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Development of Maize-Tigernut Fortified Weaning Food Using Starter cultures

Food and Nutrition Sciences 2018年第12期9卷 1444-1457页

作者： Sherifah Monilola Wakil joshua Opeyemi Ola Department of Microbiology University of Ibadan Ibadan Nigeria

The effects of starter fermentation on the nutritional qualities of maize-tigernut fortified weaning foods were investigated. The dry-milled, malted maize grains fortified with dry-milled roasted tigernut flours (70:30) were subjected to 48 hrs of spontaneous and starter fermentation (singly and as combined starters). Nutritional, sensory characteristics and feeding trials of the weaning foods were evaluated. Four fermented weaning blends were formulated: FMT (spontaneously fermented maize-tigernut), SFMT1 (Lactobacillus plantarum F2c fermented maize-tigernut), SFMT2 (Lactobacillus plantarum U2A fermented maize-tigernut) and SFMT3 (combined starter-fermented maize-tigernut). SFMT2 had the highest crude protein, fat, fibre, ash and least carbohydrate content among the blends. The highest energy content (456.84 Kcal/100 g) was observed in blend SMFT2 which was also higher than that of both negative (Nutrend) and positive (conventional animal feed) controls. The least antinutrient and vitamin contents were recorded in SFMT2. Blend SFMT1 had the highest Vitamin B1 (0.67 mg/100 g), Vitamin A (472.60 ug/100 g), phosphorus (75.45 mg/100 g) and zinc (1.05 mg/100 g) contents while the highest calcium (17.17 mg/100 g) and iron (22.82 mg/100 g) were recorded in SFMT2. Sample SFMT2 was rated the highest in all of the sensory characteristics except colour and the highest overall acceptability (6.00) which was not different significantly from all other starter produce blends. Biological evaluation showed blend SFMT2 fed animals having the highest weight by 28 days (73.14 g), mean weight gain (5.46 g), mean feed intake (18.71 g) and mean protein efficiency ratio PER (3.65). However, all the PER values including that of controls (2.30) were higher than the value of 2.10 recommended by the Protein Advisory Group (PAG) for complementary foods. The RBc, WBc and PcV of the trial groups were within the rat hematologic reference ranges. Blend SFMT2 (L. plantarum U2A fermented blend) gave

关键词： Fortification Tigernut Nutritional Evaluation Biological Evaluation Starter-Fermentation

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In-Situ carbon control in the Preparation of Precursors to Boron carbide by a Non-Aqueous Solution Technique

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材料科学与工程（中英文A版） 2015年第1期5卷 8-20页

作者： joshua L. Watts Peter c.Talbot Jose A. Alarco Ian D. R. Mackinnon Institute for Future Environments Queensland University of Technology Brisbane 4001 Australia Science and Engineering Faculty School of Chemistry Queensland University of Technology Brisbane 4001 Australia

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Live-cell Imaging of NADPHProduction from Specific Pathways

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ccS chemistry 2021年第6期3卷 1642-1648页

作者： Senlian Hong Tao chen Ling Liu chen cao Fengxiang Lv joshua DRabinowitz Yanyi Huang Xing chen college of chemistry and Molecular Engineering Peking UniversityBeijing 100871 Peking-Tsinghua center for Life Sciences Peking UniversityBeijing 100871 Beijing National Laboratory for Molecular Sciences Peking UniversityBeijing 100871 college of Engineering Peking UniversityBeijing 100871 Biomedical Pioneering Innovation center Peking UniversityBeijing 100871 Beijing Advanced Innovation center for Genomics Peking UniversityBeijing 100871 Lewis-Sigler Institute for Integrative Genomics Princeton UniversityPrincetonNJ 08544 Department of chemistry Princeton UniversityPrincetonNJ 08544 Institute of Molecular Medicine Peking UniversityBeijing 100871 Shenzhen Bey Laboratory Institute for Cell AnalysisPeking UniversityBeijing 100871 Synthetic and Functional Biomolecule center Peking UniversityBeijing 100871 Key Laboratory of Bioorganic chemistry and Molecular Engineering of Ministry of Education Peking UniversityBeijing 100871 Department of Molecular Medicine The Scripps Research InstituteLa JollaCA 92037 Huffington center on Aging Baylor College of MedicineHoustonTX 77030

As anconversion of essential cofactor for lipid biosynthesisand antioxidant defense, reduced nicotinamideadenine dinucleotide phosphate (NADPH) isproduced via various pathways, including the oxidativepentose phosphate pathway (oxPPP) and themalic enzyme 1 (ME1)-catalyzed conversion of malateto pyruvate. Live-cell detection of NADPH productionroutes remains challenging. Here, we reporttracing hydrides into lipid droplets (THILD), achemical imaging strategy for the detection ofpathway-specific NADPH generation in live cells. Thisstrategy exploits deuterium (2H)-labeled glucose([2H]Glc) tracers that transfer deuterides to NADPHvia specific pathways. The NADP^(2)H, in turn, transfersdeuterides to lipids, resulting in accumulation of c-2Hbonds in lipid droplets, which can be visualized bybioorthogonal stimulated Raman scattering (SRS)microscopy. We used this concept to demonstratethe imaging of oxPPP-produced NADPH using theoxPPP-specific tracer, [3-2H]Glc. Furthermore, the“switch on” of NADPH production by ME1 in differentiatingadipocytes was imaged by [4-2H]Glc. Finally,comparison of [3-2H]Glc and [4-2H]Glc THILDimaging of adipocytes showed that hypoxia inducessuppression of ME1-mediated NADPH productionand oxPPP-produced NADPH becomes the mainsource.

关键词： NADPH metabolic reprogramming bioorthogonal Raman imaging deuterium tracing SRS microscopy pathway specificity

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Lubiprostone used with polyethylene glycol in diabetic patients enhances colonoscopy preparation quality

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World Journal of Gastrointestinal Endoscopy 2010年第7期2卷 263-267页

作者： Erika Grigg Moonkyung c Schubert joshua Hall Fadi Rahhal Dimple Raina Subbaramiah Sridhar Sherman M chamberlain Section of Gastroenterology and Hepatology Medical College of GeorgiaAugustaGA 30912United States

AIM: To assess the additive effect of lubiprostone on the quality of colon preparation in diabetics given single-dosed polyethylene glycol electrolyte(PEG)for ***:This was an investigator-initiated,singlecenter,single-blinded prospective trial comparing the efficacy of L+PEG to PEG alone on colon preparation quality in diabetics undergoing screening *** study was approved by our institution’s *** PEG was given as a single-dose to address patientcompliance concerns voiced by our IRB with *** patients received only clear liquids the day prior to *** group(Grp L)received PEG+1 dose L 2 h prior to and 2 h after PEG *** group(Grp c)received only PEG the evening prior to the *** were randomly assigned to one of the 2 *** endoscopist was blinded to which colon prep was given and all colonoscopies were *** colonoscopy completion,the endoscopist rated the colon prep-quality by a validated 5-point Likert scale(1-excellent to 5-inadequate).RESULTS:Sixty patients were enrolled in the study;30 Grp L and 30 Grp ***,patients were excluded due to study non-completion in 12(41%)Grp L and 5(17%) Grp c,P=*** colon preparation score Grp L =2.47 and Grp c=3.00,P=*** this was not statistically significant,there was a trend towards improved colon prep in Grp *** significance may have been achieved if completion rates had been similar between both study ***:Use of 2-L capsules with PEG resulted in a trend towards improved colon prep over PEG alone in diabetic patients when given as a single-dose regimen.

关键词： Lubiprostone Polyethylene glycol Diabetes colonoscopy colon preparation

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Application of a long short-term memory for deconvoluting conductance contributions at charged ferroelectric domain walls

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npj computational Materials 2020年第1期6卷 319-325页

作者： Theodor S.Holstad Trygve M.Ræder Donald M.Evans Didirk R.Småbråten Stephan Krohns Jakob Schaab Zewu Yan Edith Bourret Antonius T.Jvan Helvoort Tor Grande Sverre M.Selbach joshua c.Agar Dennis Meier Department of Materials Science and Engineering Norwegian University of Science and Technology(NTNU)7491 TrondheimNorway Department of Materials Science and Engineering Lehigh UniversityBethlehemPA 18015USA Experimental Physics V Center for Electronic Correlations and MagnetismUniversity of Augsburg86159 AugsburgGermany Department of Materials ETH Zurich8093 ZürichSwitzerland Materials Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of Physics ETH Zurich8093 ZürichSwitzerland Department of Physics Norwegian University of Science and Technology(NTNU)7491 TrondheimNorway

Ferroelectric domain walls are promising quasi-2D structures that can be leveraged for miniaturization of electronics components and new mechanisms to control electronic signals at the *** the significant progress in experiment and theory,however,most investigations on ferroelectric domain walls are still on a fundamental level,and reliable characterization of emergent transport phenomena remains a challenging task.

关键词： walls ferroelectric conductance

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Trends of seasonal forage yield changes of triticale in the southern Great Plains of the United States

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Grassland Research 2022年第3期1卷 166-173页

作者： Tadele T.Kumssa joshua D.Anderson James P.Johnson Shawn Norton Malay c.Saha Michael A.Trammell James K.Rogers Twain J.Butler Xue-Feng Ma Noble Research Institute ArdmoreOklahomaUSA University of Illinois at Urbana-champaign UrbanaIllinoisUSA Oklahoma State University ShawneeOklahomaUSA Forage Genetics International West SalemWisconsinUSA

Background:The focus of triticale breeding in the southern Great Plains of the United States has been to increase forage yield for autumn-winter seasons when most other forage species are *** study aims to estimate the trends of seasonal yield changes over ***:Yield trials had been conducted in a randomized complete block design for up to two *** yield changes over time were estimated using linear regression ***:The analysis revealed a significant positive relation between autumn forage yield(relative to common checks)and calendar years when the trials were *** estimated improvement of autumn forage yield was about 1.9%per year on medium and heavy soil at Ardmore,Oklahoma,and about 5.4%per year on light soil at Burneyville,***,winter forage yield change was minimal and the spring forage yield increase was negative,although this decline was not *** forage yield improvements were about 0.6%and 0.7%per year at Ardmore and Burneyville,*** results were also observed when years of cultivars'introduction were used ***:The results indicate a significant gain in autumn forage yield,but a minor gain in the total forage yield due to the yield tradeoff between the autumn and spring seasons.

关键词： cultivar improvement forage yield grazing tolerance regrowth triticale

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Probing the Impact of Solvent on the Strength of Lewis Acids via Fluorescent Lewis Adducts

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Precision chemistry 2023年第1期1卷 49-56页

作者： Amy E.Laturski joshua R.Gaffen Paul Demay-Drouhard christopher B.caputo Thomas Baumgartner Department of chemistry York UniversityTorontoON M3J 1P3Canada

Various methods have been developed to measure the strength of a Lewis acid.A major challenge for these measurements lies in the complexity that arises from variable solvent interactions and perturbations of Lewis acids as their reaction environment ***,we investigate the impact of solvent effects on Lewis acids for the first time as measured by the fluorescent Lewis adduct(FLA)*** binding of a Lewis acid in various solvents reveals a measurable dichotomy between both polarity and donor ability of the *** not strictly separable,we observe that the influence of solvent polarity on Lewis acid unit(LAU)values is distinctly opposite to the influence of donor *** dichotomy was confirmed by titration data,illustrating that solvation effects can be appropriately and precisely gauged by the FLA method.

关键词： Fluorescence Fluorescent Lewis adducts Lewis acids Effective Lewis acidity Solvent polarity Solvent donor strength

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Medical Informatics and Opportunity for Anesthesiologists

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麻醉与监护论坛 2013年第4期20卷 258-262页

作者： Ren-yu Liu Meghan Lane-Fall c. William Hanson joshua Atkins Jia-bin Liu Lee Fleisher Department of Anesthesiology and critical care Perelman School of Medicine at the University of Pennsylvania

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Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis

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World Journal of Diabetes 2018年第2期9卷 53-58页

作者： Patrick R Wood Evan Manning joshua F Baker Bryant England Lisa Davis Grant W cannon Ted R Mikuls Liron caplan Denver Veterans Affairs Medical center Division of Rheumatology University of Colorado Philadelphia Veterans Affairs Medical center Division of Rheumatology University of Pennsylvania Omaha Veterans Affairs Medical center Division of Rheumatology University of Nebraska Denver Health and Hospital Division of Rheumatology University of Colorado George Wahlen Veterans Affairs Medical center Division of Rheumatology University of Utah

AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1c values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1c measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and *** Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P cally significant decrease in A1c was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P chloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1c values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not

关键词： Disease modifying anti-rheumatic drugs Drug toxicity Glucocorticoids Rheumatoid arthritis Tumor necrosis factor inhibitors

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Wideband and Low-Loss Metamaterial Antennas and Arrays

Wideband and Low-Loss Metamaterial Antennas and Arrays

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2013年全国天线年会

作者： joshua Le-Wei Li Monash University Malaysia University of Electronic Science ＆ Technology of china

Over the past decade,the metamaterials research has been intensively conducted over the entire spectrum covering optical wave,Terahertz,and microwave/RF *** the research progresses in metamaterials in optics look very encouraging and successful,metamaterial research for the microwave and radio frequency（RF） applications are still facing some *** difficulties faced earlier and still being faced right now in developments include（1） efficient solvers and/or tools for metamaterial designs;and（2） design and fabrications of metamaterials of low loss and broad frequency *** high loss and narrow bandwidth are not key issues in optical region,they are in fact the major issues of the metamaterial research in microwave and RF *** recent several years,metamaterials research has moved toward practical engineering *** this talk,some new progresses of the metamaterial microstrip antennas and arrays are reported and new results are *** physics behind the metamaterial antennas is also discussed and the bandwidth broadening mechanism is *** different layouts and configurations are considered in the designs,and their corresponding radiation characteristics are presented and *** and feeding networks are also designed and *** design experiences will be shared with,and their results of antenna impedance bandwidth,radiation patterns,and radiation efficiencies ***,experimental data are presented together with the design results to validate the designs and to gain more physical insights of the new layouts in the designs.

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