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Optical Detection of Distal Lung Enzyme Activity in Human Inflammatory Lung Disease

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Biomedical Engineering Frontiers 2021年第1期2卷 44-54页

作者： Alicia Megia-Fernandez Adam Marshall Ahsan R.Akram Bethany Mills Sunay V.Chankeshwara Emma Scholefield Amy Miele Bruce C.McGorum Chesney michaels Nathan Knighton Tom Vercauteren Francois Lacombe Veronique Dentan Annya M.Bruce Joanne Mair Robert Hitchcock Nik Hirani Chris Haslett Mark Bradley Kevin Dhaliwal EaStCHEM The University of Edinburgh School of ChemistryJoseph Black BuildingWest Mains RoadEdinburghUK EH93FJ Translational Healthcare Technologies Group Centre for Inflammation ResearchQueen’s Medical Research InstituteUniversity of Edinburgh47 Little France CrescentEdinburgh BioQuarterEdinburghUK EH164TJ the Roslin Institute and Royal(Dick)School of Veterinary Studies University of EdinburghEaster BushMidlothianUK EH259RG Department of Biomedical Engineering University of Utah36 S Wasatch DrSalt Lake CityUT 84112USA School of Biomedical Engineering&Imaging Sciences King’s College LondonLondonUK SE17EH Mauna Kea Technologies 9Rue d’EnghienParisFrance 75010

Objective and Impact *** is a need to develop platforms delineating inflammatory biology of the distal human *** describe a platform technology approach to detect in situ enzyme activity and observe drug inhibition in the distal human lung using a combination of matrix metalloproteinase(MMP)optical reporters,fibered confocal fluorescence microscopy(FCFM),and a bespoke delivery *** development of new therapeutic agents is hindered by the lack of in vivo in situ experimental methodologies that can rapidly evaluate the biological activity or drug-target engagement in *** optimised a novel highly quenched optical molecular reporter of enzyme activity(FIB One)and developed a translational pathway for in-human *** demonstrate the specificity for matrix metalloproteases(MMPs)2,9,and 13 and probe dequenching within physiological levels of MMPs and feasibility of imaging within whole lung models in preclinical ***,in a first-in-human exploratory experimental medicine study of patients with fibroproliferative lung disease,we demonstrate,through FCFM,the MMP activity in the alveolar space measured through FIB One fluorescence increase(with pharmacological inhibition).*** translational in situ approach enables a new methodology to demonstrate active drug target effects of the distal lung and consequently may inform therapeutic drug development pathways.

关键词： Lung lung specificity

超体质量减肥手术后体形塑造术的并发症：术后处理和治疗

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中国美容整形外科杂志 2013年第7期24卷 I0022-I0022页

作者： joseph michaels V Devin Coon J. Peter Rubin 朱丽娜(译) 魏峰(译) 高景恒(译) 张晨(译) 私人诊所美国马里兰州巴尔的摩和北贝塞斯达美国约翰霍普金斯医疗机构颌面整形和再造外科匹兹堡大学医学中心整形和再造外科美国宾夕法尼亚州匹兹堡《中国美容整形外科杂志》编辑部大连大学附属新华医院

【摘要】体形塑造患者适当的术后管理对术后远期的满意结果是必不可少的。普遍问题，如引流管处理、营养和活动限制，与所有患者均相关。尽管术后并发症十分罕见，但本文描述的处理轻度并发症的有效措施也是非常有价值的。

关键词：术后并发症体形塑造术后处理超体质量手术后治疗减肥术后管理

超体质量减肥手术后体形塑造术并发症：评估和预防策略

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中国美容整形外科杂志 2013年第7期24卷 I0022-I0022页

作者： joseph michaels V Devin Coon J. Peter Rubin 朱丽娜(译) 魏峰(译) 高景恒(译) 张晨(译) 美国马里兰州北贝塞斯达巴尔的摩匹兹堡《中国美容整形外科杂志》编辑部大连大学附属新华医院

【摘要】体质量大量减轻的患者对整形医师来说是一个特别的挑战。回顾这些问题，对不是专门研究该领域的外科医师是有价值的。手术要想取得良好结果，需要综合的围手术方法、开始时正确的患者选择和正确的手术预期。术中注意事项（如低... 详细信息

【摘要】体质量大量减轻的患者对整形医师来说是一个特别的挑战。回顾这些问题，对不是专门研究该领域的外科医师是有价值的。手术要想取得良好结果，需要综合的围手术方法、开始时正确的患者选择和正确的手术预期。术中注意事项（如低体温症的预防和血栓栓塞的预防）对改善结果和降低发病率均有积极作用。适当的术后护理可让患者和医师对结果都满意。

关键词：预防策略超体质量手术后术并发症体形塑造减肥术中注意事项整形医师

Erratum to “Optical Detection of Distal Lung Enzyme Activity in Human Inflammatory Lung Disease”

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Biomedical Engineering Frontiers 2023年第1期4卷 30-30页

作者： Alicia Megia-Fernandez Adam Marshall Ahsan R.Akram Bethany Mills Sunay V.Chankeshwara Emma Scholefield Amy Miele Bruce C.McGorum Chesney michaels Nathan Knighton Tom Vercauteren Francois Lacombe Veronique Dentan Annya M.Bruce Joanne Mair Robert Hitchcock Nik Hirani Chris Haslett Mark Bradley Kevin Dhaliwal EaStCHEM The University of Edinburgh School of ChemistryJoseph Black BuildingWest Mains RoadEdinburgh EH93FJUK Translational Healthcare Technologies Group Centre for Inflammation ResearchQueen’s Medical Research InstituteUniversity of Edinburgh47 Little France CrescentEdinburgh BioQuarterEdinburgh EH164TJUK the Roslin Institute and Royal(Dick)School of Veterinary Studies University of EdinburghEaster BushMidlothian EH259RGUK Department of Biomedical Engineering University of Utah36 S Wasatch DrSalt Lake CityUT 84112USA School of Biomedical Engineering&Imaging Sciences King’s College LondonLondon SE17EHUK Mauna Kea Technologies 9Rue d’EnghienParis 75010France

In the research article“Optical Detection of Distal Lung Enzyme Activity in Human Inflammatory Lung Disease”[1],the data availability statement was inadvertently omitted by the *** has now been corrected in the PDF ... 详细信息

关键词： HTML Human Optical