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Bioactive profile of Plakortis nigra,a sea sponge from Mauritius Islands

Journal of Coastal Life Medicine 2015年第1期 44-51页

作者： Sandrine Tangman joyce govinden soulange Daniel Marie Department of Agriculture and Food Science Faculty of AgricultureUniversity of MauritiusRéduitMauritius Mauritius Oceanography Institute Quatre BornesMauritius

Objective:To investigate the in vitro antibacterial and antioxidant activities of crude and fractionated extracts of the Plakortis nigra(***)sea sponge from Mauritius sea ***:Preliminary qualitative chemical screening of the sponge extracts was conducted by using standard methods while the total phenolic content(TPC)was estimated through the Folin-Ciocalteu *** activity was evaluated against Staphylococcus aureus,Escherichia coli and Proteus *** minimum inhibitory concentration was determined by the broth microdilution *** sponge extracts were assessed for antioxidant activity via the 1,1-diphenyl-2-picrylhydrazyl free radical scavenging in vitro ***:Alkaloids,phenols,steroids,terpenoids,tannins and saponins were detected in the sponge extracts and TPC varied from(2.280±0.072)mg to(12.790±0.236)mg gallic acid equivalents per gram extract(P<0.05).All the extracts inhibited the growth of at least two bacterial strains whilst the most potent in vitro antibacterial activities were observed in the most polar ethyl acetate and butanol fractions(minimum inhibitory concentration values 0.103–0.211 mg/mL)of *** extract scavenged 1,1-diphenyl-2-picrylhydrazyl free radicals while the hexane fraction displayed the highest scavenging ability at(27.50±1.85)%(P<0.05).Antioxidant activity was positively correlated with TPC(R^(2)=0.843).Contrary relationships were also found between antibacterial activity and ***:The present study validates the antioxidant and antibacterial activity of marine sponge(***)extracts and depicts the sea sponge as a potential source of pharmaceutical leads against infectious and degenerative diseases.

关键词： Plakortis nigra Antibacterial Antioxidant DPPH Phenolics

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