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Tumor cell-intrinsic PD-L1 promotes tumor-initiating cellgeneration and functions in melanoma and ovarian cancer

Signal Transduction and Targeted Therapy 2016年第1期1卷 1-9页

作者： Harshita B Gupta Curtis A Clark Bin Yuan Gangadhara Sareddy Srilakshmi Pandeswara Alvaro S Padron Vincent Hurez jose Conejo-Garcia Ratna Vadlamudi Rong Li Tyler J Curiel Department of Medicine University of Texas Health Science CenterSan AntonioTXUSA The Graduate School of Biomedical Sciences University of Texas Health Science CenterSan AntonioTXUSA Department of Molecular Medicine University of Texas Health Science CenterSan AntonioTXUSA Department of Obstetrics and Gynecology University of Texas Health Science CenterSan AntonioTXUSA Tumor Microenvironment and Metastasis Program The Wistar InstitutePhiladelphiaPAUSA Cancer Therapy and Research Center University of Texas Health Science CenterSan AntonioTXUSA Department of Microbiology and Immunology University of Texas Health Science CenterSan AntonioTXUSA

As tumor PD-L1 provides signals to anti-tumor PD-1^(+)T cells that blunt their functions,αPD-1 andαPD-L1 antibodies have been developed as anti-cancer immunotherapies based on interrupting this signaling ***,tumor cell-intrinsic PD-L1 signals also regulate immune-independent tumor cell proliferation and mTOR signals,among other important ***-initiating cells(TICs)generate carcinomas,resist treatments and promote *** show here that in murine B16 melanoma and ID8agg ovarian carcinoma cells,TICs express more PD-L1 versus *** PD-L1 in B16 and ID8agg cells by shRNA(‘PD-L1lo’)reduced TIC numbers,the canonical TIC genes nanog and pou5f1(oct4),and functions as assessed by tumorosphere development,immune-dependent and immune-independent tumorigenesis,and serial transplantability in ***,tumor PD-L1 sensitized TIC to interferon-γand rapamycin in ***-intrinsic PD-L1 similarly drove functional TIC generation,canonical TIC gene expression and sensitivity to interferon-γand rapamycin in human ES2 ovarian cancer ***,tumor-intrinsic PD-L1 signals promote TIC generation and virulence,possibly by promoting canonical TIC gene expression,suggesting that PD-L1 has novel signaling effects on cancer pathogenesis and treatment responses.

关键词： melanoma interferon initiating

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iTBS作为未应用药物治疗的MDD患者的一线治疗

iTBS作为未应用药物治疗的MDD患者的一线治疗

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中国睡眠研究会第十四届全国学术年会

作者： jose CRUZ 孙晴晴汤琪唐铭阳王赞吉林大学第一医院

目的:经颅磁刺激(TMS)已成为有效且安全的治疗方法,用于诊断患有重度抑郁症但尚未发现抗抑郁药有益的患者。迄今为止,大多数研究都集中在治疗抵抗性抑郁症(TRD)上,并且缺乏将TMS作为一线治疗进行调查的试验。方法:本研究旨在比较33名未...

目的:经颅磁刺激(TMS)已成为有效且安全的治疗方法,用于诊断患有重度抑郁症但尚未发现抗抑郁药有益的患者。迄今为止,大多数研究都集中在治疗抵抗性抑郁症(TRD)上,并且缺乏将TMS作为一线治疗进行调查的试验。方法:本研究旨在比较33名未接受药物治疗的患者与33名TRD患者的比较组中35次间歇性theta爆发刺激(iTBS)的疗效。目标将通过左背外侧前额叶皮层(IDLFPC)上的神经导航定位。PHQ9评分量表用于比较rTMS刺激前和后的疗效。结果:所有36名患者都完成了研究,没有明显的副作用。两组35次治疗后部分缓解的比例为26%,无反应的比例为7%。比较两组TMS前后PHQ9评分的P值评分为P <0.001。交互治疗PHQ9分数的P=0.171。结论:本研究表明,TMS不仅适用于难治性抑郁症患者,也适用于从未服药的患者,可作为一线治疗。

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用于重力测量自动地形改正的FORTRAN程序

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地球物理学进展 1990年第3期5卷 92-92页

作者： Hugo Ranier Ballina lopez 柯忍

布格异常地形改正的计算中,数字计算机的使用大大简化了计算过程而且减少了所需工时的80%. 本文提出的FORTRAN语言程序是为UNIVAC1100/90计算机(该程序适用于备有FORTRAN编辑语言的任何类型的计算机)编写的,它已被成功地用于墨西哥Jalis... 详细信息

布格异常地形改正的计算中,数字计算机的使用大大简化了计算过程而且减少了所需工时的80%. 本文提出的FORTRAN语言程序是为UNIVAC1100/90计算机(该程序适用于备有FORTRAN编辑语言的任何类型的计算机)编写的,它已被成功地用于墨西哥Jaliso州地热区的地球物理研究中,在那里使用了一个103X82km的矩阵.

关键词：地形改正 FORTRAN 重力测量地球物理研究数字计算机布格异常语言程序

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My Life in Beijing

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China's Foreign Trade 2011年第6期 84-84页

作者： jose Alberto Limas G. Second Secretary of Embassy Of Mexico in China Responsible of Commercial Affairs

I came to live in Beijing in February *** is the first city I live abroad Mexico and after five year, I feel it like a second home.I enjoy when I travel to another city in China, but after a few days,I miss Beijing. I am from Mexico City,which is very similar to *** are really big 20 million people or *** are old cities,deeply proud to be the capitals and cultural centers of countries with a long and incredibly rich *** and Mexico City are perfect combinations of the old and the new,tradition and modernity, convenience and *** are organized around a magnificent square surrounded by the symbols of tradition, history and political *** City was the first city from a developing coun-

关键词：北京生活墨西哥城市

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Diversity and host assemblage of avian haemosporidians in different terrestrial ecoregions of Peru

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Current Zoology 2022年第1期68卷 27-40页

作者： Luz GARCIA-LONGORIA Jaime MURIEL Sergio MAGALLANES Zaira Hellen VILLA-GALARCE Leonila RICOPA Wilson Giancarlo INGA-DIAZ Esteban FONG Daniel VECCO Cesar GUERRA-SALDANA Teresa SALAS-RENGIFO Wendy FLORES-SAAVEDRA Kathya ESPINOZA Carlos MENDOZA Blanca SALDANA Manuel GONZALEZ-BLAZQUEZ Henry GONZALES-PINEDO Charlene LUJAN-VEGA Carlos Alberto Del AGUILA Yessica VILCA-HERRERA Carlos Alberto PINEDA Carmen REATEGUI Jorge Manuel CARDENAS-CALLIRGOS joseAlberto IANNACONE Jorge luis MENDOZA Ravinder NMSEHGAL Alfonso MARZAL Departamento de Anatomia Biologia Celular y ZoologiaUniversidad de ExtremaduraBadajoz E-506071Spain Molecular Ecology and Evolution Lab Department of BiologyLund UniversitySolvegatan 37SE-22362 LundSweden Instituto Pirenaico de Ecologıa-IPE(CSIC) Avda.Nuestra Senora de la Victoria 16Jaca 22700Spain DIRESA Direccion Regional de SaludLoreto 16001Peru Departamento Academico de Microbiologia y Parasitologia.Facultad de Ciencias Biologicas Universidad Nacional de la Amazonia PeruanaIquitos 16001Peru Facultad de Ciencias Agropecuarias Universidad Alas PeruanasLima 15823Peru EverGreen Institute-San Rafael Distrito de IndianaLoreto 16200Peru Observatorio de Aves Loreto(LBO) Distrito de San JuanLoreto 16008Peru Centro Urku de Estudios Amazonicos Tarapoto 22200Peru Servicio Nacional de Areas Naturales Protegidas por el Estado 15036Peru Sanidad Animal-Facultad de Zootecnia Universidad Nacional Agraria La MolinaLima 15012Peru Laboratorio de Microbiologia Facultad de Medicina Veterinaria y ZootecniaUniversidad CientUfica del SurLima 15067Peru Laboratorio de Analisis Clinico Moraleslab SAC MoralesSan Martin 22201Peru Asociacion Ecosistemas Andinos(ECOAN) Cuzco 08002Peru Pharmacology and Toxicology Graduate Group University of CaliforniaDavisDA 95616USA Global Health Initiative Wabash CollegeCrawfordsvilleIN 47933USA Facultad de Ciencias Biologicas Universidad Nacional Mayor de San MarcosLima 15081Peru Facultad de Medicina Veterinaria Universidad Nacional Hermilio ValdizanHuanuco10160Peru Asociacion Peruana de Helmintologia e Invertebrados Afines Lima 15054Peru Laboratorio de Ecologia y Biodiversidad Animal Universidad Nacional Federico VillarrealEl AgustinoLima 15007Peru Laboratorio de Invertebrados Universidad Ricardo Palma-Santiago de SurcoLima 15537Peru Department of Biology San Francisco State UniversitySan FranciscoCA 94132USA

Characterizing the diversity and structure of host–parasite communities is crucial to understandingtheir eco-evolutionary *** and related haemosporidian parasites are responsible forfitness loss and mortality in bird species ***,despite exhibiting the greatest ornithologicalbiodiversity,avian haemosporidians from Neotropical regions are quite ***,we analyze the genetic diversity of bird haemosporidian parasites(Plasmodium andHaemoproteus)in 1,336 individuals belonging to 206 bird species to explore for differences in diversityof parasite lineages and bird species across 5 well-differentiated Peruvian *** 70 different haemosporidian lineages infecting 74 bird *** showed that 25 out ofthe 70 haplotypes had not been previously ***,we also identified 81 new host–parasite interactions representing new host records for these haemosporidian *** outcomesrevealed that the effective diversity(as well as the richness,abundance,and Shannon–Weaver index)for both birds and parasite lineages was higher in Amazon basin ***,we also showed that ecoregions with greater diversity of bird species also had highparasite richness,hence suggesting that host community is crucial in explaining parasite *** parasites were found in ecoregions with lower bird diversity,implying that the abundanceand richness of hosts may shape the exploitation strategy followed by haemosporidian *** outcomes reveal that Neotropical region is a major reservoir of unidentified *** studies analyzing host distribution and specificity of these parasites inthe tropics will provide important knowledge about phylogenetic relationships,phylogeography,and patterns of evolution and distribution of haemosporidian parasites.

关键词： Amazonia avian malaria generalist parasite habitat specificity Haemoproteus Plasmodium specialist parasite

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Troubleshooting a Difficult Trans-Tibial/Fibula Amputation: A Case Report

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Surgical Science 2023年第6期14卷 414-427页

作者： Amy C. Ross Alejandra Navarro Castaneda Jared D. Stucki Katharine A. Dishner Marisse A. Lardizabal Bryan J. Roth luis G. Fernandez Samantha A. Delapena Marc R. Matthews Department of Podiatry Valleywise Health Medical Center Phoenix Arizona USA Department of Surgery Arrowhead Medical Center Glendale Arizona USA Department of Surgery Mountain Vista Medical Center Mesa Arizona USA Valleywise Health Medical Center Phoenix Arizona USA Department of Surgery Division of Trauma Surgery/Surgical Critical Care The University of Texas Health Science Center Tyler Texas USA School of Medicine Bill Barrett Endowed Chair in Trauma Surgery The University of Texas-Tyler Tyler Texas USA Trauma Wound Care UT Health East Tyler Texas USA Department of Surgery University of Texas Medical Branch Galveston Texas USA Department of Medicine and Nursing University of Texas Arlington Texas USA Past Commanding General TXSG Medical Brigade Austin Texas USA Department of Surgery Weill Cornell Medical Center New York NY USA Department of Surgery New York Presbyterian Hospital New York NY USA Department of Surgery Banner University of Arizona/University Medical Center Tucson Arizona USA

Necrotic feet secondary to vascular compromise in the diabetic patient may require an emergent guillotine amputation. Unrecognized, retained hardware in a distal ankle years after fracture repair may complicate the intraoperative guillotine amputation at the transtibial/fibula level. Troubleshooting such an unexpected surgical problem is not necessarily straightforward depending on the clinical situation. Presented is a case report where a patient with a necrotic burned foot failed to inform the burn team that he had implanted ankle hardware, prior to his surgical intervention. A successful amputation was completed after proceeding down a specific algorithm devised for such a scenario.

关键词： Guillotine Amputation Difficult Amputation Amputation Retained Hardware Titanium Plate Trans-Tibia Amputation

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EXPO SHANGHAI,Really Impressive and Unforgettable for Me!

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China's Foreign Trade 2011年第5期 91-91页

作者： jose Alberto Limas G. Second Secretary of Embassy of Mexico in China Responsible of Commercial Affairs

Time *** the moment last year,I was expecting the beginning of the World Expo *** one year has passed since the curtain of Expo Shanghai *** my stay in China,one of the most impressive things for me,I should say,is the Expo Shanghai. There were just so many things which impressed *** Expo site was impressive for its size,all the facilities built,the magnificent and creative pavilions,the army of people and volunteers assisting the thousands of visitors, but perhaps the most impressive thing was the will of China to reach the world hosting the Expo and the relevant will of the rest of the world

关键词：对外贸易进出口贸易 CPI 中国

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Photovoltaic energy balance estimation based on the building integration level

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建筑节能（中英文） 2023年第3期51卷 36-36页

作者： I.Lillo-Bravo Anton lopez-Roman Sara Moreno-Tejera J.M.Delgado-SanchezArticle 112786

The photovoltaic module building integration level affects the module temperature and,consequently,its output *** this work,a methodology has been proposed to estimate the influence of the level of architectural photovoltaic integration on the photovoltaic energy balance with natural ventilation or with forced cooling *** developed methodology is applied for five photovoltaic module technologies(m⁃Si,p⁃Si,a⁃Si,CdTe,and CIGS)on four characteristic locations(Athens,Davos,Stockholm,and Würzburg).To this end,a photovoltaic module thermal radiation parameter,PVj,is introduced in the characterization of the PV module technology,rendering the correlations suitable for building⁃integrated photovoltaic(BIPV)applications,with natural ventilation or with forced cooling *** results show that PVj has a significant influence on the energy balances,according to the architectural photovoltaic integration and climatic ***:Photovoltaic cooling;BIPV;Photovoltaic;Ventilation;Photovoltaic integration level in building【OA】(2)Graph⁃Based methodology for Multi⁃Scale generation of energy analysis models from IFC,by Asier Mediavilla,Peru Elguezabal,Natalia Lasarte,Article 112795 Abstract:Process digitalisation and automation is unstoppable in all industries,including ***,its widespread adoption,even for non⁃experts,demands easy⁃to⁃use tools that reduce technical *** to BEM(Building Energy Models)workflows are a clear example,where ad⁃hoc prepared models are *** paper describes a methodology,based on graph techniques,to automate it by highly reducing the input BIM requirements found in similar approaches,being applicable to almost any *** is especially relevant in retrofitting,where reality capture tools(e.g.,3D laser scanning,object recognition in drawings)are prone to create geometry clashes and other inconsistencies,posing higher challenges for *** innovation presented is its multi⁃scale nature,e

关键词： Open BIM BEM Multiscale models Building graphs Process automation IFC gbXML Energy Plus

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美国大型低地河流和洪泛区重建中的泥沙管理(英文)

美国大型低地河流和洪泛区重建中的泥沙管理(英文)

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2009水资源与可持续发展高层论坛

作者： Thomas Dunne jose A.Constantine Michael B.Singer Bren School of Environmental Science and Management University of California Santa BarbaraCalifornia 93106USA School of Earth and Ocean Sciences Cardiff UniversityCardiff CF10 3YEUnited Kingdom School of Geography and Geosciences University of Saint AndrewsFifeScotlandKY16 9ALUnited Kingdom International Forum on Water Resources and Sustainable Development Wuhan University Sept.22-242009

＜正＞Recent decades in the United States,have witnessed a reappraisal of how rivers and their floodplains should be *** general trend is towards naturalization of flow regimes and the re-establishment of sediment fluxes,river channel mobility,and of the hydraulic and biotic connections between river channels and their floodplains within the bounds of the control that is required for public *** intentions of this policy include reducing damage from flooding,reducing the cost of river control,improving biological productivity and diversity,and conserving esthetic *** new management strategy requires new understanding of how river channel and floodplain dynamics are driven by natural and managed river discharge regimes and sediment supplies from the drainage *** is in contrast to earlier research strategies which tended to concentrate on how steady-state channel forms are scaled to a single channel-forming discharge and the effects of overbank discharges in connecting the channel to its floodplain were lesser *** describe some elements of a research agenda for understanding and predicting the dynamic interactions of channels and floodplains and the resulting landform and habitat complexity.

关键词： River Restoration Sedimentation Fluvial Geomorphology

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利用反射地震数据和XBT数据联合反演海水的温盐分布

利用反射地震数据和XBT数据联合反演海水的温盐分布

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中国科学院地质与地球物理研究所第11届（2011年度）学术年会

作者：黄兴辉宋海斌 luis M.Pinheiro 拜阳中国科学院地质与地球物理研究所中国科学院油气资源研究重点实验室中国科学院研究生院

利用地震数据反演海水的温盐分布是地震海洋学研究的一个重要方向.本文分析了采集于伊比利亚半岛西南缘海域的GOLR12低频地震数据和同步观测的XBT(eXpendable BathyThermograph)、CTD(Conductivity Temperature Depth)资料,将叠后约束... 详细信息

利用地震数据反演海水的温盐分布是地震海洋学研究的一个重要方向.本文分析了采集于伊比利亚半岛西南缘海域的GOLR12低频地震数据和同步观测的XBT(eXpendable BathyThermograph)、CTD(Conductivity Temperature Depth)资料,将叠后约束波阻抗反演方法应用到海水温度、盐度剖面的计算当中,计算结果显示这种反演方法可以提供水平分辨率为6.25 m的温度和盐度资料,温度的精度约为0.1 6℃,可以为物理海洋学研究提供高横向分辨率的基础数据.

关键词：地震海洋学叠后反演温盐分布地中海涡旋

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