检索结果-南通市图书馆

突发性感音神经性听力损失患者高压氧治疗的临床意义

在线全文

学校读者我要写书评

暂无评论

听力学及言语疾病杂志 2024年第3期32卷 289-289页

作者：焦沃尔(摘译) 陈始明(审校) joshua TG Ayub A Wijesinghe P 武汉大学人民医院耳鼻咽喉头颈外科武汉430060 武汉大学耳鼻咽喉头颈外科研究所不详

本研究通过Meta分析系统回顾已有文献,研究HBOT是否可以作为SSNHL患者单一治疗手段或补充疗法。研究对2000年1月到2020年4月期间的10个国际数据库进行系统回顾,检索词包括:高压氧、突发性听力损失、感音神经性听力损失以及相关缩写词。... 详细信息

本研究通过Meta分析系统回顾已有文献,研究HBOT是否可以作为SSNHL患者单一治疗手段或补充疗法。研究对2000年1月到2020年4月期间的10个国际数据库进行系统回顾,检索词包括:高压氧、突发性听力损失、感音神经性听力损失以及相关缩写词。研究纳入了将HBOT作为单一或联合疗法并与其他疗法(例如激素口服、静脉输注以及鼓室内给药或使用安慰剂)进行比较的文章,并排除非英语及无法获得全文的文章。提取的主要指标包括:听力损失的严重程度,HBOT的次数和持续时间,其他治疗细节(即药物类型、给药方法、剂量和治疗开始时间),治疗前后PTA,患者听力恢复比例,治疗相关的不良反应。共检索到826篇文献,除去358篇重复文献以及468篇文献不符合纳入标准,最后有3篇文献共150例SSNHL患者进行了评估。Cho等纳入60例≥70 dB HL的SSNHL患者,对照组(30例)采用激素口服和鼓室内给药的方式,联合治疗组(30例)在此基础上加上HBOT[持续10 d,每天在2.5个绝对大气压(ATA)下进行60 min]。Kraj ovi ová等纳入了68例中度听力损失(41~60 dB HL)的SSNHL患者,对照组(21例)采用激素静脉给药和口服、口服扩血管药物的方式,联合治疗组(47例)在此基础上加上HBOT(持续10 d,每天在2个ATA下进行90 min)。Khater等招募22例SSNHL患者(未描述听力损失程度),对照组(11例)采用激素口服和鼓室内给药、口服抗病毒药物的方式,联合治疗组(11例)在此基础上加上HBOT(持续20 d,每天在2个ATA下进行60 min)。

关键词：绝对大气压听力损失程度扩血管药物其他疗法联合疗法高压氧治疗听力恢复抗病毒药物

An analysis of key process parameters for hybrid manufacturing by material extrusion and CNC machining

在线全文

学校读者我要写书评

暂无评论

Bio-design and Manufacturing 2018年第4期1卷 237-244页

作者： Ruben Paz Javier Santamarta Mario d.Monzon joshua Garcfa Eujin Pei departamento de Ingenierfa Mecainica Universidad de Las Palmas de Gran CanariaLas Palmas de Gran Canaria 35017 Spain Institute of Materials and Manufacturing Brunel University LondonKingston LaneUxbridge UB83PHUK

Hybrid Manufacturing combines the advantages of Additive Manufacturing (AM)and Subtractive Manufacturing on a single *** previous research has provided a good background of the manufacturing parameters,the analysis is often carried out separately and there is a lack of combined *** purpose of this research is to examine the influence of the main manufacturing parameters involved in AM and subtracfive processes using different ***,the study is focused on the Material Extrusion process concerning the layer height,fill angle and fill density;as well as two factors related to machining,including stepover and pass *** parameters that were examined include the dimension,hardness, flatness,weight and roughness.A mulfifactofial design of Experiments was proposed with a total of 64 ***,a statistical analysis was carried out to assess the influence of the different groups on the response ***,a decision table presented and facilitated the selection of parameters depending on the desired objectives,leading to a framework that was applied to a case study for *** decision guide could enable designers and engineers to select the best strategy for a specific application,leading to a more efficient approach for manufacturing.

关键词： Hybrid manufacturing Material extrusion Additive manufacturing Subtractive manufacturing ~Machining Statistical analysis

Natural nest substrates influence squamate embryo physiology but have little effect on hatchling phenotypes

在线全文

学校读者我要写书评

暂无评论

Integrative Zoology 2022年第4期17卷 550-566页

作者： joshua M.HALL Jocelyn MIRACLE Cindy d.SCRUGGS daniel A.WARNER department of Biological Sciences Auburn UniversityAuburnAlabamaUSA

Vertebrate embryos require access to water;however,many species nest in terrestrial habitats that vary considerably in moisture ***,non-avian reptiles have served as models to understand how environmental factors,like moisture availability,influence development because eggs are often exposed to prevailing environments in the absence of parental *** much research demonstrates the importance of water absorption by eggs,many ecological factors that influence moisture availability in natural nests have received little *** example,the type of substrate in which nests are constructed is *** experimentally incubated eggs of the brown anole lizard(Anolis sagrei)in 2 naturally occurring nest substrates that were treated with varying amounts of water to determine how natural substrates influence development at different moisture *** substrate consisted of sand and crushed seashells and the other was mostly organic material(*** plant material).Both are common nesting substrates at our field *** controlling for water uptake by eggs,we found that egg survival and hatchling phenotypes were similar between substrates;however,embryos developed more quickly in the sand/shell substrate than the organic substrate,indicating substrate-specific effects on embryo *** results demonstrate that different natural substrates can result in similar developmental outcomes if the water available to eggs is comparable;however,some aspects of development,like developmental rate,are affected by the type of substrate,independent of water *** study is required to determine how natural substrates influence embryo physiology independent of water content.

关键词： developmental plasticity egg incubation hydric conditions nesting behavior nest-site selection

Influence of climate fluctuations on Pinus palustris growth and drought resilience

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Forest Ecosystems 2023年第6期10卷 681-689页

作者： Joao Campoa joshua Puhlick CENSE–Center for Environmental and Sustainability Research CHANGE-Global Change and Sustainability InstituteDepartment of Environmental Sciences and EngineeringNOVA School of Science and TechnologyNOVA University LisbonCampus de Caparica2829-516 CaparicaPortugal The Jones Center at Ichauway 3988 Jones Center Drive39870NewtonGAUSA

The longleaf pine(Pinus palustris Mill.)ecosystem is an endangered ecosystem in the southeastern USA,and efforts to restore the species are ***,in recent decades,the region has experienced drastic fluctuations between wet and dry growing season conditions from year to year,and it is not fully understood how these fluctuations have influenced the growth of *** address this topic,we cored *** trees in woodlands of southwest Georgia and used dendrochronology techniques to determine how climate fluctuations have influenced the growth and drought resilience of *** also cored slash pine(Pinus elliottii Engelm.)trees in the same woodlands to compare growth between *** *** growth was less impacted by adverse climate conditions compared to ***,the strength of correlations between *** growth and temperature,precipitation,and Palmer drought Severity Index(PdSI)changed over *** recent decades,climate conditions during the growing season became more influential on *** growth than the previous year's *** is concerning given that drought severity during the growing season has been *** results also indicate that *** was less resilient to droughts during the 2000s and 2010s than to those of the *** this new climate paradigm,our results suggest that *** might be more susceptible to growth reductions and less resistant to droughts than once *** work highlights the importance of understanding the impact of novel climate conditions on *** and has implications for restoration efforts,such as using silvicultural treatments that reduce tree vulnerability to drought(e.g.,thinning)and promote other climate-adapted species in mixture with ***.

关键词： Longleaf pine Slash pine Pinus elliottii Climate change dendrochronology dendroclimatology Forest disturbances

Protein-protein interface analysis of the non-ribosomal peptide synthetase peptidyl carrier protein and enzymatic domains

在线全文

学校读者我要写书评

暂无评论

Synthetic and Systems Biotechnology 2022年第2期7卷 671-682页

作者： joshua C.Corpuz Javier O.Sanlley Michael d.Burkart department of Chemistry and Biochemistry University of California-San Diego9500 Gilman DriveLa JollaCA92093-0358USA

Non-ribosomal peptide synthetases(NRPSs)are attractive targets for biosynthetic pathway engineering due to their modular architecture and the therapeutic relevance of their *** catalysis mediated by specific protein-protein interactions formed between the peptidyl carrier protein(PCP)and its partner enzymes,NRPS enzymology and control remains fertile ground for *** review focuses on the recent efforts within structural biology by compiling high-resolution structural data that shed light into the various protein-protein interfaces formed between the PCP and its partner enzymes,including the phosphopantetheinyl transferase(PPTase),adenylation(A)domain,condensation(C)domain,thioesterase(TE)domain and other tailoring enzymes within the *** our understanding of how the PCP recognizes partner proteins with the potential to use directed evolution and combinatorial biosynthetic methods will enhance future efforts in discovery and production of new bioactive compounds.

关键词： Natural products Protein-protein interactions Non-ribosomal peptide synthetase Peptidyl carrier protein Combinatorial biosynthesis Synthetic biology

The influence of misspecified covariance on false discovery control when usingposterior probabilities

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Statistical Theory and Related Fields 2017年第2期1卷 205-215页

作者： Ye Liang joshua d.Habiger Xiaoyi Min department of Statistics Oklahoma State UniversityStillwaterOKUSA department of Mathematics and Statistics Georgia State UniversityAtlantaGAUSA

This paper focuses on the influence of a misspecified covariance structure on false discoveryrate for the large-scale multiple testing ***,we evaluate the influence on themarginal distribution of local false discovery rate statistics,which are used in many multiple testing procedures and related to Bayesian posterior *** forms of the marginaldistributions under both correctly specified and incorrectly specified models are ***–Leibler divergence is used to quantify the influence caused by a *** numerical examples are provided to illustrate the influence.A real spatio-temporal data onsoil humidity is discussed.

关键词： Multiple testing Bayes dependent data div

Microglia as hackers of the matrix:sculpting synapses and the extracellular space

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第11期18卷 2472-2488页

作者： joshua d.Crapser Miguel A.Arreola Kate I.Tsourmas Kim N.Green department of Neurobiology and Behavior University of CaliforniaIrvineCAUSA

Microglia shape the synaptic environment in health and disease,but synapses do not exist in a ***,pre-and postsynaptic terminals are surrounded by extracellular matrix(ECM),which together with glia comprise the four elements of the contemporary tetrapartite synapse *** research in this area is still just beginning,accumulating evidence points toward a novel role for microglia in regulating the ECM during normal brain homeostasis,and such processes may,in turn,become dysfunctional in *** it relates to synapses,microglia are reported to modify the perisynaptic matrix,which is the diffuse matrix that surrounds dendritic and axonal terminals,as well as perineuronal nets(PNNs),specialized reticular formations of compact ECM that enwrap neuronal subsets and stabilize proximal *** interconnected relationship between synapses and the ECM in which they are embedded suggests that alterations in one structure necessarily affect the dynamics of the other,and microglia may need to sculpt the matrix to modify the synapses ***,we provide an overview of the microglial regulation of synapses,perisynaptic matrix,and PNNs,propose candidate mechanisms by which these structures may be modified,and present the implications of such modifications in normal brain homeostasis and in disease.

关键词： Neuroscience Perineuronal nets Microglia Extracellular matrix Neuroinflammation

Hepatocellular carcinoma locoregional therapies:Outcomes and future horizons

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第43期27卷 7462-7479页

作者： Mina S Makary Stuart Ramsell Eric Miller Eliza W Beal joshua d dowell department of Radiology The Ohio State University Wexner Medical CenterColumbusOH 43210United States department of Radiation Oncology The Ohio State University Wexner Medical CenterColumbusOH 43210United States department of Surgery The Ohio State University Wexner Medical CenterColumbusOH 43210United States department of Radiology Northwest RadiologySt.Vincent HealthIndianapolisIN 46260United States

Hepatocellular carcinoma(HCC)is the most common primary cancer of the liver and has an overall five-year survival rate of less than twenty *** patients with unresectable disease,evolving liver-directed locoregional therapies provide efficacious treatment across the spectrum of disease stages and via a variety of catheter-directed and percutaneous *** of locoregional therapies in HCC may include curative intent in early-stage disease,bridging or downstaging to surgical resection or transplantation for early or intermediate-stage disease,and local disease control and palliation in advanced-stage *** review explores the outcomes of chemoembolization,bland embolization,radioembolization,and percutaneous ablative *** is also given to prognostic factors related to each of the respective techniques,as well as future directions of locoregional therapies for HCC.

关键词： Hepatocellular carcinoma Bland embolization Chemoembolization Radioembolization Transarterial embolization Thermal ablation Locoregional therapy

Is it time for elective left main percutaneous coronary intervention to become 'main stream'?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2006年第1期3卷 57-58页

作者： joshua Cohen Andrew d.Michaels division of Cardiology University of California San Francisco San Francisco CA 94143-0124 USA

　　Left main (LM) stenting is considered by many to be one of the last frontiers of interventional cardiology. Beginning with the VA cooperative study published in 1976 demonstrating a mortality benefit for patients undergoing coronary artery bypass grafting (CABG), i the standard of care for treatment of left main coronary artery disease has been *** most recent 2005 update of the ACC/AHA/SCAI Practice Guidelines on PCI 2 again notes that "CABG using IMA grafting is the 'gold standard' for treatment of unprotected left main disease and has proven benefit on long-term outcomes."……

关键词： left IVUS Is it time for elective left main percutaneous coronary intervention to become main stream time