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A novel predictor of unsustained return of spontaneous circulation in cardiac arrest patients through a combination of capnography and pulse oximetry: a multicenter observational study

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World Journal of Emergency Medicine 2024年第1期15卷 16-22页

作者： Jing Yang Hanqi Tang Shihuan Shao Feng Xu Yangyang Fu Shengyong Xu Chen Li Yan Li Yang Liu joseph Harold Walline Huadong Zhu Yuguo Chen Xuezhong Yu Jun Xu Emergency Department State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Emergency Department Peking University People’s HospitalBeijing 100044China Department of Emergency and Chest Pain Center Shandong Provincial Clinical Research Center for Emergency and Critical Care MedicineKey Laboratory of Emergency and Critical Care Medicine of Shandong ProvinceQilu Hospital of Shandong UniversityJinan 250012China Emergency Department Beijing Jishuitan HospitalBeijing 100035China Emergency Department Tianjin Medical University General HospitalTianjin 300052China Department of Emergency Medicine Penn State Health Milton S.Hershey Medical Center and Penn State College of MedicineHershey 17033USA

BACKGrOUND:Unsustained return of spontaneous circulation(rOSC)is a critical barrier to survival in cardiac arrest *** study examined whether end-tidal carbon dioxide(ETCO_(2))and pulse oximetry photoplethysmogram(POP)parameters can be used to identify unsustained ***:We conducted a multicenter observational prospective cohort study of consecutive patients with cardiac arrest from 2013 to ***’general information,ETCO_(2),and POP parameters were collected and statistically ***:The included 105 rOSC episodes(from 80 cardiac arrest patients)comprised 51 sustained rOSC episodes and 54 unsustained rOSC *** 24-hour survival rate was significantly higher in the sustained rOSC group than in the unsustained rOSC group(29.2%vs.9.4%,Pregression analysis showed that the difference between after and before rOSC in ETCO_(2)(ΔETCO_(2))and the difference between after and before rOCS in area under the curve of POP(ΔAUCp)were independently associated with sustained rOSC(odds ratio[Or]=0.931,95%confi dence interval[95%CI]0.881-0.984,P=0.011 and Or=0.998,95%CI 0.997-0.999,Prea under the receiver operating characteristic curve ofΔETCO_(2),ΔAUCp,and the combination of both to predict unsustained rOSC were 0.752(95%CI 0.660-0.844),0.883(95%CI 0.818-0.948),and 0.902(95%CI 0.842-0.962),***:Patients with unsustained rOSC have a poor *** combination ofΔETCO_(2) andΔAUCp showed signifi cant predictive value for unsustained rOSC.

关键词： return of spontaneous circulation Pulse oximetry photoplethysmogram End-tidal carbon dioxide Cardiac arrest Cardiopulmonary resuscitation

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Diabetic cardiomyopathy:Emerging therapeutic options

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World Journal of Diabetes 2024年第8期15卷 1677-1682页

作者： Cornelius James Fernandez Sahana Shetty joseph M Pappachan Department of Endocrinology&Metabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom Department of Endocrinology Kasturba Medical CollegeManipal Academy of Higher EducationManipal 576104KarnatakaIndia Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom

Diabetic cardiomyopathy(DbCM)is a common but underrecognized complication of patients with diabetes mellitus(DM).Although the pathobiology of other cardiac complications of diabetes such as ischemic heart disease and cardiac autonomic neuropathy are mostly known with reasonable therapeutic options,the mechanisms and management options for DbCM are still not fully *** its early stages,DbCM presents with diastolic dysfunction followed by heart failure(HF)with preserved ejection fraction that can progress to systolic dysfunction and HF with reduced ejection fraction in its advanced stages unless appropriately *** from prompt control of DM with lifestyle changes and antidiabetic medications,disease-modifying therapy for DbCM includes prompt control of hypertension and dyslipidemia inherent to patients with DM as in other forms of heart diseases and the use of treatments with proven efficacy in HF.A basic study by Zhang et al,in a recent issue of the World Journal of Diabetes elaborates the potential pathophysiological alterations and the therapeutic role of teneligliptin in diabetic mouse models with *** this preliminary basic study might help to improve our understanding of DbCM and offer a potential new management option for patients with the disease,the positive results from such animal models might not always translate to clinical practice as the pathobiology of DbCM in humans could be ***,such experimental studies can encourage more scientific efforts to find a better solution to treat patients with this enigmatic disease.

关键词： Diabetic cardiomyopathy Diabetic cardiomyopathy Heart failure Pathobiology Teneligliptin

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Will artificial intelligence reach any limit in gastroenterology?

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Artificial Intelligence in Gastroenterology 2024年第2期5卷 1-9页

作者： joseph Bou Jaoude rose Al Bacha Bassam Abboud Department of Gastroenterology Levant HospitalBeirut 166830Lebanon Department of General Surgery Geitaoui HospitalFaculty of MedicineLebanese UniversityLebanonBeirut 166830Lebanon

Endoscopy is the cornerstone in the management of digestive *** the last few decades,technology has played an important role in the development of this field,helping endoscopists in better detecting and characterizing luminal ***,despite ongoing advancements in endoscopic technology,the incidence of missed pre-neoplastic and neoplastic lesions remains high due to the operator-dependent nature of endoscopy and the challenging learning curve associated with new *** intelligence(AI),an operator-independent field,could be an invaluable *** can serve as a“second observer”,enhancing the performance of endoscopists in detecting and characterizing luminal *** utilizing deep learning(DL),an innovation within machine learning,AI automatically extracts input features from targeted endoscopic *** encompasses both computer-aided detection and computer-aided diagnosis,assisting endoscopists in reducing missed detection rates and predicting the histology of luminal digestive *** applications in clinical gastrointestinal diseases are continuously expanding and evolving the entire digestive *** all published studies,real-time AI assists endoscopists in improving the performance of non-expert gastroenterologists,bringing it to a level comparable to that of *** development of DL may be affected by selection *** have utilized different AI-assisted models,which are *** the future,algorithms need validation through large,randomized ***,AI has no limit to assist endoscopists in increasing the accuracy and the quality of endoscopic ***,practically,we still have a long way to go before standardizing our AI models to be accepted and applied by all gastroenterologists.

关键词： Artificial intelligence Digestive tract Gastroenterology Gastroscopy Coloscopy

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Bridging the divide: Harmonizing polarized clinical laboratory medicine practices

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iLABMED 2024年第2期2卷 67-69页

作者： Yi-Wei Tang joseph D.Yao Medical Affairs Danaher Corporation/CepheidNew YorkNew YorkUSA Division of Clinical Microbiology Department of Laboratory Medicine and PathologyMayo ClinicRochesterMinnesotaUSA

In today's healthcare,clinical laboratory medicine stands as a cornerstone of patient care,providing vital diagnostic insights that inform decisions in disease ***,within this crucial field,a dichotomy persists between two predominant models of laboratory testing to support clinical practice:point-of-care testing(PoCT)and central laboratory testing[1].This schism,while born of practical necessity and evolving technology,presents both opportunities and challenges that warrant closer examination.

关键词： central laboratory testing clinical microbiology point-of-care testing

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Knowledge and the Attitude on the Use of Mouthwash among Two Selected Senior High Schools in Kumasi

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Open Journal of Stomatology 2024年第5期14卷 218-234页

作者： Ama Agyeibea Amuasi Kwame A. Koranteng joseph Abu-Sakyi The Department Child Oral Health & Orthodontics School of Medicine and Dentistry College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana The Department of Community Dentistry School of Medicine and Dentistry College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana

BACKGrOUND: The route of most systemic diseases begins in the oral cavity. Oral health knowledge of mouthwashes and their uses is indispensable for the general population and especially adolescents. The use of mouthwash by adolescents can be a beneficial adjunct to their oral hygiene routine, providing additional protection against dental diseases and promoting fresher breath. Overuse or misuse of mouthwash, particularly those containing alcohol or other potentially irritating ingredients, may lead to adverse effects such as oral mucosal irritation, dry mouth, or alteration of the oral microbiome. OBJECTIVES: To determine the knowledge, attitude, and use of mouthwash among senior high school students in Kumasi. METHODOLOGY: 120 students responded to a standard questionnaire by a convenient sample technique. The Statistical Package for Social Sciences (SPSS) 22.0 and MS Excel were used for data management and analysis. The results of the study were presented using tables, bar charts, and pie chart. rESULTS: The ages of the respondents ranged from 14 to 20 years. Out of the 120 participants, 71 students that represent 59.2% of the total, used mouthwash. Majority of the participants (63%) utilized a mouthwash after brushing their teeth. 49% of the participants reported using mouthwash to address halitosis, 37% used it to combat periodontal disease, and 10% used it for relief from a sore throat. CONCLUSION: In general, most of the participants who use mouthwash had excellent knowledge and a positive attitude toward the use of mouthwash.

关键词： Oral Cavity Mouthwash Plaque Biofilm Gingivitis Convenient Sampling

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Geochemistry of Micas from Issia Granite Complexe: A Marker of Geodynamic Evolution

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Open Journal of Geology 2024年第8期14卷 787-804页

作者： Koffi joseph Brou Alain Nicaise Kouamelan Koffi raoul Teha Universit Flix Houphout-Boigny (UFHB) Abidjan Cte dIvoire

The granites and pegmatites located in the southern part of the Issia region, near the columbo-tantaliferous placers, are characterized by the presence of rare metals such as beryl, lithium and Nb-Ta oxides. They mainly consist of micas, quartz, plagioclase and potassium feldspar. The work carried out on the micas of these granites and pegmatites (EPMA analyses) has provided new geochemical data contributing to the understanding of the magmatic evolution of the Issia granite complex. Mineralogically, the most evolved G3 granites are characterized by their abundance of muscovite compared to biotite and the presence of pegmatite veins. Geochemically, the muscovites of the G1 and G2 granites are more ferriferous than those of the G3 granites, however, the latter display higher Na contents than the G2 and G3. The muscovites of the granites show an evolution from the pure muscovite series to the zinnwaldite series (micas of the pegmatites) which are lithium-bearing micas. The mineralogical and chemical data of the micas show that they are S-type peraluminous granites and demonstrate the formation of granites and pegmatites through fractional crystallization of the same parental magma.

关键词： G3 Granites Peraluminous Granites rare Metals Fractional Crystallization

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护理人员对医院护理科研学术氛围感知的质性研究

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International Journal of Nursing Sciences 2024年第2期11卷 233-240页

作者： Ejercito Mangawa Balay-odao Jonas Preposi Cruz joseph UAlmazan Department of Medicine School of MedicineNazarbayev UniversityAstanaKazakhstan

目的医疗机构面临的挑战是建立一种促进护理科研发展的组织文化。护理科研的建设一直被认为是护理学科进步的重要组成部分。因此,本研究描述了护士对所在医院护理科研学术氛围的看法。方法采用半结构式个人访谈法收集资料。于2022年12月... 详细信息

目的医疗机构面临的挑战是建立一种促进护理科研发展的组织文化。护理科研的建设一直被认为是护理学科进步的重要组成部分。因此,本研究描述了护士对所在医院护理科研学术氛围的看法。方法采用半结构式个人访谈法收集资料。于2022年12月至2023年4月,在菲律宾东部1所医院选取17名护士参与研究。采用Braun和Clarke主题分析法对数据进行分析。结果共提炼出3个主题及7个副主题:影响护士的行为和绩效(帮助获取研究信息和学习、灵活性和适应性、护士之间的合作与沟通),影响护士的研究参与(领导策略、培训与专业发展),以及影响医院对变化的适应(组织绩效与成功、护士参与和工作满意度)。结论积极的护理研究文化对塑造护士的行为和绩效、参与护理研究以及医院对变化的适应具有至关重要的作用,因此对医院护理研究文化的益处提供了支持。总之,提炼出的主题有助于护理管理者更深入地了解护理研究文化对医疗保健系统各层面的影响。

关键词：文化医院护理人员菲律宾定性研究研究

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Serum ferritin and the risk of early-onset colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3496-3506页

作者： Adam L Urback Kylee Martens Hannah Stowe McMurry Emerson Y Chen Caitlin Citti Anil Sharma Adel Kardosh joseph J Shatzel Division of Internal Medicine Oregon Health&Science UniversityPortlandOR 97239United States Division of Hematology and Medical Oncology Knight Cancer InstituteOregon Health&Science UniversityPortlandOR 97239United States Division of Gastroenterology&Hepatology Oregon Health&Science UniversityPortlandOR 97239United States

BACKGrOUND The incidence of early-onset colorectal cancer(EO-CrC)is rising in the United States,and is often diagnosed at advanced *** serum ferritin is often incidentally discovered in young adults,however,the indication for endoscopy in EO-CrC is *** To compare serum ferritin between patients with EO-CrC and healthy controls(HCs),and examine the association of serum ferritin in EO-CrC with patient-and disease-specific *** A retrospective study of patientsrs with newly-diagnosed EO-CrC was conducted from 1/2013-12/*** were included if serum ferritin was measured within 2 years prior to 1 year following CrC histologic *** supplement the analysis,a cohort of HCs meeting similar inclusion and exclusion criteria were identified for comparison.A sensitivity analysis including only patients with serum ferritin obtained at or before diagnosis was separately performed to minimize risk of *** Among 85 patients identified with EO-CrC(48 females),the median serum ferritin level was 26 ng/mL(rangered to HCs(n=80211),there were a higher proportion of individuals with EO-CrC with serum ferritinrsus HCs(female 32.1%,male 7.2%)age 29-39 years(P=0.002 and Prespectively).Stage IV disease was associated with significantly higher serum ferritin compared to less advanced stages(Prum ferritin obtained before or at the time of diagnosis was lower than levels obtained after *** findings were confirmed in the sensitivity *** Severe iron deficiency may indicate an increased risk of EO-CrC,particularly at earlier *** studies defining the optimal serum ferritin threshold and routine incorporation of serum ferritin in screening algorithms is essential to develop more effective screening strategies for EO-CrC.

关键词： Early-onset Young-onset Colorectal cancer Age Ferritin Iron deficiency

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Satellite Multi-Temporal Data and Cropping Pattern Approach for Green Gram Crop Management in the Lower Midland Zone IV and V in Kenya

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Advances in remote Sensing 2024年第2期13卷 41-71页

作者： Kalekye Hilda Manzi Shadrack Ngene joseph P. Gweyi-Onyango Department of Agriculture Science and Technology School of Agriculture and Enterprise Development Kenyatta University Nairobi Kenya Kenya Wildlife Service Spatial Ecology and Biodiversity Monitoring Nairobi Kenya

Creation of a spectral signature reflectance data, which aids in the identification of the crops is important in determining size and location crop fields. Therefore, we developed a spectral signature reflectance for the vegetative stage of the green gram (Vigna. radiata L.) over 5 years (2020, 2018, 2017, 2015, and 2013) for agroecological zone IV and V in Kenya. The years chosen were those whose satellite resolution data was available for the vegetative stage of crop growth in the short rain season (October, November, December (OND)). We used Landsat 8 OLI satellite imagery in this study. Cropping pattern data for the study area were evaluated by calculating the Top of Atmosphere reflectance. Farms geo-referencing, along with field data collection, was undertaken to extract Top of Atmosphere reflectance for bands 2, 3, 4 and 7. We also carried a spectral similarity assessment on the various cropping patterns. The spectral reflectance ranged from 0.07696 - 0.09632, 0.07466 - 0.09467, 0.0704047 - 0.12188,0.19822 - 0.24387, 0.19269 - 0.26900, and 0.11354 - 0.20815 for bands 2, 3, 4, 5, 6, and 7 for green gram, respectively. The results showed a dissimilarity among the various cropping patterns. The lowest dissimilarity index was 0.027 for the maize (Zea mays L.) bean (Phaseolus vulgaris) versus the maize-pigeon pea (Cajanus cajan) crop, while the highest dissimilarity index was 0.443 for the maize bean versus the maize bean and cowpea cropping patterns. High crop dissimilarities experienced across the cropping pattern through these spectral reflectance values confirm that the green gram was potentially identifiable. The results can be used in crop type identification in agroecological lower midland zone IV and V for mung bean management. This study therefore suggests that use of reflectance data in remote sensing of agricultural ecosystems would aid in planning, management, and crop allocation to different ecozones.

关键词： Multi-Temporal Cropping Patterns Spectral Signatures Landsat 8 Crop Identification

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The Sigma-1 receptor as a Pharmacologic Chaperone: Energetics

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Journal of Biosciences and Medicines 2024年第8期12卷 347-356页

作者： robert B. raffa joseph V. Pergolizzi Jr. School of Pharmacy (Emeritus) Temple University Philadelphia PA USA College of Pharmacy (Adjunct) University of Arizona Tucson AZ USA NEMA research Naples FL USA

Initially thought to be an opioid receptor subtype, Sigma-1 receptors (S1r) are now known to be unique proteins that have chaperone-like properties. As such, they play critical roles in cellular signaling, homeostasis, and cell survival. These roles offer significant insight for understanding homeostasis of normal physiologic processes, and the pathophysiologic consequences of disruption of normal function. Because of the broad nature of chaperone action, S1r agonists and antagonists represent potential drug discovery goals for the pharmacotherapeutic treatment of a variety of disorders that result from dysfunctional proteins. The present study summarizes the S1r as a pharmacologic chaperone crucial for protein folding and cellular homeostasis. Through literature review and thermodynamic analysis, it explores how S1r stabilizes target proteins, influencing neuroprotection and potential drug therapies. The binding of chaperones to target proteins is thermodynamically favorable, offering insights into treating diseases linked to protein misfolding.

关键词： Chaperone Sigma-1 receptor Energetics Thermodynamics Isothermal Titration Microcalorimetry

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