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A modular microfluidic system based on a multilayered configuration to generate large-scale perfusable microvascular networks

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Microsystems & Nanoengineering 2021年第1期7卷 63-75页

作者： Tao Yue Da Zhao Duc T.T.Phan Xiaolin Wang joshua Jonghyun park Zayn Biviji Christopher C.W.Hughes Abraham P.Lee Department of Biomedical Engineering University of CaliforniaIrvineCAUSA School of Mechatronic Engineering and Automation Shanghai UniversityShanghaiChina Department of Molecular Biology and Biochemistry University of CaliforniaIrvineCAUSA Department of Micro/Nano Electronics Shanghai Jiao Tong UniversityShanghaiChina National Key Laboratory of Science and Technology for Micro/Nano Fabrication Shanghai Jiao Tong UniversityShanghaiChina Key Laboratory for Thin Film and Micro Fabrication of the Ministry of Education Shanghai Jiao Tong UniversityShanghaiChina Department of Electrical Engineering and Computer Science University of CaliforniaIrvineCAUSA. Department of Applied Mathematics-Biology Brown UniversityProvidenceRIUSA. Department of Mechanical and Aerospace Engineering University of CaliforniaIrvineCAUSA

The vascular network of the circulatory system plays a vital role in maintaining homeostasis in the human *** this paper,a novel modular microfluidic system with a vertical two-layered configuration is developed to generate largescale perfused microvascular networks in *** two-layer polydimethylsiloxane(PDMS)configuration allows the tissue chambers and medium channels not only to be designed and fabricated independently but also to be aligned and bonded *** method can produce a modular microfluidic system that has high flexibility and scalability to design an integrated platform with multiple perfused vascularized tissues with high *** medium channel was designed with a rhombic shape and fabricated to be semiclosed to form a capillary burst valve in the vertical direction,serving as the interface between the medium channels and tissue *** and anastomosis at the vertical interface were successfully achieved by using different combinations of tissue chambers and medium *** large-scale microvascular networks were generated and quantified in terms of vessel length and *** leakage of the perfused 70-kDa FITC-dextran confirmed the lumenization of the microvascular networks and the formation of tight vertical interconnections between the microvascular networks and medium channels in different structural *** platform enables the culturing of interconnected,large-scale perfused vascularized tissue networks with high density and scalability for a wide range of multiorgan-on-a-chip applications,including basic biological studies and drug screening.

关键词： interconnection networks configuration

Magnetic resonance imaging biomarkers for pulsed focused ultrasound treatment of pancreatic ductal adenocarcinoma

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World Journal of Gastroenterology 2020年第9期26卷 904-917页

作者： Ezekiel Maloney Yak-Nam Wang Ravneet Vohra Helena Son Stella Whang Tatiana Khokhlova joshua park Kayla Gravelle Stephanie Totten Joo Ha Hwang Donghoon Lee Department of Radiology University of WashingtonSeattleWA 98195United States Applied Physics Laboratory University of WashingtonSeattleWA 98195United States Division of Gastroenterology University of WashingtonSeattle 98195WAUnited States Division of Gastroenterology&Hepatology Stanford University School of MedicineRedwood CityCA 94063United States

BACKGROUND The robust fibroinflammatory stroma characteristic of pancreatic ductal adenocarcinoma(PDA)impedes effective drug *** focused ultrasound(pFUS)can disrupt this stroma and has improved survival in an early clinical ***-invasive methods to characterize pFUS treatment effects are desirable for advancement of this promising treatment modality in larger clinical *** To identify promising,non-invasive pre-clinical imaging methods to characterize acute pFUS treatment effects for in vivo models of *** We utilized quantitative magnetic resonance imaging methods at 14 tesla in three mouse models of PDA(subcutaneous,orthotopic and transgenic-KrasLSLG12D/+,Trp53LSL-R172H/+,Cre or“KPC”)to assess immediate tumor response to pFUS treatment(VIFU 2000 Alpinion Medical Systems;475 W peak electric power,1 ms pulse duration,1 Hz,duty cycle 0.1%)vs sham therapy,and correlated our results with histochemical *** pFUS treatment parameters were previously shown to enhance tumor permeability to chemotherapeutics.T1 and T2 relaxation maps,high(126,180,234,340,549)vs low(7,47,81)b-value apparent diffusion coefficient(ADC)maps,magnetization transfer ratio(MTR)maps,and chemical exchange saturation transfer(CEST)maps for the amide proton spectrum(3.5 parts per million or“ppm”)and the glycosaminoglycan spectrum(0.5-1.5 ppm)were generated and analyzed pre-treatment,and immediately post-treatment,using *** were sacrificed immediately following post-treatment *** whole-tumor was selected as the region of interest for data analysis and subsequent statistical analysis.T-tests and Pearson correlation were used for statistical *** Mean high-b value ADC measurements increased significantly with pFUS treatment for all *** glycosaminoglycan CEST and T2 measurements decreased significantly post-treatment for the KPC *** MTR and amide CEST values increased significantly for the KPC *** acid focal int

关键词： Pancreatic adenocarcinoma Multiparametric magnetic resonance imaging Focused ultrasound

Mechanically driven assembly of biomimetic 2D-material microtextures with bioinspired multifunctionality

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Nano Research 2024年第2期17卷 663-678页

作者： Yang Li Lin Jing joshua M.Little Haochen Yang Tsai-Chun Chung Po-Yen Chen Department of Chemical and Biomolecular Engineering University of MarylandCollege ParkMD 20740USA Maryland Robotics Center University of MarylandCollege ParkMD 20742USA School of Materials Science and Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore

Nature provides a wealth of bio-inspiration for advanced material *** various nanomaterials into biomimetic microtextures with bioinspired functionalities has spurred increasing research interests and facilitated technological advances in various *** recent years,two-dimensional materials(2DMs)have emerged as important building block units in the biomimicry field due to their distinct chemical,physical,electrical,electrochemical,and catalytic *** this review article,various mechanically driven assembly approaches are summarized to fabricate various genealogies of biomimetic 2DM microtextures with bio-inspired ***,sequential deformation strategies are discussed to programmably construct higher dimensional 2DM microtextures,ranging from wrinkles/crumples(one-time deformation)to multiscale hierarchies(multiple deformations).Next,the current progress using higher dimensional 2DM microtextures to imitate different biological structures and/or induce bio-inspired multifunctionality is systematically *** showcases of bio-inspiration and biomimicry using different 2DM nanosheets are highlighted:(1)wrinkle patterns of an earthworm that spur the design of strain sensors with programmable working ranges and sensitivities,(2)wrinkle appearance of a Shar-Pei dog that motivates the fabrication of stretchable energy storage devices,(3)hierarchical scale textures of a desert lizard that inspire cation-induced gelation platforms for 2DM aerogels,and(4)wrinkle skin of an elephant that influences the development of 2DM protective skin for soft ***,challenges and future opportunities of adopting 2DM nanosheets to assemble biomimetic microstructures with synergistic functionalities are discussed.

关键词： two-dimensional(2D)materials mechanically driven assembly biomimetic microtextures functional nanocomposite bio-inspired multifunctionality

Standaertsite公园,根特,比利时

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世界建筑 2024年第6期 60-65页

作者：无 Michiel De Cleene(摄影) Jef Geldof(摄影) joshua Delissen(摄影) Murmuur建筑事务所 Carton123建筑事务所 AE-建筑事务所不详

前身为自助商店“Standaert”的旧址与莱德贝格两条人口稠密的中心街道相连。除此以外,该场地还深入内部区域,被花园围墙和附属建筑所环绕。通过移除一部分场地周边的环境,设计师在城市中打开了一个开口,使其突然出现了一个景观。设计... 详细信息

前身为自助商店“Standaert”的旧址与莱德贝格两条人口稠密的中心街道相连。除此以外,该场地还深入内部区域,被花园围墙和附属建筑所环绕。通过移除一部分场地周边的环境,设计师在城市中打开了一个开口,使其突然出现了一个景观。设计师的主要意图是尽可能保持公园的规模,同时也对这个密集城市结构中的两条街道产生影响。有限的建筑空间被合理利用。

关键词：附属建筑内部区域主要意图人口稠密公园街道比利时

Emerging roles of circular RNAs in retinal diseases

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Neural Regeneration Research 2022年第9期17卷 1875-1880页

作者： Aneliya Hanineva Karen Sophia park joshua J.Wang Margaret M.DeAngelis Michael H.Farkas Sarah X.Zhang Department of Ophthalmology and Ross Eye Institute Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloState University of New YorkBuffaloNYUSA Research Service Veterans Administration Western New York Healthcare SystemBuffaloNYUSA Department of Biochemistry Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloState University of New YorkBuffaloNYUSA

Retinal disorders are a group of ocular diseases whose onset is associated with a number of aberrant molecular and cellular processes or physical damages that affect retinal structure and function resulting in neural and vascular degeneration in the *** research has primarily focused on delaying retinal disease with minimal success in preventing or reversing neuronal *** this review,we explore a relatively new field of research involving circular RNAs,whose potential roles as biomarkers and mediators of retinal disease pathogenesis have only just *** knowledge of circular RNAs function is limited given its novelty,current evidence has highlighted their roles as modulators of microRNAs,regulators of gene transcription,and biomarkers of disease development and ***,we summarize how circular RNAs may be implicated in the pathogenesis of common retinal diseases including diabetic retinopathy,glaucoma,proliferative vitreoretinopathy,and age-related macular ***,we explore the potential of circular RNAs as novel biomarkers and therapeutic targets for the diagnosis and treatment of retinal diseases.

关键词： age-related macular degeneration circular RNA diabetic retinopathy glaucoma microRNA proliferative vitreoretinopathy retina

Serological profiling of Crohn’s disease and ulcerative colitis patients reveals anti-microbial antibody signatures

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World Journal of Gastroenterology 2022年第30期28卷 4089-4101页

作者： Mahasish Shome Lusheng Song Stacy Williams Yunro Chung Vel Murugan Jin G park William Faubion Shabana F Pasha Jonathan A Leighton joshua LaBaer Ji Qiu Virginia G.Piper Center for Personalized Diagnostics Biodesign InstituteArizona State UniversityTempeAZ 85281United States Department of Internal Medicine Mayo ClinicRochesterMN 55902United States Department of Internal Medicine Division of Gastroenterology and HepatologyMayo Clinic ArizonaScottsdaleAZ 85259United States Division of Gastroenterology Mayo Clinic School of MedicineScottsdaleAZ 85259United States

BACKGROUND The healthcare burden of inflammatory bowel disease(IBD)is rising globally and there are limited non-invasive biomarkers for accurate and early *** To understand the important role that intestinal microbiota play in IBD pathogenesis and identify anti-microbial antibody signatures that benefit clinical management of IBD *** We performed serological profiling of 100 Crohn’s disease(CD)patients,100 ulcerative colitis(UC)patients and 100 healthy controls against 1173 bacterial and 397 viral proteins from 50 bacteria and 33 viruses on protein *** study subjects were randomly divided into discovery(n=150)and validation(n=150)*** analysis was performed using R *** Anti-bacterial antibody responses showed greater differential prevalence among the three subject groups than anti-viral antibody *** identified novel antibodies against the antigens of Bacteroidetes vulgatus(BVU_0562)and Streptococcus pneumoniae(SP_1992)showing higher prevalence in CD patients relative to healthy *** also identified antibodies against the antigen of Streptococcus pyogenes(SPy_2009)showing higher prevalence in healthy controls relative to UC *** these novel antibodies,we built biomarker panels with area under the curve(AUC)of 0.81,0.87,and 0.82 distinguishing CD vs control,UC vs control,and CD vs UC,*** analysis revealed that penetrating CD behavior,colonic CD location,CD patients with a history of surgery,and extensive UC exhibited highest antibody prevalence among all *** demonstrated that autoantibodies and anti-microbial antibodies in CD patients had minimal *** We have identified antibody signatures for CD and UC using a comprehensive analysis of antimicrobial antibody response in *** antibodies and the source microorganisms of their target antigens improve our understanding of the role of specific microorganisms in IBD pathogenesis and,after f

关键词： Inflammatory bowel disease Anti-microbial antibody Protein microarray Crohn’s disease Ulcerative colitis Gut microbiome

Exploration of channel width scaling and edge states in transition metal dichalcogenides

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Nano Research 2018年第4期11卷 1768-1774页

作者： Feng Zhang Chia-Hui Lee joshua A. Robinson Joerg Appenzeller Department of Electrical and Computer Engineering Brick Nanotechnology Center Purdue University West Lafayette IN 47907 USA Department of Materials Science and Engineering The Pennsylvania State University University Park PA 16802 USA

We explore the impact of edge states in three types of transition metal dichalcogenides （TMDs）, namely metallic Td-phase WTe2 and semiconducting 2H-phase MoTe2 and MoS2, by patterning thin flakes into ribbons with varying channel widths. No obvious charge depletion at the edges is observed for any of these three materials, in contrast to observations made for graphene nanoribbon devices. The semiconducting ribbons are characterized in a three-terminal field-effect transistor （FET） geometry. In addition, two ribbon array designs have been carefully investigated and found to exhibit current levels higher than those observed for conventional one-channel devices. Our results suggest that device structures incorporating a high number of edges can improve the performance of TMD FETs. This improvement is attributed to a higher local electric field, resulting from the edges, increasing the effective number of charge carriers, and the absence of any detrimental edge-related scattering.

关键词： two-dimensional (2D)-layered materials edge states WTe2 MoTe2 MoS2 channel width scaling

Light-Programmable Assemblies of Isotropic Micromotors

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Research 2022年第4期2022卷 481-492页

作者： Shengping Che Jianhua Zhang Fangzhi Mou Xia Guo joshua E.Kauffman Ayusman Sen Jianguo Guan State Key Laboratory of Advanced Technology for Materials Synthesis and Processing International School of Materials Science and EngineeringWuhan University of Technology122Luoshi RoadWuhan 430070China Department of Chemistry The Pennsylvania State UniversityUniversity ParkPA16802USA

“Life-like”nonequilibrium assemblies are of increasing significance,but suffering from limited steerability as they are generally based on micro/nanomotors with inherent asymmetry in chemical composition or geometry,of which the vigorous random Brownian rotations disturb the local ***,we demonstrate that isotropic photocatalytic micromotors,due to the persistent phoretic flow from the lluminated to shadowed side rrespective of their Brownian rotations,experience lightprogrammable local interactions(reversibly from atraction to repulsion and/or alignment)depending on the direction of the incident ***,they can be organized into a variety of tunable nonequilibrium assemblies,such as apolar solids(i.e.,immobile colloidal crystal),polar liquids(ie.,phototactic colloidal stream),and polar solids(i.e.,phototactic colloidal crystal),which can further be“cut”into a predesigned pattern by utilizing the switching motor-motor interactions at superimposedlight *** work facilitates the development of active matters and motile functional microdevices.

关键词： Brownian rotation nonequilibrium

Behavioral and Neurobiological Assessments of Predator-Based Fear Conditioning and Extinction

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Journal of Behavioral and Brain Science 2016年第8期6卷 337-356页

作者： joshua D. Halonen Phillip R. Zoladz Collin R. park David M. Diamond Department of Psychology University of Tampa Tampa Florida USA Department of Psychology University of South Florida Tampa Florida USA Department of Psychology Sociology & Criminal Justice Ohio Northern University Ada Ohio USA Department of Molecular Pharmacology & Physiology University of South Florida Tampa Florida USA Center for Preclinical & Clinical Research on PTSD University of South Florida Tampa Florida USA

Shock, immobilization, and exposure to predator-related stimuli have all been used to study fear conditioning in rodents, but they have never been used in conjunction in a single study. Experiment 1 compared the effects of these three reinforcers, alone and in various combinations, on the expression of long-term conditioned fear memory and extinction in adult male rats. Whereas foot shock conditioning, alone, was rapidly extinguished;the combination of immobilization and cat exposure, or all 3 stimuli together, produced a significant increase in the magnitude of fear conditioning and greater resistance to extinction, which persisted for at least 5 weeks post-training (p < 0.05). Experiment 2 assessed the role of the hippocampus in predator-based context and cued fear conditioning. Pharmacological suppression of hippocampal activity during fear conditioning produced a selective impairment of contextual, but not cued, fear memory. Experiment 3 investigated the effects of sleep deprivation prior to fear conditioning on the expression of fear memory. This experiment demonstrated that pre-training sleep deprivation blocked the expression of contextual (hippocampal-dependent), but not cued (hippocampal-independent), fear memory. Overall, this series of experiments has extended the use of predator exposure in conjunction with conventional reinforcers, such as foot shock and immobilization, to advance our understanding of the neurobiology of traumatic memory.

关键词： Fear Conditioning Predator Exposure Hippocampus Sleep Deprivation