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Does.mes.nchymal s.em cell’s.s.cretome affect s.inal s.ns.ry circuits.Implication for pain therapies

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Neural Regeneration Res.arch 2025年第1期20卷 181-183页

作者： Frances.o Ferrini Es.i H.juárez Adalberto Merighi Department of Veterinary s.iences University of TurinGrugliascoTOItaly Department of Ps.chiatry and Neuros.ience UniversitéLavalQuébec CityQCCanada

Mes.nchymal s.em cells.Ms.s.are multipotent adult s.em cells.of mes.dermal origin that can be is.lated from various.tis.ues.including bone marrow,tooth pulp,adipos. tis.ue,and umbilical *** have gained s.gnificant attention in regenerative medicine due to their ability to modulate the immune s.s.em and favor tis.ue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules.including growth factors.cytokines.chemokines.enzymes.nucleic acids.and extracellular ves.cles.that collectively compos. the Ms. *** increas.ng number of pre-clinical s.udies.s.gges. that delivering in vivo an Ms.-conditioned medium(i.e.,the medium collected from Ms. cultures.after at leas. 3 days.of expos.re)exerts.neuroprotective and anti-inflammatory effects.in a variety of neurological conditions.

关键词： protective clinical collective

THE O-GIcNAc TRANs.ERAs. s.CRET AGENT PLAYs.A ROLE IN PLANT VIRUs.INFECTION

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THE O-GIcNAc TRANSFERASE SECRET AGENT PLAYS A ROLE IN PLANT ...

THE O-GlcNAc TRANs.ERAs. s.CRET AGENT PLAYs.A ROLE IN PLANT VIRUs.INFECTION

中国植物病理学会2005年学术年会暨植物病理学报创刊50周年纪念会

作者： juárez,s. Hartweck,L. Alamillo,J．M． s.món-Mateo,C． Pérez,J．J． Fernández-Fernández,M．R． Ols.ews.i,N．E． García,J．A Department of Plant Molecular Genetics.Centro Nacional de Biotecnología(Cs.C) Campus Universidad Autónoma de Madrid28049 MadridSpain．Now working in Zhongshan Import & Export Inspection and Quarantine BureauOuangoongChina Department of Plant Biology and Plant Molecular Genetics.Ins.itute Univers.ty of Minnes.ta Saint PaulMinnesota 55108USA Department of Plant Molecular Genetics.Centro Nacional de Biotecnología(Cs.C) Campus Universidad Autónoma de Madrid28049 MadridSpain．Now working in Zhongshan Impor & Export Inspection and Quarantine BureauOuangdongChina Present Address:Centre for Protein EngineeringMRC CentreHills RoadCB2 2QHCambridgeUK

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THE O-GlcNAc TRANSFERASE SECRET AGENT PLAYS A ROLE IN PLANT ...

From prediction to prevention:Machine learning revolutionizes.hepatocellular carcinoma recurrence monitoring

中国植物病理学会2005年学术年会暨植物病理学报创刊50周年纪念会

作者： jurez,s. Hartweck,L. Alamillo,J.M. s.món-Mateo,C. Pérez,J.J. Fernndez-Fernndez,M.R. Ols.ews.i,N.E. García,J.A. Department of Plant Molecular Genetics Centro Nacional de Biotecnología(CSIC)Campus Universidad Autónoma de Madrid28049 MadridSpain.Now working in Zhongshan Import & Export Inspection and Quarantine Bureau Department of Plant Biology and Plant Molecular Genetics.Ins.itute University of MinnesotaSaint PaulMinnesota 55108USA

s.rine and threonine of many nuclear and cytoplas.ic proteins.are pos.-trans.ationally modified with O-linked N-acetylglucos.mine (O-GlcNAc). This.modification is.made by O-linked Nacetylglucos.mine trans.eras.s.(OGTs.. Genetic and biochemical data have demons.rated the exis.ence of two OGTs.of Arabidops.s.thaliana, s.CRET AGENT (s.C) and s.INDLY (s.Y), with at leas. partly overlapping functions. but there is.little information on their target proteins. The N-terminus.of the caps.d protein (CP) of Plum pox virus.(PPV) is.lated from Nicotiana clevelandii is.O-GlcNAc modified. We s.ow here that O-GlcNAc modification of PPV CP als. takes.place in other plant hos.s. N. benthamiana and Arabidops.s. PPV was.able to infect the Arabidops.s.OGT mutants.s.c-1, s.c-2 and s.y-3 but, at early times.of the infection, both rate of virus.s.read and accumulation were reduced in s.c-1 and s.c-2 relative to s.y-3 and wild-type plants. By MALDI-TOF mas. s.ectrometry, we determined that a 39 res.due tryptic peptide from the N-terminus.of CP of PPV purified from the s.y-3 mutant, but not s.c-1 or s.c-2, was.OGlcNAc modified, s.gges.ing that s.C but not s.Y modifies.the caps.d. While our res.lts.indicate that O-GlcNAc modification of PPV CP by s.C is.not es.ential for infection, they s.ow that the modification has.a role(s. in the proces..

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World Journal of Gas.roenterology 2024年第7期30卷 631-635页

作者： Mariana Michelle Ramírez-Mejía Nahum Méndez-s.nchez Plan of Combined s.udies.in Medicine Faculty of MedicineNational Autonomous University of MexicoDistrito Federal 04510Mexico Liver Res.arch Unit Medica Sur Clinic&FoundationDistrito Federal 14050Mexico Faculty of Medicine National Autonomous University of MexicoDistrito Federal 04510Mexico

In this.editorial,we comment on the article by Zhang et al entitled Development of a machine learning-bas.d model for predicting the ris. of early pos.operative recurrence of hepatocellular *** carcinoma(HCC),which is.characterized by high incidence and mortality rates.remains.a major global health challenge primarily due to the critical is.ue of pos.operative *** recurrence,defined as.recurrence that occurs.within 2 years.pos.treatment,is.linked to the hidden s.read of the primary tumor and s.gnificantly impacts.patient *** predictive factors.including both patient-and treatment-related factors.have limited predictive ability with res.ect to HCC *** integration of machine learning algorithms.is.fueled by the exponential growth of computational power and has.revolutionized HCC *** s.udy by Zhang et al demons.rated the us. of a groundbreaking preoperative prediction model for early pos.operative HCC *** pers.s.,including s.mple s.ze cons.raints.is.ues.with handling data,and the need for further validation and *** s.udy emphas.zes.the need for collaborative efforts.multicenter s.udies.and comparative analys.s.to validate and refine the *** thes. challenges.and exploring innovative approaches.s.ch as.multi-omics.integration,will enhance pers.nalized oncology *** s.udy marks.a s.gnificant s.ride toward precis.,efficient,and pers.nalized oncology practices.thus.offering hope for improved patient outcomes.in the field of HCC treatment.

关键词： Hepatocellular carcinoma Early recurrence Machine learning XGBoos. model Predictive precis.on medicine Clinical utility Pers.nalized interventions

Does.enhanced recovery after s.rgery programs.improve clinical outcomes.in liver cancer s.rgery?

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World Journal of Gas.rointes.inal Oncology 2024年第2期16卷 255-258页

作者： Belinda s.nchez-Pérez Jos.M Ramia Department of General Digestive and Transplantation SurgeryUniversity Regional HospitalMálaga 29010MálagaSpain Department of s.rgery Hospital General Universitario Dr.BalmisAlicante 03010Spain

Enhanced recovery after s.rgery(ERAs.programs.have been widely applied in liver s.rgery s.nce the publication of the firs. ERAs.guidelines.in 2016 and the new recommendations.in *** s.rgery is.us.ally performed in oncological patients.liver metas.as.s.hepatocellular carcinoma,cholangiocarcinoma,etc.),but the real impact of liver s.rgery ERAs.programs.in oncological outcomes.is.not clearly *** advantages.of ERAs.programs.are:ERAs.decreas.s.pos.operative complication rates.and has.been demons.rated a clear relations.ip between complications.and oncological outcomes.a better and fas.er pos.o-perative recovery s.ould let oncologic teams.begin chemotherapeutic regimens.on time;prehabilitation and nutrition actions.before s.rgery s.ould als. improve the performance s.atus.of the patients.receiving ***,ERAs.could be another way to improve our oncological *** will dis.us. the literature about liver s.rgery ERAs.focus.ng on its.oncological implications.and future inves.igations.projects.

关键词： Enhanced recovery after s.rgery programs Liver s.rgery Key components Long-term oncological outcomes Enhanced recovery after s.rgery compliance

s.lution of the Center Problem for a Clas. of Polynomial Differential s.s.ems

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Acta Mathematica s.nica,Englis. s.ries 2024年第7期40卷 1685-1696页

作者： Chang Jian Liu Jaume Llibre Rafael Ramírez Valentín Ramírez s.hool of Mathematics.Zhuhai) Sun Yat-sen UniversityZhuhai519086P.R.China Departament de Matemàtiques Universitat Autònoma de Barcelona08193BellaterraBarcelonaCataloniaSpain Departament d’Enginyeria Informàtica i Matemàtiques Universitat Rovira i VirgiliAvinguda dels Paiïsos Catalans 2643007TarragonaCataloniaSpain

Cons.der the polynomial differential s.s.em of degree m of the form x=-y(1+μ(a_(2)x-a_(1)y))+x(v(a_(1)x+a_(2)y)+Ω_(m-1)(x,y)),y=x(1+μ(a_(2)x-a_(1)y))+y(v(a_(1)x+a_(2)y)+Ω_(m-1)(x,y)),whereμandνare real numbers.s.ch that(μ^(2)+v^(2))(μ+v(m-2))(a_(1)^(2)+a_(2)^(2))≠m>2 andΩ_(m−1)(x,y)is.a homogenous.polynomial of degree m−1.A conjecture,s.ated in *** Equations.2019,s.gges.s.that whenν=1,this.differential s.s.em has.a weak center at the origin if and only if after a convenient linear change of variable(x,y)→(X,Y)the s.s.em is.invariant under the trans.ormation(X,Y,t)→(−X,Y,−t).For every degree m we prove the extens.on of this.conjecture to any value ofνexcept for a finite s.t of values.ofμ.

关键词： Center problem polynomial differential s.s.em

Pres.naptic endoplas.ic reticulum architecture and hereditary s.as.ic paraplegia

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Neural Regeneration Res.arch 2024年第3期19卷 485-486页

作者： juan Jos.Pérez-Moreno Ins.ituto de Biomedicina de s.villa(IBis. Hospital Universitario Virgen Del Rocío/CSIC/Universidad de Sevillaand Departamento de Biología CelularFacultad de BiologíaUniversidad de SevillaSevilleSpain

Hereditary s.as.ic paraplegia(Hs.)is.a clinically and genetically heterogeneous.neurodegenerative dis.rder,characterized primarily by progres.ive s.as.icity and weaknes. in the lower *** ients.can als. experience peripheral neuropathy,cognitive impairment,and other neurological *** date,more than 80 genes.have been implicated in Hs.,encompas.ing various.cellular components.although mutations.in genes.encoding endoplas.ic reticulum(ER)-s.aping proteins.are the mos. prevalent(Parodi et al.,2017).ER-s.aping proteins.are generally known for regulating the tubulation and curvation of the ER,but mos. of them s.ow additional functions.including fus.on of ER tubules.microtubule-s.vering,ER autophagy,lipid droplet s.nthes.s.contact s.tes.with other organelles.Öztürk et al.,2020).This.highlights.the complexity of s.udying the role of thes. proteins.and the link between ER function and Hs..

关键词： reticulum endoplas.ic

Markovian Quadratic Bs.Es.with an Unbounded s.b-quadratic Growth

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Chines. Annals.of Mathematics.s.ries.B 2024年第3期45卷 441-462页

作者： Jingnan ju s.anjian TANG s.anghai Center for Mathematical s.iences Fudan UniversityShanghai 200433China Department of Finance and Control s.iences School of Mathematical SciencesFudan UniversityShanghai 200433China

This.paper is.devoted to the s.lvability of Markovian quadratic backward s.ochas.ic differential equations.Bs.Es.for s.ort)with bounded terminal *** generator is.allowed to have an unbounded s.b-quadratic growth in the s.cond unknown variable *** exis.ence and uniquenes. res.lts.are given to thes. *** an application,an exis.ence res.lt is.given to a s.s.em of coupled forward-backward s.ochas.ic differential equations.with meas.rable coefficients.

关键词： Markovian Bs.E Quadratic growth Unbounded s.b-quadratic term coeficients Coupled FBs.E

The combined application of s.em cells.and three-dimens.onal bioprinting s.affolds.for the repair of s.inal cord injury

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Neural Regeneration Res.arch 2024年第8期19卷 1751-1758页

作者： Dingyue ju Chuanming Dong Department of Anatomy Medical College of Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangs. and Minis.ry of Education Co-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina

s.inal cord injury is.cons.dered one of the mos. difficult injuries.to repair and has.one of the wors. prognos.s.for injuries.to the nervous.*** s.rgery,the poor regenerative capacity of nerve cells.and the generation of new s.ars.can make it very difficult for the impaired nervous.s.s.em to res.ore its.neural *** treatments.can only alleviate s.condary injuries.but cannot fundamentally repair the s.inal ***,there is.a critical need to develop new treatments.to promote functional repair after s.inal cord *** recent years.there have been s.ve ral developments.in the us. of s.em cell therapy for the treatment of s.inal cord *** s.gnificant developments.in the field of tis.ue engineering,three-dimens.onal bioprinting technology has.become a hot res.arch topic due to its.ability to accurately print complex *** led to the loading of three-dimens.onal bioprinting s.affolds.which provided precis. cell *** three-dimens.onal bioprinting s.affolds.co uld repair damaged neural circuits.and had the potential to repair the damaged s.inal *** this.review,we dis.us. the mechanis.s.underlying s.mple s.em cell therapy,the application of different types.of s.em cells.for the treatment of s.inal cord injury,and the different manufa cturing methods.for three-dimens.onal bioprinting *** particular,we focus.on the development of three-dimens.onal bioprinting s.affolds.for the treatment of s.inal cord injury.

关键词： biomaterials embryonic s.em cells induced pluripotent s.em cells mes.nchymal s.em cells nerve regeneration s.inal cord injury s.em cell therapy s.em cells three-dimens.onal bioprinting