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Effects of serum inflammatory factors,health index and disease activity scores on ankylosing spondylitis patients with sleep disorder

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World Journal of Psychiatry 2024年第6期14卷 866-875页

作者： Hui Wang jia-Ying Sun Yue zhang Department of Rheumatology and Immunology The First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina

BACKGROUND Patients with ankylosing spondylitis(AS)frequently suffer from comorbid sleep disorders,exacerbating the burden of the disease and affecting their quality of *** To investigate the clinical significance of serum inflammatory factors,health index and disease activity scores in patients with AS complicated by sleep *** A total of 106 AS patients with comorbid sleep disorders were included in the *** patients were grouped into the desirable and undesirable prognosis groups in accordance with their clinical *** serum levels of inflammatory factors,including C-reactive protein,erythrocyte sedimentation rate,interleukin(IL)-6,tumour necrosis factor-αand IL-1β,were *** activity scores,such as the Bath AS functional index,Bath AS disease activity index,Bath AS metrology index and AS disease activity score,were *** health index was obtained through the Short Form-36 *** The study found significant associations amongst serum inflammatory factors,health index and disease activity scores in AS patients with comorbid sleep *** correlations were found between serum inflammatory factors and disease activity scores,indicating the influence of heightened systemic inflammation on disease severity and functional ***,negative correlations were found between disease activity scores and health index parameters,highlighting the effect of disease activity on various aspects of healthrelated quality of *** regression analysis further confirmed the predictive value of these factors on patient outcomes,underscoring their potential utility in risk assessment and *** The findings demonstrate the intricate interplay amongst disease activity,systemic inflammation and patientreported health outcomes in AS patients complicated by sleep *** results emphasise the need for comprehensive care strategies that address the diverse needs and challe

关键词： Inflammatory factors Disease activity scores Health index Ankylosing spondylitis Sleep disorders

Train wheel-rail force collaborative calibration based on GNN-LSTM

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High-Speed Railway 2024年第2期2卷 85-91页

作者： Changfan zhang Zihao Yu Lin jia College of Railway Transportation Hunan University of TechnologyZhuzhou 412007China College of Electrical and Information Engineering Hunan University of TechnologyZhuzhou 412007China

Accurate wheel-rail force data serves as the cornerstone for analyzing the wheel-rail ***,achieving continuous and precise measurement of this force remains a significant challenge in the *** article introduces a calibration algorithm for the wheel-rail force that leverages graph neural networks and long short-term memory ***,a comprehensive wheel-rail force detection system for trains was constructed,encompassing two key components:an instrumented wheelset and a ground wheel-rail force measuring ***,utilizing this system,two distinct datasets were acquired from the track inspection vehicle:instrumented wheelset data and ground wheel-rail force data,a feedforward neural network was employed to calibrate the instrumented wheelset data,referencing the ground wheel-rail force ***,ground wheel-rail force data for the locomotive was obtained for the corresponding road *** data was then integrated with the calibrated instrumented wheelset data from the track inspection *** the GNN-LSTM network,the article establishes a mapping relationship model between the wheel-rail force of the track inspection vehicle and the locomotive wheel-rail *** model facilitates continuous measurement of locomotive wheel-rail forces across three typical scenarios:straight sections,long and steep downhill sections,and small curve radius sections.

关键词： Railway Wheel-rail force Deep learning Instrumented wheelset Ground wheel-rail force measuring system

Surface vitrification of carbon by laser treatment: Insights of glass formation from molecular dynamics

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Journal of Advanced Ceramics 2024年第6期13卷 729-735页

作者： Yanhui zhang Haifeng Yu Yongying jia Zhisheng Zhao Li-Min Wang Riping Liu Center for Advanced Structural Materials State Key Laboratory of Metastable Materials Science and TechnologyYanshan UniversityQinhuangdao 066004China

Microstructural modification of carbon materials,such as carbon fibers(Cf)and pyrolytically deposited carbon,is important for engineering ***,the regulation of these materials is not an effortless *** understand the impacts of thermal spikes from pulsed laser processing on the structural adaptation of amorphous carbon(a-C),we performed melt quenching by molecular dynamics(MD)*** results confirm that the vitrification behavior of carbon can be tuned by adjusting the cooling rate(R),which is controlled by the thermal spikes of laser ***,we set up a two-step way to locate the critical cooling rate(R_(c))of monoatomic carbon,which is refined by the sharp change in the environmental similarity *** this novel technique,we demonstrate that the ordering degree and the local atomic motif can be largely modified by going across a bar of 100 K/ps,which is extracted as the critical cooling rate to ensure the complete amorphization of *** approach provides a criterion for both experimentally processing and theoretically simulating a-C ***,this work provides guidelines on how to tune the amorphous carbon structures of engineering materials and provides an outlook for the wonderland of amorphous carbon materials.

关键词： molecular dynamics(MD) structural order carbon fibers(Cf) vitrification critical cooling rate(R_(c))

Analysis of Intelligent Equipment Usage for Work-Related Musculoskeletal Disorders Prevention in Miners—Shanxi Province,China,2023

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China CDC weekly 2024年第34期6卷 862-866页

作者： Haimiao Yu Zepeng Xu Ying Xia Shuo zhang Xiaoting jia School of Economics and Management China University of Mining and TechnologyXuzhouJiangsu ProvinceChina Administrators Training Center National Health Commission of the People’s Republic of ChinaBeijingChina

Summary What is already known about this topic?Work-related musculoskeletal disorders(WMSDs)are prevalent in the workforce and occur across various *** show that the prevalence of WMSDs among miners is generally over 50%.What is added by this report?High levels of intelligent equipment usage(IEU)can decrease the prevalence of WMSDs among miners by 7.49%and reduce pain by 13.69%on average.

关键词： WMS Work skeletal

Artificial intelligence in individualized retinal disease management

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1519-1530页

作者： Zi-Ran zhang jia-jun Li Ke-Ran Li The Affiliated Eye Hospital of Nanjing Medical University Nanjing 210029Jiangsu ProvinceChina Nanjing Medical University Nanjing 210029Jiangsu ProvinceChina

Owing to the rapid development of modern computer technologies,artificial intelligence(AI)has emerged as an essential instrument for intelligent analysis across a range of *** has been proven to be highly effective in ophthalmology,where it is frequently used for identifying,diagnosing,and typing retinal *** increasing number of researchers have begun to comprehensively map patients’retinal diseases using AI,which has made individualized clinical prediction and treatment *** include prognostic improvement,risk prediction,progression assessment,and interventional therapies for retinal *** have used a range of input data methods to increase the accuracy and dependability of the results,including the use of tabular,textual,or image-based input *** also combined the analyses of multiple types of input *** give ophthalmologists access to precise,individualized,and high-quality treatment strategies that will further optimize treatment outcomes,this review summarizes the latest findings in AI research related to the prediction and guidance of clinical diagnosis and treatment of retinal diseases.

关键词： artificial intelligence artificial intelligence in ophthalmology retinal disease

Preparation of single atom catalysts for high sensitive gas sensing

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International Journal of Extreme Manufacturing 2024年第3期6卷 216-248页

作者： Xinxin He Ping Guo Xuyang An Yuyang Li jiatai Chen Xingyu zhang Lifeng Wang Mingjin Dai Chaoliang Tan jia zhang Key Laboratory of Microsystems and Microstructure Manufacturing Ministry of EducationHarbin Institute of TechnologyHarbin 150080People’s Republic of China Institute for Frontier Materials Deakin UniversityWaurn Ponds CampusLocked Bag 20000Victoria 3220Australia School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore Department of Electrical and Electronic Engineering The University of Hong KongPokfulam RoadHong Kong Special Administrative Region of China 999077People’s Republic of China Chongqing Research Institute Harbin Institute of TechnologyChongqing 401120People’s Republic of China

Single atom catalysts(SACs)have garnered significant attention in the field of catalysis over the past decade due to their exceptional atom utilization efficiency and distinct physical and chemical *** the semiconductor-based electrical gas sensor,the core is the catalysis process of target gas molecules on the sensitive *** this context,the SACs offer great potential for highly sensitive and selective gas sensing,however,only some of the bubbles come to the *** facilitate practical applications,we present a comprehensive review of the preparation strategies for SACs,with a focus on overcoming the challenges of aggregation and low *** research efforts have been devoted to investigating the gas sensing mechanism,exploring sensitive materials,optimizing device structures,and refining signal post-processing ***,the challenges and future perspectives on the SACs based gas sensing are presented.

关键词： single atom catalysts preparation sensing mechanism gas sensing

Changes in macrophage infiltration and podocyte injury in lupus nephritis patients with repeated renal biopsy: Report of three cases

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World Journal of Clinical Cases 2024年第1期12卷 188-195页

作者： Shi-Yuan Liu Hao Chen Li-jia He Chun-Kai Huang Pu Wang zhang-Ru Rui jue Wu Yang Yuan Yue zhang Wen-ju Wang Xiao-Dan Wang Central Laboratory Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan ProvinceYan'an Hospital Affiliated to Kunming Medical UniversityKunming 650051Yunnan ProvinceChina Department of Nephropathy Yan'an Hospital Affiliated to Kunming Medical UniversityKunming 650051Yunnan ProvinceChina

BACKGROUND In this study,we retrospectively analysed macrophage infiltration and podocyte injury in three patients with diffuse proliferative lupus nephritis(LN)who un-derwent repeated renal *** SUMMARY Clinical data of three diffuse proliferative LN patients with different pathological characteristics(case 1 was LN IV-G(A),case 2 was LN IV-G(A)+V,and case 3 was LN IV-G(A)+thrombotic microangiopathy)were *** patients underwent repeated renal biopsies 6 mo later,and renal biopsy specimens were *** infiltration was assessed by CD68 expression detected by immunohistochemical staining,and an immunofluorescence assay was used to detect podocin expression to assess podocyte *** treatment,Case 1 changed to LN III-(A),Case 2 remained as type V LN lesions,and Case 3,which changed to LN IV-S(A),had the worst *** observed reduced macro-phage infiltration after ***,two of the patients with active lesions after treatment still showed macrophage infiltration in the renal *** treatment,the three patients showed discontinuous expression of ***,the integrity of podocin was restored after treatment in Case *** It may be possible to reverse podocyte damage and decrease the infiltrating ma-crophages in LN patients through effective treatment.

关键词： Lupus nephritis Macrophage Podocyte Repeat renal biopsy Thrombotic microangiopathy Case report

Progression from ductal carcinoma in situ to invasive breast cancer:molecular features and clinical significance

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1841-1868页

作者： Jing Wang Baizhou Li Meng Luo jia Huang Kun zhang Shu Zheng Suzhan zhang jiaojiao Zhou The Key Laboratory of Cancer Prevention and Intervention China National Ministry of Educationthe Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Department of Breast Surgery and Oncology the Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Zhejiang Provincial Clinical Research Center for Cancer HangzhouChina Department of Pathology the Fourth Affiliated HospitalZhejiang University School of MedicineYiwuChina Department of Plastic Surgery the Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Cancer Center Zhejiang UniversityHangzhouChina

Ductal carcinoma in situ(DCIS)represents pre-invasive breast *** untreated cases,25-60%DCIS progress to invasive ductal carcinoma(IDC).The challenge lies in distinguishing between non-progressive and progressive DCIS,often resulting in over-or under-treatment in many *** increasing screen-detected DCIS in these years,the nature of DCIS has aroused worldwide attention.A deeper understanding of the biological nature of DCIS and the molecular journey of the DCIS-IDC transition is crucial for more effective clinical ***,we reviewed the key signaling pathways in breast cancer that may contribute to DCIS initiation and *** also explored the molecular features of DCIS and IDC,shedding light on the progression of DCIS through both inherent changes within tumor cells and alterations in the tumor *** addition,valuable research tools utilized in studying DCIS including preclinical models and newer advanced technologies such as single-cell sequencing,spatial transcriptomics and artificial intelligence,have been systematically ***,we thoroughly discussed the clinical advancements in DCIS and IDC,including prognostic biomarkers and clinical managements,with the aim of facilitating more personalized treatment strategies in the *** on DCIS has already yielded significant insights into breast carcinogenesis and will continue to pave the way for practical clinical applications.

关键词： clinical breast alterations

Geochemical and Isotopic Techniques Constraints on the Origin,Evolution,and Residence Time of Low-enthalpy Geothermal Water in Western Wugongshan,SE China

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Acta Geologica Sinica(English Edition) 2024年第3期98卷 801-818页

作者： WANG Luyao LIU Kai MA Yan zhang Yaoyao TONG jue jia Wuhui zhang Shouchuan SUN junliang Chinese Academy of Geological Sciences Beijing 100037China School of Water Resources and Environment China University of Geoscience(Beijing)Beijing 100083China The Fourth Geological Brigade of jiangxi Geological Bureau PingxiangJiangxi 337000China

Geothermal resources are increasingly gaining attention as a competitive,clean energy source to address the energy crisis and mitigate climate *** Wugongshan area,situated in the southeast coast geothermal belt of China,is a typical geothermal anomaly and contains abundant medium-and low-temperature geothermal *** study employed hydrogeochemical and isotopic techniques to explore the cyclic evolution of geothermal water in the western Wugongshan region,encompassing the recharge origin,water-rock interaction mechanisms,and residence *** results show that the geothermal water in the western region of Wugongshan is weakly alkaline,with low enthalpy and mineralization *** hydrochemistry of geothermal waters is dominated by Na-HCO_(3)and Na-SO_(4),while the hydrochemistry types of cold springs are all Na-HCO_(3).The hydrochemistry types of surface waters and rain waters are NaHCO_(3)or Ca-HCO_(3).The δD and δ^(18)O values reveal that the geothermal waters are recharged by atmospheric precipitation at an altitude between 550.0 and 1218.6 *** ratios of maj or solutes and isotopic compositions of^(87)Sr/^(86)Sr underscore the significant role of silicate weathering,dissolution,and cation exchange in controlling geothermal water ***,geothermal waters experienced varying degrees of mixing with cold water during their ***δ^(13)C values suggest that the primary sources of carbon in the geothermal waters were biogenic and ***δ^(34)S value suggests that the sulfates in geothermal water originate from sulfide minerals in the surrounding *** dating using 3H and^(14)C isotopes suggests that geothermal waters have a residence time exceeding 1 kaBP and undergo a long-distance cycling process.

关键词： geothermal water hydrochemistry isotope residence time Wugongshan area