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大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析

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英国医学杂志中文版 2021年第8期24卷 435-442页

作者：孟夏刘聪(校) 陈仁杰郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia jan kysely Ales Urban Hans Orru Marek Maasikmets jouni j k jaakkola Niilo Ryti Veronika Huber Alexandra Schneider klea katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes joão Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti joel Schwartz Tangchun Wu Antonio Gasparrini 复旦大学公共卫生学院、公共卫生安全教育部重点实验室(复旦大学)、卫生部卫生技术评估重点实验室(复旦大学) 中国上海北京大学公共卫生学院复旦大学公共卫生学院不详

目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高... 详细信息

目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。

关键词：总死亡率 meta分析总死亡人数死亡风险广义线性模型二氧化氮高收入国家结局指标

Research agenda for the Russian Far East and utilization of multiplatform comprehensive environmental observations

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International journal of Digital Earth 2021年第3期14卷 311-337页

作者： Tuukka Petäjä kirill S.Ganzei Hanna k.Lappalainen ksenia Tabakova Risto Makkonen jouni Räisänen Sergey Chalov Markku kulmala Sergej Zilitinkevich Petr Ya Baklanov Renat B.Shakirov Natalia V.Mishina Evgeny G.Egidarev Igor I.kondrat’ev Institute for Atmospheric and Earth System Research/Physics Faculty of ScienceUniversity of HelsinkiHelsinkiFinland Department of Cryosphere Tyumen State University TyumenRussia Pacific Geographical Institute of the Far Eastern Branch of Russian Academy of Sciences VladivostokRussia Finnish Meteorological Institute HelsinkiFinland Faculty of Geography Lomonosov Moscow State UniversityMoscowRussia V.I.Ilyichov Pacific Oceanological Institute of the Far Eastern Branch of Russian Academy of Sciences VladivostokRussia

The Russian Far East is a region between China and the Russian Arctic with a diverse climatological,geophysical,oceanic,and economical *** southern region is located in the Far East monsoon sector,while the northern parts are affected by the Arctic Ocean and cold air masses penetrating far to the *** economic activities and traffic connected to the China Belt and Road Initiative together with climate change are placing an increased pressure upon the Russian Far East *** is an urgent need to improve the capacity to measure the atmospheric and environmental pollution and analyze their sources and to quantify the relative roles of local and transported pollution emissions in the *** the paper,we characterize the current environmental and socio-economical landscape of the Russian Far East and summarize the future climate scenarios and identify the key regional research *** discuss the research infrastructure concept,which is needed to answer the identified research *** integrated observations,filling in the critical observational gap at the Northern Eurasian context,are required to provide state-of-the-art observations and enable follow-up procedures that support local,regional,and global decision making in the environmental context.

关键词： Russian Far East greenhouse gases aerosol particles insitu observations Earth observation data

Efficient Management of Fines in the Stock Flow prior to Headbox in Paper,Board,and Tissue Production

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Paper And Biomaterials 2022年第1期7卷 45-54页

作者： jouni Matula jussi Matula jukka Nokelainen Tommi Niskanen Lasse kauppinen Eemeli Siitonen Wetend Technologies Ltd. KaartilantieSavonlinnaFI-57230Finland Valmet Automation Inc. Kehräämöntie PO Box177 KajaaniFI-87101Finland 3.Fincet Ltd.Kehräämöntie 7KajaaniFI-87101Finland Solenis Inc. Kolmihaarankatu 7TampereFI-33330Finland

Fines represent a significant volume of biobased wood material and filler,which is of significant importance to sheet *** imaging technology reveals the true nature of the behavior of fines in the retention *** study illustrates new chemical mixing systems,novel and efficient flash mixing methods,and active measurement and automation systems pertaining to efficient management of fines in the stock flow prior to headbox in paper,board,and tissue production,which can reduce additive,fresh water,energy consumption,and the carbon footprint of production to improve sustainability and provide novel opportunities for fines and filler management.

关键词： paper board fines and fillers headbox flash mixing stock camera image technology

行冠状动脉CTA检查的连续病人中升主动脉扩张出现率高

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国际医学放射学杂志 2020年第2期 251-252页

作者： S.P.kauhanen P.Saari P.jaakkola M.korhonen j.Parkkonen j.Vienonen 王天达 Doctoral Programme of Clinical Research University of Eastern Finland

目的探讨按照ESC2014指南诊断升主动脉(AA)扩张的患病率和危险因素。方法本研究包括1000例接受诊断性冠状动脉CTA检查的连续病人。回顾性测量以

关键词：升主动脉扩张危险因素冠状动脉 CTA 出现率

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芬兰研究型教师教育述评

上海教育科研 2009年第1期 21-25页

作者： jouni Vlijrvi 陆璟芬兰于韦斯屈莱大学教育研究所上海市教育科学研究院普教所 200032

芬兰教育成功的重要原因之一是芬兰的研究型教师教育。新的教师教育课程要求所有的师范生都要开展一项他们自己的研究,以发展理论与实践结合的专业能力。本文介绍了芬兰研究型教师教育发展的背景、基本特点,以及实施的主要环节。

关键词：研究型教师教育芬兰教育教师专业性

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在靠近流浆箱处淀粉和填料同时混合工艺

中国造纸 2012年第7期31卷 52-56页

作者：尤尼.马杜拉芬兰温德造纸湿部技术公司

采用闪急混合工艺使得在最接近流浆箱处向浆料中加入助留剂和施胶化学品等造纸添加剂,并使之迅速和有效地混合。这项多功能混合技术可以做到在同一地点同时将填料、助留剂一起加入到流浆箱中。该工艺操作简单,具有非常短的响应时间,填... 详细信息

采用闪急混合工艺使得在最接近流浆箱处向浆料中加入助留剂和施胶化学品等造纸添加剂,并使之迅速和有效地混合。这项多功能混合技术可以做到在同一地点同时将填料、助留剂一起加入到流浆箱中。该工艺操作简单,具有非常短的响应时间,填料留着率更高,纸张性能更优越。由于减少了添加剂在过程中的循环,响应时间非常快速,减少了传统混合过程的水或滤液的量,从而降低了能源消耗,降低了添加剂用量并使工艺过程净化。

关键词：闪急混合添加剂快速响应

Neonatal Fc receptor-targeted lignin-encapsulated porous silicon nanoparticles for enhanced cellular interactions and insulin permeation across the intestinal epithelium

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Bioactive Materials 2022年第3期7卷 299-315页

作者： joao P.Martins Patrícia Figueiredo Shiqi Wang Erika Espo Elena Celi Beatriz Martins Marianna kemell karina Moslova Ermei Makil jarno Salonen Mauri A.kostiainen Christian Celia Vincenzo Cerullo Tapani Viitala Bruno Sarmento jouni Hirvonen Helder A.Santos Drug Research Program Division of Pharmaceutical Chemistry and TechnologyFaculty of PharmacyUniversity of HelsinkiFI-00014HelsinkiFinland Department of Pharmacy University of Chieti-Pescara“G d’Annunzio”I-66100ChietiItaly Drug Research Program Division of Pharmaceutical BiosciencesFaculty of PharmacyUniversity of HelsinkiFI-00014HelsinkiFinland Department of Chemistry University of HelsinkiFI-00014HelsinkiFinland Department of Physics and Astronomy University of TurkuFI-20014TurkuFinland Biohybrid Materials Department of Bioproducts and BiosystemsAalto UniversityFI-00076AaltoFinland i3S-Instituto de Investigaçao e Inovaçao em Saúde University of Porto4200-135PortoPortugal INEB-Instituto de Engenharia Biomedica University of Porto4200-135PortoPortugal CESPU-Instituto de Investigaçao e Formaçao Avançada em Ciencias e Tecnologias da Saúde 4585-116GandraPortugal Helsinki Institute of Life Science(HiLIFE) University of HelsinkiFI-00014HelsinkiFinland

Oral insulin delivery could change the life of millions of diabetic patients as an effective,safe,easy-to-use,and affordable alternative to insulin injections,known by an inherently thwarted patient ***,we designed a multistage nanoparticle(NP)system capable of circumventing the biological barriers that lead to poor drug absorption and bioavailability after oral *** nanosystem consists of an insulin-loaded porous silicon NP encapsulated into a pH-responsive lignin matrix,and surface-functionalized with the Fc fragment of immunoglobulin G,which acts as a targeting ligand for the neonatal Fc receptor(FcRn).The developed NPs presented small size(211±1 nm)and narrow size *** NPs remained intact in stomach and intestinal pH conditions,releasing the drug exclusively at pH 7.4,which mimics blood *** formulation showed to be highly cytocompatible,and surface plasmon resonance studies demonstrated that FcRn-targeted NPs present higher capacity to interact and being internalized by the Caco-2 cells,which express FcRn,as demonstrated by Western ***,in vitro permeability studies showed that Fc-functionalized NPs induced an increase in the amount of insulin that permeated across a Caco-2/HT29-MTX co-culture model,showing apparent permeability coefficients(Papp)of 2.37×10􀀀6 cm/s,over the 1.66×10􀀀6 cm/s observed for their non-functionalized ***,these results demonstrate the potential of these NPs for oral delivery of anti-diabetic drugs.

关键词： Nanoparticles Porous silicon Lignin FcRn Insulin Oral drug delivery

锶板近距放射治疗渗出性老年性黄斑变性:3年随机研究结果

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世界核心医学期刊文摘（眼科学分册） 2005年第11期1卷 43-44页

作者： jaakkola A. Heikkonen j. Tommila P. I. Immonen 张鹏 Department of Opht halmology Helsinki University Central Hospital Haartmanink. 4C FIN-00029 HUS JP220 FinlandDr.

Objective: To determine the efficacy of strontium plaque (Sr90) brachytherapy for age-related macular degeneration (AMD) with subfoveal choroidal neovascular ization (CNV). Design: Randomized clinical trial. Participants: Eighty-eight eyes of 86 patients with subfoveal CNV secondary to AMD were randomized either to plaque radiotherapy or to observation. Intervention: Radiotherapy was given as episcleral brachytherapy using Sr 90 plaques. Two different plaque types were used. Plaque I had a diameter of 8mm and delivered a dose of 15 Gy at a depth o f 1.75 mm in 54 minutes. With plaque II, the corresponding values were 4 mm, 12. 6 Gy, and 11 minutes. The control group was observed without any treatment. Main Outcome Measures: The primary outcome measure was visual acuity at 6, 12, 24, a nd 36 months. Other outcome variables were contrast sensitivity, fluorescein ang iographic, and clinically evaluated changes in the macula. Results: Eighty-two patients (84 eyes [95%]) completed the 1-year follow-up, and 80 (93%) and 74 (86%) patients completed the 2-and 3-year follow-ups, respectively. At 6 mo nths, visual loss of < 3 lines occurred in 20%of treated patients and 42%of co ntrol patients (P=0.031). At 12 months, a visual loss of < 3 lines occurred in 4 5%(treated) and 56%(controls) (P=0.325); at 24 months, in 73%and 71%(P=0.914 ); and at 36 months, in 80%and 84%of patients (P=0.591), respectively. Patient s irradiated with plaque I had better results: a visual loss of < 3 lines occurr ed in 6%at 6 months (P=0.008, relative to controls), in 18%at 12 months (P=0.0 07), in 59%at 24 months (P=0.348), and in 71%at 36 months (P=0.212). In patien ts treated with plaque II, the corresponding values were 29%(P=0.032), 65%(P=0 .459), 83%(P=0.317), and 80%(P=0.687) at 6, 12, 24, and 36 months, respectivel y. Conclusions: The short-term clinical course of exudativeAMD is affected by S r90 brachytherapy, but by 12 months, there was no treatment benefit.

关键词：老年性黄斑变性随机研究渗出性放射治疗随机临床试验放射剂量对比敏感度荧光血管造影治疗作用临床病程

b型流感嗜血杆菌在儿童急性下呼吸道感染中的地位

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中华医学杂志 2000年第5期80卷 373-374页

作者：杨永弘王亚娟姚德秀燕润菊王春连幺远 Anne jaakkola Maija Leinonen Didier Leboulleux Heikki Peltola 北京儿科研究所首都医科大学附属北京儿童医院内科 100045 NationalPublicHealthInstitute DepartmentinOulu