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城市漫步（GBA版） 2024年第4期 3-3页

作者： joshua Cawthorpe 不详

Welcome to the first themed *** the media landscape is embracing diversity and inclusion,That's magazines will dive headfirst into homogeny with each monthly issue revolving around a single core ***,dining and art coverage will be interspersed within each issue,but you can expect a handful of features that remain true to one common *** the Two Sessions taking place in Beijing last month and focusing heavily on economic rejuvenation,it seems only fitting that we kick off the spring issues witha business theme.

关键词： Session spring landscape

DEEP:Getting to Know Gin

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城市漫步（GBA版） 2024年第6期 31-31页

作者： joshua Cawthorpe 不详

Tucked away on a quiet laneway onlya stone's throw from Guangzhou'sTaikoo Hui is *** warm and intimate space is one ofthe city's well-kept secrets as it calls only themost dedicated epicureans. On the menu:craft gin and craft beer. DEEP'S owner AnnChi explains that the two choices on offerboth represent the fengwei (风味) or speciallocal flavor that emerges from carefullychosen ingredients.

关键词： DEE craft Guangzhou

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城市漫步（GBA版） 2024年第9期 1-1页

作者： joshua Cawthorpe 不详

The culture surrounding food in the Middle Kingdom is possibly its most romanticized *** you arrive in China,there are a number of food-related philosophies that must be *** is medicine,and *** eat too little is a great *** offer the perfect amount is an utter failure of the *** slurp is *** stab the chopsticks upright in a bowl of *** list goes onandon.

关键词： perfect Middle culture

维普期刊数据库

Recurrent gene flow between Neanderthals and modern humans over the past 200,000 years

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四川生理科学杂志 2024年第7期46卷 1621-1621页

作者： Liming Li Troy J. Comi Rob F. Bierman joshua M. Akey Department of Medical Genetics and Developmental Biology School of Medicine The Key Laboratory of Developmental Genes and Human Diseases Ministry of Education Southeast University Nanjing 210009 China. The Lewis-Sigler Institute for Integrative Genomics Princeton University Princeton NJ 08540 USA. The Lewis-Sigler Institute for Integrative Genomics Princeton University Princeton NJ 08540 USA.

Although it is well known that the ancestors of modern humans and Neanderthals admixed,the effects of gene flow on the Neanderthal genome are not well *** develop methods to estimate the amount of human-introgressed s... 详细信息

关键词： flow modern apply

Proximate analyses,in vitro antioxidant activity and GC-MS analyses of fermented Pentaclethra macrophylla seeds

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Life Research 2024年第3期7卷 2-8页

作者： Ikechukwu Okoro Parker joshua Innocent Okagu Christian Amah Nnamani Ikenna Nene Chiaka-Onyemeze Emeka Anaduaka David Obasi Prince Okoroh Daniel Orieke Victor Ogugua Department of Medical Biochemistry College of Health SciencesDavid Umahi Federal University of Health SciencesUburuNigeria Department of Biochemistry University of NigeriaNsukkaNigeria Department of Biochemistry State University of Medical and Applied SciencesIgbo-EnoNigeria Department of Medical Laboratory Sciences State University of Medical and Applied SciencesIgbo-EnoNigeria

The present study assessed the proximate composition,in vitro antioxidant activity and GC-MS analyses of fermented Pentaclethra macrophylla seeds extract(FPMSE).The in vitro antioxidant activity was assessed using 2,2-diphenyl-1-picrylhydrazl(DPPH)while Gas Chromatography-Mass Spectrophotometry(GC-MS)technique was used to identify the volatile compounds in *** revealed a dose dependent percentage inhibition of the extract on DPPH *** composition of FPMSE constitutes respectively;ash(0.33±0.12%),protein(2.19±0.08%),fats and oil(80.60±0.00%),carbohydrate(16.88±0.00%)while moisture and fibre were not ***,the pulverised sample constitute respectively;ash(1.27±0.58%),protein(10.51±0.60%),moisture(8.27±0.12%),fats and oil(32.33±0.12%),fibre(7.27±0.12%)and carbohydrate(40.35±0.00%).GC-MS analyses revealed fourteen(14)fatty acids including Octadecanoic acid(1.95%),Benzyloxymethylimine(43.89%),2-Allylpent-4-enoic acid benzyl ester(26.25%),Hexadecanoic acid,methyl ester(1.09%),Oleic Acid(0.25%),9,12-Octadecadienoic acid,methyl ester(Omega-6-fatty acid)(1.52%).The bioactive compounds identified in FPMSE could contribute to the pharmacological properties of *** seeds and hence,could be of considerable interest for the development of new drugs.

关键词： Pentaclethra macrophylla in vitro antioxidant GC-MS fatty acids

Estimating geographic variation of infection fatality ratios during epidemics

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Infectious Disease Modelling 2024年第2期9卷 634-643页

作者： joshua Ladau Eoin L.Brodie Nicola Falco Ishan Bansal Elijah B.Hoffman Marcin P.Joachimiak Ana M.Mora Angelica M.Walker Haruko M.Wainwright Yulun Wu Mirko Pavicic Daniel Jacobson Matthias Hess James B.Brown Katrina Abuabara Departments of Computational Precision Health and Dermatology University of CaliforniaSan FranciscoCA94115USA Arva Intelligence Inc.Salt Lake CityUT84101USA Computational Biosciences Group Lawrence Berkeley National LaboratoryBerkeleyCA94720USA Earth and Environmental Sciences Area Lawrence Berkeley National LaboratoryBerkeleyCA94720USA Graduate Group in Biostatistics University of CaliforniaBerkeleyCA94720USA Biosystems Data Science Environmental Genomics and Systems BiologyLawrence Berkeley National LaboratoryBerkeleyCA94720USA Center for Environmental Research and Community Health(CERCH) School of Public HealthUniversity of CaliforniaBerkeleyCA94720USA Bredesen Center for Interdisciplinary Research and Graduate Education University of TennesseeKnoxvilleTN37996USA Department of Nuclear Science and Engineering Massachusetts Institute of TechnologyBostonMA02139USA Biosciences Oak Ridge National LaboratoryOak RidgeTN37830USA University of California DavisCA95616USA Statistics Department University of CaliforniaBerkeleyCA94720USA Division of Epidemiology and Biostatistics University of California Berkeley School of Public Health2121 Berkeley WayBerkeleyCA94720USA

Objectives We aim to estimate geographic variability in total numbers of infections and infection fatality ratios(IFR;the number of deaths caused by an infection per 1,000 infected people)when the availability and quality of data on disease burden are limited during an *** We develop a noncentral hypergeometric framework that accounts for differential probabilities of positive tests and reflects the fact that symptomatic people are more likely to seek *** demonstrate the robustness,accuracy,and precision of this framework,and apply it to the United States(U.S.)COVID-19 pandemic to estimate county-level SARS-CoV-2 *** The estimators for the numbers of infections and IFRs showed high accuracy and precision;for instance,when applied to simulated validation data sets,across counties,Pearson correlation coefficients between estimator means and true values were 0.996 and 0.928,respectively,and they showed strong robustness to model *** the county-level estimators to the real,unsimulated COVID-19 data spanning April 1,2020 to September 30,2020 from across the U.S.,we found that IFRs varied from 0 to 44.69,with a standard deviation of 3.55 and a median of *** The proposed estimation framework can be used to identify geographic variation in IFRs across settings.

关键词： Infection fatality ratio Infection fatality rate Noncentral hypergeometric distribution COVID-19 SARS-CoV-2

L-Arginine Supplementation Mitigates Dichlorvos-Induced Haematocardiotoxicity, and Oxidative Stress in Male Wistar Rats

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Open Journal of Applied Sciences 2024年第7期14卷 1886-1903页

作者： Waidi Adeoye Saka Yusuff Dimeji Igbayilola Jabba Hamidu Lawan Taoheed Kolawole Muftaudeen Ridwanullahi Adejumo Tolulope Deborah Alu Mary Ikuomola joshua Tinuade Ojelere Victor Odufa Adegoke Department of Physiology College of Health Sciences Ladoke Akintola University of Technology Ogbomoso Oyo State Nigeria Department of Human Physiology College of Medicine and Health Sciences Baze University Abuja Nigeria Department of Biological Sciences Faculty of Computing and Applied Sciences Baze University Abuja Nigeria

Due to its toxicity, dichlorvos—a common organophosphate pesticide—poses significant risks to human health. This study utilized male Wistar rats to explore the potential protective effects of L-arginine supplementation against dichlorvos-induced toxicity, focusing on cardiotoxicity, haematotoxicity and oxidative stress. The rats were divided into four groups: Control, L-arginine (L), Dichlorvos (D), and L-arginine + Dichlorvos (L + D). Dichlorvos was administered to the D group, L-arginine (100 mg/kg) to the L group, and both L-arginine and dichlorvos to the L + D group. The study evaluated various parameters, including cardiovascular, oxidative stress markers, and haematological indices. Significant changes in haematological parameters such as haemoglobin (Hb), haematocrit (HCT), and red blood cell count (RBC) indicated haematotoxicity after dichlorvos administration. Additionally, elevated cardiac markers, including lactate dehydrogenase (LDH) and creatine kinase-MB (CK-MB), suggested cardiotoxic effects. Exposure to dichlorvos also resulted in decreased antioxidant enzyme levels and increased oxidative stress indicators like malondialdehyde (MDA). Remarkably, L-arginine supplementation mitigated the damage caused by dichlorvos. It normalized the altered haematological parameters, demonstrating its protective effect against haematotoxicity. The rise in cardiac markers was reduced with L-arginine supplementation, indicating protection against cardiotoxicity. Moreover, L-arginine significantly decreased oxidative stress, as evidenced by lower MDA levels and restored antioxidant enzyme activity. In conclusion, L-arginine supplementation in male Wistar rats showed promising protective effects against dichlorvos-induced cardiotoxicity, haematotoxicity and oxidative stress. This suggests that L-arginine may offer a beneficial intervention to mitigate the adverse effects of dichlorvos on blood and heart health, paving the way for potential treatments for pesticide poison

关键词： Dichlorvos L-Arginine Cardiovascular Function Haematological Parameters Oxidative Stress

Storylines of family medicine Ⅻ:family medicine and the healthcare system

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Family Medicine and Community Health 2024年第S03期12卷 109-118页

作者： William B Ventres Leslie A Stone Jeannette E South-Paul Kendall M Campbell Aerial R Petty Hima Ekanadham Kurt C Stange Rebecca S Etz William L Miller Robert L Ferrer Marianna Kong Thomas Bodenheimer Roger Strasser Sharon C M Reece joshua Freeman John M Westfall Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Meharry Medical College NashvilleTennesseeUSA Family Medicine University of Texas Medical Branch at Galveston School of MedicineGalvestonTexasUSA Family Medicine Residency Program New York-Presbyterian Columbia University Medical CenterNew YorkNew YorkUSA Center for Family and Community Medicine Columbia University Vagelos College of Physicians and SurgeonsNew YorkNew YorkUSA Center for Community Health Integration Case Western Reserve University School of MedicineClevelandOhioUSA Family Medicine and Population Health Virginia Commonwealth University School of MedicineRichmondVirginiaUSA Family Medicine Lehigh Valley Health NetworkAllentownPennsylvaniaUSA University of South Florida Morsani College of Medicine TampaFloridaUSA Family and Community Medicine UT Health San Antonio Long School of MedicineSan AntonioTexasUSA Family and Community Medicine University of California San Francisco School of MedicineSan FranciscoCaliforniaUSA Northern Ontario School of Medicine University SudburyOntarioCanada Family Medicine Baylor Scott and White HealthTempleTexasUSA Family Medicine University of Kansas School of MedicineKansas CityKansasUSA DARTNet Insitute AuroraColoradoUSA

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅻ:Family medicine and the future of the healthcare system’,authors address the following themes:‘Leadership in family medicine’,‘Becoming an academic family physician’,‘Advocare—our call to act’,‘The paradox of primary care and three simple rules’,‘The quadruple aim—melding the patient and the health system’,‘Fit-for-purpose medical workforce’,‘Universal healthcare—coverage for all’,‘The futures of family medicine’and‘The 100th essay.’May readers of these essays feel empowered to be part of family medicine’s exciting future.

关键词： system illustration family

First-Principles Investigation of Charge Transfer Mechanism of B-Doped 3C-SiC Semiconductor Material

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World Journal of Condensed Matter Physics 2024年第2期14卷 35-44页

作者： Abdullahi Alkali Dauda Muhammad Yusuf Onimisi Adeyemi joshua Owolabi Hameed Adeneyi Lawal Hassan Muhammad Gambo Bashir Mohammed Aliyu Surajo Bala Muhammad Lamido Madugu Muhammad Abdurrahman Nainna Johnson Akinade Bamikole Physics Department Faculty of Science Air Force Institute of Technology Kaduna Nigeria Physics Department Faculty of Science Nigeria Defence Academy Kaduna Nigeria Physics Department Umaru Musa Yar&#8217adua University Batagarawa Nigeria Physics Department Faculty of Science Gombe State University Gombe Nigeria Physics Department Federal University of Lafia Lafia Nigeria

This study delves into the charge transfer mechanism of boron (B)-doped 3C-SiC through first-principles investigations. We explore the effects of B doping on the electronic properties of 3C-SiC, focusing on a 12.5% impurity concentration. Our comprehensive analysis encompasses structural properties, electronic band structures, and charge density distributions. The optimized lattice constant and band gap energy of 3C-SiC were found to be 4.373 Å and 1.36 eV respectively, which is in agreement with previous research (Bui, 2012;Muchiri et al., 2018). Our results show that B doping narrows the band gap, enhances electrical conductivity, and influences charge transfer interactions. The charge density analysis reveals substantial interactions between B dopants and surrounding carbon atoms. This work not only enhances our understanding of the material’s electronic properties, but also highlights the importance of charge density analysis for characterizing charge transfer mechanisms and their implications in the 3C-SiC semiconductors.

关键词： First-Principles Calculations DFT Boron (B)-Doped 3C-SiC Charge Transfer