检索结果-南通市图书馆

Growth-promoting activity of Hominis Placenta extract on regenerating sciatic nerve

Acta Pharmacologica Sinica 2006年第1期27卷 50-58页

作者： Tae-beom SEO In-sun HAN Jin-hwan YOON In-chan SEOL Yun-sik RIM Hyun-kyung jo joung-jo an Kwon-eui HONG Young-bae SEO Dong-hee KIM Seung-kiel PARK Deok-chun YANG Uk NAMGUNG Korea Department of Oriental Medicine.Daejeon University Daejeon 300-716Korea Korea Department of Biochemistry College of Medicine Chungnam National University.Daejeon 301-130Korea Korea

Aim:Extract of Hominis Placenta (HP) has been used in oriental medicine as anagent for improving physiological *** present study was conducted toinvestigate whether HP treatment in an experimental sciatic nerve injury animalmodel produces growth-promoting effects on regenerating peripheral nerve fibersafter ***:After HP was injected into a sciatic nerve injury site,changesin protein levels were analyzed in the regenerating nerve area by Western blottingand immunofluorescence staining *** quantitative assessment of ax-onal regeneration,a retrograde tracing technique was used to identify the neu-ronal cell bodies corresponding to regenerating axons,and the extent of neuriteoutgrowth in cultured dorsal root ganglia (DRG) sensory neurons prepared fromanimals that had experienced a sciatic nerve crush injury 7d before neuron collec-tion was ***:Induction levels of axonal growth-associated protein(GAP-43) in the injured sciatic nerves were elevated by HP *** treat-ment also upregulated cell division cycle 2 (Cdc2) protein levels in the distalstump of the injured sciatic *** Cdc2 protein was detected in Schwanncells,suggesting that Cdc2 kinase activity may be involved in the growth-promot-ing activity of regenerating axons via Schwann cell *** body mea-surement by retrograde tracing indicated that HP treatment produced significantincreases in regenerating motor ***,HP treatment of cultured DRGsensory neurons significantly increased neurite arborization and ***:HP promotes the regeneration of injured sciatic axons by upregulatingthe synthesis of regeneration-related protein factors such as GAP-43 and Cdc2.

关键词： hominis placenta axonal regeneration sciatic nerve GAP-43 protein Cyclindepend kinase 2

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Corticotropin-releasing factor stimulates colonic motility via muscarinic receptors in the rat

引用

World journal of Gastroenterology 2017年第21期23卷 3825-3831页

作者： Kyung-jo Kim Ki Bae Kim Soon Man Yoon joung-Ho Han Hee Bok Chae Seon Mee Park Sei Jin Youn Department of Gastroenterology University of Ulsan College of Medicine Asan Medical Center Department of Internal Medicine Chungbuk National University College of Medicine

AIM To measure exogenous corticotropin-releasing factor(CRF)-induced motility of the isolated rat colon and to demonstrate the effect of pharmacologic inhibition on CRF-induced motility. METHODS The isolated vascularly-perfused rat colon was used. Luminal pressure was monitored via microtip catheter pressure transducers in the proximal and distal colon. At first, exogenous CRF was administered in a stepwise manner and the concentration of CRF yielding maximal colonic motility was selected. After recording basal colonic motility, hexamethonium, phentolamine, propranolol, atropine and tetrodotoxin were infused into the isolated colon. Initially, only the test drug was infused; then, CRF was added. The motility index was expressed as percentage change over basal level. RESULTS Administration of 1.4, 14.4, 144 and 288 pmol/L CRF progressively increased colonic motility in the proximal and distal colon. Infusion of atropine or tetrodotoxin reduced CRF-induced motility of both the proximal and distal colon, whereas hexamethonium, phentolamine and propranolol had no *** CRF-induced colonic motility appears to be mediated by local cholinergic signaling via muscarinic receptors. Muscarinic receptors are potential targets for counteracting CRF-induced colonic hypermotility.

关键词： Gastrointestinal motility Rats Stress Colon Corticotropin-releasing factor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Attenuated FOLFIRINOX in the salvage treatment of gemcitabine-refractory advanced pancreatic cancer: a phase II study

引用

Cancer Communications 2018年第1期38卷 344-351页

作者： Jung Hoon Kim Sang-Cheol Lee Sung Yong Oh Seo-Young Song Namsu Lee Eun Mi Nam Soonil Lee In Gyu Hwang Hyo Rak Lee Kyu Taek Lee Sang-Byung Bae Han jo Kim joung Soon Jang Do Hyoung Lim Hyun Woo Lee Seok Yun Kang Jung Hun Kang Department of Internal Medicine Institute of Health SciencesGyeongsang National University15 Jinju-daero 816beon-gilJinju 52727Republic of Korea Divsion of Hematology and Oncology Department of Internal MedicineSoonchunhyang University Hospital CheonanCheonan 31151Republic of Korea Department of Internal Medicine Dong-A University HospitalBusan 49201Republic of Korea Department of Internal Medicine Kangwon National University School of MedicineChuncheon 24289Republic of Korea Divsion of Hematology and Oncology Department of Internal MedicineSoonchunhyang University Hospital SeoulSeoul 04401Republic of Korea Department of Internal Medicine Ewha Womans UniversityCollege of MedicineSeoul 07985Republic of Korea Department of Internal Medicine Dankook University HospitalCheonan 31116Republic of Korea Department of Internal Medicine Chung-Ang UniversityCollege of MedicineSeoul 06973Republic of Korea Division of Hematology and Medical Oncology Department of Internal MedicineKorea Cancer HospitalSeoul 01812Republic of Korea Department of Hematology-Oncology Ajou University HospitalSuwon 16499Republic of Korea

Background:Combination therapy with oxaliplatin,irinotecan,fluorouracil,and leucovorin(FOLFIRINOX)chemotherapy drastically improves survival of advanced pancreatic cancer ***,the efficacy of FOLFIRINOX as a second-line treatment after gemcitabine failure has not been tested *** investigated the feasibility and safety of attenuated FOLFIRINOX in patients with gemcitabine-refractory advanced pancreatic ***:A multicenter phase II prospective open-label,single-arm study was conducted at 14 *** with histologically proven invasive ductal pancreatic adenocarcinoma,a measurable or evaluable lesion,Eastern Cooperative Oncology Group performance status 0 or 1,adequate organ function,and aged 19 years or older were *** FOLFIRINOX consisted of oxaliplatin 65 mg/m2,irinotecan 135 mg/m2,and leucovorin 400 mg/m2 injected intravenously on day 1 and 5-fluorouracil 2000 mg/m2 continuously infused intravenously over 46 h on days 1-2,repeated every 2 *** primary endpoint was progression-free survival from the initiation of *** endpoints were the objective response rate,disease control rate,overall survival,safety,and *** estimated overall survival and progression-free survival using the Kaplan-Meier ***:We enrolled 39 patients from 14 *** objective response rate was 10.3%,while the disease control rate was 64.1%.The 6-month and 1-year overall survival rates were 59.0%and 15.4%,*** progression-free survival and overall survival were 3.8 months(95%confidence interval[CI]1.5-6.0 months)and 8.5 months(95%CI 5.6-11.4 months),*** 3 or 4 adverse events were neutropenia(41.0%),nausea(10.3%),anorexia(10.3%),anemia(7.7%),mucositis(7.7%),pneumonia/pleural effusion(5.1%),and fatigue(5.1%).One treatment-related death attributable to septic shock ***:Attenuated FOLFIRINOX may be promising as a second-line therapy for gemcitabin

关键词： Attenuated FOLFIRINOX Second-line Pancreatic cancer Gemcitabine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of Composted Cattle Manure Application on the Productivity of Forages Under Rye and Whole Crop Rice Double Cropping System in Asan,Korea

Effects of Composted Cattle Manure Application on the Produc...

引用

The 3rd Korea-China-Japan joint Symposium on Grassland Agriculture and Livestock Production

作者： Young Chul Lim Min Woong Jung Sei Hyung Yoon joung Kyong Lee Nam Chul jo Ki-Won Lee Wan Bang Yook National Institute of Animal Science RDACheonan-SiChungnam 330-801 Korea College of Animal Bioscience and Technology Konkuk University

The experimental work was conducted to investigate the effects of the application level of composted cattle manure(CCM) on forage productivity using rye-whole crop rice(WCR) double cropping system for 3 *** plot was consisted of application level of CCM such as 150%,200%and control *** total DMY of of rye-WCR in treatment of CCM 150%significantly decreased as compared with that of treatment of CF and CCM 200%.However, NDF,ADF and CP content of rye and WCR were hardly influenced by CCM application.

关键词： Whole crop rice Composted Cattle manure Cropping system

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

减量FOLFIRINOX方案挽救性治疗吉西他滨抵抗的晚期胰腺癌:一项Ⅱ期研究

引用

癌症 2018年第8期37卷 327-335页

作者： Jung Hoon Kim Sang-Cheol Lee Sung Yong Oh Seo-Young Song Namsu Lee Eun Mi Nam Soonil Lee In Gyu Hwang Hyo Rak Lee Kyu Taek Lee Sang-Byung Bae Han jo Kim joung Soon Jang Do Hyoung Lim Hyun Woo Lee Seok Yun Kang Jung Hun Kang Department of Internal Medicine Institute of Health SciencesGyeongsang National University Divsion of Hematology and Oncology Department of Internal MedicineSoonchunhyang University HospitalCheonan Department of Internal Medicine Dong-A University Hospital Department of Internal Medicine Kangwon National University School of Medicine Divsion of Hematology and Oncology Department of Internal MedicineSoonchunhyang University HospitalSeoul Department of Internal Medicine Ewha Womans UniversityCollege of Medicine Department of Internal Medicine Dankook University Hospital Department of Internal Medicine Chung-Ang UniversityCollege of Medicine Division of Hematology and Medical Oncology Department of Internal MedicineKorea Cancer Hospital Department of Hematology-Oncology Ajou University Hospital

背景与目的奥沙利铂、伊立替康、氟尿嘧啶和亚叶酸的联合化疗方案(FOLFIRINOX)极大提高了晚期胰腺癌患者的生存期。然而,FOLFIRINOX方案作为吉西他滨失败后二线治疗的疗效尚未进行前瞻性的检测。我们研究了减量FOLFIRINOX方案治疗吉西... 详细信息

背景与目的奥沙利铂、伊立替康、氟尿嘧啶和亚叶酸的联合化疗方案(FOLFIRINOX)极大提高了晚期胰腺癌患者的生存期。然而,FOLFIRINOX方案作为吉西他滨失败后二线治疗的疗效尚未进行前瞻性的检测。我们研究了减量FOLFIRINOX方案治疗吉西他滨抵抗的晚期胰腺癌患者的可行性和安全性。方法在14家医院进行了这一多中心II期前瞻、开放标签的单臂研究。经组织学确诊为胰腺浸润性导管腺癌、有可测量或可评价的病灶、东部肿瘤协作组体能状况评分0或1分、器官功能良好、年龄19岁或以上的患者符合入组条件。减量FOLFIRINOX方案的组成:奥沙利铂65 mg/m2、伊立替康135 mg/m2和亚叶酸400 mg/m2,第1天静脉注射;5?氟尿嘧啶2000 mg/m2,第1–2天持续静脉输注46 h;每2周重复。主要终点为FOLIFLIOX治疗起始后的无进展生存期。次要终点为客观缓解率、疾病控制率、总生存期、安全性和耐受性。采用Kaplan?Meier法评估了总生存期和无进展生存期。结果我们招募了来自14个中心的39例患者。客观缓解率为10.3%,疾病控制率为64.1%。6个月和1年总生存率分别为59.0%和15.4%。中位无进展生存期和总生存期分别为3.8个月[95%置信区间(confidence interval,CI)=1.5–6.0个月]和8.5个月(95%CI=5.6–11.4个月)。3或4级不良事件为中性粒细胞减少(41%)、恶心(10.3%)、食欲减退(10.3%)、贫血(7.7%)、黏膜炎(7.7%)、肺炎/胸膜融合(5.1%)和乏力(5.1%)。发生1例由感染性休克引起的治疗相关死亡。结论减量FOLFIRINOX方案有望作为二线方案治疗吉西他滨抵抗的胰腺癌。

关键词：减量FOLFIRINOX方案二线治疗胰腺癌吉西他滨

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：