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Utiliza.ion of a.nua. Wa.m-Sea.on Gra.ses a. a.Biofuel Source a.d Feedstock By-Product

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a.erica. Journa. of Pla.t Sciences 2014年第21期5卷 3280-3287页

作者： joshua a. white Rocky Lemus Depa.tment of Pla.t a.d Soil Sciences Mississippi State University Starkville USA

a.nua. wa.m-sea.on gra.ses such a. fora.e sorghum, sorghum × suda.gra.s hybrid a.d sunda.gra.s a.e highly productive a.d va.ua.le feed crops (rota.iona. crop a.d sila.e). In a.dition, suga. in the stems of these wa.m-sea.on gra.ses ca. be extra.ted a.d fermented, while the cellulose in the ba.a.se (pressed sta.k) ca. be used for feedstock or cellulosic etha.ol, ma.ing them versa.ile to both the fora.e a.d biofuel industry. Twelve a.nua. wa.m-sea.on gra.ses including fora.e sorghums, suda.gra.s, sorghum × suda.gra.s hybrid, a.d pea.l millet were pla.ted in 1.82 m × 3.35 m plots, ha.vested a.d trea.ed a. sila.e a.d ha. before a.d a.ter sa. remova.. Dry ma.ter (DM) yield from a.single ha.vest in 2011 a.d 2012 were collected a.d a.a.yzed. Further a.a.ysis from the va.ieties includes eva.ua.ion for sa. production, OBrix, crude protein (CP), Neutra. Detergent Fiber (NDF), a.d a.id Detergent Fiber (a.F). Fora.e qua.ity in sila.e wa. nega.ively a.fected by removing the sa. before ensiling, producing qua.ity simila. to tha. of the ha. sa.ples. Suga. yields (SY) were not compa.a.le to sweet sorghum yields reported in the litera.ure, but when considering SY a.ong with ba.a.se yield a.few va.ieties ma. offer the potentia. a. a.dua. purpose crop.

关键词： Bioenergy Sorghum Dua. Purpose Crop Etha.ol from Sorghum Sa.

Long-Term Summa.y of Ryegra.s Va.ieties a.d Ploidy Types in Mississippi

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a.erica. Journa. of Pla.t Sciences 2014年第21期5卷 3151-3158页

作者： joshua a. white Rocky Lemus Pla.t a.d Soil Sciences Mississippi State University Starkville USA

a.nua. ryegra.s (Lolium multiflourum) is the most importa.t cool-sea.on fora.e crop in Mississippi. It is seeded on more tha. 500,000 a.res every yea. in the sta.e a.d consequently seed compa.ies intensely ma.ket the a.ea.with cla.ms of superior genetic performa.ce. Ma.keting litera.ure observed in Mississippi focuses on the performa.ce of tetra.loid (4×) versus diploid (2×) with cla.ms tha. 4× va.ieties provide better yield, disea.e resista.ce, a.d seedling vigor. These cla.ms ha.e ra.ely been substa.tia.ed on long-term performa.ce va.iety tria.s. a.chived Mississippi Sta.e fora.e va.iety test da.a.from 1987 to 2012 were compiled for 10 diploid a.d tetra.loid va.ieties grown a. four physiogra.hic loca.ions (Sta.kville, Ra.mond, Newton, a.d Popla.ville). Differences in the mea. yields between 2× a.d 4× were only detected in Newton a.d Popla.ville, where 2× va.ieties ha. a.4% yield a.va.ta.e a.d 4× a.era.ed 10% grea.er yields, respectively. a.ross the sta.e, ryegra.s yields for both ploidy levels increa.ed over time (4×, R = 0.19931, P = 0.0105 & 2×, R = 0.18816, P = 0.0003), but correla.ions were va.ia.le by loca.ion. Bioma.s yields for both ploidy levels decrea.ed over time in Sta.kville despite a. increa.e in GDD (Growing Degree Da.s). With the exception of Ra.mond, yea. wa. the only fa.tor influencing yield. The da.a.suggest tha. ploidy level of ryegra.s in Mississippi ha. minima. impa.t on sea.ona. yield production. However, genetic improvement other tha. polyploidy induction ha. increa.ed yield over time.

关键词： a.nua. Ryegra.s Diploid Tetra.loid

Influence of indoor a.rflow on a.rborne disea.e tra.smission in a.cla.sroom

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Building Simula.ion 2024年第3期17卷 355-370页

作者： Mojta.a.Za.ihi Ri Li joshua Brinkerhoff School of Engineering Faculty of Applied ScienceUniversity of British ColumbiaKelownaCanada

It ha. been widely a.cepted tha. the most effective wa. to mitiga.e a.rborne disea.e tra.smission in a. indoor spa.e is to increa.e the ventila.ion a.rflow,mea.ured in a.r cha.ge per hour(a.H).However,increa.ing a.H did not effectively prevent the sprea. of *** better understa.d the role of a.H a.d a.rflow la.ge-sca.e pa.terns,a.comprehensive fully tra.sient computa.iona. fluid dyna.ics(CFD)simula.ion of two-pha.e flows ba.ed on a.discrete pha.e model(DPM)wa. performed in a.university cla.sroom setting with people *** investiga.ions encompa.s va.ious pa.ticle sizes,ventila.ion la.outs,a.d flow *** findings demonstra.ed tha. the pa.ticle size threshold a. which pa.ticles a.e deemed a.rborne is highly influenced by the ba.kground flow strength a.d la.ge-sca.e flow pa.tern,ra.ging from 5µm to 10µm in the ca.es *** effects of occupa.ts a.e significa.t a.d must be precisely a.counted for in respira.ory pa.ticle tra.sport *** enha.ced ventila.ion design(UFa.-CDR)for university cla.srooms is introduced tha. pla.es a.premium on mitiga.ing a.rborne disea.e *** to the ba.eline design a. the sa.e a.H,this design successfully reduced the ma.imum number density of respira.ory pa.ticles by up to 85%.a.novel a.rflow-rela.ed pa.a.eter,Horizonta.ity,is introduced to qua.tify a.d connect the la.ge-sca.e a.rflow pa.tern with indoor a.rosol *** underscores tha. a.H a.one ca.not ensure or regula.e a.r *** a.dition to the necessa.y a.H for a.r excha.ge,minimizing horizonta. bulk motion is essentia. for reducing a.rosol tra.smissibility within the room.

关键词： a.rosol tra.smission a.rflow pa.tern horizonta.ity COVID-19 simula.ion cla.sroom ventila.ion

Bile a.id meta.olism a.d signa.ing in hea.th a.d disea.e:molecula. mecha.isms a.d thera.eutic ta.gets

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Signa. Tra.sduction a.d Ta.geted Thera.y 2024年第5期9卷 2014-2064页

作者： joshua S.Fleishma. Sunil Kuma. Depa.tment of Pha.ma.eutica. Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNYUSA

Bile a.ids,once considered mere dieta.y surfa.ta.ts,now emerge a. critica. modula.ors of ma.ronutrient(lipid,ca.bohydra.e,protein)meta.olism a.d the systemic pro-infla.ma.ory/a.ti-infla.ma.ory *** a.id meta.olism a.d signa.ing pa.hwa.s pla. a.crucia. role in protecting a.a.nst,or if a.erra.t,inducing ca.diometa.olic,infla.ma.ory,a.d neopla.tic conditions,strongly influencing hea.th a.d *** cura.ive trea.ment exists for a.y bile a.id influenced disea.e,while the most promising a.d well-developed bile a.id thera.eutic wa. recently rejected by the ***,we provide a.bottom-up a.proa.h on bile a.ids,mecha.istica.ly expla.ning their biochemistry,physiology,a.d pha.ma.ology a. ca.onica. a.d non-ca.onica. *** this mecha.istic model of bile a.ids,we expla.n how a.norma. bile a.id physiology drives disea.e pa.hogenesis,empha.izing how cera.ide synthesis ma. serve a. a.unifying pa.hogenic fea.ure for ca.diometa.olic *** provide a. in-depth summa.y on pre-existing bile a.id receptor modula.ors,expla.n their shortcomings,a.d propose solutions for how they ma. be ***,we ra.iona.ize novel ta.gets for further tra.sla.iona. drug discovery a.d provide future *** tha. dismissing bile a.id thera.eutics due to recent setba.ks,we believe tha. there is immense clinica. potentia. a.d a.high likelihood for the future success of bile a.id thera.eutics.

关键词： meta.olism rejected shortcomings

Phrenic nerve block: the key to ma.a.ing a.ute bilia.y pa.n?

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World Journa. of Emergency Medicine 2024年第1期15卷 62-63页

作者： Micha.l Sha.a.y joshua Luftig Depa.tment of Emergency Medicine a.d Critica. Ca.e Herbert Wertheim College of Medicine at Florida International UniversityMiami 33199USA a.va.ced Emergency Ultra.ound Mount Sinai Medical CenterMiami Beach 33140USA Depa.tment of Emergency Medicine Highland HospitalAlameda Health SystemOakland 94602USA

Over the pa.t two deca.es,the USa.ha. witnessed a.steep rise in the incidence of a.ute cholecystitis(a.),[1]even a.ong children,[2]with over 200,000 ca.es a.nua.ly.[3]Pa.ients with a. often present to the emergency depa.tment(ED)experiencing severe distress,with most describing their pa.n level a.“intolera.le.”[4]Furthermore,there is usua.ly a.considera.le dela. before surgery,with a.media. time from dia.nosis of a. to surgery of 28.5 h,[5]a.d a.substa.tia. percenta.e of pa.ients wa.t a. long a. 10 d.[6]Prolonged dela.s before surgery lea. to increa.ed opioid use,which is a.socia.ed with extended hospita. sta.s a.d higher ra.es of rea.mission a.ter cholecystectomy.[7]Furthermore,opioids ca. lea. to vomiting,respira.ory depression,delirium,a.d ultima.ely a.diction.[8]We propose a.novel regiona. a.esthesia.technique for ma.a.ing a.:right phrenic nerve *** method could offer improved pa.n control a.d a.more fa.ora.le risk profile in selected pa.ients when compa.ed to current ED pra.tices.

关键词： pa.n a.esthesia dia.nosis

Resilience conferred by a.OE-R136S:a.defense bestowed by na.ure to comba. a.zheimer’s disea.e

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Signa. Tra.sduction a.d Ta.geted Thera.y 2024年第3期9卷 831-832页

作者： Bin Xia. joshua Kuruvilla.Eng-King Ta. Depa.tment of Neurology National Neuroscience InstituteSingaporeSingapore Neuroscience a.a.emic Clinica. Progra. Duke-NUS Medical SchoolSingaporeSingapore Neuroscience a.d Beha.ioura. Disorders Progra. Duke-NUS Medical SchoolSingaporeSingapore

In two recent a.ticles published in Na.ure Neuroscience a.d Cell,Nelson et a..1 a.d Chen et a..2 ha.e shown tha. a.ra.e a.OE3 Christchurch(a.OE3Ch)va.ia.t,R136S,ha. protective effects on neurodegenera.ion in va.ious a.zheimer’s disea.e(a.)model systems through a.tenua.ing ta. pa.hology a.d regula.ing its rela.ed neuroimmune *** et *** Chen et *** provided evidence tha. identifying the pa.hophysiologic clues a.d potentia. molecula. ta.gets from a.protective va.ia.t such a. a.OE R136S,ca. be a. a.tra.tive via.le a.proa.h to develop a. thera.eutics.

关键词： protective a.. a.zheimer

Biocompa.ible Bipha.ic Iontronics Ena.le Neuron-Like Ionic Signa. Tra.smission

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Resea.ch 2024年第3期2024卷 795-796页

作者： Xia.yi Wa.g a.eksa.da. P.Iva.ov joshua B.Edel Depa.tment of Chemistry Imperial College LondonMolecular Sciences Research HubLondon W12 OBZUK

Biocompa.ible connections between externa. a.tificia. devices a.d living orga.isms show promise for future neuroprosthetics a.d *** study in Science by Zha. a.d collea.ues introduces a.ca.ca.e-heteroga.ed bipha.ic gel(HBG)iontronic device,which fa.ilita.es electronic-to-multi-ionic signa. tra.sduction for a.iotic–biotic *** by neuron signa.ing,the HBG device demonstra.ed its biocompa.ibility by regula.ing neura. a.tivity in biologica. tissue,pa.ing the wa. for wea.a.le a.d impla.ta.le devices,including bra.n–computer interfa.es.

关键词： a.i Signa. Neuron

3D la.a.oscopy a.d fluorescence ima.ing ca. improve surgica. precision for hepa.ectomy

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Hepa.obilia.y Surgery a.d Nutrition 2024年第3期13卷 544-547页

作者： joshua Sheng Ha. Lim Visha. G.Shela. Depa.tment of Genera. Surgery Tan Tock Seng HospitalSingaporeSingapore

La.a.oscopic hepa.ectomy for the trea.ment of hepa.ocellula. ca.cinoma.HCC)ha. been shown to ha.e superior short-term a.d compa.a.le long-term outcomes compa.ed with open hepa.ectomy in experienced centres(1).Short-term a.va.ta.es include sma.l incisions,reduced post-opera.ive pa.n,fa.ter recovery,reduced blood loss a.d lower risk of complica.ions(2).However,the loss of ta.tile sensa.ion ma.es it cha.lenging to a.cura.ely loca.e lesions a.d define tumour ma.gins.

关键词： 3D la.a.oscopy hepa.ocellula. ca.cinoma.HCC) indocya.ine green dye(ICG dye) liver resection

Mecha.ica.ly driven a.sembly of biomimetic 2D-ma.eria. microtextures with bioinspired multifunctiona.ity

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Na.o Resea.ch 2024年第2期17卷 663-678页

作者： Ya.g Li Lin Jing joshua M.Little Ha.chen Ya.g Tsa.-Chun Chung Po-Yen Chen Depa.tment of Chemica. a.d Biomolecula. Engineering University of MarylandCollege ParkMD 20740USA Ma.yla.d Robotics Center University of MarylandCollege ParkMD 20742USA School of Ma.eria.s Science a.d Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

Na.ure provides a.wea.th of bio-inspira.ion for a.va.ced ma.eria. *** va.ious na.oma.eria.s into biomimetic microtextures with bioinspired functiona.ities ha. spurred increa.ing resea.ch interests a.d fa.ilita.ed technologica. a.va.ces in va.ious *** recent yea.s,two-dimensiona. ma.eria.s(2DMs)ha.e emerged a. importa.t building block units in the biomimicry field due to their distinct chemica.,physica.,electrica.,electrochemica.,a.d ca.a.ytic *** this review a.ticle,va.ious mecha.ica.ly driven a.sembly a.proa.hes a.e summa.ized to fa.rica.e va.ious genea.ogies of biomimetic 2DM microtextures with bio-inspired ***,sequentia. deforma.ion stra.egies a.e discussed to progra.ma.ly construct higher dimensiona. 2DM microtextures,ra.ging from wrinkles/crumples(one-time deforma.ion)to multisca.e hiera.chies(multiple deforma.ions).Next,the current progress using higher dimensiona. 2DM microtextures to imita.e different biologica. structures a.d/or induce bio-inspired multifunctiona.ity is systema.ica.ly *** showca.es of bio-inspira.ion a.d biomimicry using different 2DM na.osheets a.e highlighted:(1)wrinkle pa.terns of a. ea.thworm tha. spur the design of stra.n sensors with progra.ma.le working ra.ges a.d sensitivities,(2)wrinkle a.pea.a.ce of a.Sha.-Pei dog tha. motiva.es the fa.rica.ion of stretcha.le energy stora.e devices,(3)hiera.chica. sca.e textures of a.desert liza.d tha. inspire ca.ion-induced gela.ion pla.forms for 2DM a.rogels,a.d(4)wrinkle skin of a. elepha.t tha. influences the development of 2DM protective skin for soft ***,cha.lenges a.d future opportunities of a.opting 2DM na.osheets to a.semble biomimetic microstructures with synergistic functiona.ities a.e discussed.

关键词： two-dimensiona.(2D)ma.eria.s mecha.ica.ly driven a.sembly biomimetic microtextures functiona. na.ocomposite bio-inspired multifunctiona.ity