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EventLFM:event camera integrated Fourier light field microscopy for ultrafast 3D imaging

Light(Science & Applications) 2024年第7期13卷 1401-1415页

作者： ruipeng Guo Qianwan Yang Andrew S.Chang Guorong Hu joseph Greene Christopher V.Gabel Sixian You Lei Tian Department of Electrical and Computer Engineering Boston UniversityBostonMA 02215USA Department of Physiology and Biophysics Boston UniversityBostonMA 02215USA. Neurophotonics Center Boston UniversityBostonMA 02215USA. research Laboratory of Electronics(rLE)in the Department of Electrical Science and Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA. Department of Biomedical Engineering Boston UniversityBostonMA 02215USA

Ultrafast 3D imaging is indispensable for visualizing complex and dynamic biological *** scanning-based techniques necessitate an inherent trade-off between acquisition speed and space-bandwidth product(SBP).Emerging single-shot 3D wide-field techniques offer a promising alternative but are bottlenecked by the synchronous readout constraints of conventional CMOS systems,thus restricting data throughput to maintain high SBP at limited frame *** address this,we introduce EventLFM,a straightforward and cost-effective system that overcomes these challenges by integrating an event camera with Fourier light field microscopy(LFM),a state-of-theart single-shot 3D wide-field imaging *** event camera operates on a novel asynchronous readout architecture,thereby bypassing the frame rate limitations inherent to conventional CMOS *** further develop a simple and robust event-driven LFM reconstruction algorithm that can reliably reconstruct 3D dynamics from the unique spatiotemporal measurements captured by *** results demonstrate that EventLFM can robustly reconstruct fast-moving and rapidly blinking 3D fluorescent samples at kHz frame ***,we highlight EventLFM’s capability for imaging of blinking neuronal signals in scattering mouse brain tissues and 3D tracking of GFP-labeled neurons in freely moving *** believe that the combined ultrafast speed and large 3D SBP offered by EventLFM may open up new possibilities across many biomedical applications.

关键词： field linking overcome

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Metabolic-associated fatty liver disease and sarcopenia:A double whammy

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World Journal of Hepatology 2024年第2期16卷 152-163页

作者： Aditya Viswanath Sherouk Fouda Cornelius James Fernandez joseph M Pappachan School of Medicine Leicester UniversityLeicester LE17RHUnited Kingdom School of Health and Biomedical Sciences Rmit UniversityMelbourne VICAustralia Department of Endocrinology and Metabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom

The prevalence of metabolic-associated fatty liver disease(MAFLD)has increased substantially in recent years because of the global obesity ***,now recognized as the number one cause of chronic liver disease in the world,not only increases liver-related morbidity and mortality among sufferers but also worsens the complications associated with other comorbid conditions such as cardiovascular disease,type 2 diabetes mellitus,obstructive sleep apnoea,lipid disorders and *** the interplay between MAFLD and these comorbidities is important to design optimal therapeutic *** can be either part of the disease process that results in MAFLD(e.g.,obesity or adiposity)or a consequence of MAFLD,especially in the advanced stages such as fibrosis and *** can also worsen MAFLD by reducing exercise capacity and by the production of various muscle-related chemical ***,it is crucial to thoroughly understand how we deal with these diseases,especially when they *** explore the pathobiological interlinks between MAFLD and sarcopenia in this comprehensive clinical update review article and propose evidence-based therapeutic strategies to enhance patient care.

关键词： Metabolic-associated fatty liver disease Sarcopenia Sarcopenic obesity Lean metabolic-associated fatty liver disease Cardiovascular disease Liver-muscle axis

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Going deep:roots,carbon,and analyzing subsoil carbon dynamics

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Molecular Plant 2024年第1期17卷 1-3页

作者： Ezhilmathi Angela joseph Fernando Michael Selvaraj Yusaku Uga Wolfgang Busch Hunt Bowers Joe Tohme Alliance of Bioversity International and CIAT Km 17 Recta Cali-PalmiraAprtado Aereo 6713Cali 763537Colombia National Institute of Agrobiological Sciences(NIAS) TsukubaIbaraki 305-0856Japan Salk Institute for Biological Studies 10010 N Torrey Pines RoadLa JollaCA 92037USA Earth Optics Suite 840ArlingtonVA 22202USA

Agricultural practices currently contribute to the emission of approximately 10%–12%atmospheric greenhouse gasses,with tillage agriculture accelerating soil disruption and carbon dioxide ***,various options exist,such as converting new lands for agriculture,promoting healthier plant-based diets,adopting advanced management technologies,and minimizing food ***,these measures alone are insufficient to ensure environmental sustainability within planetary boundaries.

关键词： soil measures carbon

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Comparative efficacy of sodium glucose cotransporter-2 inhibitors in the management of type 2 diabetes mellitus:A real-world experience

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World Journal of Diabetes 2024年第3期15卷 463-474页

作者： Lubna Islam Dhanya Jose Mohammed Alkhalifah Dania Blaibel Vishnu Chandrabalan joseph M Pappachan Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Department of Community Medicine Goa Medical CollegeGoa 403202India Department of Family Medicine King Faisal Specialist HospitalRiyadh 11564Saudi Arabia Department of Data Science Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityAll Saints BuildingManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom

BACKGrOUND Sodium glucose cotransporter-2 inhibitors(SGLT-2i)are a class of drugs with modest antidiabetic efficacy,weight loss effect,and cardiovascular benefits as proven by multiple randomised controlled trials(rCTs).However,real-world data on the comparative efficacy and safety of individual SGLT-2i medications is *** To study the comparative efficacy and safety of SGLT-2i using real-world clinical *** We evaluated the comparative efficacy data of 3 SGLT-2i drugs(dapagliflozin,canagliflozin,and empagliflozin)used for treating patients with type 2 diabetes *** on the reduction of glycated hemoglobin(HbA1c),body weight,blood pressure(BP),urine albumin creatinine ratio(ACr),and adverse effects were recorded *** Data from 467 patients with a median age of 64(14.8)years,294(62.96%)males and 375(80.5%)Caucasians were *** diabetes duration was 16.0(9.0)years,and the duration of SGLT-2i use was 3.6(2.1)***-2i molecules used were dapagliflozin 10 mg(n=227;48.6%),canagliflozin 300 mg(n=160;34.3%),and empagliflozin 25 mg(n=80;17.1).Baseline median(interquartile range)HbA1c in mmol/mol were:dapagliflozin-78.0(25.3),canagliflozin-80.0(25.5),and empagliflozin-75.0(23.5)*** respective median HbA1c reduction at 12 months and the latest review(just prior to the study)were:66.5(22.8)&69.0(24.0),67.0(16.3)&66.0(28.0),and 67.0(22.5)&66.5(25.8)respectively(Pr all comparisons from baseline).Significant improvements in body weight(in kilograms)from baseline to study end were noticed with dapagliflozin-101(29.5)to 92.2(25.6),and canagliflozin 100(28.3)to 95.3(27.5)*** reductions in median systolic and diastolic BP,from 144(21)mmHg to 139(23)mmHg;(P=0.015),and from 82(16)mmHg to 78(19)mmHg;(Prespectively were also observed.A significant reduction of microalbuminuria was observed with canagliflozin only[ACr 14.6(42.6)at baseline to 8.9(23.7)at the study end;P=0.043].Adverse effects

关键词： Sodium glucose cotransporter-2 inhibitors Empagliflozin Canagliflozin Dapagliflozin Type 2 diabetes mellitus Cardiovascular disease Albumin creatinine ratio Diabesity

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Greening the Belt and road Initiative: Evidence from emergy evaluation of China’s provincial trade with ASEAN countries

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Fundamental research 2024年第2期4卷 379-393页

作者： Xu Tian joseph Sarkis Wei Chen Yong Geng Haozhi Pan Zuoxi Liu Sergio Ulgiati SJTU-UNIDO Joint Institute of Inclusive and Sustainable Industrial Development School of International and Public AffairsShanghai Jiao Tong UniversityShanghai 200030China Worcester Polytechnic Institute Worcester MA 01609-2280USA School of Geography and Environment Shandong Normal UniversityJinan 250358China School of International and Public Affairs Shanghai Jiao Tong UniversityShanghai 200030China Key Laboratory of Clean Energy of Liaoning School of Energy and EnvironmentShenyang Aerospace UniversityShenyang 110136China Department of Science and Technology Parthenope University of NapoliNaples 80143Italy School of Environment Beijing Normal UniversityBeijing 100875China

The Belt and road Initiative(BrI)is a central policy within China’s regional development and foreign trade *** trade has typically depended on economic valuation of resources,while the embedded environmental value is rarely *** situation exists in most BrI trade *** address BrI environmental sustainability issues,we consider the role of pivotal Chinese provinces and their key trade partners(ASEAN countries)as an illustration for the environmental value of resource *** accounting is used as the valuation tool for a sample period of seventeen *** results include:(1)Emergy valuations show sustainability of sample provinces decreased over time;(2)ASEAN countries such as Indonesia,Malaysia,Singapore,Thailand,and Vietnam play significant resource roles for provincial economic systems;(3)Diverse trends in trade between pivotal provinces and ASEAN countries resulted in an unbalanced trade structure from *** implications are proposed to promote a more globally sustainable and fair trade using BrI as an established trade policy.

关键词： International trade Emergy Belt and road initiative Environmental sustainability Province

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Direct recycling of Li-ion batteries from cell to pack level:Challenges and prospects on technology,scalability,sustainability,and economics

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Carbon Energy 2024年第6期6卷 1-39页

作者： joseph Jegan roy Do Minh Phuong Vivek Verma richa Chaudhary Michael Carboni Daniel Meyer Bin Cao Madhavi Srinivasan Energy research Institute@NTU(ErI@N) SCARCE LaboratoryNanyang Technological UniversitySingaporeSingapore School of Materials Science and Engineering Nanyang Technological UniversitySingaporeSingapore CEA CNRSENSCMUniversity of MontpellierUMR 5257(ICSM)Bagnols-sur-Cèze CedexFrance School of Civil and Environmental Engineering Nanyang Technological UniversitySingaporeSingapore

Direct recycling is a novel approach to overcoming the drawbacks of conventional lithium-ion battery(LIB)recycling processes and has gained considerable attention from the academic and industrial sectors in recent *** primary objective of directly recycling LIBs is to efficiently recover and restore the active electrode materials and other components in the solid phase while retaining electrochemical *** technology's advantages over traditional pyrometallurgy and hydrometallurgy are costeffectiveness,energy efficiency,and sustainability,and it preserves the material structure and morphology and can shorten the overall recycling *** review extensively discusses the advancements in the direct recycling of LIBs,including battery sorting,pretreatment processes,separation of cathode and anode materials,and regeneration and quality enhancement of electrode *** encompasses various approaches to successfully regenerate high-value electrode materials and streamlining the recovery process without compromising their electrochemical ***,we highlight key challenges in direct recycling when scaled from lab to industries in four perspectives:(1)battery design,(2)disassembling,(3)electrode delamination,and(4)commercialization and *** on these challenges and changing market trends,a few strategies are discussed to aid direct recycling efforts,such as binders,electrolyte selection,and alternative battery designs;and recent transitions and technological advancements in the battery industry are presented.

关键词： battery design cathode regeneration direct recycling graphite recycling lithium-ion battery,scaling-up

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Ethanol steam reforming over Ni/ZSM-5 nanosheet for hydrogen production

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Chinese Journal of Chemical Engineering 2024年第3期67卷 247-256页

作者： Porapak Suriya Shanshan Xu Shengzhe Ding Sarayute Chansai Yilai Jiao joseph Hurd Daniel Lee Yuxin Zhang Christopher Hardacre Prasert reubroycharoen Xiaolei Fan Department of Chemical Engineering School of EngineeringThe University of ManchesterManchester M139PLUnited Kingdom Program of Petrochemistry and Polymer Science Faculty of ScienceChulalongkorn UniversityBangkok10330Thailand Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Liaoning Academy of Materials Shenyang 110167China Center of Excellence in Catalysis for Bioenergy and renewable Chemicals(CBrC) andDepartment of Chemical TechnologyFaculty of ScienceChulalongkorn UniversityBangkok 10330Thailand Nottingham Ningbo China Beacons of Excellence research and Innovation Institute University of Nottingham Ningbo ChinaNingbo315100China

Compared to reforming reactions using hydrocarbons,ethanol steam reforming(ESr)is a sustainable alternative for hydrogen(H_(2))production since ethanol can be produced sustainably using *** work explores the catalyst design strategies for preparing the Ni supported on ZSM-5 zeolite catalysts to promote ***,two-dimensional ZSM-5 nanosheet and conventional ZSM-5 crystal were used as the catalyst carriers and two synthesis strategies,i.e.,in situ encapsulation and wet impregnation method,were employed to prepare the *** on the comparative characterization of the catalysts and comparative catalytic assessments,it was found that the combination of the in situ encapsulation synthesis and the ZSM-5 nanosheet carrier was the effective strategy to develop catalysts for promoting H_(2) production via ESr due to the improved mass transfer(through the 2-D structure of ZSM-5 nanosheet)and formation of confined small Ni nanoparticles(resulted via the in situ encapsulation synthesis).In addition,the resulting ZSM-5 nanosheet supported Ni catalyst also showed high Ni dispersion and high accessibility to Ni sites by the reactants,being able to improve the activity and stability of catalysts and suppress metal sintering and coking during ESr at high reaction ***,the Ni supported on ZSM-5 nanosheet catalyst prepared by encapsulation showed the stable performance with~88% ethanol conversion and~65% H_(2) yield achieved during a 48-h longevity test at 550-C.

关键词： ZSM-5 nanosheet In situ encapsulation Ni catalyst Ethanol steam reforming Hydrogen production

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Monkeypox: A Viral Zoonotic Disease of rising Global Concern

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Infectious Diseases & Immunity 2024年第3期4卷 121-131页

作者： Sukumaran Ani Betsy joseph Mary Thomas Vishnupriya K.Sweety Nandita Suresh Tumos Waltimo Department of Dentistry Oral Health InstituteHamad Medical CorporationPost Box 3050DohaQatar College of Dental Medicine Qatar UniversityPost Box 2713DohaQatar Department of Periodontology Saveetha Dental College and HospitalsSaveetha Institute of Medical and Technical SciencesSaveetha UniversityChennai 600077India Department of Oral and Maxillofacial Diseases Helsinki University and University HospitalHelsinki 00014Finland Pushpagiri Institute of Medical Sciences and research Centre MedicityPerumthuruthyTiruvallaKerala 689101India Clinic for Oral Health and Medicine University Center for Dental Medicine Basel UZBUniversity of Basel4058 BaselSwitzerland.

Monkeypox(mpox)is a rare viral zoonotic disease,endemic to Central and West Africa,caused by the monkeypox virus,an orthopoxvirus similar to the variola virus(smallpox).Although sporadic travel-associated cases have historically occurred outside Africa,in May 2022,mpox began spreading globally in multiple nonendemic countries across several *** 2024,there has been an increase in globally reported confirmed cases of mpox and deaths from mpox,making it a public health emergency of international *** reasons for the unusual global spread are under investigation but likely relate to increased travel and waning population immunity to *** now appears to be mainly through close,intimate contact,especially among men who have sex with *** is usually a self-limited *** limited approved antiviral treatments are available,such as tecovirimat,which the European Medicines Agency approved in January 2022 for the treatment of mpox,their widespread availability and effectiveness in the current outbreak remain to be *** health control measures include surveillance,case identification/isolation,contact tracing,and targeted vaccination of contacts at high risk of ***,challenges remain in curtailing the current unprecedented *** knowledge gaps include animal reservoir(s)responsible for initial spillover events,viral mutations that may enhance transmissibility,optimal diagnostics for noninvasive specimens,effective antiviral therapies,next-generation vaccines providing longer-term immunity,and building global capacity for outbreak *** review summarizes the current literature on mpox virology,epidemiology,pathogenesis,clinical manifestations,diagnostics,treatment,prevention,and public health control *** investigation and research are needed to better understand mpox’s evolving epidemiology,pathogenicity,transmissibility,and ecology to guide strategies for containin

关键词： Antiviral agents Disease outbreaks Epidemiology Mpox Smallpox vaccine Zoonoses

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Management of male obesity-related secondary hypogonadism:A clinical update

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World Journal of Experimental Medicine 2024年第2期14卷 11-28页

作者： Mohan T Shenoy Sunetra Mondal Cornelius James Fernandez joseph M Pappachan Department of Endocrinology Sree Gokulam Medical Collegeand Research FoundationTrivandrum 695607KeralaIndia Department of Endocrinology NRS Medical College and HospitalKolkata 700014West BengalIndia Department of Endocrinology&Metabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine&HealthThe University of ManchesterManchester M139PLUnited Kingdom

The global obesity pandemic has resulted in a rise in the prevalence of male obesity-related secondary hypogonadism(MOSH)with emerging evidence on the role of testosterone *** aim to provide an updated and practical approach towards its *** did a comprehensive literature search across MEDLINE(via PubMed),Scopus,and Google Scholar databases using the keywords“MOSH”Or“Obesity-related hypogonadism”Or“Testosterone replacement therapy”Or“Selective estrogen receptor modulator”Or“SErM”Or“Guidelines on male hypogonadism”as well as a manual search of references within the articles.A narrative review based on available evidence,recommendations and their practical implications was *** weight loss is the ideal therapeutic strategy for patients with MOSH,achievement of significant weight reduction is usually difficult with lifestyle changes alone in real-world ***,androgen administration is often necessary in the management of hypogonadism in patients with MOSH which also improves many other comorbidities related to ***,there is conflicting evidence for the appropriate use of testosterone replacement therapy(TrT),and it can also be associated with *** evidence-based review updates the available evidence including the very recently published results of the TrAVErSE trial and provides comprehensive clinical practice pearls for the management of patients with *** starting testosterone replacement in functional hypogonadism of obesity,it would be desirable to initiate lifestyle modification to ensure weight *** should be coupled with the management of other comorbidities related to obesity in MOSH *** the risks and benefits of TrT should be considered in every patient before and during longterm management.

关键词： Male obesity-related secondary hypogonadism Androgen therapy Testosterone replacement therapy Obesity Cardiovascular benefits

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Metabolic reprogramming by Syntenin-1 directs rA FLS and endothelial cell-mediated inflammation and angiogenesis

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Cellular & Molecular Immunology 2024年第1期21卷 33-46页

作者： Anja Meyer Stephanie r.Zack Wes Nijim Adel Burgos Vishwa Patel Brian Zanotti Michael V.Volin M.Asif Amin Myles J.Lewis Costantino Pitzalis Shiva Arami joseph A.Karam Nadera J.Sweiss Shiva Shahrara Jesse Brown VA Medical Center ChicagoILUSA Department of Medicine Division of RheumatologyThe University of Illinois at ChicagoChicagoILUSA Department of Microbiology and Immunology Midwestern UniversityDowners GroveILUSA Division of rheumatology and Clinical Autoimmunity Center of Excellence University of MichiganAnn ArborMIUSA Centre for Experimental Medicine and rheumatology William Harvey Research InstituteBarts and The London School of Medicine and DentistryQueen Mary University of LondonLondonUnited Kingdom Centre for Experimental Medicine&rheumatology William Harvey Research InstituteQueen Mary University of London and Barts NIHR BRC&NHS TrustLondonUK Department of Biomedical Sciences Humanitas Universityand Humanitas Research HospitalMilanItaly Department of Orthopedic Surgery the University of Illinois at ChicagoChicagoILUSA

A novel rheumatoid arthritis(rA)synovial fluid protein,Syntenin-1,and its receptor,Syndecan-1(SDC-1),are colocalized on rA synovial tissue endothelial cells and fibroblast-like synoviocytes(FLS).Syntenin-1 exacerbates the inflammatory landscape of endothelial cells and rA FLS by upregulating transcription of IrF1/5/7/9,IL-1β,IL-6,and CCL2 through SDC-1 ligation and HIF1α,or mTOr ***,Syntenin-1 orchestrates rA FLS and endothelial cell invasion via SDC-1 and/or mTOr *** Syntenin-1 reprogrammed endothelial cells,the dynamic expression of metabolic intermediates coincides with escalated glycolysis along with unchanged oxidative factors,AMPK,PGC-1α,citrate,and inactive oxidative ***,rA FLS rewired by Syntenin-1 displayed a modest glycolytic-ATP accompanied by a robust mitochondrial-ATP *** enriched mitochondrial-ATP detected in Syntenin-1 reprogrammed rA FLS was coupled with mitochondrial fusion and fission recapitulated by escalated Mitofusin-2 and DrP1 *** found that VEGFr1/2 and Notch1 networks are responsible for the crosstalk between Syntenin-1 rewired endothelial cells and rA FLS,which are also represented in rA *** to rA explants,morphological and transcriptome studies authenticated the importance of VEGFr1/2,Notch1,rAPTOr,and HIF1αpathways in Syntenin-1 arthritic mice and their obstruction in SDC-1 deficient ***,dysregulation of SDC-1,mTOr,and HIF1αnegated Syntenin-1 inflammatory phenotype in rA explants,while inhibition of HIF1αimpaired synovial angiogenic imprint amplified by *** conclusion,since the current therapies are ineffective on Syntenin-1 and SDC-1 expression in rA synovial tissue and blood,targeting this pathway and its interconnected metabolic intermediates may provide a novel therapeutic strategy.

关键词： Syntenin-1 Syndecan-1 rA FLS rA explants immunometabolism

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