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Spectral response of spider mite infested cotton:Mite density and miticide rate study

International Journal of Agricultural and Biological Engineering 2013年第1期6卷 48-52页

作者： Yubin Lan Huihui Zhang W C Hoffmann jr.juan d lopez United States department of Agriculture Agricultural Research ServiceAreawide Pest Management Research UnitCollege StationTexasUSA United States department of Agriculture Agricultural Research ServiceWater Management Research UnitParlierCaliforniaUSA

Two-spotted spider mites are important pests in many agricultural *** mites(Acari:Tetranychidae)have been found to cause economic damage in corn,cotton,and *** glass vial bioassays indicate that Temprano™(abamectin)is the most toxic technical miticide for adult two-spotted spider *** an aerial application standpoint,additional research is needed to identify aerial application parameters for this *** objective of this study was to investigate spectral response of spider mite-infested cotton plants with different density levels of mites and treated with different rates of *** showed significantly different spectral signatures of cotton plants infested with different density levels of *** treating mite-infested cotton plants with five different Temprano rate treatments(control,one-eighth,one-fourth,one-half,and full rates),spectral reflectance curves were found to be significantly *** wavelengths of 550 nm,560 nm,680 nm and 740 nm were important for detecting the spectral differences among mite infested cotton plants treated with various rate of *** difference Vegetative Index imagery was able to detect different levels of cotton plant ***-rate application of Temprano controlled mite-infested plants as effectively as the full-rate *** findings may lead to reduced cost and quantity of miticides used to maintain effective crop production and protection.

关键词： spectral reflectance infested cotton plants crop protection Normalized difference Vegetative Index(NdVI) Temprano rate treatments

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红蜘蛛叶螨感染的棉花植株的光谱响应:螨密度和杀螨剂浓度的研究

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农业工程技术 2016年第15期36卷 80-页

作者： Yubin Lan Huihui Zhang W C Hoffmann jr.juan d lopez 王元杰王应宽美国农业部农业研究局野外害虫管理研究中心美国农业部农业研究局水资源管理研究中心

棉红蜘蛛(亚纲:叶螨科)是许多农业系统的重要害虫,现已经发现在玉米、棉花、高粱中造成过经济损失。成年红蜘蛛叶螨的生物测定指出,Temprano·(阿维菌素)对于成年叶螨来说是毒性最强的杀螨药。从航空应用的角度来看,还需要更多的研究来... 详细信息

棉红蜘蛛(亚纲:叶螨科)是许多农业系统的重要害虫,现已经发现在玉米、棉花、高粱中造成过经济损失。成年红蜘蛛叶螨的生物测定指出,Temprano·(阿维菌素)对于成年叶螨来说是毒性最强的杀螨药。从航空应用的角度来看,还需要更多的研究来确定杀螨药的航空应用参数。本研究的目的是探索感染不同叶螨密度及用不同浓度杀螨药处理的棉花植株的光谱响应。结果显示,棉花植物感染的螨虫密度不同,光谱特征明显不同。通过分析五种不同Temprano处理(对照,1/8,1/4,1/2,1)的棉花植株后发现,光谱反射率曲线明显不同。550 nm、560 nm、680 nm和740 nm四种波长对检测不同Temprano处理的叶螨感染的棉花植株光谱差异非常重要。归一化植被指数图像(NdVI)能够检测出棉花植物损伤的级别。1/2 Temprano处理的样本和1 Temprano处理的样本效果一样。本研究的发现可能会有助于降低用于作物生产和保护的杀螨药的成本和数量。

关键词：光谱反射受感染棉花植株作物保护归一化植被指数(NdVI) Temprano处理

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Unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy

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Neural Regeneration Research 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-Garcia Michael J.Bannon Irma Alicia Martínez-dávila Luis O.Soto-Rojas david Reyes-Corona Lourdes Escobedo Minerva Maldonado-Berny ME Gutierrez-Castillo Armando J.Espadas-Alvarez Manuel A.Fernandez-Parrilla juan U.Mascotte-Cruz CP Rodríguez-Oviedo Irais E.Valenzuela-Arzeta Claudia Luna-Herrera Francisco E.lopez-Salas Jaime Santoyo-Salazar daniel Martinez-Fong departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de Patogénesis Molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red de Medicina para la Educación y desarrollo y la Investigación Científica de Iztacala(Red MEdICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Nanoparticle Therapy Institute AguascalientesMéxico departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Escuela Nacional de Medicina y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico departamento de Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico departamento de Biología Molecular y Biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de Nanociencias y Nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Parkinsonism by unilateral,intranigralβ-sitosterolβ-d-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of Parkinson’s disease,a typicalα-*** Nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-d-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 *** study found that rNurr1-V5 expression but not that of the green fluorescent protein(the negative control)reducedβ-sitosterolβ-d-glucoside-induced ***,a bilateral increase in tyrosine hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine hydroxylase-positive ramifications in the *** addition,tyrosine hydroxylase-positive cells displayed less senescence markerβ-galactosidase and more neuron-cytoskeleton markerβIII-tubulin and brain-derived neurotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and neurotoxic astrocytes(positive to glial fibrillary acidic protein and complement component 3)and increased neurotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia *** effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor *** results show that unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neurodegeneration(senescence and loss of neuron-cytoskeleton and tyrosine hydroxylase-positive cells),neuroinflammation(activated microglia,neurotoxic astrocytes),α-synuclein aggregation,and sensorimotor *** neurotrophic astrocytes and

关键词： A1 astrocytes A2 astrocytes gene therapy microglia motor deficits nanoparticles neurodegeneration neuroinflammation senescence α-synuclein aggregates

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A novel fused bi-macrocyclic host for sensitive detection of Cr_(2)O_(7)^(2-)based on enrichment effect

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Chinese Chemical Letters 2024年第7期35卷 291-295页

作者： Ting-Ting Huang Jin-Fa Chen juan Liu Tai-Bao Wei Hong Yao Bingbing Shi Qi Lin Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education Key Laboratory of Eco-environmental Polymer Materials of Gansu ProvinceCollege of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou 730070China Key Laboratory of Environment-Friendly Composite Materials of the State Ethnic Affairs Commission Gansu Provincial Biomass Function Composites Engineering Research CenterCollege of Chemical EngineeringNorthwest Minzu University(Northwest University for Nationalities)Lanzhou 730000China

Improving the highly selective and sensitive binding of chemosensor to target guest is always very *** order to solve this issue,herein,the enrichment effect was introduced into the design of chemosensor molecule.A novel bi-fused-macrocyclic host molecule BPN1 was synthesized by bridging a pillar[5]arene and a naphthalene diimide(NdI)group through hydrogen-bond-rich *** the BPN1,the naphthalimide side ring is outside the cavity of the pillar[5]*** addition,Cr(VI)greatly threat human health and the environment due to its severe toxicity,and it is very important to develop effective chemosensor for sensitive and selective detection of Cr_(2)O_(7)^(2-)or its ion *** this paper,the novel bi-fused-macrocyclic host molecule BPN1 can recognize Cr_(2)O_(7)^(2-)with high selectivity and *** mechanism of BPN1 recognition of Cr_(2)O_(7)^(2-)was studied through experiments and density functional theory(dFT),the results show that BPN1 could supply enrichment effect to bind Cr_(2)O_(7)^(2-)through multiple weak interactions such as hydrogen bonds and anion-π,and achieve highly sensitive and selective detection of Cr_(2)O_(7)^(2-).It is a significant and feasible strategy for improve high selectivity and sensitivity of host to specific objects by using the enrichment effect of fused bi-macrocyclic.

关键词： Pillararene Bi-macrocyclic detection of Cr_(2)O_(7)^(2−) dFT The enrichment effect

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Staging liver fibrosis with various diffusion-weighted magnetic resonance imaging models

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World Journal of Gastroenterology 2024年第9期30卷 1164-1176页

作者： Yan-Li Jiang juan Li Peng-Fei Zhang Feng-Xian Fan Jie Zou Pin Yang Peng-Fei Wang Shao-Yu Wang Jing Zhang department of Magnetic Resonance Imaging The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina Second Clinical School Lanzhou UniversityLanzhou 730030Gansu ProvinceChina Gansu Province Clinical Research Center for Functional and Molecular Imaging The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina department of Hepatology The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina MR Scientific Marketing Siemens HealthineersXi’an 710065Shaanxi ProvinceChina

BACKGROUNd diffusion-weighted imaging(dWI)has been developed to stage liver ***,its diagnostic performance is inconsistent among ***,it is worth studying the diagnostic value of various diffusion models for liver fibrosis in one *** To evaluate the clinical potential of six diffusion-weighted models in liver fibrosis staging and compare their diagnostic *** This prospective study enrolled 59 patients suspected of liver disease and scheduled for liver biopsy and 17 healthy *** participants underwent multi-b value *** main dWI-derived parameters included Mono-apparent diffusion coefficient(AdC)from mono-exponential dWI,intravoxel incoherent motion model-derived true diffusion coefficient(IVIM-d),diffusion kurtosis imaging-derived apparent diffusivity(dKI-Md),stretched exponential model-derived distributed diffusion coefficient(SEM-ddC),fractional order calculus(FROC)model-derived diffusion coefficient(FROC-d)and FROC model-derived microstructural quantity(FROC-μ),and continuous-time random-walk(CTRW)model-derived anomalous diffusion coefficient(CTRW-d)and CTRW model-derived temporal diffusion heterogeneity index(CTRW-α).The correlations between dWI-derived parameters and fibrosis stages and the parameters’diagnostic efficacy in detecting significant fibrosis(SF)were assessed and *** CTRW-d(r=-0.356),CTRW-α(r=-0.297),dKI-Md(r=-0.297),FROC-d(r=-0.350),FROC-μ(r=-0.321),IVIM-d(r=-0.251),Mono-AdC(r=-0.362),and SEM-ddC(r=-0.263)were significantly correlated with fibrosis *** areas under the ROC curves(AUCs)of the combined index of the six models for distinguishing SF(0.697-0.747)were higher than each of the parameters alone(0.524-0.719).The dWI models’ability to detect SF was *** combined index of CTRW model parameters had the highest AUC(0.747).CONCLUSION The dWI models were similarly valuable in distinguishing SF in patients with liver *** combined index of CTRW paramet

关键词： Liver fibrosis Magnetic resonance imaging diffusion-weighted magnetic resonance Liver biopsy Significant fibrosis

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Building an interoperable space for smart agriculture

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digital Communications and Networks 2023年第1期9卷 183-193页

作者： Ioanna Roussaki Kevin doolin Antonio Skarmeta George Routis juan Antonio lopez-Morales Ethel Claffey Manuel Mora juan Antonio Martinez Institute of Communications and Computer Systems AthensGreece Walton Institute WaterfordIreland department of Information and Communications Engineering University of MurciaMurciaSpain School of Business Waterford Institute of TechnologyWaterfordIreland R&d department Odin SolutionsMurciaSpain

The digital transformation in agriculture introduces new challenges in terms of data,knowledge and technology adoption due to critical interoperability issues,and also challenges regarding the identification of the most suitable data sources to be exploited and the information models that must be ***(Building an Interoperable,data-driven,Innovative and Sustainable European Agri-Food Sector)addresses these challenges by providing an overarching solution that integrates various heterogeneous hardware and software resources(e.g.,devices,networks,platforms)and enables the seamless sharing of data and knowledge throughout the agri-food *** paper introduces the main concepts of dEMETER and its reference architecture to address the data sharing and interoperability needs of farmers,which is validated via two rounds of 20 large-scale pilots along the dEMETER *** paper elaborates on the two pilots carried out in region of Murcia in Spain,which target the arable crops sector and demonstrate the benefits of the deployed dEMETER reference architecture.

关键词： Smart agriculture Internet of things(IoT) dEMETER Reference architecture Interoperability Agricultural information model(AIM) Pilot validation

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A supramolecular oligo[2]rotaxane constructed by orthogonal platinum(Ⅱ) metallacycle and pillar[5]arene-based host–guest interactions

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Chinese Chemical Letters 2024年第10期35卷 201-204页

作者： Bingbing Shi Yuchun Wang Yi Zhou Xing-Xing Zhao Yizhou Li Nuoqian Yan Wen-juan Qu Qi Lin Tai-Bao Wei Key Laboratory of Polymer Materials of Gansu Province College of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou 730070.China

Oligo[n]rotaxanes are one of the most extensively studied categories of mechanically bonded *** this study,a supramolecular oligo[2]rotaxane is successfully constructed driven by platinum(Ⅱ)metallacycle and pillar[5]arene-based host–guest interactions in an orthogonal *** supramolecular oligo[2]rotaxane is further applied in fabricating a light harvesting system.

关键词： Pillararene Metallacycles Host-guest interactions Light-harvesting system Mechanically interlocked molecules

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基于网络药理学与非靶向代谢组学探讨细辛的肝损伤机制

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中国中药杂志 2024年第10期49卷 2575-2584页

作者：鲍慧中朱丽娟刘雪枫王丽娟罗慧英甘肃中医药大学药学院甘肃兰州730101 甘肃省中药药理与毒理学重点实验室甘肃兰州730000 陇药产业创新研究院甘肃兰州730000 西北中藏药省部共建协同创新中心甘肃兰州730000

细辛是临床常用解表药,但其毒性限制了其使用。该研究采用网络药理学与代谢组学相结合的方法探讨细辛的肝损伤机制。GEO数据库下载肝损伤相关数据集GSE54257,采用Limma包对数据集GSE54257进行差异表达基因分析。TCMSP、ECTM、TOXNET等... 详细信息

细辛是临床常用解表药,但其毒性限制了其使用。该研究采用网络药理学与代谢组学相结合的方法探讨细辛的肝损伤机制。GEO数据库下载肝损伤相关数据集GSE54257,采用Limma包对数据集GSE54257进行差异表达基因分析。TCMSP、ECTM、TOXNET等数据库筛选细辛有毒成分与靶点基因,与GSE54257差异表达基因相映射,得到细辛肝损伤靶点基因并构建PPI网络。对靶点基因进行GO和KEGG富集分析,结合上游调控miRNA信息绘制“miRNA-靶点基因-信号通路”网络。30只大鼠分为空白组与细辛高、低剂量组,每日给药1次,连续给药28 d后检测肝功能指标和肝脏病理变化。空白组与细辛高剂量组随机取5个肝脏组织样本,采用超高效液相色谱-质谱(UHPLC-MS)技术分析各组样本小分子代谢产物。利用正交偏最小二乘法判别分析(OPLS-dA)筛选差异代谢物,并对差异代谢物进行富集分析、相关性分析和聚类分析,最后利用MetaboAnalyst平台对差异代谢物进行通路富集分析。经分析发现,细辛中有毒成分有14个,对应靶点基因37个,经与GSE54257中差异表达基因映射得到12个与细辛肝脏毒性相关的基因。动物实验结果显示,细辛可以显著升高大鼠肝功能指标,降低自由基清除酶活性,改变肝脏氧化应激水平,诱发脂质过氧化损伤。非靶向代谢组学分析结果显示,与空白组比较,细辛组大鼠肝脏组织中有9个代谢物上调,16个代谢物下调,这25个代谢物相关性较强,聚类良好。通路富集分析显示,这些差异代谢物与细辛12个肝毒性靶点基因主要参与嘌呤代谢,以及缬氨酸、亮氨酸、甘氨酸、丝氨酸、苏氨酸等的生物合成与代谢。该研究证实,细辛致肝损伤作用是多成分、多靶点、多信号通路作用的结果,其机制可能与抑制核苷酸合成,影响蛋白质代谢有关。

关键词：细辛肝损伤网络药理学非靶向代谢组学

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Pancreas sparing duodenectomy in the treatment of primary duodenal neoplasms and other situations with duodenal involvement

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Hepatobiliary & Pancreatic diseases International 2021年第5期20卷 485-492页

作者： Juli Busquets Josefina lopez-dominguez Ana Gonzalez-Castillo Marina Vila Nuria Pelaez Lluis Secanella Emilio Ramos juan Fabregat department of Hepatobiliary and Pancreatic Surgery Hospital Universitari de BellvitgeResearch Group of Hepato-biliary and Pancreatic DiseasesInstitut d'InvestigacióBiomèdica de Bellvitge-IDIBELLBarcelona UniversityL’Hospitalet de LlobregatBarcelona 08907Spain department of General Surgery Hospital del MarBarcelona 08907Spain department of General Surgery Hospital de MataróBarcelona 08907Spain

Background:There are no clearly defined indications for pancreas-preserving *** present study aimed to analyze postoperative morbidity and the outcomes of patients undergoing pancreaspreserving ***:Patients undergoing pancreas-preserving duodenectomy from April 2008 to May 2020 were *** divided the series according to indication:scenario 1,primary duodenal tumors;scenario 2,tumors of another origin with duodenal involvement;and scenario 3,emergency ***:We included 35 *** duodenectomy was performed in 1 patient of adenomatous duodenal polyposis,limited duodenectomy in 7,and third+fourth duodenal portion resection in *** indications for scenario 1 were gastrointestinal stromal tumor(n=13),adenocarcinoma(n=4),neuroendocrine tumor(n=3),duodenal adenoma(n=1),and adenomatous duodenal polyposis(n=1);scenario 2:retroperitoneal desmoid tumor(n=2),recurrence of liposarcoma(n=2),retroperitoneal paraganglioma(n=1),neuroendocrine tumor in pancreatic uncinate process(n=1),and duodenal infiltration due to metastatic adenopathies of a germinal tumor with digestive hemorrhage(n=1);and scenario 3:aortoenteric fistula(n=3),duodenal trauma(n=1),erosive duodenitis(n=1),and biliopancreatic limb ischemia(n=1).Severe complications(Clavien-dindo≥IIIb)developed in 14%(5/35),and postoperative mortality was 3%(1/35).Conclusions:Pancreas-preserving duodenectomy is useful in the management of primary duodenal tumors,and is a technical option for some tumors with duodenal infiltration or in emergency interventions.

关键词： duodenectomy duodenal neoplasms Organ sparing treatments Pancreatic surgery duodenal diseases

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Advances in spray products for skin regeneration

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Bioactive Materials 2022年第10期7卷 187-203页

作者： Paula Pleguezuelos-Beltran Patricia Galvez-Martín daniel Nieto-Garcí juan Antonio Marchal Elena lopez-Ruiz Biopathology and Regenerative Medicine Institute(IBIMER) Centre for Biomedical Research(CIBM)University of GranadaGranadaSpain department of Human Anatomy and Embryology Faculty of MedicineUniversity of GranadaGranadaSpain BioFab i3d Lab-Biofabrication and 3d(bio)printing Laboratory GranadaSpain Excellence Research Unit“Modeling Nature”(MNat) University of GranadaGranadaSpain Biosanitary Research Institute of Granada(ibs.GRANAdA) University Hospitals of Granada-University of GranadaGranadaSpain R&d Human Health Bioib´erica S.A.UBarcelonaSpain department of Pharmacy and Pharmaceutical Technology Faculty of PharmacyUniversity of GranadaGranadaSpain Complex Tissue Regeneration department MERLN Institute for Technology Inspired Regenerative MedicineUniversiteitssingel 406229ER Maastrichtthe Netherlands department of Health Sciences University of Ja´enJa´enSpain

To date,skin wounds are still an issue for healthcare *** numerous approaches have been developed over the years for skin regeneration,recent advances in regenerative medicine offer very promising strategies for the fabrication of artificial skin substitutes,including 3d bioprinting,electrospinning or spraying,among *** particular,skin sprays are an innovative technique still under clinical evaluation that show great potential for the delivery of cells and hydrogels to treat acute and chronic *** sprays present significant advantages compared to conventional treatments for wound healing,such as the facility of application,the possibility to treat large wound areas,or the homogeneous distribution of the sprayed *** this article,we review the latest advances in this technology,giving a detailed description of investigational and currently commercially available acellular and cellular skin spray products,used for a variety of diseases and applying different experimental ***,as skin sprays products are subjected to different classifications,we also explain the regulatory pathways for their commercialization and include the main clinical trials for different skin diseases and their treatment ***,we argue and suggest possible future trends for the biotechnology of skin sprays for a better use in clinical dermatology.

关键词： Skin Spray Tissue engineering Fibrin Hydrogel

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