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Cluster headache as a manifestation of a stroke-like episode in a carrier of the MT-ND3 variant m.10158T>C

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World Journal of Clinical Cases 2020年第1期8卷 242-244页

作者： josef Finsterer Neurological Department Messerli Institute

In a recent article Fu et al reported about a 52 years old female with a mitochondrial disorder due to the variant m.10158T>C in the mtDNA located gene *** study has a number of *** study would particularly profit from providing more data about multisystem disease,from providing the current medication,the cerebro-spinal fluid findings,the detailed phenotypic presentation,and the genotype of first-degree *** the index patient had experienced recurrent seizures it is crucial to know the current and previous anti-seizure medication as it may strongly determine the *** of them are mitochondrion-toxic and particularly valproic acid may exhibit fatal side *** outcome may also depend on the degree of multisystem involvement why it is crucial to prospectively investigate the patient for subclinical involvement of organs not obviously ***,the outcome of the stroke-like lesions on imaging would be interesting to *** lesions may completely disappear or may end up as white matter lesion,laminar cortical necrosis,focal atrophy,cyst,or as the so-called toenail *** is also a need of discussing more profoundly the imaging findings and their diagnostic significance and to investigate first degree relatives of the index patient clinically and *** highly interesting,the presentation of this case of a mitochondrial disorder lacks clinical and genetic data of the patient and his *** parameters,such as severity of disease,degree of progression,drugs,pathogenicity of the mutation,and multisystem involvement require a profound discussion.

关键词： Heteroplasmy mtDNA Oxidative phosphorylation Stroke-like episode

Changes Unseen in A Century

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China Report ASEAN 2022年第11期7卷 28-29页

作者： josef Gregory Mahoney East China Normal University the Institute for the Development of Socialism with Chinese Characteristics at Southeast University

“Around the world,the people’s call for progress and cooperation is getting louder than ever before.”Contemporary Chinese political discourse frequently mentions“changes unseen in a century,”so often in fact that it becomes a catchphrase in many high-level *** are a number of ways to understand this phrase from a Chinese cultural,historical and Marxist perspective that might not otherwise be obvious to an international lay audience.

关键词： discourse otherwise phrase

Impact of agricultural landscape structure on the patterns of bird species diversity at a regional scale

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Avian Research 2023年第4期14卷 600-610页

作者： Denisa Dvorakova Jan Sipos josef Suchomel Department of Zoology FisheriesHydrobiology and ApicultureMendel University in BrnoZemedelska 161300BrnoCzech Republic

The loss of bird species diversity is a crucial problem in the European agricultural *** in the area coverage of major land cover types has been mentioned as one of the main factors responsible for bird biodiversity *** this study,we focused on the impact of landscape matrix characteristics on bird species richness and on Faith’s phylogenetic diversity index on a spatial scale of 1000-m radius around the measured occurrence *** investigated how land cover composition affects bird diversity on the landscape scale using nationwide citizen science *** total,168,739 records of bird occurrence in the South Moravian Region of the Czech Republic during growing season from 2009 to 2019 were *** found that the presence of water bodies and wetlands significantly corresponded to the areas of highest bird species *** also revealed that the presence of forests(~60%of the forest in the Czech Republic is occupied by commercial forests),urban areas and arable land were negatively associated with bird species richness and phylogenetic ***(both coniferous and deciduous)and urban habitats were found to have a tendency to host a clustered phylogenetic community structure in comparison with wetland and arable land.A strong negative association between forest proportion and bird diversity led us to conclude that the expansion of the forest(with simple species composition,horizontal and vertical structure)could be one of the critical drivers of the decline of bird species diversity in the European agricultural *** the other hand,our results also pointed out that small woody features(i.e.,woodlots)and scattered woodland shrub vegetation were one of the main landscape characteristics supporting a bird diversity in rural *** is in concordance with other studies which mention these landscape structures as important elements for nesting and foraging of farmland *** thus recommend to maintain and restor

关键词： Bird occurrence Citizen science Conservation Landscape influence Phylogenetic diversity Spatial heterogeneity

人乳与牛乳N-链寡糖组对小鼠肠道菌群的影响

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食品科学 2022年第1期43卷 127-134页

作者：郭晶宇陈亚然毛慧敏王婷 josef VOGLMEIR 刘丽南京农业大学食品科学技术学院江苏南京210095

目的:探究人乳N-链寡糖组(human milk N-glycome,HMN)与牛乳N-链寡糖组(bovine milk N-glycome,BMN)对小鼠肠道菌群的影响。方法:以C57BL/6J雄性小鼠为对象,首先在体外测定粪便菌群中与N-链寡糖相关的糖苷酶活性,并模拟粪便菌群对HMN与... 详细信息

目的:探究人乳N-链寡糖组(human milk N-glycome,HMN)与牛乳N-链寡糖组(bovine milk N-glycome,BMN)对小鼠肠道菌群的影响。方法:以C57BL/6J雄性小鼠为对象,首先在体外测定粪便菌群中与N-链寡糖相关的糖苷酶活性,并模拟粪便菌群对HMN与BMN的利用;然后将小鼠随机分为对照组、HMN和BMN处理组,灌胃21 d后,测定盲肠内短链脂肪酸(short chain fatty acids,SCFAs)的含量,并采用16S rDNA高通量测序分析肠道菌群的变化。结果:鼠粪便菌群中能够检测到β-半乳糖甘酶、α-岩藻糖苷酶及β-N-乙酰氨基葡萄糖苷酶等活性,且HMN与BMN均可被粪便微生物降解利用;体内实验发现,与对照组相比,HMN的摄入显著增加了肠道中总SCFAs的含量(P0.05);HMN与BMN的摄入均可显著影响鼠肠道菌群的组成,且两组之间也存在差异;在门水平上,与对照组相比,HMN的摄入降低了拟杆菌门的相对丰度,提高了厚壁菌门的相对丰度,而BMN的摄入降低了变形菌门的相对丰度;在属水平上,与对照组相比,摄入HMN与BMN后Muribaculaceae_norank与副鞭毛菌属的相对丰度均降低,拟杆菌属及粪肠球菌属的相对丰度均升高,HMN与BMN组之间的拟杆菌属、粪肠球菌属相对丰度差异不明显;此外,与对照组和BMN组相比,摄入HMN增加了小鼠肠道菌群中乳杆菌属、Erysipelotrichaceae-Unclassified与大肠埃希氏菌属的相对丰度,而BMN组的阿克曼菌属的相对丰度高于对照组与HMN处理组。结论:HMN与BMN能够显著影响小鼠肠道菌群的构成,实验可为了解N-链寡糖的功能和未来婴儿配方奶粉的开发提供参考。

关键词：人乳N-链寡糖牛乳N-链寡糖糖苷酶肠道微生物短链脂肪酸

Spatial Structure Characteristics Detecting of Landform based on Improved 3D Lacunarity Model

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Chinese Geographical Science 2012年第1期22卷 88-96页

作者： TAO Yang TANG Guo'an josef STROBL Key Laboratory of Virtual Geographic Environment Ministry of EducationNanjing Normal UniversityNanjing 210046China Department of Geography and Geology&Z_GIS-Centre for Geoinformatics University of SalzburgSalzburg 5020Austria Geomatics Center of Jiangsu Province Nanjing 210013China Austrian Academy of Sciences Salzburg 5020Austria

The spatial structure characteristics of landform are the foundation of geomorphologic classification and *** paper proposed a new method on quantifying spatial structure characteristics of terrain surface based on improved 3D Lacunarity *** curve and its numerical integration are used in this model to improve traditional classification result that different morphological types may share the close value of indexes based on global statistical *** at four test areas with different landform types show that improved 3D Lacunarity model can effectively distinguish different morphological types per texture *** sensitivity in distinguishing the tiny differences of texture characteristics of terrain surface shows that the quantification method by 3D Lacu-narity model and its numerical integration presented in this paper could contribute to improving the accuracy of land-form classifications and relative studies.

关键词：空间结构特征孔隙模型地貌分类三维基础孔隙度模型地形表面探测

Thermal behavior of friction clutch disc based on uniform pressure and uniform wear assumptions

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Friction 2016年第3期4卷 228-237页

作者： Oday I.ABDULLAH josef SCHLATTMANN System Technologies and Mechanical Design Methodology Hamburg University of Technology Hamburg 21073 GermanyDepartment of Energy Engineering College of Engineering University of Baghdad Baghdad-Aljadria 47024 Iraq System Technologies and Mechanical Design Methodology Hamburg University of Technology Hamburg 21073 Germany

High temperatures appear in the contacting surfaces of a single-disc clutch system (friction clutch disc, flywheel and pressure plate) due to the relative motion between these parts during the sliding period. These high temperatures are responsible for several disadvantages such as increasing wear rate, surface cracks and permanent distortions. In some cases, these disadvantages may lead the contacting surfaces to failure before the expected lifetime. In this work, mathematical models of the friction clutch system (single-disc clutch) were built to find the temperature field during the sliding period (single engagement). Analysis has been completed using developed axisymmetric models to simulate the friction clutch system during the engagement. The surface temperatures are found based on uniform pressure and uniform wear assumptions.

关键词： dry friction clutch thermal analysis finite element analysis uniform wear assumption uniform pressure assumption

Low levels of vitamin D in population exposed to significant pollution

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临床与病理杂志 2022年第1期42卷 1-8页

作者： josef Richter Vaclav Vetvicka Stanislava Richterova Usti nad Labem Zdravotniústav se sídlem v Usti nad Labem Usti nad LabemCzech Republic Department of Pathology University of LouisvilleLouisvilleKYUSA Usti nad Labem Zdravotni pojistovnaUsti nad LabemCzech Republic

Background:In recent years,monitoring of vitamin D levels and possible use of supplementation is gaining *** studies showed low levels of vitamin D in winter months followed by improvement during *** changes are mostly dependent on the level of sun exposure,but also on geographical location,genetic factors,social-economic status,quality of nutrition and environmental *** this observation we found significant decrease in vitamin D levels I populations exposed to extreme environmental pollution in area of central *** region is known for extreme burden from microparticles originating in chemical industry,surface coal mining and cold-based power ***:Vitamin D levels in all patients was determined by ***:Using 540 patients in our Department of clinical immunology and allergology we measured the levels of vitamin D in 2016 to 2021 *** only 4 patients(0.74%)we found vitamin D levels higher than 30 ng/*** curve of observed values does not reflect dependency on sun exposure and does not change during the ***:We discuss the effect of environmental contaminants,lifestyle and economic and social *** our observations,we propose to directly supplement population with vitamin D,particularly children and seniors.

关键词： vitamin D pollution environment

Adiponectin,a key adipokine in obesity related liver diseases

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World Journal of Gastroenterology 2011年第23期17卷 2801-2811页

作者： Christa Buechler josef Wanninger Markus Neumeier Department of Internal Medicine I University Hospital of RegensburgD-93042 RegensburgGermany

Non-alcoholic fatty liver disease (NAFLD) comprising hepatic steatosis,non-alcoholic steatohepatitis (NASH),and progressive liver fibrosis is considered the most common liver disease in western *** liver is more prevalent in overweight than normal-weight people and liver fat positively correlates with hepatic insulin *** steatosis is regarded as a benign stage of NAFLD but may progress to NASH in a subgroup of *** liver biopsy no diagnostic tools to identify patients with NASH are available,and no effective treatment has been *** obesity is a main risk factor for NAFLD and inappropriate storage of triglycerides in adipocytes and higher concentrations of free fatty acids may add to increased hepatic lipid storage,insulin resistance,and progressive liver *** of the adipose tissue-derived proteins are elevated in obesity and may contribute to systemic inflammation and liver *** is highly abundant in human serum but its levels are reduced in obesity and are even lower in patients with hepatic steatosis or *** antagonizes excess lipid storage in the liver and protects from inflammation and *** review aims to give a short survey on NAFLD and the hepatoprotective effects of adiponectin.

关键词：脂肪肝病脂联素肥胖胰岛素抵抗肝功能损害 NASH 肝脏疾病肝纤维化

Temperature analysis of a pin-on-disc tribology test using experimental and numerical approaches

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Friction 2016年第2期4卷 135-143页

作者： Oday I.ABDULLAH josef SCHLATTMANN System Technologies and Mechanical Design Methodology Hamburg University of Technology Hamburg 21073 Germany Department of Energy Engineering College of Engineering University of Baghdad Baghdad-Aljadria 47024 Iraq System Technologies and Mechanical Design Methodology Hamburg University of Technology Hamburg 21073 Germany

The high thermal stresses generated at the interface between the contacting surfaces due to the sliding between parts of sliding system such as friction clutches and brakes. In this work, pin-on-disc test rig was built to find the temperature field during the sliding operation using experimental and numerical approaches. In the experimental approach, infrared camera was used to find the temperature distribution, while in the numerical approach a finite element technique has been used. Analysis has been completed using three-dimensional model to simulate a pin-on-disc system. The numerical results have shown a good agreement compared with the experimental results.

关键词： transient thermal analysis pin-on-disc test rig temperature field frictional heat dry contact