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DEAD-box helicase 17(DDX17)protects cardiac function by promoting mitochondrial homeostasis in heart failure

Signal Transduction and Targeted Therapy 2024年第6期9卷 2774-2790页

作者： Mingjing Yan junpeng Gao Ming Lan Que Wang Yuan Cao Yuxuan Zheng Yao Yang Wenlin Li Xiaoxue Yu Xiuqing Huang Lin Dou Bing Liu junmeng Liu Hongqiang Cheng Kunfu Ouyang Kun Xu Shenghui sun Jin Liu Weiqing tang Xiyue Zhang Yong Man Liang sun Jianping Cai Qing He Fuchou tang Jian Li Tao Shen The Key Laboratory of Geriatrics Beijing Institute of GeriatricsInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing Hospital/National Center of Gerontology of National Health CommissionBeijing 100730China Peking University Fifth School of Clinical Medicine Beijing 100730China Department of Laboratory Medicine Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China Biomedical Pioneering Innovation Center School of Life SciencesPeking UniversityBeijing 100871China Emergency Center Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Cardiology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Graduate School of Peking Union Medical College Beijing 100730China Department of Health Care Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China Department of Pathology and Pathophysiology and Department of Cardiology at Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhou 310058China Department of Cardiovascular Surgery Peking University Shenzhen HospitalShenzhen 518036China Experimental Technology Center for Life Sciences at Beijing Normal University Beijing 100875China

DEAD-box helicase 17(DDX17)is a typical member of the DEAD-box family with transcriptional cofactor *** DDX17 is abundantly expressed in the myocardium,its role in heart is not fully *** generated cardiomyocyte-specific Ddx17-knockout mice(Ddx17-cKO),cardiomyocyte-specific Ddx17 transgenic mice(Ddx17-Tg),and various models of cardiomyocyte injury and heart failure(HF).DDX17 is downregulated in the myocardium of mouse models of heart failure and cardiomyocyte ***-specific knockout of Ddx17 promotes autophagic flux blockage and cardiomyocyte apoptosis,leading to progressive cardiac dysfunction,maladaptive remodeling and progression to heart *** of DDX17 expression in cardiomyocytes protects cardiac function under pathological *** studies showed that DDX17 can bind to the transcriptional repressor B-cell lymphoma 6(BCL6)and inhibit the expression of dynamin-related protein 1(DRP1).When DDX17 expression is reduced,transcriptional repression of BCL6 is attenuated,leading to increased DRP1 expression and mitochondrial fission,which in turn leads to impaired mitochondrial homeostasis and heart *** also investigated the correlation of DDX17 expression with cardiac function and DRP1 expression in myocardial biopsy samples from patients with heart *** findings suggest that DDX17 protects cardiac function by promoting mitochondrial homeostasis through the BCL6-DRP1 pathway in heart failure.

关键词： DDX17 homeostasis cardiac

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Organic-2D composite material-based RRAM with high reliability for mimicking synaptic behavior

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Journal of Materiomics 2024年第2期10卷 440-447页

作者： tangyou sun Fantao Yu Xiaosheng tang Haiou Li Fabi Zhang Zhimou Xu Qing Liao Zhiqiang Yu Xingpeng Liu Peihua Wangyang Hezhang Li Ying Peng Guangxi Key Laboratory of Precision Navigation Technology and Application Guilin University of Electronic TechnologyGuilin541004China College of Optoelectronic Engineering Chongqing UniversityChongqing400044China School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan430074China School of Electrical and Information Engineering Guangxi University of Science and TechnologyLiuzhou545006China Department of Precision Instrument Tsinghua UniversityBeijing100084China

The field of artificial intelligence and neural computing has been rapidly expanding due to the imple-mentation of resistive random-access memory(RRAM)based artificial ***,the low flexibility of conventional RRAM materials hinders their ability to mimic synaptic behavior *** overcome such limitation,organic-2D composites with high mechanical properties are proposed as the active layer of ***,we enhance the reliability of the device by ZrO_(2)insertion layer,resulting in stable synaptic *** Ag/PVA:h-BN/ZrO_(2)/ITO devices show stable bipolar resistive switching behavior with an ON/OFF ratio of over 5×10^(2),a~2400 cycles endurance and a long retention time(>6×10^(3)s),which are essential for the development of high-performance *** also study the possible synaptic mechanism and dynamic plasticity of the memory device,observing the transition from short-term potentiation(STP)to long-term potentiation(LTP)under the effect of continuous voltage ***,the device exhibits both long-term depression(LTD)and paired-pulse facili-tation(PPF)properties,which have significant implications for the design of organic-2D composite material RRAMs that aim to mimic biological synapses,representing promising avenues for the devel-opment of advanced neuromorphic computing systems.

关键词： Resistive random-access memory Synaptic mimicking Organic-2D composite material Neuromorphic computing

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Photosynthetic response dynamics in the invasive species Tithonia diversifolia and two co-occurring native shrub species under fluctuating light conditions

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Plant Diversity 2024年第2期46卷 265-273页

作者： ju Li Shu-Bin Zhang Yang-Ping Li CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglunMengla 666303YunnanChina University of Chinese Academy of Sciences Beijing 100049China

To determine the invasiveness of invasive plants,many studies have compared photosynthetic traits or strategies between invasive and native ***,few studies have compared the photosynthetic dynamics between invasive and native species during light *** compared photosynthetic induction,relaxation dynamics and leaf traits between the invasive species,Tithonia diversifolia and two native species,Clerodendrum bungei and Blumea balsamifera,in full-sun and shady *** photosynthetic dynamics and leaf traits differed among *** showed a slower induction speed and stomatal opening response but had higher average intrinsic water-use efficiency than the two native species in full-sun ***,the slow induction response may be attributed to the longer stomatal length in *** had a significant effect on photosynthetic dynamics in *** and *** but not in *** shady habitat,*** had a faster photosynthetic induction response than in full-sun habitat,leading to a higher average stomatal conductance during photosynthetic induction in *** than in the two native *** contrast,*** had a larger stomatal length and slower photosynthetic induction and relaxation response in shady habitat than in full-sun habitat,resulting in higher carbon gain during photosynthetic ***,in both habitats,*** had an overall higher carbon gain during light fluctuations than the two native *** results indicated that *** can adopt more effective response strategies under fluctuating light environments to maximize carbon gain,which may contribute to its successful invasion.

关键词： Invasive plant Photosynthetic induction Photosynthetic relaxation Carbon gain Stomatal traits Tithonia diversifolia

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Highly efficient optics/microwave beam splitter based on frequency selective surface

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Chinese Optics Letters 2024年第6期22卷 136-141页

作者： Qiao sun Nianxi Xu Haigui Yang Dongzhi Shan Yang tang Xin Chen Tongtong Wang Jinsong Gao Yu Cai Key Laboratory of Optical System Advanced Manufacturing Technology Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China State Key Laboratory of Applied Optics Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China University of Chinese Academy of Sciences Beijing 100049China Jilin Provincial Key Laboratory of Advanced Optoelectronic Equipment and Instrument Manufacturing Technology Changchun 130033China Unit 96951 of the People’s Liberation Army Beijing 100039China

The development of hybrid optics/microwave communication systems puts forward a new requirement for beam splitters to efficiently transmit microwave signals and simultaneously reflect optical signals. Owing to mechanical constraints, the physical thickness of beam splitters is of the order of tens of millimeters. The corresponding electrical thickness has the same order of magnitude as microwave wavelengths, and the resulting multi-beam interference effect significantly reduces the microwave transmittance, impacting the beam splitting *** study presents a new optics/microwave beam splitter based on the ability of the frequency selective surface(FSS) to shape the resonant curve. A beam splitter sample,whose physical thickness and substrate material are 20 mm and quartz glass, respectively, is designed, simulated, fabricated, and characterized to validate the feasibility of this strategy. The measured results show that the minimum microwave transmittance between 35 and 36.5 GHz with an incidence angle of 45° under TE polarization is 86.43%, and the mean value of the reflectance spectra from 450 to 900 nm and that from 7.7 to 10.5 μm both exceed 96%. This FSS-based optics/microwave beam splitter is expected to play a key role in hybrid optics/microwave communication systems.

关键词： beam splitter multi-beam interference frequency selective surface high transmission

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Neuropathological characteristics of abnormal white matter functional signaling in adolescents with major depression

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World Journal of Psychiatry 2024年第2期14卷 276-286页

作者： Xin-Lin Huang ju Gao Yong-Ming Wang Feng Zhu Jing Qin Qian-Nan Yao Xiao-Bin Zhang Hong-Yan sun Imaging and Nuclear Medicine Jiamusi UniversityJiamusi 154000Heilongjiang ProvinceChina Department of Psychiatry The Affiliated Guangji Hospital of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina School of Biology&Basic Medical Sciences Medical College of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina Department of Radiology Shanghai Anting HospitalShanghai 20000China Department of Radiology The Affiliated Guangji Hospital of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina

BACKGROUND Major depression disorder(MDD)constitutes a significant mental health *** surveys indicate that the lifetime prevalence of depression in adolescents is much higher than that in adults,with a corresponding increased risk of *** studying brain dysfunction associated with MDD in adolescents,research on brain white matter(WM)is *** researchers even mistakenly regard the signals generated by the WM as noise *** fact,studies have shown that WM exhibits similar blood oxygen level-dependent signal *** alterations in WM signals and their relationship with disease severity in adolescents with MDD remain *** To explore potential abnormalities in WM functional signals in adolescents with *** This study involved 48 adolescent patients with MDD and 31 healthy controls(HC).All participants were assessed using the Patient Health Questionnaire-9 Scale and the mini international neuropsychiatric interview(MINI)suicide *** addition,a Siemens Skyra 3.0T magnetic resonance scanner was used to obtain the subjects'image *** DPABI software was utilized to calculate the WM signal of the fractional amplitude of low frequency fluctuations(fALFF)and regional homogeneity,followed by a two-sample t-test between the MDD and HC *** component analysis(ICA)was also used to evaluate the WM functional ***’s correlation was performed to assess the relationship between statistical test results and clinical *** Compared to HC,individuals with MDD demonstrated a decrease in the fALFF of WM in the corpus callosum body,left posterior limb of the internal capsule,right superior corona radiata,and bilateral posterior corona radiata[P<0.001,family-wise error(FWE)voxel correction].The regional homogeneity of WM increased in the right posterior limb of internal capsule and left superior corona radiata,and decreased in the left superior longitudinal fasciculus(P<0.001,FWE voxel corre

关键词： White matter Regional homogeneity The fractional amplitude of low-frequency fluctuations Independent component analysis Adolescents Major depression disorders

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Remodeling the immune microenvironment for gastric cancer therapy through antagonism of prostaglandin E2 receptor 4

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Genes & Diseases 2024年第4期11卷 411-425页

作者： Mengmeng Guo Pan Hu Jiayi Xie Kefu tang Shixiu Hu Jialiang sun Yundong He Jing Li Weiqiang Lu Huirong Liu Mingyao Liu Zhengfang Yi Shihong Peng Shanghai Key Laboratory of Regulatory Biology School of Life SciencesEast China Normal UniversityShanghai 200241China Prenatal Diagnosis Center Department of Clinical LaboratoryChangning Maternity and Infant Health HospitalEast China Normal UniversityShanghai 200051China Key Laboratory of Acupuncture and Immunological Effects Shanghai University of Traditional Chinese MedicineShanghai 201203China Fengxian Hospital Affiliated to Southern Medical University Shanghai 201400China Shanghai Yuyao Biotech Co. Ltd.Shanghai 200241China

Gastric cancer is highly prevalent among digestive tract *** to the intri-cate nature of the gastric cancer immune microenvironment,there is currently no effective treatment available for advanced gastric ***,there is promising potential for immunotherapy targeting the prostaglandin E2 receptor subtype 4(EP4)in gastric *** our previous study,we identified a novel small molecule EP4 receptor antagonist called *** with YY001 alone demonstrated a significant reduction in gastric cancer growth and inhibited tumor metastasis to the lungs in a mouse ***,adminis-tration of YYo01 stimulated a robust immune response within the tumor microenvironment,characterized by increased infiltration of antigen-presenting cells,T cells,and M1 ***,our research revealed that YYo01 exhibited remarkable synergistic ef-fects when combined with the PD-1 antibody and the clinically targeted drug apatinib,rather than *** findings suggest that YYo01 holds great promise as a potential therapeutic strategy for gastric cancer,whether used as a standalone treatment or in combination with other drugs.

关键词： EP4 Immunomodulation Synergy Tumor microenvironment YY001

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Identification of new cotton fiber-quality QTL by multiple genomic analyses and development of markers for genomic breeding

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The Crop Journal 2024年第3期12卷 866-879页

作者： Haozhe Tan Binghui tang Mengling sun Qiulu Yin Yizan Ma Jianying Li Pengcheng Wang Zhonghua Li Guannan Zhao Maojun Wang Xianlong Zhang Chunyuan You Lili Tu National Key Laboratory of Crop Genetic Improvement Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070HubeiChina Cotton Research Institute Shihezi Academy of Agriculture ScienceShihezi 832000XinjiangChina

Cotton fiber is one of the main raw materials for the textile *** recent years,many cotton fiber quality QTL have been identified,but few were applied in *** this study,a genome wide association study(GWAS)of fiber-quality traits in 265 upland cotton breeding intermediate lines(GhBreeding),combined with genome-wide selective sweep analysis(GSSA)and genomic selection(GS),revealed 25 *** of these QTL were ignored by only using *** CRISPR/Cas9 mutants of GhMYB_D13 had shorter fiber,which indicates the credibility of QTL to a certain *** these QTL were verified in other cotton natural populations,5 stable QTL were found having broad potential for application in ***,among these 5 stable QTL,superior genotypes of 4 showed an enrichment in most improved new varieties widely cultivated *** findings provide insights for how to identify more QTL through combined multiple genomic analysis to apply in breeding.

关键词： Cotton fiber quality breeding GWAS Genome-wide selective sweep analysis Genomic selection InDel markers

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High-Performance H_(2) Photosynthesis from Pure Water over Ru−S Charge Transfer Channels

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Precision Chemistry 2024年第9期2卷 471-479页

作者： Huiping Peng Mingzi sun Fei Xue Xiaozhi Liu Shangheng Liu tang Yang Lin sun Hongbo Geng Dong Su Bolong Huang Yong Xu Xiaoqing Huang State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityKowloonHong Kong SAR 999077China Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Materials Engineering Changshu Institute of TechnologyChangshu 215500China i-lab Suzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of Sciences(CAS)Suzhou 215123China

As a versatile energy carrier,H_(2) is considered as one of the most promising sources of clean energy to tackle the current energy crisis and environmental concerns,which can be produced from photocatalytic water ***,solar-driven photocatalytic H_(2) production from pure water in the absence of sacrificial reagents remains a great ***,we demonstrate that the incorporation of Ru single atoms(SAs)into ZnIn_(2)S_(4)(Ru-ZIS)can enhance the light absorption,reduce the energy barriers for water dissociation,and construct a channel(Ru-S)for separating photogenerated electron−hole pairs,as a result of a significantly enhanced photocatalytic water splitting ***,the productivity of H_(2) reaches 735.2μmol g^(-1) h^(-1) under visible light irradiation in the absence of sacrificial *** apparent quantum efficiency(AQE)for H_(2) evolution reaches 7.5% at 420 nm,with a solarto-hydrogen(STH)efficiency of 0.58%,which is much higher than the value of natural synthetic plants(~0.10%).Moreover,Ru-ZIS exhibits steady productivity of H_(2) even after exposure to ambient conditions for 330 *** work provides a unique strategy for constructing charge transfer channels to promote the separation of photogenerated electron−hole pairs,which may motivate the fundamental researches on catalyst design for photocatalysis and beyond.

关键词： Ru single atom charge channel ZnIn_(2)S_(4) photocatalytic pure water splitting

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Inheritance of the exciton geometric structure from Bloch electrons in two-dimensional layered semiconductors

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Frontiers of physics 2024年第4期19卷 25-35页

作者： Jianju tang Songlei Wang Hongyi Yu Guangdong Provincial Key Laboratory of Quantum Metrology and Sensing&School of Physics and Astronomy Sun Yat-sen University(Zhuhai Campus)Zhuhai 519082China State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-sen University(Guangzhou Campus)Guangzhou 510275China

We theoretically studied the exciton geometric structure in layered semiconducting transition metal *** on a three-orbital tight-binding model for Bloch electrons which incorporates their geometric structures,an effective exciton Hamiltonian is constructed and solved perturbatively to reveal the relation between the exciton and its electron/hole *** show that the electron−hole Coulomb interaction gives rise to a non-trivial inheritance of the exciton geometric structure from Bloch electrons,which manifests as a valley-dependent center-of-mass anomalous Hall velocity of the exciton when two external fields are applied on the electron and hole constituents,*** obtained center-of-mass anomalous velocity is found to exhibit a non-trivial dependence on the fields,as well as the wave function and valley index of the *** findings can serve as a general guide for the field-control of the valley-dependent exciton transport,enabling the design of novel quantum optoelectronic and valleytronic devices.

关键词： transition metal dichalcogenides exciton geometric structure Berry curvature van der Waals stacking

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Skyway:Accelerate Graph Applications with a Dual-Path Architecture and Fine-Grained Data Management

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Journal of Computer Science & Technology 2024年第4期39卷 871-894页

作者： Mo Zou Ming-Zhe Zhang Ru-Jia Wang Xian-He sun Xiao-Chun Ye Dong-Rui Fan Zhi-Min tang Institute of Computing Technology Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Institute of Information Engineering Chinese Academy of SciencesBeijing 100045China Department of Computer Science Illinois Institute of TechnologyChicagoIL 60616U.S.A.

Graph processing is a vital component of many AI and big data ***,due to its poor locality and complex data access patterns,graph processing is also a known performance killer of AI and big data *** this work,we propose to enhance graph processing applications by leveraging fine-grained memory access patterns with a dual-path architecture on top of existing software-based graph *** first identify that memory accesses to the offset,edge,and state array have distinct locality and impact on *** then introduce the Skyway architecture,which consists of two primary components:1)a dedicated direct data path between the core and memory to transfer state array elements efficiently,and 2)a data-type aware fine-grained memory-side row buffer hardware for both the newly designed direct data path and the regular memory hierarchy data *** proposed Skyway architecture is able to improve the overall performance by reducing the memory access interference and improving data access efficiency with a minimal *** evaluate Skyway on a set of diverse algorithms using large real-world *** a simulated fourcore system,Skyway improves the performance by 23%on average over the best-performing graph-specialized hardware optimizations.

关键词： graph application computer architecture memory hierarchy

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