MS ewes had a better(P=0.02)BCS than *** increased(P=0.03)ewe plasma glucose *** liver global DNA methylation increased(P<0.01)in FS and *** treatments modify the mRNA relative expression on some of the genes *** the fetal liver,FS increased(P=0.04)the mRNA relative expression of arachidonate-5-lipoxygenase-activatingprotein and tended to decrease(P=0.06)***,MS decreased(P=0.04)DNA-methyltransferase-1 and tended to decrease(P=0.08)free-fatty-acid-receptor-1 mRNA relative ***,FS-MS decreased mRNA relative expression of tumor-necrosis-factor-alpha(P=0.05),peroxisomeproliferator-activated-receptor-delta(P=0.03)and gamma(P=0.04),tended to decrease(P≤0.09)interleukin-6,fatty-acid-transport-protein-1,and delta-5-desaturase,and increased adenosylhomocysteinase(P=0.04)mRNA relative *** cotyledon,FS tended to decrease fatty acid binding protein 4(P=0.09)mRNA relative ***:Omega-3 PUFA and Met s

关键词： Fat supplementation Fetal programming Maternal nutrition Nutrients Rumen protected methionine

Alliance Free and Alliance Cover Sets

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Acta Mathematica Sinica,English Series 2011年第3期27卷 497-504页

作者： juan Alberto rodriguez-velazquez Jose Maria SIGARRETA Ismael GONZALEZ YERO Sergio BERMUDO Departament d'Enginyeria Informdtica i Matematiques Universitat Rovira i Virgili Av. Paisos Catalans 26 43007 Tarragona Spain Faculty of Mathematics Autonomous University of Guerrero Carlos E. Adame 5 Col. La Garita Acapuleo Guerrero Mexico Departament d'Enginyeria Informatica i Matematiques Universitat Rovira i Virgili Av. Pai'sos Catalans 26 43007 Tarragona Spain Department of Economy Quantitative Methods and Economic History Pablo de Olavide University Carretera de Utrera Kin. 1 41013 Sevilla Spain

A defensive （offensive） k-alliance in F = （V, E） is a set S C V such that every v in S （in the boundary of S） has at least k more neighbors in S than it has in V ／ S. A set X C_ V is defensive （offensive） k-alliance free, if for all defensive （offensive） k-alliance S, S／ X ≠ 0, i.e., X does not contain any defensive （offensive） k-alliance as a subset. A set Y C V is a defensive （offensive） k-alliance cover, if for all defensive （offensive） k-alliance S, S ∩ Y ≠ 0, i.e., Y contains at least one vertex from each defensive （offensive） k-alliance of F. In this paper we show several mathematical properties of defensive （offensive） k-alliance free sets and defensive （offensive） k-alliance cover sets, including tight bounds on their cardinality.

关键词： Defensive alliance offensive alliance alliance free set alliance cover set

Optimizing the delivery of combination therapy for tumors： A mathematical model

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International Journal of Biomathematics 2017年第3期10卷 179-194页

作者： Clara Rojas rodriguez juan Belmonte-Beitia Departamento de Matematicas E. T. S. de Ingenieros Industriales Universidad de CastiUa-La Mancha 13071 Ciudad Real Spain Instituto de Matemdtica Aplicada a la Ciencia y la Ingenierla (IMA CI) Universidad de Castilla-La Mancha 13071 Ciudad Real Spain

We present in this paper a new mathematical model for the scheduling of angiogenic inhibitors in combination with a chemotherapeutic agent for a tumor. Our model takes into account the process of angiogenesis and the quality of the vasculature discriminating between stable blood vessels and unstable blood vessels. We characterize theoretically the optimal controls on drug distribution to minimize the number of cancer cells at the end of the treatment in a free horizon time problem with restrictions on the total amount of drug doses. Finally, we solve the optimal control problem by using numerical simulations, obtaining as a result that, despite the number of the tumor cells decrease with anti-angiogenic treatment, the best results are reached at the end of the chemotherapy treatment.

关键词： Mathematical modeling of tumor growth anti-angiogenic treatment chemotherapy singular control bang bang control.

Small-signal Model for Dual-active-bridge Converter Considering Total Elimination of Reactive Current

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Journal of Modern Power Systems and Clean Energy 2021年第2期9卷 450-458页

作者： juan Ramon rodriguez-rodriguez Nadia Maria Salgado-Herrera Jacinto Torres-Jimenez Nestor Gonzalez-Cabrera David Granados-Lieberman Martin Valtierra.rodriguez the Universidad Nacional Autonoma de Mexico Facultad de IngenieriaDepto.Energia Electri-ca.Av.Universidad 3000Col.UNAM CUCoyoacanCDMXMexico the Instituto de Energias Renovables Universidad Nacional Autonoma de MexicoPriv.Xochicalco s/nCol.Centro.TemixcoMorelosMexico the Instituto Tec-nologico Superior de Irapuato Carretera Irapuato-Silao km 12.5.IrapuatoGuanajuatoMexico the Universidad Autonoma de Queretaro Campus San Juan del RioRio Moctezuma 249San Juan del RioQueretaroMexico

Emerging technologies such as electric vehicles,solid-state transformers,and DC transformers are implemented using the closed-loop bi-directional dual-active-bridge(DAB)*** this context,it is necessary to have average models that provide an efficient way of tuning the proportional integral(PI)compensator parameters for large-and small-signal *** present a novel small-signal model(SSM)for DAB converter with a single closed-loop PI controller and the total elimination of reactive current(IQ=0).The method applies a modulation technique for IQ=0 and introduces a composite function in the controller while reducing the original nonlinear switching model,which allows to decrease the order of the transfer function and analyze the closed-loop *** proposed SSM is analyzed using different response time,load,and DC voltage *** simulation and experimental results demonstrate the ease of implementation and effectiveness of the proposed model with respect to other SSM techniques.

关键词： Small-signal model(SSM) dual-active-bridge(DAB)converter reactive current elimination proportional integral(PI)control

Role of apoptosis-inducing factor in perinatal hypoxic-ischemic brain injury

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Neural Regeneration Research 2021年第2期16卷 205-213页

作者： juan rodriguez Tao Li Yiran Xu Yanyan Sun Changlian Zhu Center for Brain Repair and Rehabilitation Institute of Neuroscience and PhysiologySahlgrenska AcademyUniversity of GothenburgGothenburgSweden Henan Key Laboratory of Child Brain Injury Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Anatomy School of Basic Medical ScienceZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Women’s and Children’s Health Karolinska InstitutetStockholmSweden

Perinatal complications,such as asphyxia,can cause brain injuries that are often associated with subsequent neurological deficits,such as cerebral palsy or mental *** mechanisms of perinatal brain injury are not fully understood,but mitochondria play a prominent role not only due to their central function in metabolism but also because many proteins with apoptosis-related functions are located in the *** these proteins,apoptosis-inducing factor has already been shown to be an important factor involved in neuronal cell death upon hypoxia-ischemia,but a better understanding of the mechanisms behind these processes is required for the development of more effective treatments during the early stages of perinatal brain *** this review,we focus on the molecular mechanisms of hypoxic-ischemic encephalopathy,specifically on the importance of apoptosis-inducing *** relevance of apoptosis-inducing factor is based not only because it participates in the caspase-independent apoptotic pathway but also because it plays a crucial role in mitochondrial energetic functionality,especially with regard to the maintenance of electron transport during oxidative phosphorylation and in oxidative stress,acting as a free radical *** also discuss all the different apoptosis-inducing factor isoforms discovered,focusing especially on apoptosis-inducing factor 2,which is only expressed in the brain and the functions of which are starting now to be ***,we summarized the interaction of apoptosis-inducing factor with several proteins that are crucial for both apoptosis-inducing factor functions(prosurvival and pro-apoptotic)and that are highly important in order to develop promising therapeutic targets for improving outcomes after perinatal brain injury.

关键词： apoptosis apoptosis inducing factor asphyxia cell death free radical hypoxia-ischemia mitochondria neonates oxidative stress

Virtual globes for UAV-based data integration:Sputnik GIS and Google Earth^(TM) applications

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International Journal of Digital Earth 2019年第5期12卷 583-593页

作者： Marcos Arza-Garci Mariluz Gil-Docampo juan Ortiz-Sanz Santiago Martinez-rodriguez Agroforestry Engineering Department University of Santiago de CompostelaEscuela Politecnica SuperiorLugoSpain

The integration of local measurements and monitoring via global-scale Earth observations has become a new challenge in digital Earth *** increasing accessibility and ease of use of virtual globes(VGs)represent primary advantages of this integration,and the digital Earth scientific community has adopted this technology as one of the main methods for disseminating the results of scientific *** this study,the best VG software for the dissemination and analysis of highresolution UAV(Unmanned Aerial Vehicle)data is identified for global and continuous geographic scope *** VGs Google Earth and Sputnik Geographic Information System(GIS)are selected and compared for this *** Earth is a free platform and one of the most widely used VGs,and one of its best features its ability to provide users with quality visual *** proprietary software Sputnik GIS more closely approximates the analytical capacity of a traditional GIS and provides outstanding advantages,such as DEM overlapping and visualization for its dissemination.

关键词： Virtual reality geospatial data geographic visualization multiscale DEM

BASKETBALL SCORING IN NBA GAMES:AN EXAMPLE OF COMPLEXITY

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Journal of Systems Science & Complexity 2013年第1期26卷 94-103页

作者： DE SA GUERRA Yves MARTíN GONZALEZ juan Manuel SARMIENTO MONTESDEOCA Samuel rodriguez RUIZ David ARJONILLA LóPEZ Nieves GARCíA-MANSO juan Manuel Departament of Phisical Education University of Las Palmas de Gran Canaria Departament of Physics University of Las Palmas de Gran Canaria

Scoring in a basketball game is a highly dynamic, non-linear process. NBA teams try to be more and more competitive each season. For instance, they incorporate into their rosters the best players in the world. This and other mechanisms concur to make the scoring process in NBA games exciting and rarely predictable. This paper is to study the behavior of timing and scoring in basketball gaines. The authors analyze all the games in five NBA regular seasons （2005-06, 2006-07, 2007-08, 2008-09, 2009-10）, for a total of 6150 games. Scoring does not behave uniformly; therefore, the authors also analyze the distributions of the differences in points in the basketball games. To further analyze the behavior of the tail of the distribution, the authors also carry out a semilog-plot and a log-log plot to verify whether this trend approaches a Poisson distribution or a PL. This paper reveals different areas of behavior related to the score, with specific instances of time that could be considered tipping points of the game. The presence of these critical points suggests that there are phase transitions where the dynamic scoring of the games varies significantly.

关键词： Complexity NBA non-linear Poisson power law.

Assessing a novel modelling approach with high resolution UAV imagery for monitoring health status in priority riparian forests

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Forest Ecosystems 2021年第4期8卷 810-830页

作者： juan Guerra-Hernandez Ramon A.Diaz-Varela juan Gabriel Avarez-Gonzalez Patricia Maria.rodriguez-Gonzalez edata Centro de iniciativas empresariaisFundacion CEL.O Palomar s/n27004 LugoSpain Forest Research Centre School of AgricultureUniversity of LisbonInstituto Superior de Agronomia(ISA)Tapada da Ajuda1349-017 LisbonPortugal Biodiversity and Applied Botany Unit(GI BIOAPLIC 1809) Department of BotanyEscuela Politecnica SuperiorR/Benigno LedoUniversity of Santiago de CompostelaCampus Universitario27002 LugoSpain Sustainable Forest Management Unit(UXFS) Department of Agroforestry EngineeringEscuela Politecnica SuperiorR/Benigno LedoUniversity of Santiago de CompostelaCampus UniversitarioE-27002 LugoSpain

Background:Black alder(Alnus glutinosa)forests are in severe decline across their area of distribution due to a disease caused by the soil-borne pathogenic Phytophthora alni species complex(class Oomycetes),“alder Phytopththora”.Mapping of the different types of damages caused by the disease is challenging in high density ecosystems in which spectral variability is high due to canopy *** obtained by unmanned aerial vehicles(UAVs)may be particularly useful for such tasks due to the high resolution,flexibility of acquisition and cost efficiency of this type of *** this study,*** decline was assessed by considering four categories of tree health status in the field:asymptomatic,dead and defoliation above and below a 50% threshold.A combination of multispectral Parrot Sequoia and UAV unmanned aerial vehicles-red green blue(RGB)data were analysed using classical random forest(RF)and a simple and robust three-step logistic modelling approaches to identify the most important forest health indicators while adhering to the principle of parsimony.A total of 34 remote sensing variables were considered,including a set of vegetation indices,texture features from the normalized difference vegetation index(NDVI)and a digital surface model(DSM),topographic and digital aerial photogrammetry-derived structural data from the DSM at crown ***:The four categories identified by the RF yielded an overall accuracy of 67%,while aggregation of the legend to three classes(asymptomatic,defoliated,dead)and to two classes(alive,dead)improved the overall accuracy to 72% and 91% *** the other hand,the confusion matrix,computed from the three logistic models by using the leave-out cross-validation method yielded overall accuracies of 75%,80% and 94% for four-,three-and two-level classifications,***:The study findings provide forest managers with an alternative robust classification method for the rapid,effective assessment of area

关键词： Alder RPAS Multi-spectral Defoliation Texture variables 3D point cloud Tree health monitoring

Extending JASAG with data processing techniques for speeding up agricultural simulation applications:A case study with Simugan

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Information Processing in Agriculture 2016年第4期3卷 235-243页

作者： Mathias Longo Mauricio Arroqui juan rodriguez Claudio Machado Cristian Mateos Alejandro Zunino ISISTAN–CONICET.Tandil(B7001BBO) Buenos AiresArgentina Consejo Nacional de Investigaciones Cientı´ficas y Te´cnicas(CONICET) Argentina Facultad de Ciencias Veterinarias–UNICEN.Tandil(B7001BBO) Buenos AiresArgentina Agencia Nacional de Promocio´n Cientı´fica y Tecnolo´gica(ANPCyT) Argentina

Resource-intensive agricultural simulation applications have increased the need for gridification tools–i.e.,software to transform and scale up the applications using Grid infrastructures–.Previous research has proposed JASAG,a generic gridification tool for agricultural applications,through which the performance of a whole-farm simulation application called Simugan improved ***,JASAG still lacks proper support for efficiently exploiting Grid storage resources,causing significant delays for assembling and summarizing the generated *** this application note,two different data processing techniques in the context of JASAG are presented to tackle this *** was again employed to validate the benefits of these *** using data processing techniques show that the execution time of Simugan was accelerated by a factor of up to 34.34.

关键词： Agricultural simulation applications Grid Computing Gridification JASAG Data processing Simugan