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maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang ju-Yun ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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Study on concentration and turbulence of solid-liquid FAE in dispersal process

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Defence Technology（防务技术） 2018年第6期14卷 657-660页

作者： Jia-chen Chen Xin ma Qiu-ju ma China Zhongyuan Engineering Corporation Beijing 100191China China Ordnance Society Beijing 100089China College of Resources&Safety Engineering China University of Mining&Technology(Beijing)Beijing 100083China

This paper describes numerical simulation on dispersion of the solid-liquid mixed fuel driven by explosion load. A model used in numerical calculation for dispersion of solid-liquid mixed fuel was established in this study. The concentration and turbulent intensity in the multiphase cloud of the solidliquid mixed fuel were obtained by numerical simulation. It was found that the fuel concentration tended to be 0.15 kg/m^3, the turbulence intensity tended to be 7 in 90 ms. The numerical results agree with those measured in the experiment.

关键词： Solid-liquid mixed fuel Concentration Turbulence intensity Numerical simulation

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Minor and Minimum Cycle Bases of a 3-connected Planar Graph

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Acta mathematica Sinica,English Series 2009年第4期25卷 649-656页

作者： Deng ju ma Han REN Department of mathematics East China Normal University Shanghai 200241 P.R. China School of Science Nantong University Jiangsu Province Nantong 226007 P. R. China Department of mathematics East China Normal University Shanghai 200241 P. R. China

In this paper, we prove that if any set of ｜E（G）｜- ｜V（G）｜＋ 1 facial cycles of a 3-connected planar graph G embedded in the plane doesn＇t form a minimum cycle base of G, then any minimum cycle base of G contains a separating cycle, and G has a minor isomorphic to T6, where T6 is the graph obtained from the complete graph K6 by deleting a path with four edges.

关键词： cycle space minimum cycle base 3-connected planar graph

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The Nonorientable Genus of the Join of Two Cycles

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Acta mathematica Sinica,English Series 2013年第12期29卷 2305-2320页

作者： Deng ju ma Han REN School of Sciences Nantong University Department of mathematics East China Normal University

In this paper, we show that the nonorientable genus of Cm ＋ Cn, the join of two cycles Cm and Cn, is equal to [（（m-2）（n-2））/2] if m = 3, n ≡ 1 （mod 2）, or m ≥ 4, n ≥ 4, （m, n）（4, 4）. We determine that the nonorientable genus of C4 ＋C4 is 3, and that the nonorientable genus of C3 ＋Cn is n/2 if n ≡ 0 （mod 2）. Our results show that a minimum nonorientable genus embedding of the complete bipartite graph Km,n cannot be extended to an embedding of the join of two cycles without increasing the genus of the surface.

关键词： Surface nonorientable genus of a graph the join of two graphs

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Quantitative Investigation of Tomographic Effects in Abnormal Regions of Complex Structures

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Engineering 2021年第7期7卷 1011-1022页

作者： Longjun Dong Xiaojie Tong ju ma School of Resources and Safety Engineering Central South UniversityChangsha 410083China

The detection of abnormal regions in complex structures is one of the most challenging targets for underground space *** or artificial geologic variations reduce the effectiveness of conventional exploration *** the emergence of real-time monitoring,seismic wave velocity tomography allows the detection and imaging of abnormal regions to be accurate,intuitive,and *** tomographic results are affected by multiple factors in practical small-scale applications,it is necessary to quantitatively investigate those *** adopted an improved three-dimensional(3D)tomography method combining passive acoustic emission acquisition and active ultrasonic *** varying individual parameters(i.e.,prior model,sensor configuration,ray coverage,event distributions,and event location errors),37 comparative tests were *** quantitative impact of different factors was *** experiments showed that the method could effectively adapt to complex *** optimal input parameters based on quantization results can significantly improve the detection reliability in abnormal regions.

关键词： Detection of abnormal regions Tomographic effects Wave velocity Ray path

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Numerical simulation on directional solidification and heat treatment processes of turbine blades

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China Foundry 2024年第5期21卷 476-490页

作者： Ye-yuan Hu ju-huai ma Qing-yan Xu School of materials Science and Engineering Tsinghua UniversityKey Laboratory for Advanced Materials Processing TechnologyMinistry of EducationBeijing 100084China

Study on turbine blades is crucial due to their critical role in ensuring the efficient and reliable operation of aircraft ***-based single crystal superalloys are extensively used in the hot manufacturing of turbine blades due to their exceptional high-temperature mechanical *** hot manufacturing of single crystal blades involves directional solidification and heat *** manufacturing of these blades is time-consuming,capital-intensive,and often insufficient to meet industrial *** simulation techniques have gained widespread acceptance in blade manufacturing research due to their low energy consumption,high efficiency,and rapid turnaround *** article introduces the modeling and simulation of hot manufacturing in single crystal *** discussion outlines the prevalent mathematical models employed in numerical simulations related to blade hot *** encapsulates the advancements in research concerning macro to micro-level numerical simulation techniques for directional solidification and heat treatment ***,potential future trajectories for the numerical simulation of single crystal blade hot manufacturing are also discussed.

关键词： single crystal blades Ni-based superalloy directional solidification heat treatment numerical simulation

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A Simple Cement Hydration Model Considering the Influences ofWater-to-Cement Ratio and Mineral Composition

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Computer Modeling in Engineering & Sciences 2021年第6期127卷 1059-1067页

作者： Baoyu ma Guansuo Dui Zhenglin Jia Bo Yang Chunyan Yang Quangui Gao Longhua Qin ju ma College of Physics and Electronic Engineering Yuxi Normal UniversityYuxi653100China Institute of Mechanics Beijing Jiaotong UniversityBeijing100044China

A simple hydration model is used here by taking the composition of the cement and the initial water: cementratio (w/c) into account explicitly. Its conceptual basis is a combination of the Avrami equation and Bentz’s modelbased on simple spatial considerations. In this model, the Avrami equation determines the initial reaction, andBentz’s model describes the following hydration stage. The model favors engineers for it relies on one experimentalparameter and has a reliable approximation in the practice.

关键词： Hydration model water/cement ratio composition of the cement engineering practicability only one parameter

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Theoretical Studies on Intermolecular Interactions of 4-Amino-5-nitro-1,2,3-triazole Dimers

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Chinese Journal of Structural Chemistry 2006年第8期25卷 1004-1010页

作者： LU Ya-Lin GONG Xue-Dong ju Xue-Hai ma Xiu-Fang XIAO He-Ming School of Chemical Engineering Nanjing Universityof Science and Technology Nanjing 210094 China

Seven optimized configurations and their electronic structures of 4-amino-5-nitro- 1,2,3-triazole dimers on their potential energy surface have been obtained by using density functional theory （DPT） method at the B3LYP/6-311＋＋G＊＊ level. The maximum intermolecular interaction energy is -35.42 kJ/mol via the basis set superposition error-correction （BSSE） and zero point energy-correction （ZPE）. Charge transfers between the two subsystems are small. The vibration analysis of optimized configurations was performed, and the thermodynamic property changes from monomer to dimer have been obtained with the temperature ranging from 200 to 800 K on the basis of statistical thermodynamics. It is found that the hydrogen bonds contribute to the dimers dominantly, and the extent of intermolecular interaction is mainly determined by the hydrogen bonds＇ strength rather than their number. The dimerization processes of Ⅳ, Ⅴand Ⅵ can occur spontaneously at 200 K.

关键词： 4-amino-5-nitro-1,2,3-triazole intermolecular interaction density functional theory thermodynamic properties

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A New Route for Identification of Precipitates on Austenite Grain Boundary in an Nb-V-Ti Microalloyed Steel

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Journal of Iron and Steel Research International 2011年第8期18卷 53-57页

作者： SHA Qing-yun HUANG Guo-jian GUAN ju ma Xiao-jun LI Da-hang Technology Center Angang Steel Company Limited Anshan 114009 Liaoning China

The precipitates on austenite grain boundaries in an Nb-V-Ti microalloyed steel have been investigated by transmission electron microscope （TEM） examination of carbon extraction replica. The replica was prepared from specimen etched with saturated picric solution rather than Nital which is conventionally used. Then particles on both grain boundaries and triple point of grain [aoundaries were clearly observed and identified as （Nb,Ti）（C, N） parti- cles. In case of conventional way, it is difficult to determine the location of particles with respect to austenite grain boundaries. The number of particles observed in new way developed was greatly reduced compared with that found in replica prepared by the conventional way, which may be caused by the dissolution of partial precipitates during the etching with longer time and at higher temperature involved in new way. Despite this, the new way developed pro- vides an effective way to determine the precipitate particles on austenite urain boundaries_

关键词： precipitate austenite grain boundary replica etch

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The influence of adding niobium and vanadium on hydrogen diffusion in 22MnB5 hot stamping steel

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Journal of Iron and Steel Research International 2023年第10期30卷 2031-2042页

作者： Peng-wei Zhou Zhi-yi Yan Ke Wang Tao Liu Si-jia Chen Zhen ma ju-sha ma Wei Ding Yi Luo Bing-gang Liu Wei Li Shanghai Institute of Space Power-Sources Shanghai 200245China State Key Lab of Metal matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200245China

Adding alloying elements is always considered as an effective method to enhance the resistance against hydrogen embrittlement in *** and V were added into 22MnB5 hot stamping steel,and then their influences on hydrogen permeation of 22MnB5 steel suffering from corrosion in 3.5%NaCl aqueous solution were *** results showed that the addition of Nb/V could reduce the hydrogen permeation content due to solution *** techniques including electrochemical impedance spectroscopy and overpotential stepping hydrogen permeation test con-firmed that compared to the original 22MnB5 steel,22MnB5-NbN steel owned a higher corrosion resistance and a higher hydrogen diffusion ***,it was confirmed that Nb-V-alloyed 22MnB5 steel showed higher resistance against hydrogen embrittlement than the Nb-V-free counterpart,which should be related to the presentence of nanoscaled Nb/V-containing precipitates as the irreversible trapping sites for hydrogen detected by thermal desorption ***,the lattice diffusion coefficient of hydrogen DL was determined in steels with and without Nb and V.

关键词： Hydrogen permeation Corrosion Hot stamping steel Niobium Vanadium Thermal desorption spectroscopy

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