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Probing the subcellular nanostructure of engineered human cardiomyocytes in 3D tissue

Microsystems & Nanoengineering 2021年第1期7卷 133-140页

作者： Josh Javor jourdan k.ewoldt Paige E.Cloonan Anant Chopra Rebeccah J.Luu Guillaume Freychet Mikhail Zhernenkov karl Ludwig Jonathan G.Seidman Christine E.Seidman Christopher S.Chen David J.Bishop Department of Mechanical Engineering Boston UniversityBostonMA 02215USA Department of Biomedical Engineering Boston UniversityBostonMA 02215USA SMI Beamline 12-ID Brookhaven National LaboratoryUptonNY 11973USA Department of Physics Boston UniversityBostonMA 02215USA Division of Materials Science Boston UniversityBostonMassachusetts 02215USA Department of Genetics Harvard Medical SchoolBostonMA 02215USA Department of Electrical Engineering Boston UniversityBostonMA 02215USA

The structural and functional maturation of human induced pluripotent stem cell-derived cardiomyocytes(hiPSC-CMs)is essential for pharmaceutical testing,disease modeling,and ultimately therapeutic *** 3D-tissue platforms have improved the functional maturation of hiPSC-CMs,but probing cardiac contractile properties in a 3D environment remains challenging,especially at depth and in live *** small-angle X-ray scattering(SAXS)imaging,we show that hiPSC-CMs matured and examined in a 3D environment exhibit a periodic spatial arrangement of the myofilament lattice,which has not been previously detected in *** contractile force is found to correlate with both the scattering intensity(R^(2)=0.44)and lattice spacing(R^(2)=0.46).The scattering intensity also correlates with lattice spacing(R^(2)=0.81),suggestive of lower noise in our structural measurement than in the functional ***,we observed decreased myofilament ordering in tissues with a myofilament mutation known to lead to hypertrophic cardiomyopathy(HCM).Our results highlight the progress of human cardiac tissue engineering and enable unprecedented study of structural maturation in hiPSC-CMs.

关键词： cardiac cardiomyocytes spacing

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The“Bitcoin Generator”Scam

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Blockchain(Research and Applications) 2022年第3期3卷 70-88页

作者： Emad Badawi Guy-Vincent jourdan Iosif-Viorel Onut Faculty of Engineering University of OttawaOttawaON K1N 6N5Canada IBM Centre for Advanced Studies OttawaON K1R 7Y6Canada

The“Bitcoin Generator Scam”(BGS)is a cyberattack in which scammers promise to provide victims with free cryptocurrencies in exchange for a small mining *** this paper,we present a data-driven system to detect,track,and analyze the *** works as follows:we first formulate search queries related to BGS and use search engines to find potential instances of the *** then use a crawler to access these pages and a classifier to differentiate actual scam instances from benign ***,we automatically monitor the BGS instances to extract the cryptocurrency addresses used in the scam.A unique feature of our system is that it proactively searches for and detects the scam ***,we can find addresses that have not yet received any *** data collection project spanned 16 months,from November 2019 to February *** uncovered more than 8,000 cryptocurrency addresses directly associated with the scam,hosted on over 1,000 ***,these addresses have received around 8.7 million USD,with an average of 49.24 USD per *** 70%of the active addresses that we are capturing are detected before they receive any transactions,that is,before anyone is *** also present some post-processing analysis of the dataset that we have captured to aggregate attacks that can be reasonably confidently linked to the same attacker or *** system is one of the first academic feeds to the APWG eCrime Exchange *** has been actively and automatically feeding the database since November 2020.

关键词： Cryptocurrency Scam analysis Cyberattack Fraud detection Bitcoin Blockchain analysis Data mining

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华夏板块东南部中——新生代构造热事件的热年代学记录

华夏板块东南部中——新生代构造热事件的热年代学记录

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2016中国地球科学联合学术年会

作者：陶霓 Zheng-Xiang Li Martin Dani?ík Noreen J.Evans Geoffrey E.Batt 李武显厐崇进徐义刚 Fred jourdan 长安大学地球科学与资源学院澳大利亚科廷大学澳大利亚西澳大利亚大学中国科学院广州地球化学研究所桂林理工大学

以磷灰石、锆石(U-Th)/He分析为代表的低温热年代学已成为揭示区域岩石冷却历史、恢复构造抬升过程的重要方法。重建赣南-粤北地区中生代砂岩地层和花岗岩体的中—新生代剥露、冷却历史,对于进一步探索华夏板块东南部中—新生代的构造... 详细信息

以磷灰石、锆石(U-Th)/He分析为代表的低温热年代学已成为揭示区域岩石冷却历史、恢复构造抬升过程的重要方法。重建赣南-粤北地区中生代砂岩地层和花岗岩体的中—新生代剥露、冷却历史,对于进一步探索华夏板块东南部中—新生代的构造热演化过程具有重要意义。大席地区区域上位于华夏板块东南部,保存有较为完好的晚三叠纪到早侏罗纪砂岩地层,并内分布有三叠纪-侏罗纪花岗岩(Tao,2014)。沉积学和古地理记录表明,大席地区在中-新生代经历过较

关键词：热年代学磷灰石三叠纪冷却历史砂岩地层

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