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Resveratrol inhibits pancreatic cancer proliferation and metastasis by depleting senescent tumor-associated fibroblasts

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3980-3993页

作者： He Jiang guo-Tai Wang zheng Wang Qing-Yong Ma Zhen-Hua Ma Department of Hepatobiliary Surgery The First Affiliated HospitalXi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Hepatobiliary Surgery Affiliated Hospital of Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina

BACKGROUND Pancreatic cancer,a formidable gastrointestinal neoplasm,is characterized by its insidious onset,rapid progression,and resistance to treatment,which often lead to a grim *** the complex pathogenesis of pancreatic cancer is well recognized,recent attention has focused on the oncogenic roles of senescent tumor-associated ***,their precise role in pancreatic cancer remains *** is a natural polyphenol known for its multifaceted biological actions,including antioxidative and neuroprotective properties,as well as its potential to inhibit tumor proliferation and *** current investigation builds on prior research and reveals the remarkable ability of resveratrol to inhibit pancreatic cancer proliferation and *** To explore the potential of resveratrol in inhibiting pancreatic cancer by targeting senescent tumor-associated *** Immunofluorescence staining of pancreatic cancer tissues revealed prominent coexpression ofα-SMA and ***-1 expression was determined using *** were treated with the senescence-inducing factors known as ***-term growth assays confirmed that 3CKs significantly decreased the CAF growth *** blotting was conducted to assess the expression levels of p16 and *** was performed to assess LaminB1 *** real-time polymerase chain reaction was used to measure the levels of several senescence-associated secretory phenotype factors,including IL-4,IL-6,IL-8,IL-13,MMP-2,MMP-9,CXCL1,and CXCL12.A scratch assay was used to assess the migratory capacity of the cells,whereas Transwell assays were used to evaluate their invasive *** Specifically,we identified the presence of senescent tumor-associated fibroblasts within pancreatic cancer tissues,linking their abundance to cancer ***,Resveratrol effectively eradicated these fibroblasts and hindered their senescence,which co

关键词： Resveratrol Pancreatic Cancer Proliferation Metastasis Senescent Fibroblasts

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sTREM-1 as promising prognostic biomarker for acute-on-chronic liver failure and mortality in patients with acute decompensation of cirrhosis

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World Journal of Gastroenterology 2024年第9期30卷 1177-1188页

作者： song-Man Yu Hai Li guo-Hong Deng Xian-Bo Wang Xin zheng Jin-Jun Chen Zhong-Ji Meng Yu-Bao zheng Yan-Hang Gao Zhi-Ping Qian Feng Liu Xiao-Bo Lu Yu Shi Jia Shang Ruo-Chan Chen Yan Huang Department of Infectious Diseases Xiangya HospitalCentral South UniversityChangsha 410000Hunan ProvinceChina Department of Gastroenterology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Infectious Diseases Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100020China Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430020Hubei ProvinceChina Department of Infectious Diseases Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Infectious Disease Taihe HospitalHubei University of MedicineShiyan 442009Hubei ProvinceChina Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 200093China Tianjin Institute of Hepatology Nankai University Second People's HospitalTianjin 300192China Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital of School of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvineChina Department of Infectious Diseases Henan Provincial People's HospitalZhengzhou 463599Henan ProvineChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 110051Hunan ProvineChina

BACKGROUND Acute decompensation(AD)of cirrhosis is associated with high short-term mortality,mainly due to the development of acute-on-chronic liver failure(ACLF).Thus,there is a need for biomarkers for early and accurate identification of AD patients with high risk of development of ACLF and *** triggering receptor expressed on myeloid cells-1(sTREM-1)is released from activated innate immune cells and correlated with various inflammatory *** To explore the prognostic value of sTREM-1 in patients with AD of *** A multicenter prospective cohort of 442 patients with cirrhosis hospitalized for AD was divided into a study cohort(n=309)and validation cohort(n=133).Demographic and clinical data were collected,and serum sTREM-1 was measured at *** enrolled patients were followed-up for at least 1 *** In patients with AD and cirrhosis,serum sTREM-1 was an independent prognosis predictor for 1-year survival and correlated with liver,coagulation,cerebral and kidney failure.A new prognostic model of AD(P-AD)incorporating sTREM-1,blood urea nitrogen(BUN),total bilirubin(TBil),international normalized ratio(INR)and hepatic encephalopathy grades was established and performed better than the model for end-stage liver disease(MELD),MELD-sodium(MELD-Na),chronic liver failure-consortium(CLIF-C)ACLF and CLIF-C AD ***,sTREM-1 was increased in ACLF and predicted the development of ACLF during first 28-d *** ACLF risk score incorporating serum sTREM-1,BUN,INR,TBil and aspartate aminotransferase levels was established and significantly superior to MELD,MELD-Na,CLIF-C ACLF,CLIF-C AD and P-AD in predicting risk of ACLF *** Serum sTREM-1 is a promising prognostic biomarker for ACLF development and mortality in patients with AD of cirrhosis.

关键词： Soluble triggering receptor expressed on myeloid cell-1 Acute decompensation Cirrhosis Acute-on-chronic liver failure Prognostic biomarker

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Differential Impact of Fertility on Health-Adjusted Life Expectancy of Older Adults Across Countries of Various Levels of Socio-Demographic Index—Worldwide,1995-2019

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China CDC weekly 2024年第39期6卷 991-995页

作者： Shuai guo Chen Chen Yunhe Wang Yi Cao Zhiwei Leng Xiaoying zheng Department of Population Health and Aging Science School of Population Medicine and Public HealthChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijingChina School of Population Medicine and Public Health Chinese Academy of Medical Sciences/Peking Union Medical CollegeBeijingChina Nuffield Department of Population Health University of OxfordOxfordUK Center for Health Policy and Health Economics National Infrastructures for Translational MedicineInstitute of Clinical MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijingChina Institute for Global Health and Development Peking UniversityBeijingChina

What is already known about this topic?Health-adjusted life expectancy(HALE)is a crucial indicator of global health,which is strongly correlated with the socio-demographic index(SDI)and population *** is added by this report?This study revealed that the correlation between total fertility rate(TFR)and HALE of older adults varies across countries with different SDI levels,offering valuable insights for the development of more targeted health promotion programs and *** are the implications for public health practice?Different health interventions should be tailored to countries with different levels of *** countries with both low fertility rates and low SDI,advanced measures are needed to address the challenge of an aging population that may live longer but face poorer health in the future.

关键词： demographic fertility offering

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Accelerating Asteroidal Period and Pole Inversion from Multiple Lightcurves Using Parallel Differential Evolution and Cellinoid Shape Model

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Research in Astronomy and Astrophysics 2024年第4期24卷 271-286页

作者： Yong-Xiong Zhang Wen-Xiu guo Xiao-Ping Lu Hua zheng Hai-Bin Zhao Jun Tian Wei-Lin Wang School of Engineering Guangzhou College of Technology and BusinessGuangzhou 510850China School of Computer Science and Engineering Macao University of Science and TechnologyTaipaMacao 999078China School of Mathematics and Statistics Shaoguan UniversityShaoguan 512099China State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacao 999078China Key Laboratory of Planetary Sciences Purple Mountain ObservatoryCASNanjing 210023China

Determining asteroid properties provides valuable physical insights but inverting them from photometric lightcurves remains computationally *** paper presents a new approach that combines a simplified Cellinoid shape model with the Parallel Differential Evolution(PDE)algorithm to accelerate *** PDE algorithm is more efficient than the Differential Evolution algorithm,achieving an extraordinary speedup of 37.983 with 64 workers on multicore *** PDE algorithm accurately derives period and pole values from simulated *** analysis of real asteroid lightcurves validates the method’s reliability:in comparison with results published elsewhere,the PDE algorithm accurately recovers the rotational periods and,given adequate viewing geometries,closely matches the pole *** PDE approach converges to solutions within 20,000 iterations and under one hour,demonstrating its potential for large-scale data *** work provides a promising new tool for unveiling asteroid physical properties by overcoming key computational bottlenecks.

关键词： methods:numerical minor planets asteroids:general techniques:photometric astrom

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Spray pyrolysis feasibility of tungsten substitution for cobalt in nickel-rich cathode materials

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International Journal of Minerals,Metallurgy and Materials 2024年第10期31卷 2244-2252页

作者： Zihan Hou Lisheng guo Xianlong Fu Hongxian zheng Yuqing Dai Zhixing Wang Hui Duan Mingxia Dong Wenjie Peng guochun Yan Jiexi Wang Key Laboratory of Value-added Metallurgy of Hunan Province Engineering Research Center of the Ministry of Education for Advanced Battery MaterialsSchool of Metallurgy and EnvironmentCentral South UniversityChangsha 410083China BASF Shanshan Battery Materials Co.Ltd. Changsha 410205China

Cobalt(Co)serves as a stabilizer in the lattice structure of high-capacity nickel(Ni)-rich cathode ***,its high cost and toxicity still limit its *** general,it is possible to perform transition metal substitution to reduce the Co ***,the traditional coprecipitation method cannot satisfy the requirements of multielement coprecipitation and uniform distribution of elements due to the differences between element concentration and deposition *** this work,spray pyrolysis was used to prepare LiNi_(0.9)Co_(0.1-x)W_(x)O_(2)(LNCW).In this regard,the pyrolysis behavior of ammonium metatungstate was analyzed,together with the substitu-tion of W for *** the possibility of spray pyrolysis,the Ni-Co-W-containing oxide precursor presents a homogeneous distribution of metal elements,which is beneficial for the uniform substitution of W in the final *** was observed that with W substitution,the size of primary particles decreased from 338.06 to 71.76 nm,and cation disordering was as low as 3.34%.As a consequence,the pre-pared LNCW exhibited significantly improved electrochemical *** optimal conditions,the lithium-ion battery assembled with LiNi_(0.9)Co_(0.0925)W_(0.0075)O_(2)(LNCW-0.75mol%)had an improved capacity retention of 82.7%after 200 cycles,which provides insight in-to the development of Ni-rich low-Co *** work presents that W can compensate for the loss caused by Co deficiency to a cer-tain extent.

关键词： lithium-ion batteries Ni-rich low-cobalt W substitution spray pyrolysis

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Controllable fabrication of FeCoS_(4) nanoparticles/S-doped bowl-shaped hollow carbon as efficient lithium storage anode

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Chinese Journal of Chemical Engineering 2024年第3期67卷 78-88页

作者： Ming Zhou Mengrong Wu Haiwei Yu Xiangjun zheng Kuan Shen Xingmei guo Yuanjun Liu Fu Cao Hongxing Gu Qinghong Kong Junhao Zhang School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China Jiangsu Hengshen Co. LtdZhenjiang 212314China School of the Environment and Safety Engineering Jiangsu UniversityZhenjiang 212013China

To address the low conductivity and easy agglomeration of transition metal sulfide nanoparticles,FeCoS_(4) nanoparticles embedded in S-doped hollow carbon(FeCoS_(4)@S-HC)composites were successfully fabricated through a combination of hydrothermal processes and sulfidation *** unique bowlshaped FeCoS_(4)/S-HC composites exhibit excellent structural stability with a high specific surface area of 303.7 m^(2)·g^(-1) and a pore volume of 0.93 cm^(3)·g^(-1).When applied as anode material for lithium-ion batteries,the FeCoS_(4)@S-HC anode exhibits efficient lithium storage with high reversible specific capacity(970.2 mA·h·g^(-1) at 100 mA·g^(-1))and enhanced cycling stability(574 mA·h·g^(-1) at 0.2 A·g^(-1) after 350 cycles,a capacity retention of 84%).The excellent lithium storage is attributed to the fact that the bimetallic FeCoS_(4) nanoparticles with abundant active sites can accelerate the electrochemical reaction kinetics,and the bowl-shaped S-HC structure can provide a stable mechanical structure to suppress volume expansion.

关键词： Bimetallic sulfides Bowl-shaped hollow carbon S doping Buffering volume expand Lithium-ion batteries

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Neural network mapping of gelastic behavior in children with hypothalamus hamartoma

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World Journal of Pediatrics 2024年第7期20卷 735-745页

作者： Zhi‑Hao guo Jian‑guo Zhang Xiao‑Qiu Shao Wen‑Han Hu Lin Sang Zhong zheng Chao Zhang Xiu Wang Chun‑De Li Jia‑Jie Mo Kai Zhang Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityNo.119 South 4th Ring West RoadFengtai DistrictBeijing 100070China Department of Neurosurgery Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery Beijing Fengtai HospitalBeijingChina

Background Hypothalamus hamartomas(HHs)are rare,congenital,tumor-like,and nonprogressive malformations resulting in drug-resistant epilepsy,mainly affecting *** seizures(GS)are an early hallmark of epilepsy with *** aim of this study was to explore the disease progression and the underlying physiopathological mechanisms of pathological laughter in *** We obtained clinical information and metabolic images of 56 HH patients and utilized ictal semiology evaluation to stratify the specimens into GS-only,GS-plus,and no-GS subgroups and then applied contrasted trajectories inference(cTI)to calculate the pseudotime value and evaluate GS *** logistic regression was performed to identify neuroimaging-clinical predictors of GS,and then voxelwise lesion network-symptom mapping(LNSM)was applied to explore GS-associated brain *** cTI inferred the specific metabolism trajectories of GS progression and revealed increased complexity from GS to other seizure *** was further validated via actual disease duration(Pearson R=0.532,P=0.028).Male sex[odds ratio(OR)=2.611,P=0.013],low age at seizure onset(OR=0.361,P=0.005),high normalized HH metabolism(OR=−1.971,P=0.037)and severe seizure burden(OR=−0.006,P=0.032)were significant neuroimaging clinical *** revealed that the dysfunctional cortico-subcortico-cerebellar network of GS and the somatosensory cortex(S1)represented a negative *** This study sheds light on the clinical characteristics and progression of GS in children with *** identified distinct subtypes of GS and demonstrated the involvement of specific brain regions at the cortical–subcortical–cerebellar *** valuable results contribute to our understanding of the neural correlates of GS.

关键词： Contrasted trajectories inference Gelastic seizure Hypothalamus hamartoma Lesion network-symptom mapping Neural basis

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Recovering from prolonged cardiac arrest induced by electric shock:A case report

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World Journal of Clinical Cases 2024年第13期12卷 2248-2253页

作者： Jian Zhang Yan-Ru Qiao Ya-Dong Yang guo-zheng Pan Chong-Qing Lv Department of General Surgery Shengli Oilfield Central HospitalDongying 257000Shandong ProvinceChina Department of Emergency Medicine Shengli Oilfield Central HospitalDongying 257000Shandong ProvinceChina

BACKGROUND Cardiac arrest(CA)induced by electric shock is a rare occurrence,particularly in cases of prolonged ***,there is limited literature on similar incidents,and we present a relevant case *** SUMMARY A 27-year-old Asian male man,experiencing respiratory CA due to electric shock,was successfully restored to sinus rhythm after 50 min of cardiopulmonary resuscitation and 8 electrical defibrillation *** the subsequent stages,the patient received multiple organ function protection measures,leading to a successful recovery and eventual discharge from the *** Prolonging resuscitation time can enhance the chances of survival for patients,this study provide valuable insights into the management of electric shock-induced CA.

关键词： Electric shock Cardiac arrest Prolonged cardiopulmonary resuscitation Cerebral resuscitation Case report

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Analysis of ancient Rongcharong landslide dam failure events in the Suwalong reach of the upper reaches of the Jinsha River

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Journal of Earth Science 2024年

作者： Yongchao Li songfeng guo Bowen zheng Yu Zou Shengyuan song Yiwei Zhang Jianhua Yan Muhammad Faisal Waqar Khan Zada Shengwen Qi Jianping Chen Institute of Geology and Geophysics， Chinese Academy of Sciences Innovation Academy for Earth Science， Chinese Academy of Sciences College of Construction Engineering， Jilin University College of Earth and Planetary Science， University of Chinese Academy of Sciences School of City and Architecture Engineering， Zaozhuang University School of Earth Sciences and Engineering， Hohai University Geo-technical and Geo-Environmental Engineering Division， National Engineering Service Pakistan

Active tectonic movements and geological disasters frequently occur in the upper reaches of the Jinsha River， increasing the likelihood of landslides obstructing the river. Taking the ancient Rongcharong landslide dam failure events in the Suwalong reach as an example， this paper first analyzes the accuracy and applicability of the commonly used methods in calculating the peak flow of the dam failure， such as the empirical formula， the numerical method based on the physical mechanism， and the computational fluid dynamics (CFD) method. Then， the peak flood flow of the Rongcharong-dammed lake when it overflows the dam is determined to be 28393～64272m3/s. At the same time， the failure process of landslide dam due to flood erosion was elucidated using the CFD method， which can be divided into three stages: gradual erosion in the initial stage， rapid development in the middle stage， and gradual expansion in the final stage. Finally， the factors that affect the peak flow of floods are analyzed， and suggestions for emergency treatment of landslide dams are put forward. The findings of this research can serve as a valuable reference for disaster prevention and mitigation strategies to adapt to the increasing frequency of landslide-induced river blockages.

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Facile construction of Mxene-supported niobium hydride nanoparticles toward reversible hydrogen storage in magnesium borohydride

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Rare Metals 2024年第9期43卷 4387-4400页

作者： Ao Xia Jia-Guang zheng Qing-Bo Zhang Yu-Gang Shu Cheng-guo Yan Liu-Ting Zhang Zhan-Liang Tao Li-Xin Chen School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071China State Key Laboratory of Silicon and Advanced Semiconductor Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China

The facile construction of nanoscale NbH_(x)supported by Ti_(3)C_(2)(NbH_(x)@Ti_(3)C_(2))was achieved using facile ball milling strategy to improve the hydrogen desorption kinetics and reversibility of magnesium borohydride(Mg(BH_(4))_(2)).The doping of 30 wt%NbH_(x)@Ti_(3)C_(2)catalyst reduced the onset dehydrogenation temperature of Mg(BH_(4))_(2)to 71.2℃.Additionally,the Mg(BH_(4))_(2)+30NbH_(x)@Ti_(3)C_(2)composite achieved remarkable hydrogen release of over 9.2 wt%at a temperature as low as 230℃,indicating unexpected dehydrogenation ***,the reversibility of NbH_(x)@Ti_(3)C_(2)doped Mg(BH_(4))_(2)was retained to more than 4.2 wt%after four cycles,which was increased by 68%compared to that of undoped Mg(BH_(4))_(2).The strong catalysis of NbH_(x)@Ti_(3)C_(2)catalyst could be attributed to the synergistic effect of NbH_(x)and Ti_(3)C_(2)in hydrogen spillover and ***_(x)acted as a"hydrogen pump"for effective hydrogen spillover,while Ti_(3)C_(2)created numerous diffusion channels for hydrogen dissolution and provided the active catalytic site to facilitate the re/dehydrogenation of Mg(BH_(4))_(2).

关键词： Hydrogen storage Magnesium borohydride Catalysts Mxene

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