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Atmospheric fate of typical liquid crystal monomers in the tropospheric gas,liquid,and granular phases

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Journal of Environmental Sciences 2024年第2期136卷 348-360页

作者： Yanru Huo Zexiu An Mingxue Li Jinchan Jiang Yuxin Zhou ju xie Jianguo Zhang Maoxia He Environment Research Institute Shandong UniversityQingdao 266237China College of Plant Protection Hebei Agricultural UniversityBaoding 071000China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China Jinan Environmental Research Academy Jinan 250000China

Mineral aerosol particles significantly impact environmental risk prediction of liquid crystal monomers(LCMs).In this work,we investigated the reaction mechanisms and kinetics of three typical LCMs(4-cyano-3,5-difluorophenyl 4-ethylbenzoate(CEB-2F),4-cyano-3-fluorophenyl 4-ethylbenzoate(CEB-F),and 4-cyanophenyl 4-ethylbenzoate(CEB))with ozone(O_(3))in the atmospheric gas,liquid,and particle phases employing density functional theory(DFT).Here,O_(3)is prone to add to the benzene ring without F atom(s)in the selected *** ozonolysis products are aldehydes,carboxylic acids,epoxides,and unsaturated hydrocarbons containing aromatic *** products undergo secondary ozonolysis to generate small molecular compounds such as glyoxal,which is beneficial for generating secondary organic aerosol(SOA).Titanium dioxide(TiO_(2)),an essential component of mineral aerosol particles,has good adsorption properties for LCMs;however,it slightly reduces the reactivity with O_(3).At 298 K,the reaction rate constant of the selected LCMs reacting with O_(3)in the gas and atmospheric liquid phases is(2.74–5.53)×10^(-24)cm^(3)/(mol·sec)and 5.58×10^(-3)–39.1 L/(mol·sec),while CEB-2F reacting with O_(3)on(TiO_(2))_(6)cluster is 1.84×10^(-24)cm^(3)/(mol·sec).The existence of TiO_(2)clusters increases the persistence and long-distance transportability of LCMs,which enlarges the contaminated area of LCMs.

关键词： Liquid crystal monomers(LCMs) Ozonolysis TiO_(2)clusters Adsorption Toxicity assessment

e^(+)e^(-)→Λ_(c)+Λ_(c)^(- ) Cross Sections and the Λ_(c)^(+) Electromagnetic Form Factors within the Extended Vector Meson Dominance Model

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Chinese Physics Letters 2024年第2期41卷 36-41页

作者：陈诚闫冰谢聚军 Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Sciences and Technology University of Chinese Academy of SciencesBeijing 101408China College of Mathematics and Physics Chengdu University of TechnologyChengdu 610059China Southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China

Within the extended vector meson dominance model,we investigate the𝑒e^(+)e^(-)→Λ_(c)+Λ_(c)^(- ) reaction and the electromagnetic form factors of the charmed baryon𝛬 Λ_(c)^(+)𝑐.The model parameters are determined by fitting them to the cross sections of the process𝑒e^(+)e^(-)→Λ_(c)+Λ_(c)^(- ) and the magnetic form factor|G_(M)|of Λ_(c)^(+) .By considering four charmonium-like states,called𝜓(4500),𝜓(4660),𝜓(4790),and𝜓(4900),we can well describe the current data on the𝑒e^(+)e^(-)→Λ_(c)+Λ_(c)^(- ) reaction from the reaction threshold up to 4.96 *** addition to the total cross sections and|𝐺M|,the ratio|G_(E)/G_(M)|and the effective form factor|Geff|for Λ_(c)^(+) 𝑐are also calculated,and found that these calculations are consistent with the experimental *** the fitted model parameters,we have also estimated the charge radius of the charmed Λ_(c)^(+) baryon.

关键词： fitted radius meson

Exploring the molecular mechanism of Solanum nigrum L in breast cancer treatment through network pharmacology and molecular docking validation

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Pharmacology Discovery 2024年第3期4卷 1-16页

作者： Mei Zheng ju-Min xie Hubei Key Laboratory of Renal Disease Occurrence and Intervention Hubei Polytechnic UniversityHuangshi 435003China

In 2020,breast cancer emerged as the leading type of cancer worldwide,surpassing lung cancer in the number of new *** high cost and frequent failure of current treatments due to drug resistance and other challenges underscore the urgent need for novel,affordable,efficient,and less toxic breast cancer therapies with fewer side *** study aims to investigate the molecular mechanisms by which Solanum Nigrum *** breast cancer,employing network pharmacology and molecular docking ***:The study identified the primary active compounds of Solanum Nigrum *** databases such as TCMSP,TCM-ID,NPASS,and *** of the compounds'targets was facilitated by the SwissADME website,while main breast cancer targets were sourced from the GeneCards,OMIM,and TTD *** identified drug-disease intersection targets were analyzed using the STRING platform to construct a protein interaction network,which was then visualized and refined to select hub targets using Cytoscape 3.9.0 *** Metascape database's MOCDE functional plugin was employed for identifying potential functional modules within the protein interaction ***,the DAVID database was utilized for GO and KEGG enrichment analyses of the intersection *** docking of key active compounds with core targets was performed using AutoDock Tools 1.5.7 ***,the GEPIA2.0 database was used for predicting overall survival curves of hub targets and conducting a pan-cancer ***:Eleven active compounds of Solanum Nigrum L.,including Diosgenin,Tigogenin,and Quercetin,were identified from traditional Chinese medicine *** discovered 113 targets common to both Solanum Nigrum *** breast *** Nigrum *** anti-breast cancer properties through interactions with 14 key targets,including SRC,PIK3R1,HSP90AA1,PIK3CA,AKT1,VEGFA,and *** interactions influence several critical signaling pathways,notably the cancer signaling pa

关键词： anti-cancer molecular docking network pharmacology Solanum Nigrum L

COVID-19 pandemic amplified mortality rates among adolescents with bipolar disorder through family-related factors

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World Journal of Clinical Cases 2024年第11期12卷 1929-1935页

作者： Zhuo-Fan Ye Yi-Han Hong Jian-Lin Yang Meng-Qing Tan ju-Min xie Zu-Cai Xu Department of Neurology The Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Hubei Key Laboratory of Renal Disease Occurrence and Intervention Medical SchoolHubei Polytechnic UniversityHuangshi 435003Hubei ProvinceChina Psychological Children's Ward Mental Health Center of HuangshiHuangshi 435111Hubei ProvinceChina The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina

BACKGROUND Recently,a growing number of adolescents have been afflicted with mental disorders,with annual morbidity rates on the *** trend has been exacerbated by the global coronavirus disease 2019(COVID-19)pandemic,leading to a surge in suicide and self-harm rates among this *** To investigate the impact of the COVID-19 pandemic on adolescent bipolar disorder(BD),along with the underlying factors contributing to heightened rates of suicide and self-harm among *** A comprehensive statistical analysis was conducted utilizing clinical interviews and self-reports obtained from patients or their *** criteria for BDs were based on the Diagnostic and statistical manual of mental disorders,international classification of diseases-11,and the National institute of mental health research domain *** analyses were performed using SPSS 26.0 software,with significance set at P<*** A cohort of 171 adolescents diagnosed with BD between January 1,2018,and December 31,2022,was included in the *** gender distribution was 2.8:1(female to male),with ages ranging from 11 to 18 years *** factors contributing to adolescent BDs included familial influences,academic stress,genetic predisposition and exposure to school-related ***,a significant increase in suicide attempts and self-harm incidents was observed among adolescents with BD during the COVID-19 *** analysis indicated that the pandemic exacerbated familial discord and heightened academic stress,thereby amplifying the prevalence of suicidal behavior and self-harm among *** The COVID-19 pandemic has exacerbated familial tensions and intensified the incidence of suicide and self-harm among adolescents diagnosed with *** study underscores the urgent need for societal,familial and educational support systems to prioritize the well-being of adolescents and offers valuable insights and guidelines

关键词： Adolescents Bipolar disorder COVID-19 Suicide Self-harm

Investigating the molecular mechanism of Chelidonii Herba against liver cancer using network pharmacology and molecular docking validation

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Integrative Medicine Discovery 2024年第22期8卷 1-12页

作者： Ming-Zhi Yang Zi-Xuan Yang Zhang Yu ju-Min xie Hubei Key Laboratory of Renal Disease Occurrence and Intervention Medical SchoolHubei Polytechnic UniversityHuangshi 435003China

Background:The molecular mechanism of Chelidonii Herba in treating hepatocellular carcinoma was investigated using network pharmacology and molecular docking ***:The main active components of Chelidonii Herba were screened using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform database,and the targets of these active ingredients were identified using the SwissTargetPrediction *** related to liver cancer were sourced from GeneCards,Therapeutic Targets Database,and Online Mendelian Inheritance in Man *** targets between the active components of Chelidonii Herba and liver cancer were determined using the jvenn online *** protein interaction network was analyzed via STRING database and visualized using Cytoscape *** targets were identified and further analyzed within the protein interaction *** Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted for the intersection targets using the DAVID database to correlate gene *** bubble diagrams for Gene Ontology enrichment analysis and circular diagrams for Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were generated using CNSknowall and SangerBox online *** docking and visualization were performed using AutoDockTools 1.5.7 and PyMOL 2.5.7 software,*** survival and pan-cancer analysis of core targets were conducted using the GEPIA2 online ***:Twelve active components of Chelidonii Herba were identified through screening.A total of 103 intersection targets and 12 core targets were found between these active constituents of Chelidonii Herba and liver *** Herba may exert its effects on liver cancer through these 12 core *** signaling pathways are implicated,including chemical carcinogen-receptor activation,endocrine resistance,HIF-1 signaling pathway,and proteoglycans in ***

关键词： Chelidonii Herba liver cancer network pharmacology molecular docking

Treatment of a patient with severe cerebral malaria during the COVID-19 pandemic in China:A case report

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World Journal of Clinical Cases 2024年第20期12卷 4419-4426页

作者： Yan-Fang Zhu Wen-Jing Xia Wei Liu ju-Min xie Department of Critical Care Medicine Huangshi Hospital of TCM(Infectious Disease Hospital)Huangshi 435000Hubei ProvinceChina Hubei Key Laboratory of Renal Disease Occurrence and Intervention Medical SchoolHubei Polytechnic UniversityHuangshi 435003Hubei ProvinceChina

BACKGROUND On june 30,2021,China received certification from the World Health Organization for malaria ***,this certification does not signify the absence of malaria within *** to the increasing frequency of international exchanges and collaborations,the threat of imported malaria persists in ***,the prevention and control of imported malaria have become a primary focus for our country to maintain its malaria elimination *** SUMMARY Herein,we present a case report of a 53-year-old Chinese man who worked in Africa for nearly two *** was diagnosed with malaria in the Democratic Republic of the Congo between November 19 and November 23,*** receiving effective treatment with oral antimalarial drugs,his condition improved,allowing him to return to *** was later admitted to our hospital on January 12,2023,during the coronavirus disease 2019 pandemic in Huangshi,*** a thorough evaluation of the patient's symptoms,clinical signs,imaging and laboratory test results,and epidemiological data,he was rapidly diagnosed with severe cerebral *** patient underwent successful treatment through a series of intensive care unit *** The successful treatment of this imported case of severe cerebral malaria provides a valuable reference for managing patients with similar malaria infections and has significant clinical implications.

关键词： Pernicious malaria Severe cerebral malaria Imported patients Traditional Chinese medicine Angong niuhuang Pill Case report

地方高等医学本科院校专业自评体系的构建与实践

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教育教学论坛 2024年第12期 31-34页

作者：李萍谢协驹王冬菊海南医学院教务处海南海口571199 海南医学院基础医学与生命科学学院海南海口571199

通过构建以专业定位和培养方案、师资建设、专业建设与改革、教学管理、人才培养质量基本教学条件和使用、专业特色为核心的校内本科专业评估指标体系,通过组织专业自评、专家线上评审及实地考察三个阶段的校级专业评估,促进专业内涵建... 详细信息

通过构建以专业定位和培养方案、师资建设、专业建设与改革、教学管理、人才培养质量基本教学条件和使用、专业特色为核心的校内本科专业评估指标体系,通过组织专业自评、专家线上评审及实地考察三个阶段的校级专业评估,促进专业内涵建设得到普遍重视、专业建设队伍水平不断提高,逐步形成了具有热带医学特色方向的本科专业培养模式。通过第一轮的校内专业自评实践,体会到今后进一步完善校内本科专业自评体系建设,应建立完善的专业评估长效机制,积极引入第三机构参与专业评估,并建立专业自评体系的动态调整和改进机制,确保专业评估取得实效。

关键词：普通高等学校专业评价内部教学质量评价

补肾祛瘀汤联合常规治疗对肾虚血瘀型绝经后骨质疏松症患者的临床疗效

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中成药 2024年第8期46卷 2601-2605页

作者：肖丽谢菊英刘韵胡丽萍曹夏石峻林湘南学院医学影像检验与康复学院湖南郴州423000 湘南学院附属医院康复医学科湖南郴州423000 湘南学院临床学院湖南郴州423000

目的考察补肾祛瘀汤联合常规治疗对肾虚血瘀型绝经后骨质疏松症患者的临床疗效。方法106例患者随机分为对照组和观察组,每组53例,对照组给予常规治疗,观察组在对照组基础上加用补肾祛瘀汤,疗程6个月。检测临床疗效、中医证候评分、骨代... 详细信息

目的考察补肾祛瘀汤联合常规治疗对肾虚血瘀型绝经后骨质疏松症患者的临床疗效。方法106例患者随机分为对照组和观察组,每组53例,对照组给予常规治疗,观察组在对照组基础上加用补肾祛瘀汤,疗程6个月。检测临床疗效、中医证候评分、骨代谢指标(β-CTX、PINP、BGP)、骨密度、氧化应激指标(SOD、AOPP、MAOA)、不良反应发生率变化。结果观察组总有效率高于对照组(P0.05)。结论补肾祛瘀汤联合常规治疗可安全有效地改善肾虚血瘀型绝经后骨质疏松症患者骨密度和骨代谢指标,减轻机体氧化应激反应。

关键词：补肾祛瘀汤常规治疗绝经后骨质疏松症肾虚血瘀

Electromagnetic Form Factors of Λ Hyperon in the Vector Meson Dominance Model and a Possible Explanation of the Near-Threshold Enhancement of the e^(+)e^(-)→ ΛΛ Reaction

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Chinese Physics Letters 2022年第1期39卷 11-16页

作者： Zhong-Yi Li An-Xin Dai ju-jun xie Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 101408China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China Lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu ProvinceLanzhou UniversityLanzhou 730000China

The near-threshold e^(+)e^(-)→ΛΛ reaction is studied with the assumption that the production mechanism is due to a near-ΛΛ-threshold bound state. The cross section of the e^(+)e^(-)→ΛΛ reaction is parameterized in terms of the electromagnetic form factors of Λ hyperon, which are obtained with the vector meson dominance *** is shown that the contribution to the e^(+)e^(-)→ΛΛ reaction from a new narrow state with quantum numbersJ~(PC)= 1--is dominant for energies very close to threshold. The mass of this new state is around 2231 Me V,which is very close to the mass threshold of ΛΛ, while its width is just a few Me V. This gives a possible solution to the problem that all previous calculations seriously underestimated the near-threshold total cross section of the e^(+)e^(-)→ΛΛ reaction. We also note that the near-threshold enhancement can also be reproduced by including these well established vector resonances ω(1420), ω(1650), Φ(1680), or Φ(2170) with a Flatté form for their total decay width, and a strong coupling to the ΛΛ channel.

关键词： reaction. state. narrow