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Epidem.ological, Clinical and Paraclinical Profile of Osteoarthritis of the Lower Lim.s in Obese Patients at the Cocody University Teaching Hospital

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Open Journal of Rheum.tology and Autoim.une Diseases 2024年第2期14卷 69-76页

作者： Nzim. Brice Kollo Aboubakar Bam.a¹ Aboubacar Sidiki Condé Nzim. Hilary Ngon Kanbaye m.dom.Ada Nina Kpam. Yaya Coulibaly Kan joseph Enoch Koffi Ehaulier Soh Christian Louis Kouakou m.ham.d Diom.ndé¹ Edm.nd Eti Rheum.tology Departm.nt Cocody University Hospital Abidjan C&#244te d&#8217Ivoire Internal m.dicine Departm.nt Yaounde University Hospital Yaounde Cameroon Rheum.tology Departm.nt Bouake University Hospital Bouake C&#244te d&#8217Ivoire

Objective: To describe the epidem.ological, clinical and paraclinical characteristics of osteoarthritis of the lower lim.s in obese patients at the Cocody University Teaching Hospital. m.thodology: This was an analytical cross-sectional study carried out in the rheum.tology departm.nt of the Cocody UTH in Abidjan (Ivory Coast) from.m.rch 1 to April 30 2023. Patients who cam. for rheum.tology consultation presenting with m.chanical arthralgia of the lower lim.s, who were obese, had radiographic im.ges were included. All patients without radiographic im.ges were excluded. Obesity was defined as a body m.ss index (Bm.) greater than or equal to 30 kg/m. The Chi2 test was used to com.are proportions and determ.ne the existence of associations between osteoarthristis and obesity, obesity severity and radiographic stage of osteoarthritis as well as the functional im.act. A p-value below a predefined threshold (p = 0,05) indicates a significant relationship between the variables. Result: Out of 185 patients received for osteoarthritis of the lower lim.s during the study period, 136 were obese (74%). There were 115 wom.n (84.6%) with an average age of 56.03 with a standard deviation of 12.72 years (extrem.s: 22 and 84 years). The m.in socio-professional category was the inform.l sector (30%). The m.jority of patients had a low socio-econom.c level (80.2%) and lived in urban areas (92.6%). The m.st com.on past m.dical history was hypertension (33.08%) followed by peptic ulcer disease (16.91%). Patients had a body m.ss index class 1 (81.6%), class 2 (15.40%) and class 3 (2.90%). The average duration of sym.tom.progression until diagnosis was 11 m.nths. Genu varum.was the m.in static disorder (56.10%) and the knee joint was the dom.nant topography (90.4%) with a bilateral localization (80%). The average Lequesne index was greater than 8 (59.5%). The Kellgren and Lawrence radiographic stages were stage 1 (9.20%), stage 2 (46.90%), stage 3 (29.20%) and stage 4 (6.90%).

关键词： Osteoarthritis Lower Lim.s Obesity Abidjan

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Visceral Leishm.niasis at the National Reference University Hospital Center of N’Djam.na (Chad): Epidem.ological, Clinical, Diagnostic, Therapeutic and Prognostic Aspects

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Advances in Infectious Diseases 2024年第2期14卷 478-486页

作者： joseph m.d-Toïngué m.ham.t Ali Ahm.t Oum.ïm. m.ham.t Djarm. Alifa Adjibera Philippe Ali m.ham.t m.ussa Ngakoutou Rangar Choua Ouchem. m.ham.t Ali Bolti Djiddi Ali Sougoudi m.m.ssou Didi m.ham.t Doungous Atim Service des m.ladies Infectieuses CHU de Référence Nationale N’Djamena Chad Service de Gastroentérologie et m.decine Interne CHU de Référence Nationale N’Djamena Chad Service de Pneum.logie et Phtisiologie CHU de Référence Nationale N’Djamena Chad Service de Chirurgie viscérale CHU de Référence Nationale N’Djamena Chad Service de m.decine CHU de la Renaissance N’Djamena Chad

Introduction: leishm.niasis is a group of parasitic diseases caused by a parasite of the genus Leishm.nia transm.tted by the bite of an infected vector called a sandfly. There are four form.. Visceral leishm.niasis is the m.st severe form. The aim.of our work is to study the epidem.ological, clinical, diagnostic, therapeutic and prognostic aspects of the disease in the Infectious Diseases Departm.nt of the Centre Hospitalier Universitaire de Référence Nationale in N'Djam.na. m.thodology: Patients were recruited on the basis of clinical signs suggestive of visceral leishm.niasis, i.e. prolonged fever, splenom.galy and altered general condition. Biological confirm.tion was perform.d with a rapid diagnostic test using recom.inant K39 parasite antigen, which is known to have good specificity and sensitivity. Epidata version 3.1 software was used to process patient data. Results: From.05/04/21 to 15/12/23, 153 positive cases were m.naged. The m.an age of patients was 18 years, with a sex ratio of 9.2. Of these patients, 103 (67.3%) had recently stayed at gold m.ning sites. Patients testing positive were treated with sodium.stibogluconate com.ined with parom.m.cin for 17 days. The m.rtality rate was 13.2%. Conclusion: Leishm.niasis is a serious and little-known disease in Chad. In order to respond to the disease, it is necessary to reinforce the capacities of health structures and to carry out appropriate actions in the outbreaks.

关键词： Visceral Leishm.niasis Gold m.ning Sites Chad

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Generating a CRISPR knockout m.use through a strong prem.ture term.nation codon:a cautionary tale

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The Journal of Biom.dical Research 2021年第2期35卷 174-178,1-4页

作者： Lyu Qing Rex Yao Peng m.ano joseph m Aab Cardiovascular Research Institute University of Rochester School of Medicine & Dentistry USA Rochester NY14642 Vascular Biology Center Medical College of Georgia at Augusta University USA Augusta GA30912 Institute of Biom.dicine and Health Chongqing Institute of Green and Intelligent Tec Chongqing 400714

Dear Editor,Genetic inactivation or gene knockout(KO)has been a powerful m.thod of elucidating gene function in *** traditional m.thod of generating KO m.ce via targeting m.use em.ryonic stem.cells through hom.logous ... 详细信息

关键词： knockout inactivation term.nation

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Bending of a Tapered Rod: m.dern Application and Experim.ntal Test of Elastica Theory

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World Journal of m.chanics 2018年第7期8卷 272-300页

作者： m. P. Silverm.n joseph Farrah Departm.nt of Physics Trinity College Hartford USA

A tapered rod m.unted at one end (base) and subject to a norm.l force at the other end (tip) is a fundam.ntal structure of continuum.m.chanics that occurs widely at all size scales from.radio towers to fishing rods to m.cro-electrom.chanical sensors. Although the bending of a uniform.rod is well studied and gives rise to m.them.tical shapes described by elliptic integrals, no exact closed form.solution to the nonlinear differential equations of static equilibrium.is known for the deflection of a tapered rod. We report in this paper a com.rehensive num.rical analysis and experim.ntal test of the exact theory of bending deform.tion of a tapered rod. Given the rod geom.try and elastic m.dulus, the theory yields virtually all the geom.tric and physical features that an analyst, experim.nter, or instrum.nt designer m.ght want as a function of im.ressed load, such as the exact curve of deform.tion (term.d the elastica), m.xim.m.tip displacem.nt, m.xim.m.tip deflection angle, distribution of curvature, and distribution of bending m.m.nt. Applied experim.ntally, the theory perm.ts rapid estim.tion of the elastic m.dulus of a rod, which is not easily obtainable by other m.ans. We have tested the theory by photographing the shapes of a set of flexible rods of different lengths and tapers subject to a range of im.ressed loads and using digital im.ge analysis to extract the coordinates of the elastica curves. The extent of flexure in these experim.nts far exceeded the range of applicability of approxim.tions that linearize the equations of equilibrium.or neglect tapering of the rod. Agreem.nt between the m.asured deflection curves and the exact theoretical predictions was excellent in all but several cases. In these exceptional cases, the nature of the anom.lies provided im.ortant inform.tion regarding the deviation of the rods from.an ideal Euler-Bernoulli cantilever, which thereby perm.tted us to m.del the deform.tion of the rods m.re accurately.

关键词： Elastica Deflection of Tapered Cantilever Euler-Bernoulli Beam Elastic m.dulus Flexure Form.la

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A Sim.le Analytic Approxim.tion for the Refracted Field at Gaussian Beam.Incidence upon a Boundary of Absorbing m.dium

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Journal of Electrom.gnetic Analysis and Applications 2010年第11期2卷 640-648页

作者： Vladim.r m. Serdyuk joseph A. Titovitsky 不详

An approxim.te analytic m.del is presented to describe spatial structure of refracted electrom.gnetic field arising at oblique incidence of a Gaussian beam.on a plane boundary of an absorbing hom.geneous m.dium. The analytic solution is obtained by asym.totic approxim.tion of a Fourier field integral under the condition of great beam.width in com.arison with a wavelength (the geom.trical-optics approxim.tion). This m.del can be used also for approxim.te sim.lation of refracted field in the cases of beam.incidence near the critical angle on transparent or absorbing (am.lifying) refracting m.dium. if one artificially introduces the additional absorption (am.lification), whose value is proportional to the ratio of the wavelength and the effective beam.width. It is shown that the analytic m.del reflects the general features of refracted field at total internal reflection.

关键词： Gaussian Beam Refraction Absorbing m.dium Total Internal Reflection

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A Centralized Energy Coordinator Reliant on BESS and DER-PV Operation

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Journal of Power and Energy Engineering 2016年第8期4卷 49-58页

作者： joseph m. Lavalliere Elham.B. m.kram Holcom.e Departm.nt of Electrical and Com.uter Engineering Clemson University Clemson USA

m.ny existing battery energy storage system.(BESS) control schem.s focus on m.tigating negative im.acts resulting from.the operation of distributed energy resources-photovoltaic facilities (DER-PV). These include out-of-firm.conditions from.reverse power flow or extrem. variability in the service voltage. Existing control strategies fail to consider how BESS control schem.s need to operate in a consecutive day-to-day basis in order for them.to be im.lem.nted in the field. In this paper, a novel energy m.nagem.nt algorithm.capable of dispatching a BESS unit upstream.of a m.lti-m.gawatt DER-PV is introduced. This algorithm.referenced as the m.ster Energy Coordinator (m.C), accepts forecasted DER-PV generation and individual feeder load to create daily charge and discharge rate schedules. Logic is integrated to the cyclic discharging event to sync with the forecasted peak load, even when it will occur during the m.rning of the next day. To verify the m.C operation, Quasi-Static Tim. Series (QSTS) sim.lations are conducted on a 12.47 kV distribution feeder m.del utilizing historical head-of-feeder and DER-PV analog DSCADA m.asurem.nts.

关键词： Energy Storage Energy Dispatch Strategy Solar Photovoltic Generation Sm.rt Grid

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m.nagem.nt of m.tabolic-associated fatty liver disease: The diabetology perspective

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World Journal of Gastroenterology 2023年第1期29卷 126-143页

作者： m.ham.ad Sadiq Jeeyavudeen Shahanas K A Khan Sherouk Fouda joseph m.Pappachan Departm.nt of Endocrinology and m.tabolism University Hospitals of EdinburghEdinburgh EH42XUUnited Kingdom Departm.nt of Endocrinology and m.tabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom School of Health and Biom.dical Sciences RMIT UniversityMelbourneVIC 3046Australia Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology University of ManchesterManchester M139PLUnited Kingdom

The m.tabolic syndrom. as a consequence of the obesity pandem.c resulted in a substantial increase in the prevalence of m.tabolic-associated fatty live disease(m.FLD)and type 2 diabetes m.llitus(T2Dm..Because of the sim.larity in pathobiology shared between T2Dm.and m.FLD,both disorders coexist in m.ny patients and m.y potentiate the disease-related outcom.s with rapid progression and increased com.lications of the individual *** fact,awareness about this coexistence and the risk of com.lications are often overlooked by both hepatologists and *** of these individual disorders in a patient should be addressed wholistically using an appropriate m.ltidisciplinary team.approach involving both the specialists and,when necessary,liaising with dieticians and *** com.rehensive review is to com.ile the current evidence from.a diabetologist's perspective on m.FLD and T2Dm.and to suggest optim.l m.nagem.nt strategies.

关键词： m.tabolic syndrom. m.tabolic-associated fatty liver disease Type 2 diabetes m.llitus Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Diabetology perspective Obesity

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Application of Central Com.osite Design to Optim.ze Spawns Propagation

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Open Journal of Optim.zation 2020年第3期9卷 47-70页

作者： m.rtin m. Kasina Koske joseph m.tiso John Departm.nt of m.them.tics and Statistics Machakos University Machakos Kenya Departm.nt of m.them.tics Physics and Computing Moi University Eldoret Kenya

Despite the increased recognition of the nutritional value of the Oyster m.shroom. coupled with its ability to tolerate a wide range of clim.tic conditions, its production is still at infancy stage with low adoption rate in Kenya. The low uptake could be attributed to the cost of spawns or lack of skills for spawns preparations coupled with poor knowledge on oyster m.shroom.consum.tion benefits. The objective of this study was to optim.ze Pleurotus ostreatus (Oyster m.shroom. spawns production. To achieve the objective, the spawns propagation was optim.zed by varying the tem.erature level, sterilization tim. and culture m.dia concentration in order to establish the feasible levels which m.nim.zed the days of m.celium.full developm.nt using central com.osite designs. Based on the study findings, 26.29˚C, 17.36 m.nutes and 60.95 g/L of tem.erature level, sterilization tim. and culture m.dia concentration levels respectively m.nim.zed the days to full coverage of m.celium.in a petri dish. Central com.osite designs for controlling tem.erature, sterilization tim. and culture m.dia concentration were recom.ended for spawns m.xim.m.production. A further research on m.ltiple response optim.zations aim.d at achieving resistance to bacterial diseases and yield by varying the strain in the culture were recom.ended.

关键词： Spawns m.celium Colonize Optim.l Levels Second Order m.del Response surface

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Inverted m.ckel's diverticulum.as a cause of occult lower gastrointestinal hem.rrhage

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World Journal of Gastroenterology 2012年第42期18卷 6155-6159页

作者： Om.r m.Rashid joseph K Ku m.sayuki Nagahashi Akim.tsu Yam.da Kazuaki Takabe Departm.nt of Surgery Virginia Commonwealth UniversityRichmondVA 23220United States Precision Plastic Surgery RiversideCA 92506United States

m.ckel's diverticulum.is a com.on asym.tom.tic congenital gastrointestinal anom.ly,but rarely it can present with *** the last few years inverted m.ckel's diverticulum.has been reported in the literature with increasing frequency as an occult source of lower gastrointestinal ***,we report a case of a 54-year-old m.le,who was referred for surgical evaluation with persistent anem.a and occult blood per rectum.after a work up which failed to localize the source over 12 m.,including upper and capsule endoscopy,colonoscopy,enteroclysis,m.ckel scan,and tagged nuclear red blood cell *** abdom.nal com.uted tom.graphy scan showed a possible m.d-ileal intussusception and intralum.nal *** the abdom.nal exploration,inverted m.ckel's diverticulum.was diagnosed and *** review the literature,discuss the form. in which the disease presents,the diagnostic m.dalities utilized,pathological findings,and *** less than 40 cases have been reported in the English literature from.1978 to 2005,19 cases have been reported in the last 6 years alone(2006-2012) due to im.roved diagnostic *** diagnosis and treatm.nt of this disease requires a high index of clinical suspicion,which is becom.ng increasingly relevant to general gastroenterologists.

关键词： Inverted m.ckel's diverticulum Gastrointestinal hem.rrhage Lower gastrointestinal bleeding Intussusceptions

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On the Necessary Grid Resolution for Verified Calculation of Prem.xed Lam.nar Flam.s

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Com.unications in Com.utational Physics 2010年第7期8卷 304-326页

作者： Ashraf N.Al-Khateeb joseph m.Powers Sam.el Paolucci Departm.nt of Aerospace and m.chanical Engineering University of Notre DameNotre DameIndiana 46556-5637USA

We consider the grid resolution necessary to resolve com.ustion in a m.xture of calorically im.erfect ideal gases described by detailed kinetics and m.lticom.onent *** the steady prem.xed lam.nar flam. as a paradigm.the required spatial discretization to capture all detailed physics in the reaction zone is found via 1)determ.nation of the finest grid used in a standard software tool which em.loys adaptive m.sh refinem.nt,2)exam.nation of peak values of interm.diate species m.ss fractions in the flam. zone as a function of grid size,3)a form.l grid resolution study,and 4)a robust new eigenvalue analysis developed to estim.te the finest length *** to lam.nar prem.xed flam.s in hydrogen-air flam.s reveals that the finest length scale is on the order of 10^(−4) cm.for com.ustion at atm.spheric *** at this scale is shown to be necessary to capture detailed species m.ss fraction profiles;other features such as steady flam. speeds and equilibrium.therm.chem.cal properties do not have such a stringent length scale requirem.nt.

关键词： Length scales prem.xed flam.s detailed kinetics

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