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Phenolic constituents and anticancer properties of Morus alba(white mulberry) leaves

Journal of Integrative Medicine 2020年第3期18卷 189-195页

作者： Eric Wei Chiang Chan Siu Kuin Wong joseph tangah Tomomi Inoue Hung Tuck Chan Faculty of Applied Sciences UCSI University56000 CherasKuala LumpurMalaysia School of Foundation Studies Xiamen University Malaysia43900 SepangSelangorMalaysia Forest Research Centre Sabah Forestry Department90009 SandakanSabahMalaysia Centre for Environmental Biology and Ecosystem Studies National Institute for Environmental Studies(NIES)OnogawaTsukuba 305-0053Japan Secretariat of International Society for Mangrove Ecosystems(ISME) Faculty of AgricultureUniversity of the RyukyusOkinawa 903-0129Japan

Flavonoids are by far the most dominant class of phenolic compounds isolated from Morus alba leaves(MAL). Other classes of compounds are benzofurans, phenolic acids, alkaloids, coumarins, chalcones and stilbenes. Major flavonoids are kuwanons, moracinflavans, moragrols and morkotins. Other major compounds include moracins(benzofurans), caffeoylquinic acids(phenolic acids) and morachalcones(chalcones). Research on the anticancer properties of MAL entailed in vitro and in vivo cytotoxicity of extracts or isolated compounds. Flavonoids, benzofurans, chalcones and alkaloids are classes of compounds from MAL that have been found to be cytotoxic towards human cancer cell lines. Further studies on the phytochemistry and anticancer of MAL are suggested. Sources of information were Pub Med,Pub Med Central, Science Direct, Google, Google Scholar, J-Stage, Pub Chem and China National Knowledge Infrastructure.

关键词： Flavonoids Benzofurans Cytotoxic Moracins Morachalcones Chalcomoracin

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A synopsis on flavonoids from the roots of Scutellaria baicalensis with some insights on baicalein and its anti-cancer properties

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Journal of Chinese Pharmaceutical Sciences 2019年第4期28卷 217-228页

作者： Eric Wei Chiang Chan Siu Kuin Wong joseph tangah Tomomi Inoue Hung Tuck Chan Faculty of Applied Sciences UCSI University School of Science Monash University Sunway Forest Research Centre Sabah Forestry Department Centre for Environmental Biology and Ecosystem Studies National Institute for Environmental Studies(NIES) Secretariat of the International Society for Mangrove Ecosystems Faculty of Agriculture University of the Ryukyus

Flavones are the most dominant type of flavonoids isolated from the roots of Scutellaria baicalensis(Radix Scutellariae), which is a traditional medicinal plant in East Asian countries, including China, Japan and *** of the flavones are derivatives with methoxyl and hydroxyl groups, and they include baicalein, baicalin, chrysin, norwogonin, oroxylin A and *** possesses anti-cancer activities against a wide spectrum of human cancer cells by inducing apoptosis and cell cycle arrest, and by inhibiting angiogenesis, metastasis and *** examples of the effects of baicalein on apoptosis, cell cycle arrest and metastasis are presented with discussion on the molecular targets and *** on the structure-activity relationships of flavonoid cytotoxicity towards human cancer cells show that the potent cytotoxic activities of baicalein can be attributed to its-OH groupsat C5, C6 and C7(triple hydroxylation) of ring A, carbonyl group at C4 of ring C, and C2–C3 double bond of ring *** on structural modifications of baicalein have shown that the configurations at C6 of ring A are critical factors influencing its anti-proliferative *** the remarkable anti-cancer properties, the future prospects for developing baicalein into an anti-cancer drug are promising.

关键词： Radix Scutellariae Baicalein Flavones Structure-activity relationships

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