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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： ju zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

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Diverse Roles of Immune Cells in Transplant Rejection and Immune Tolerance

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Engineering 2022年第3期8卷 44-56页

作者： Xiaojie Gan Jian Gu zheng ju Ling Lu Hepatobiliary Center The First Affiliated Hospital of Nanjing Medical University&Research Unit of Liver Transplantation and Transplant ImmunologyChinese Academy of Medical SciencesNanjing 210029China

Organ transplant rejection(OTR)is a complex immune reaction involving multiple cells,and it determines graft survival and patient *** present,most transplant recipients are administered a combination of immunosuppressive and biological agents to protect them from ***,immunosuppressive agents negatively impact the immune system of the patients,causing them to suffer from serious complications,such as chronic infection and malignant ***,a thorough understanding of the mechanisms involved in immune tolerance and immune rejection with regard to organ transplant(OT)is essential for developing better treatment options and improving patient *** article reviews the role of immune cells in OTR and organ transplant tolerance(OTT),including the novel cell therapies that are currently under clinical trials for transplant recipients.

关键词： Immune cells Innate immune cells Adaptive immune cells Organ transplant Immune tolerance

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Upconversion Luminescence of SrTiO3：Er^3＋ Ultrafine Powders Produced by 785 nm Laser

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Chinese Journal of Chemical Physics 2008年第3期21卷 233-238页

作者： Hai Guo Yan-min Qiao ju-fang zheng Lei-hong Zhao Department of Physics Zhejiang Normal University Jinhua 321004 China Zhejiang Key Laboratory for Reactive Chemistry on 5olicl Surfaces Institute of Physical Chemistry Zhejiang Normal University Jinhua 321004 China

Er^3＋ doped SrTiO3 ultrafine powders were prepared by solid state reaction in a molten NaCl flux. The structural properties were characterized by X-ray diffraction, field emission scanning electron microscopy, and Fourier transform infrared spectroscopy. The Stokes emission spectra of Er^3＋ in SrTiO3：Er^3＋ ranging from green to near infrared region were investigated under 514.5 nm laser excitation. The green and red upconverted luminescence spectra of Er^3＋ were measured under excitation into the 419/2 level by 785 nm laser. The upconversion mechanisms were studied in detail through laser power dependence and Er^3＋ ion concentration dependence of upconverted emissions, and results show that excited state absorption and energy transfer process are the possible mechanisms for the upconversion. The upconversion properties indicate that SrTiO3：Er^3＋ may be used in upconversion phosphors.

关键词： SrTiO3 Upconversion luminescence Excited state absorption Energy transfer

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Partial embolization as re-treatment of hypersplenism after unsuccessful splenic artery ligation

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World Journal of Gastroenterology 2015年第4期21卷 1365-1370页

作者： zheng-ju Xu Lian-Qiu zheng Xing-Nan Pan Clinical Liver Center 180~(th) Hospital of the People’s Liberation Army

Ligation of splenic artery(LSA) is used for the treatment of liver cirrhosis with hypersplenism. However, hypersplenism is not significantly improved following LSA treatment in some cases, and there are few reports of retreatment of hypersplenism after LSA. We report the case of a47-year-old man with liver cirrhosis and hypersplenism who underwent LSA treatment, but did not significantly improve. Laboratory tests revealed severe leukocytopeniaand thrombocytopenia. Celiac computed tomography arteriogram and digital subtraction angiography revealed two compensatory arteries connected to the hilar splenic artery from the left gastro-epiploic artery and from the dorsal pancreatic artery. Partial splenic embolization(PSE) was performed through the compensatory arteries. As a result, the patient achieved partial splenic ischemic infarction, and white blood cell and platelet counts rose and remained in the normal range. PSE is an effective therapeutic modality for the retreatment of hypersplenism when other modalities have failed.

关键词： Hypersplenism Partial splenic embolization Splenic

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Nutri-microbiome epidemiology,an emerging field to disentangle the interplay between nutrition and microbiome for human health

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Protein & Cell 2023年第11期14卷 787-806页

作者： Wanglong Gou Zelei Miao Kui Deng ju-Sheng zheng Westlake Intelligent Biomarker Discovery Lab Westlake Laboratory of Life Sciences and BiomedicineHangzhou 310024China Research Center for Industries of the Future Key Laboratory of Growth Regulation and Translational Research of Zhejiang ProvinceSchool of Life SciencesWestlake UniversityHangzhou 310030China Institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzhou 310024China

Diet and nutrition have a substantial impact on the human microbiome,and interact with the microbiome,especially gut microbiome,to modulate various diseases and health *** research has also guided the nutrition field to a more integrative direction,becoming an essential component of the rising area of precision *** this review,we provide a broad insight into the interplay among diet,nutrition,microbiome,and microbial metabolites for their roles in the human *** the microbiome epidemiological studies regarding the associations of diet and nutrition with microbiome and its derived metabolites,we summarize those most reliable findings and highlight evidence for the relationships between diet and disease-associated microbiome and its functional ***,the latest advances of the microbiome-based precision nutrition research and multidisciplinary integration are ***,we discuss several outstanding challenges and opportunities in the field of nutri-microbiome epidemiology.

关键词： microbiome nutrition human health epidemiology

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An Observation on the Microphase Separation of Poly(methyl methacrylate)-block-Polystyrene Copolymer

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Chinese Chemical Letters 2001年第5期12卷 467-470页

作者： Jie DENG Xin Song LI zheng Mei WANG Gang SHAO ju zheng LIU Department of Chemical Engineering Southeast UniversityNanjing 210096

The phase behavior of a well-defined poly(methyl methacrylate)- b- polystyrene block copolymer was studied by transmission electron microscope. The results show that a microphase transition may have occurred in the copolymer film. A kind of lamellae and an ordered bicontinuous double-diamond morphology are observed clearly. The lamellar morphology reveals a larger period of about 400 nm.

关键词： Block copolymer phase separation atom transfer radical polymerization TEM

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Genetic mapping of plasma proteome on brain structure

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Journal of Genetics and Genomics 2024年第7期51卷 774-777页

作者： Shengyi Ma Fengzhe Xu Yuanqing Fu ju-Sheng zheng Fudan University Shanghai 200433China School of Life Sciences Westlake UniversityHangzhouZhejiang 310030China Westlake Center for Intelligent Proteomics Westlake Laboratory of Life Sciences and BiomedicineHangzhouZhejiang 310030China

The emergence of high-throughput techniques for proteomics measurement has led to an increasing number of proteogenomic studies that aim to reveal protein quantitative trait loci(pQTL)based on large cohorts(Suhre et a... 详细信息

关键词： mapping structure throughput

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Ecotourism in nature reserves in China:current situation,problems and solutions

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Forestry Studies in China 2008年第2期10卷 130-133页

作者： LUO ju-chun zheng Jing-ming Key Laboratory for Silviculture and Conservation of Ministry of Education Beijing Forestry University Beijing 100083 P. R. China

Our presentation focuses on some important issues associated with ecotourism in nature reserves in China's Mainland. Conducting ecotourism in certain areas in nature reserves is important for its protection. However, some problems do exist because of special conditions in our society and in the current projects of nature reserves themselves, such as water and air pollution, unplanned construction of roads and facilities, damage of core zones and buffer zones, and confused ownership of nature reserves. These problems are discussed and solutions are proposed in detail, and we emphasize the participation of local communities in order to help residents fight against poverty.

关键词： ecotourism nature reserve participation of local communities

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Open metallocenes——Ⅺ. A pentadienyl compound of heavier rare earth element [2,4-(CH_3)_2-η~5-C_5H_5]_3Tb·1/2THF

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Chinese Journal of Chemistry 1991年第1期9卷 10-19页

作者： QIU,Xin LIU,ju-zheng Intitute of Theoretical Chemistry Jilin UniversityChangchun 130023

Perfluoroalkyl iodides reacted with conjugated dienes in aqueous acetonitrile solution in the presence of sodium dithionite at room temperature to give dimerization products, whereas, perfluo- roalkanesulfonyl bromide... 详细信息

关键词： A pentadienyl compound of heavier rare earth element C5H5 CH3 Open metallocenes THF

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Dynamic evolution characteristics of the “source-reservoir” integration of gray marl and its geological significance to unconventional gas: Insights from pyrolysis experiments

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Petroleum Science 2023年第2期20卷 705-720页

作者： Zhang-Hu Wang Zhong-Liang Ma Lun-ju zheng jun-Yu Wang Zhi-Gang Wen Chen-Yang Si Cooperative Innovation Center of Unconventional Oil and Gas Yangtze UniversityWuhanHubei430100China Key Laboratory of Oil and Gas Resources and Exploration Technology Ministry of EducationCollege of Resources and EnvironmentYangtze UniversityWuhanHubei430100China Wuxi Research Institute of Petroleum Geology Sinopec Exploration and Production Research InstituteWuxiJiangsu214126China State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective Development WuxiJiangsu214126China School of Metallurgy and Environment Central South UniversityChangshaHunan410083China

The marl–limestone rhythmic strata of the Permian Maokou Formation have been identified as hosts of unconventional gas reservoirs with “source–reservoir” integration. The lack of research on the pore structure evolution of organic-rich carbonate rock restricts gas exploration of these strata. Here, pyrolysis experiments were performed on the Mao-1 carbonate to simulate hydrocarbon generation, expulsion and diagenesis in gray marl from low maturity to overmaturity. The pore structure of this marl is dominated by mesopores and macropores, and the proportion of macropores increases gradually with temperature. The macropores are mainly pores in the organic matter and shrinkage microcracks. Additionally, micropores and mesopores, dominated by clay mineral interlayer pores and pyrite intergranular pores, are developed in the high mature stage and subsequently compressed in the overmature stage. The main contributors to the specific surface area are micropores and mesopores, which are conducive to natural gas adsorption. After the same pyrolysis treatment, the available porosity of grey marl is higher than that of marine/lacustrine shales, and exhibits an obvious decrease in the low mature–mature stage. These suggest that the abundant residual oil generated blocked the organic and inorganic pores in the gray marl, providing a pivotal material foundation for the gas generation. Micropores and mesopores developed during the high mature stage ensure the gas accumulation and preservation. The above indicate the organic-rich carbonate at the high mature–overmature stage (Ro = 1.7%–2.5%) in the Sichuan Basin may be a favorable exploration horizon for unconventional oil and gas.

关键词： Residual oil Organic pores Porosity Sepiolite Hydrocarbon generation

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