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Complementary and alternative medicine practices,traditional healing practices,and cultural competency in pediatric oncology in Hawai'i

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Journal of Integrative Medicine 2016年第5期14卷 374-379页

作者： Asad Ghiasuddin joyce wong Andrea M.Siu Department of Psychiatry John A. Burns School of MedicineUniversity of Hawai'i Integrative Services Coordinator Kapi'olani Medical Center for Women and Children Regulatory Document Coordinator Hawai'i Pacific Health Research Institute

OBJECTIVE： Hawai＇i is an ethnically diverse island state with a high rate of both traditional healing （TH） and complementary and alternative medicine （CAM） use. The aim of this project was to assess TH and CAM use within the pediatric oncology population in Honolulu and improve the delivery of culturally competent care. METHODS： A 9-item survey was distributed to all pediatric oncology patients at Kapi＇olani Medical Center for Women and Children for 3 months. The survey inquired about patient ethnicity, TH practices CAM practices and perception of cultural competence of the care received. Descriptive statistics were calculated for the survey items. Qualitative analysis was done with participant comments to identify themes. RESULTS： Sixty-two surveys were completed. TH was used by 39% of the respondents in the home, and 10% in the hospital （top method was traditional foods）. CAM was used by 27% of the respondents in the home, and 68% in the hospital （top method was healing touch）. Ninety-seven percent of the respondents reported receiving culturally competent care. Areas for improvement included language services and dietary choices. CONCLUSION： CAM and TH are used frequently by pediatric oncology patients in Hawai＇i, and the vast majority of patients and families felt that the care they received was culturally competent.

关键词： cultural competency medicine, complementary and alternative traditional healing ethnicity pediatric, cancer

A Retrospective Study of Radiographic Anatomy of Wrist in Chinese Population

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E-Health Telecommunication Systems and Networks 2018年第3期7卷 57-65页

作者： Chris Yuk Kwan Tang Fung Kwok Keung Boris Fok Margaret Woon Man Lee Juliana Tsz Yan Aslam Muhammad Zeeshan Fang Benjamin wong joyce Yeung Kelvin Department of Orthopaedics and Traumatology University of Hong Kong Medical Centre Queen Mary Hospital Hong Kong China Department of Radiology Queen Mary Hospital Hong Kong China

In wrist pathology, there is a need to establish the normal range of radiographic measurement parameters. Previous study showed that the contralateral wrist might not be valid as a reference for all parameters. There is a lack of literature describing the normal range of wrist radiographic parameters in literature. As a result, a retrospective study was carried out. Patients who underwent standard wrist x-rays during the period February 2012 to February 2013 (one single year) were retrospectively reviewed. 71 patients were included. Scapholunate angle was 54.7° (±6.5°). Scapholunate interval was 2.0 mm (±0.4 mm). Ulnar variance was +1.0 mm (±1.8 mm). Carpal height was 31.8 mm (±3.0 mm). Radial inclination was 25.1° (±2.1°). All 71 patients had 1 sesamoid bone at first metacarpal. 16.9% (12 out of 71) patients had positive cortical ring signs. All these parameters are valuable clinically, especially in monitoring of the wrist disease progression, in the design of wrist implants and for future clinical research.

关键词： Radiographic Anatomy Wrist Chinese

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潜力巨大的微技术世界

国外测井技术 2008年第5期23卷 60-67页

作者： Dan E.Angelescu Christopher Harrison Ronald van Hal joyce wong Eric Donzier Olivier Vancauwenberghe Anthony R.H.Goodwin Maria Manrique Yu-Chong Tai 美国马萨诸塞州Cambridge 法国Elancourt 美国得克萨斯州Sugar Land 英国剑桥加利福尼亚理工学院

20世纪80年代，在集成电路技术的基础上诞生了世界首套微机电和微流体系统。从那时起，微技术领域的发展可谓日新月异。如今，微技术已在环境条件极为复杂的油田领域得到广泛应用。

关键词：微技术世界集成电路技术微流体系统微机电

The potential development of drug resistance in rheumatoid arthritis patients identified with p53 mutations

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Genes & Diseases 2023年第6期10卷 2252-2255页

作者： Congling Qiu joyce Tsz Wai Chan David Wei Zhang Io Nam wong Yaling Zeng Betty Yuen Kwan Law Simon Wing Fai Mok Ivo Ricardo De Seabra Rodrigues Dias Wenfeng Liu Liang Liu Vincent Kam Wai wong Dr.Neher's Biophysics Laboratory for Innovative Drug Discovery State Key Laboratory of Quality Research in Chinese MedicineMacao University of Science and TechnologyMacao SAR 999078China Department of Public Health and Preventive Medicine School of MedicineJinan UniversityGuangzhouGuangdong 510000China Faculty of Medicine Macao University of Science and TechnologyMacao SAR 999078China School of Biotechnology and Health Sciences Wuyi UniversityJiangmenGuangdong 529000China

Rheumatoid arthritis(RA)is a chronic inflammatory disease characterized by cartilage and bone damage with the presence of pannus formation which causes uncontrollable proliferation and invasion of fibroblast-like synoviocytes(FLS).Since rheumatoid arthritis is a chronic disorder,the patients normally need to undergo prolonged antirheumatic treatment with the use of disease-modifying antirheumatic drugs(DMARDs),steroids,and nonsteroidal anti-inflammatory drugs(NSAIDs).The efficacy of such long-term pharmaceutical intervention can be significantly affected by the development of drug *** pathological relationship between rheumatoid arthritis and cancer hinted that some chemotherapeutic drugs,such as methotrexate(MTX),could be used for RA *** idea was reinforced by the analysis of mutations in p53 tumor suppressor *** 50%of p53 somatic mutations observed from various cancers are also identified in the synovium of RA patients1(Fig.1A).Of note,the hyperplastic synovium in RA with overexpressed p53 mutants contributed to the destruction of joints in patients with erosive RA.

关键词： patients drugs rheumatoid

Intracellular signaling mechanisms regulating the activation of human eosinophils by the novel Th2 cytokine IL-33:implications for allergic inflammation

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Cellular & Molecular Immunology 2010年第1期7卷 26-34页

作者： joyce YS Chow Chun K wong Phyllis FY Cheung Christopher WK Lam Department of Chemical Pathology The Chinese University of Hong KongPrince of Wales HospitalShatinNTHong KongChina Macao Institute for Applied Research in Medicine and Health Macao University of Science and Technology FoundationMacaoChina

The novel interleukin(IL)-1 family cytokine IL-33 has been shown to activate T helper 2(Th2)lymphocytes,mast cells and basophils to produce an array of proinflammatory cytokines,as well as to mediate blood eosinophilia,IgE secretion and hypertrophy of airway epithelium in *** the present study,we characterized the activation of human eosinophils by IL-33,and investigated the underlying intracellular signaling ***-33 markedly enhanced eosinophil survival and upregulated cell surface expression of the adhesion molecule intercellular adhesion molecule(ICAM)-1 on eosinophils,but it suppressed that of ICAM-3 and *** addition,IL-33 mediates significant release of the proinflammatory cytokine IL-6 and the chemokines CXCL8 and *** found that IL33-mediated enhancement of survival,induction of adhesion molecules,and release of cytokines and chemokines were differentially regulated by activation of the nuclear factor(NF)-KB,p38 mitogen-activated protein kinase(MAPK)and extracellular signal-regulated kinase(ERK)***,we compared the above IL-33 activities with two structurally and functionally related cytokines,IL-1 B and ***-1β,but not IL-18,markedly upregulated cell surface expression of ***-1βand IL-18 also significantly enhanced eosinophil survival,and induced the release of IL-6 and chemokines CXCL8 and CCL2 via the activation of the NF-κB,p38 MAPK and ERK *** efects on the release of IL-6 were also observed in combined treatment withIL-1B,IL-18 and *** together,our findings provide insight into IL-33-mediated activation of eosinophils via differential intracellular signaling cascades in the immunopathogenesis of allergic inflammation.

关键词： allergy cytokines eosinophils signal transduction

MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergistic effects on cell motility

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Frontiers of Medicine 2015年第3期9卷 331-343页

作者： Felice Ho-Ching Tsang Sandy Leung-Kuen Au Lai Wei Dorothy Ngo-Yin Fan joyce Man-Fong Lee Carmen Chak-Lui wong Irene Oi-Lin Ng Chun-Ming wong State Key Laboratory for Liver Research and Department of Pathology Li Ka Shing Faculty of Medicine The University of Hong Kong HongKong SAR China

MicroRNAs （miRNAs）, an important class of small non-coding RNAs, regulate gene expression at the post-transcriptional level, miRNAs are involved in a wide range of biological processes and implicated in different diseases, including cancers. In this study, miRNA profiling and qRT-PCR validation revealed that miR-142-3p and miR-142-5p were significantly downregulated in hepatocellular carcinoma （HCC） and their expression levels decreased as the disease progressed. The ectopic expression of miR-142 significantly reduced HCC cell migration and invasion. Overexpression of either miR-142-3p or miR-142-5p suppressed HCC cell migration, and overexpression of both synergistically inhibited cell migration, which indicated that miR-142-3p and miR-142-5p may cooperatively regulate cell movement, miR-142-3p and miR-142-5p, which are mature miRNAs derived from the 3＇- and 5＇-strands of the precursor miR-142, target distinct pools of genes because of their different seed sequences. Pathway enrichment analysis showed a strong association of the putative gene targets of miR-142-3p and miR-142-5p with several cell motility-associated pathways, including those regulating actin cytoskeleton, adherens junctions, and focal adhesion. Importantly, a number of the putative gene targets were also significantly upregulated in human HCC cells. Moreover, overexpression of miR-142 significantly abrogated stress fiber formation in HCC cells and led to cell shrinkage. This study shows that mature miR-142 pairs collaboratively regulate different components of distinct signaling cascades and therefore affects the motility of HCC cells.

关键词： hepatocellular carcinoma microRNA metastasis cytoskeletal reorganization

Exploring the band structure of Wurtzite InAs nanowires using photocurrent spectroscopy

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Nano Research 2020年第6期13卷 1586-1591页

作者： Seyyedesadaf Pournia Samuel Linser Giriraj Jnawali Howard E.Jackson Leigh M.Smith Amira Ameruddin Philippe Caroff Jennifer wong-Leung Hark Hoe Tan Chennupati Jagadish Hannah J.joyce Department of Physics University of CincinnatiCincinnatiOH45221-0011USA Department of Electronic Materials Engineering Research School of PhysicsThe Australian National UniversityCanberraACT2601Australia Department of Engineering University of Cambridge9 JJ Thomson AvenueCambridgeCB30FAUK

Nano Research volume We use polarized photocurrent spectroscopy in a nanowire device to investigate the band structure of hexagonal Wurtzite *** of optical transitions between four valence bands and two conduction bands are observed which are consistent with the symmetries expected from group *** ground state transition energy identified from photocurrent spectra is seen to be consistent with photoluminescence emitted from a cluster of nanowires from the same growth *** the energies of the observed bands we determine the spin orbit and crystal field energies in Wurtzite *** information is vital to the development of crystal phase engineering of this important III-V semiconductor.

关键词： nanowires Wurtzite InAs photocurrent measurement optical selection rules energy band structure

Identification of optimal contemporary antiemetic prophylaxis for doxorubicin-cyclophosphamide chemotherapy in Chinese cancer patients: post-hoc analysis of 3 prospective studies

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Cancer Biology & Medicine 2021年第3期18卷 825-832页

作者： Winnie Yeo Leung Li Thomas KH Lau Kwai T Lai Vicky,TC Chan Kwan H wong Christopher CH Yip Elizabeth Pang Maggie Cheung Vivian Chan Carol CH Kwok joyce JS Suen Frankie KF Mo Department of Clinical Oncology Prince of Wales HospitalFaculty of MedicineHong Kong Cancer InstituteHong KongChina State Key Laboratory of Translational Oncology The Chinese University of Hong KongHong KongChina Department of Clinical Oncology Princess Margaret HospitalHong KongChina

Objective:Chemotherapy-induced nausea and vomiting(CINV)are common with doxorubicin-cyclophosphamide(AC)*** antiemetic regimens incorporate neurokinin-1 receptor antagonist(NK1 RA),5-hydroxytryptamine type-3 receptor antagonist(5 HT3 RA),corticosteroid,and dopamine *** post-hoc analysis compared results of 3 prospective antiemetic studies conducted among Chinese breast cancer patients who received(neo)adjuvant AC,in order to identify optimal antiemetic ***:A total of 304 patients were included:Group 1,ondansetron/dexamethasone(D1);Group 2,aprepitant/ondansetron/dexamethasone(D1);Group 3,aprepitant/ondansetron/dexamethasone(D1–3);Group 4,aprepitant/ondansetron/dexamethasone(D1–3)/olanzapine;and Group 5,netupitant/palonosetron/dexamethasone(D1–3).Antiemetic efficacies of Groups 3,4,and 5 during cycle 1 of AC were individually compared with Group *** addition,emesis outcomes of patients in Groups 3 and 5,and those of Groups 2 and 3,were ***:When comparing efficacies of a historical doublet(5 HT3 RA/dexamethasone)with triplet antiemetic regimens(NK1 RA/5 HT3 RA/dexamethasone)with/without olanzapine,complete response(CR)percentages and quality of life(QOL)in overall phase of cycle 1 AC were compared between Group 1 and the other groups:Group 1 vs.3,41.9%vs.38.3%(P=0.6849);Group 1 vs.4,41.9%vs.65.0%(P=0.0107);and Group 1 vs.5,41.9%vs.60.0%(P=0.0460).Groups 4 and 5 achieved a better *** comparing netupitant-based(Group 3)with aprepitant-based(Group 5)triplet antiemetics,CR percentages were 38.3%vs.60.0%,respectively(P=0.0176);Group 5 achieved a better *** comparing 1 day(Group 2)vs.3 day(Group 3)dexamethasone,CR percentages were 46.8%and 38.3%,respectively(P=0.3459);Group 3 had a worse ***:Aprepitant-containing triplets were non-superior to doublet ***-containing triplets and adding olanzapine to aprepitant-containing triplets were superior to ***/palono

关键词： Netupitant palonosetron aprepitant olanzapine NEPA Asians

Effects of Ving Tsun sticking-hand training on upper-limb sensorimotor performance in community-dwelling middle-aged and older adults: A randomized controlled trial

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International Journal of Nursing Sciences 2020年第1期7卷 29-34页

作者： Joanne W.Y.Chung Shirley S.M.Fong Yang Gao Timothy T.T.Yam Yvonne T.C.Chak joyce C.Y.Leung Thomas K.S.wong Department of Health and Physical Education Education University of Hong KongHong KongChina School of Nursing and Healthcare Hong Kong Nang Yan College of Higher EducationHong KongChina Hong Kong Martial Arts Institute Hong KongChina School of Public Health University of Hong KongHong KongChina Department of Sport and Physical Education Hong Kong Baptist UniversityHong KongChina Hong Kong Christian Service Hong KongChina School of Nursing and Health Studies Open University of Hong KongHong KongChina Department of Social Work and Social Administration University of Hong KongHong KongChina

Objective:To evaluate the effects of Ving Tsun(VT)sticking-hand training on upper-limb joint position sense and muscular performance in community-dwelling middle-aged and older ***:Thirty-three adults were randomly allocated to either a VT group or a control *** VT group received VT sticking-hand training twice per week for 3 *** were taken before and after the intervention *** primary outcome was elbow-joint repositioning error,which was measured by an elbow-joint passive positioning and active repositioning test using a universal *** outcomes were upper-limb muscles'peak force and time taken to reach peak force as measured by a hand-held ***:No significant time,group or time-by-group interaction effects were found for elbow-joint repositioning error or upper-limb muscle peak force *** flexor time to peak force decreased by 33.8%from pre-test to post-test in the VT group(P=0.007).Shoulder abductor,internal and external rotator,and elbow extensor times to peak force decreased by 30.0%-35.9%in the VT%roup(P<0.05)and by 30.4%-37.1%in the control group(P<0.05).Conclusions:VT sticking-hand training does not improve elbow-joint position sense or the maximum strength of upper-limb muscles in middle-aged and older ***,VT can improve shoulder flexor muscles'time to reach peak force in these *** had no obvious effect on the time required to reach peak force in other shoulder muscles and elbow extensors.

关键词： Aged Exercise movement techniques Joint position sense Middle aged Muscle strength Upper extremities