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Increased glacier melt enhances future extreme floods in the southern Tibetan Plateau

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Advances in Climate Change Research 2024年第3期15卷 431-441页

作者： He sun Tan-Dong YAO Feng-Ge SU Tinghai Ou Zhihua HE Guoqiang tang Deliang CHEN State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Regional Climate Group Department of Earth SciencesUniversity of GothenburgGothenburg 40530Sweden Centre for Hydrology University of SaskatchewanSaskatoon S7N 1K2Canada Climate and Global Dynamics National Center for Atmospheric ResearchBoulder CO 80307USA

Mountainous areas are of special hydrological concern because topography and atmospheric conditions can result in large and sudden floods,posing serious risks to water-related safety in neighbouring *** Yarlung Zangbo(YZ)River basin is the largest river basin on the Tibetan Plateau(TP),but how floods will discharge in this basin and how the role of glacier melt in floods will change throughout the 21st-century under shared socioeconomic pathways scenarios(SSP2-4.5 and SSP5-8.5)remain ***,we comprehensively address this scientific question based on a well-validated large-scale glacier-hydrology *** results indicate that extreme floods was projected to increase in the YZ basin,and was mainly reflected in increased duration(4–10 d per decade)and intensity(153–985 m^(3)s^(−1)per decade).Glacier runoff was projected to increase(2–30 mm per decade)throughout the 21st-century,but there was also a noticeable decrease or deceleration in glacier runoff growth in the late first half of the century under the SSP2-4.5,and in the latter half of the century under the *** melt was projected to enhance the duration(12%–23%)and intensity(15%–21%)of extreme floods under both SSPs,which would aggravate the impact of future floods on the socioeconomics of the YZ *** effect was gradually overwhelmed by precipitation-induced floods from glacier areas to YZ *** study takes the YZ basin as a projection framework example to help enrich the understanding of future flood hazards in basins affected by rainfall-or meltwater across the TP,and to help policy-makers and water managers develop future plans.

关键词： floods glacier Tibetan

Validating the use of ROS-scavenging bacteria as probiotics to increase coral resilience to thermal stress

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Journal of Oceanology and Limnology 2024年第4期42卷 1242-1260页

作者： Xiaoyu tang Qingsong YANG Ying ZHANG Hanzhang WANG juan LING Haiyan sun junde DONG Yanying ZHANG CAS Key Laboratory of Tropical Marine Bio-resources and Ecology South China Sea Institute of Oceanology(SCSIO)Guangzhou 510301China Ocean School Yantai UniversityYantai 264005China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China Sanya National Marine Ecosystem Research Station and Key Laboratory of Tropical Marine Biotechnology of Hainan Province Sanya Institute of OceanologySCSIOSanya 572000China Institute of Deep-sea Science and Engineering Chinese Academy of SciencesSanya 572000China University of Chinese Academy of Sciences Beijing 100049China

Thermal stress causes the overproduction and toxic accumulation of reactive oxygen species(ROS),which seems to be correlated with coral bleaching and,ultimately,*** reduction of ROS concentration within the coral holobiont could minimize the effects of thermal stress and support efforts to reduce coral decline *** the current study,we explored the physiological responses of Pocillopora damicornis to ROS-scavenging bacteria inoculation as well as the microbiome restructuring that correlates with ***’s resilience to thermal stress after probiotic *** of corals with ROS-scavenging bacteria enhanced coral health and reduced ROS ***,the enhanced coral thermal resistance promoted by ROS-scavenging bacteria was also correlated with an overall coral microbiome *** addition,the complex network relationships between bacteria and Symbiodiniaceae in corals after ROS-scavenging bacteria inoculation contributed to corals’resilience to high ***,coral heat tolerance bacterial biomarkers,such as Myxococcota,were enriched in corals with added ROS-scavenging ***,our findings validate the selected ROS-scavenging bacteria as coral probiotics that could help corals resist thermal stress on a short ***,our data contribute to our understanding of the potential interactions between different members of the coral holobiont and the use of probiotics as tools to aid coral restoration efforts.

关键词： coral beneficial microorganisms for corals(BMCs) Symbiodiniaceae thermal stress coral bleaching

In vivo imaging of the neuronal response to spinal cord injury:a narrative review

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Neural Regeneration Research 2024年第4期19卷 811-817页

作者： junhao Deng Chang sun Ying Zheng Jianpeng Gao Xiang Cui Yu Wang Licheng Zhang Peifu tang Department of Orthopedics The Fourth Medical Center of Chinese PLA General Hospital National Clinical Research Center for Orthopedics Sports Medicine and Rehabilitation School of Life Sciences Tsinghua University Department of Orthopedics Air Force Medical CenterPLA Medical School of Chinese PLA Institute of Orthopedics The First Medical CenterChinese PLA General Hospital Key Lab of Regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma and War Injuries PLA

Deciphering the neuronal response to injury in the spinal cord is essential for exploring treatment strategies for spinal cord injury(SCI).However,this subject has been neglected in part because appropriate tools are *** in vivo imaging and labeling methods offer great potential for observing dynamic neural processes in the central nervous system in conditions of health and *** review first discusses in vivo imaging of the mouse spinal cord with a focus on the latest imaging techniques,and then analyzes the dynamic biological response of spinal cord sensory and motor neurons to *** then summarize and compare the techniques behind these studies and clarify the advantages of in vivo imaging compared with traditional neuroscience ***,we identify the challenges and possible solutions for spinal cord neuron imaging.

关键词： anterior horn neurons calcium imaging central nervous system dorsal horn neurons dorsal root ganglion in vivo imaging neuronal response spinal cord injury spinal cord two-photon microscopy

An amorphous FeMoO_(4) nanorod array enabled high-efficiency oxygen evolution electrocatalysis in alkaline seawater

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Nano Research 2024年第4期17卷 2270-2275页

作者： Jie tang Shengjun sun Xun He Hui Zhang Chaoxin Yang Min Zhang Meng Yue Hefeng Wang Yuntong sun Yonglan Luo Sulaiman Alfaifi Asmaa Farouk Mohamed S.Hamdy Xuping sun Huiqing Wang Binwu Ying Department of Laboratory Medicine West China HospitalSichuan UniversityChengdu 610041China College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinan 250014China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Chemistry Department Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Chemistry College of ScienceKing Khalid UniversityAbha 61413Saudi Arabia Medical Simulation Centre West China Second University HospitalSichuan UniversityChengdu 610041China

The development of highly efficient and durable oxygen evolution reaction(OER)catalysts for seawater electrolysis is of great importance for ***,an amorphous FeMoO_(4) nanorod array on Ni foam is reported as a highly active OER electrocatalyst in alkaline seawater,requiring only overpotentials of 303 and 332 mV to achieve 100 and 300 mA·cm^(-2),***,it shows strong long-term electrochemical durability for at least 50 h.

关键词： amorphous material FeMoO_(4) nanorod array electrocatalyst seawater electrolysis oxygen evolution reaction

FUT8-mediated aberrant N-glycosylation of SEMA7A promotes head and neck squamous cell carcinoma progression

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International Journal of Oral Science 2024年第2期16卷 333-348页

作者： Zhonglong Liu Xiaoyan Meng Yuxin Zhang Jingjing sun Xiao tang Zhiyuan Zhang Liu Liu Yue He Department of Oral Maxillofacial&Head and Neck Oncology Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineNational Clinical Research Center for Oral DiseaseShanghaiChina Department of Oral Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghaiChina Department of Oral Pathology Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineNational Clinical Research Center for Oral Disease ShanghaiShanghaiChina

SEMA7A belongs to the Semaphorin family and is involved in the oncogenesis and tumor *** glycosylation has been intricately linked with immune escape and tumor ***7A is a highly glycosylated protein with five glycosylated *** underlying mechanisms of SEMA7A glycosylation and its contribution to immunosuppression and tumorigenesis are ***,we identify overexpression and aberrant N-glycosylation of SEMA7A in head and neck squamous cell carcinoma,and elucidate fucosyltransferase FUT8 catalyzes aberrant core fucosylation in SEMA7A at N-linked oligosaccharides(Asn 105,157,258,330,and 602)via a direct protein‒protein interaction.A glycosylated statue of SEMA7A is necessary for its intra-cellular trafficking from the cytoplasm to the *** EGF triggers SEMA7A N-glycosylation through increasing the binding affinity of SEMA7A toward FUT8,whereas TGF-β1 promotes abnormal glycosylation of SEMA7A via induction of epithelial–mesenchymal *** N-glycosylation of SEMA7A leads to the differentiation of CD8^(+)T cells along a trajectory toward an exhausted state,thus shaping an immunosuppressive microenvironment and being resistant immunogenic cell *** of SEMA7A significantly improves the clinical outcome of EGFR-targeted and anti-PD-L1-based ***,we also define RBM4,a splice regulator,as a downstream effector of glycosylated SEMA7A and a pivotal mediator of PD-L1 alternative *** findings suggest that targeting FUT8-SEMA7A axis might be a promising strategy for improving antitumor responses in head and neck squamous cell carcinoma patients.

关键词： aberrant squamous SEMA

Facile preparation of a SiC@SiO_(2)nanowire-toughened ZrB_(2)-SiC/SiC bilayer coating with good interfacial bonding,high toughness,and excellent cyclic ablation resistance on C/CA composites

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Journal of Advanced Ceramics 2024年第4期13卷 486-495页

作者： Meng Yan Chenglong Hu Jian Li Shengyang Pang Bohui sun Rida Zhao Bin Liang Rui Luo Sufang tang Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China

Preparing antioxidant coatings to address the inherent oxidation sensitivity of carbon fiber-reinforced carbon aerogel(C/CA)composites is a feasible way to promote their application in oxidizing environments as thermal insulation ***,preparing the coatings with excellent oxidation and ablation resistance while avoiding evident damage to the C/CA substrate still remains a ***,a SiC@SiO_(2)nanowire-toughened ZrB2–SiC/SiC bilayer coating with a large thickness of 500μm was prepared on C/CA using a one-step low-temperature reaction sintering method,which simultaneously formed a sintered outer layer with even-distributed nanowires and a siliconized gradient inner *** courtesy of the synergic thermal response of the layers and the crack deflection induced by the nanowires,the resulting coating has moderate residual compressive stress of 0.08–1.22 GPa in the interface,high interfacial bonding strength of 6.02 MPa,and good fracture toughness of 4.36 MPa·m^(1/2).Benefited from the optimum components and improved structure,the coating shows excellent cyclic ablation resistance with linear ablation rates of 0.1μm/s at 1650℃for 1500 s(300 s×5 cycles)and 0.4μm/s at 1850℃for 900 s(300 s×3 cycles).The one-step preparation strategy contributes to little damage to the substrate,thus showing the well-preserved mechanical and thermal insulation properties.

关键词： coating carbon fiber reinforced carbon aerogel(C/CA)composites toughness interface residual stress

Fast-response,high-sensitivity multi-modal tactile sensors based on PPy/Ti_(3)C_(2)T_(x) films for multifunctional applications

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Nano Research 2024年第5期17卷 4410-4419页

作者： Guangshuai Xi Dongzhi Zhang Mingcong tang Hao Zhang Yuehang sun Yubiao Zhang Haolin Cai Hui Xia Dandi Zhou College of Control Science and Engineering China University of Petroleum(East China)Qingdao 266580China

In recent years,multi-modal flexible tactile sensors have become an important direction in the development of electronic skin because of their excellent sensitivity,flexibility and wearable *** this work,a humidity-pressure multi-modal flexible sensor based on polypyrrole(PPy)/Ti_(3)C_(2)T_(x) sensitive film packaged with porous polydimethylsiloxane(PDMS)is investigated by combining the sensitive structure generation mechanism of in situ polymerization to achieve the simultaneous detection of humidity and pressure,which has a sensitivity of 89,113.4Ω/%RH in a large humidity range of 0%-97%RH,and response/recovery time of 2.5/1.9 *** tactile pressure sensing has a high sensitivity,a fast response of 67/52 ms,and a wide detection *** device also has excellent performance in terms of stability and repeatability,making it promising for respiratory pattern and motion *** work provides a new solution to address the construction of multi-modal tactile sensors with potential applications in the fields of medical health,epidemic prevention.

关键词： multi-modal sensors humidity-pressure tactile sensors resistive sensors Ti3C2Tx human respiratory and motion detection

Divergence of trafficking and polarization mechanisms for PIN auxin transporters during land plant evolution

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Plant Communications 2024年第1期5卷 116-129页

作者： Han tang Kuan-ju Lu YuZhou Zhang You-Liang Cheng Shih-Long Tu Jiri Friml Institute of Science and Technology Austria(ISTA) Am Campus 13400 KlosterneuburgAustria Graduate Institute of Biotechnology National Chung Hsing UniversityNo.145Xingda Rd.South Dist.Taichung 40227TaiwanR.O.C College of Life Sciences Northwest A&F UniversityShaanxiYanglingChina Institute of Plant and Microbial Biology Academia Sinica128 Sec.2Academia RdNankangTaipei 11529TaiwanR.O.C Present address:Graduate Institute of Biochemistry National Chung Hsing UniversityNo.145Xingda Rd.South Dist.Taichung 40227TaiwanR.O.C

The phytohormone auxin,and its directional transport through tissues,plays a fundamental role in the development of higher *** polar auxin transport predominantly relies on PIN-FORMED(PIN)auxin ***,PIN polarization is crucial for development,but its evolution during the rise of morpho-logical complexity in land plants remains ***,we performed a cross-species investigation by observing the trafficking and localization of endogenous and exogenous PINs in two bryophytes,Physco-mitrium patens and Marchantia polymorpha,and in theflowering plant Arabidopsis *** confirmed that the GFP fusion did not compromise the auxin export function of all examined PINs by using a radioac-tive auxin export assay and by observing the phenotypic changes in transgenic *** PINs polarize tofilamentous apices,while exogenous Arabidopsis PINs distribute symmetrically on the membrane in both *** the Arabidopsis root epidermis,bryophytic PINs have no defined *** interference revealed a strong cytoskeletal dependence of bryophytic but not Arabidopsis PIN *** divergence of PIN polarization and trafficking is also observed within the bryophyte clade and between tissues of individual *** results collectively reveal the divergence of PIN traf-ficking and polarity mechanisms throughout land plant evolution and the co-evolution of PIN sequence-based and cell-based polarity mechanisms.

关键词： Arabidopsis evolution Marchantia Physcomitrium PINs polarization protein trafficking

OsNAC120 balances plant growth and drought tolerance by integrating GA and ABA signaling in rice

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Plant Communications 2024年第3期5卷 197-215页

作者： Zizhao Xie Liang Jin Ying sun Chenghang Zhan Siqi tang Tian Qin Nian Liu junli Huang Key Laboratory of Biorheological Science and Technology of Ministry of Education Bioengineering College of Chongqing UniversityChongqingChina

The crosstalk between gibberellin(GA)and abscisic acid(ABA)signaling is crucial for balancing plant growth and adaption to environmental ***,the molecular mechanism of their mutual antagonism still remains to be fully *** this study,we found that knockout of the rice NAC(NAM,ATAF1/2,CUC2)tran-scription factor gene OsNAC120 inhibits plant growth but enhances drought tolerance,whereas OsNAC120 overexpression produces the opposite *** GA can rescue the semi-dwarf phenotype of osnac120 mutants,and further study showed that OsNAC120 promotes GA biosynthesis by transcriptionally activating the GA biosynthetic genes OsGA20ox1 and *** DELLA protein SLENDER RICE1(SLR1)interacts with OsNAC120 and impedes its transactivation ability,and GA treatment can remove the inhi-bition of transactivation activity caused by *** the other hand,OsNAC120 negatively regulates rice drought tolerance by repressing ABA-induced stomatal *** investigation revealed that OsNAC120 inhibits ABA biosynthesis via transcriptional repression of the ABA biosynthetic genes OsNCED3 and *** OSMOTIC STRESS/ABA-ACTIVATED PROTEIN KINASE 9(OsSAPK9)physically interacts with OsNAC120 and mediates its phosphorylation,which results in OsNAC120 *** treatment ac-celerates OsNAC120 degradation and reduces its transactivation ***,ourndings provide evi-dencethatOsNAC120playscriticalrolesinbalancingGA-mediatedgrowthandABA-induceddroughttolerance in *** research will help us to understand the mechanisms underlying the trade-off between plant growth and stress tolerance and to engineer stress-resistant,high-yielding crops.

关键词： abscisic acid ABA drought stress gibberellin GA OsNAC120 OsSAPK9 rice Oryza sativa L. SLR1