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An Alternative Proposal for Financing for the Agricultural Sector (Agricultural SME’s Bonds)

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Journal of Business Administration Research 2019年第1期2卷 23-33页

作者： jose A.Trigueros Pina Department of Economic and Financial Studies Building“La Galia”Campus of ElcheAvenue of the University s/n–03202Miguel Hernandez UniversitySpain

In today’s environment,where SME’s financing continues to be a serious problem,systems that facilitate non-bank financing models different from traditional ones should be *** the present article a model of financing based on bonds for SME’s is proposed,very suitable for the agricultural sector or any group with little access to traditional *** improve the analysis,a fuzzy logic system is proposed that allows the most representative variables to be properly selected and take into account the uncertainty of the environment and the subjectivity of the analysts.

关键词： Problematic financing SME Agricultural Bonus Fuzzy logic Development aid

PANDAS PARTICIPAN EN HOCKEY Y CANAN

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China & The World Cultural Exchange 2022年第2期88卷 F0004-F0004页

作者： jose Eduardo Cadena Ortiz 不详

咪喹莫特治疗上皮样血管内皮瘤及乳房Paget病的临床及组织病理观察

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世界核心医学期刊文摘（皮肤病学分册） 2006年第9期2卷 58-59页

作者： sanchez-Carpintero I Martnez M.I Mihm Jr. M.C 潘敏

An epithelioid hemangioendothelioma and Paget’s disease of the breast were treated with topical imiquimod 5% cream with very impressive results. In both of the tumors complete disappearance of the lesions occurred. In this article, in addition to describing the treatment approach, the findings in biopsy specimens of the epithelioid hemangioendothelioma and the Paget’ sdisease before, during, and after therapy will be described. The histologic findings show ample evidence that there is both alymphocytic T helper 1-like and T helper 2-like response from imiquimod. Direct evidence of lymphocytotoxicity was found. Furthermore, mast cells appear to be involved in the development of regression in the vascular tumor. Although the study is very limited and reports only two cases, the results are *** considered it important to describe these findings because of their possible use in developing strategies for the application of imiquimod in the treatment of other tumors in human beings.

关键词：乳房Paget病上皮样血管内皮瘤 5%咪喹莫特乳膏治疗组织学病理观察淋巴细胞毒性临床

Handwriting Command Recognition and Digital Operation Using Digitalized Pen

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通讯和计算机（中英文版） 2016年第4期13卷 164-170页

作者： Naoya Toyozumi Junji Takahashi Guillaume lopez Department of Integrated Information Technology A oyama Gakuin University 1-10-5 Fuchinobe Chuo-ku Saganihara Kanagawa252-5258 Japan

Internet addiction and problematic Internet use: A systematic review of clinical research

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World Journal of Psychiatry 2016年第1期6卷 143-176页

作者： Daria J Kuss Olatz lopez-Fernandez International Gaming Research Unit Nottingham Trent University Laboratory for Experimental Psycho-pathology Psychological Sciences Research InstituteUniversité Catholique de Louvain

AIM: To provide a comprehensive overview of clinical studies on the clinical picture of Internet-use related addictions from a holistic perspective. A literature search was conducted using the database Web of ***: Over the last 15 years, the number of Internet users has increased by 1000%, and at the same time, research on addictive Internet use has proliferated. Internet addiction has not yet been understood very well, and research on its etiology and natural history is still in its infancy. In 2013, the American Psychiatric Association included Internet Gaming Disorder in the appendix of the updated version of the Diagnostic and Statistical Manual for Mental Disorders(DSM-5) as condition that requires further research prior to official inclusion in the main manual, with important repercussions for research and treatment. To date, reviews have focused on clinical and treatment studies of Internet addiction and Internet Gaming Disorder. This arguably limits the analysis to a specific diagnosis of a potential disorder that has not yet been officially recognised in the Western world, rather than a comprehensive and inclusive investigation of Internet-use related addictions(including problematic Internet use) more generally. RESULTS: The systematic literature review identified a total of 46 relevant studies. The included studies used clinical samples, and focused on characteristics of treatment seekers and online addiction treatment. Four main types of clinical research studies were identified, namely research involving(1) treatment seeker characteristics;(2) psychopharmacotherapy;(3) psychological therapy; and(4) combined treatment. CONCLUSION: A consensus regarding diagnostic criteria and measures is needed to improve reliability across studies and to develop effective and efficient treatment approaches for treatment seekers.

关键词： Internet addiction Problematic Internet use Gaming addiction Internet Gaming Disorder Clinical studies Treatment seekers Treatment Therapy

Evaluation of Changes in Actin Filaments of RK13 Cells Infected with <i>Malassezia pachydermatis</i>

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Open Journal of Veterinary Medicine 2018年第2期8卷 15-24页

作者： Iris del Socorro Flores Rodríguez Tonatiuh Alejandro Cruz Sánchez José luis Nieto Bordes Francisco Rodolfo González Díaz Carlos Ignacio Soto Zárate Carlos Gerardo García Tovar Laboratorio 6 de Bioprospección Microbiológica Unidad de Investigación Multidisciplinaria (UIM) Facultad de Estudios Superiores Cuautitlán UNAM Cuautitlán Izcallí México Laboratorio 4 de Morfología Veterinaria y Biología Celular Unidad de Investigación Multidisciplinaria (UIM) Facultad de Estudios Superiores Cuautitlán UNAM Cuautitlán Izcallí México

Background: Malassezia pachydermatis is the main causative agent of canine otitis and also of a myriad of dermatological problems in companion animals;its interaction mechanisms with host cells are still unclear. Objectives: To establish an in vitro infection model of M. pachydermatis-exposed RK13 cells in order to evaluate cell morphological changes as well as changes in the structure of actin filaments. Methods: Cultures of RK13 cells were infected with M. pachydermatis, alterations caused by the yeast were evaluated by optical and fluorescence microscopy. Results: M. pachydermatis adheres itself to the cell and produces the formation of multiple agglomerates that cause changes in cell morphology, formation of cell aggregates in overlays, presence of syncytia and destruction of cell culture structure. The damaged cells presented changes in the actin filaments consisting of thickening of the cell cortex and loss of stress fibers. On the other hand, the formation of perinuclear actin rings in the yeasts was observed. Conclusions: An in vitro infection model was established with M. pachydermatis and alterations in cell morphology were observed consisting of changes in the structure of the actin filaments, overgrowth of the cells and the presence of syncytia.

关键词： Malassezia pachydermatis RK13 Cells Actin Filaments

Prevalence of Family History of Cancer among Gastric Cancer Patients at Brazilian National Cancer Institute

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Health 2017年第1期9卷 25-37页

作者： Tamara Figueiredo Maria Teresa Santos Guedes luis Paulo Souza e Souza Antonio Abílio Santa Rosa Antonio Carlos Accetta Maria Aparecida de Luca Nascimento Lais Santiago Deivite Danilo Ferreira Alcantara Department of Postgraduate in Adult Health Federal University of Minas GeraisBelo HorizonteBrazil Department of Radiotherapy Health Foundation Dilson de Quadros GodinhoMontes ClarosBrazil National Tumor/DNA Bank National Cancer Institute Rio de JaneiroBrazil Department of Postgraduate Course in Nursing and Biosciences Federal University of Rio de Janeiro StateRio de JaneiroBrazil Department of Postgraduation in Public Health Federal University of Minas GeraisBelo HorizonteBrazil Department of Medicine Federal University of Sao Joao del ReiSao Joao del ReiBrazil Research Department of the Bonsucesso General Hospital Ethics Committee National Cancer InstituteRio de JaneiroBrazil Department of Abdominal-Pelvic Surgery National Cancer InstituteRio de JaneiroBrazil Department of Chemotherapy National Cancer InstituteRio de JaneiroBrazil

Background: Gastric cancer is the third most incident malignancy and the fifth leading cause of death in the world. In Brazil, it is the fourth most common tumour in men and the fifth in women. Familial aggregation of this tumour is being studied and discussed by experts. Aim: Determine the frequency of family history of cancer in patients with gastric cancer, suggesting familial aggregation or increased risk for hereditary cancer syndromes. Methods: This is a retrospective cross-sectional study carried out from January 2011 to March 2015 at the Department of Abdominal and Pelvic Surgery of the Brazilian National Cancer Institute (INCA). Data were collected from electronic medical records and analyzed using SPSS Statistics? version 20. Results: 873 patients with gastric adenocarcinoma were analyzed. A family history of cancer was reported by 451 patients (51.6%), which reported cancer in 878 relatives, of which 110 (12.6%), reported having more than three relatives with any type of cancer. The most prevalent malignancies among these relatives were gastric cancer (21.3%) and breast cancer (9.5%). Conclusion: Most of the patients had cancer family history, being gastric cancer the most common. The high percentage of cancer family history confirms the importance of collecting this information, whose lack reflects professional negligence, as family history study can serve as a low-cost tool, favoring prevention and early diagnosis, situations where morbidity and mortality are smaller, thus reducing health costs and assistance and preserving lives.

关键词： Stomach Neoplasms Family History Hereditary Aggregation Hospital Records Cross-Sectional Studies

Effects of primovaccination and booster vaccination on serum cortisol and humoral immune response in cattle

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Advances in Bioscience and Biotechnology 2013年第5期4卷 607-611页

作者： luis S.L.S.Reis Paulo E.Pardo Neusa M.Frazatti-Gallina Rosana L.Paoli Eunice Oba Sergio N.Kronka Aline S.Camargos Department of Bromatology Food and Animal NutritionUniversidade de Santo AmaroSao PauloBrazil Department of Medical Clinic Universidade do Oeste PaulistaPresidente PrudenteBrazil Section of Rabies of Instituto Butantan Sao PauloBrazil Department of Animal Reproduction and Veterinary Radiology Universidade Estadual PaulistaFaculdade de Medicina Veterinaria e ZootecniaCampus BotucatuBrazil Universidade Estadual Paulista Faculdade de Ciencias Agrarias e Veterinarias de JaboticabalCampus JaboticabalBrazil

The objective of this study was to evaluate the effect of one or two doses of the anti-rabies vaccination on the serum concentration of cortisol and the humoral immune response in cattle as well as the correlation between serum cortisol concentrations and the titers of rabies-neutralizing antibodies. Nelore cattle were randomly assigned to one of three groups, which were vaccinated with one dose of rabies vaccine (group GVSR, N = 15), two doses of rabies vaccine (group GVR, N = 15) or were not vaccinated (group Gc, N = 15). A commercial liquid inactivated rabies vaccine was used. The stressors imposed on the cattle were vaccination, corral handling and the presence of people. Blood samples were collected on days 0, 30 and 60 post-vaccination. Serum cortisol concentrations were determined using a solid-phase radioimmunoassay, and rabies antibody titers were determined using a serum neutralization test with BHK21 cells (RFFIT). Both serum cortisol concentrations and antibody titers increased after the second (booster) vaccination (P < 0.05). In all the groups, the serum cortisol concentrations increased after the cattle were handled in the corral (P < 0.05). No correlation was observed between the serum cortisol concentrations and the antibody titers with any treatment or on any observation day. In conclusion, booster vaccination is indispensable for primovaccinated cattle in achieving high and protective levels of rabies antibodies. Although booster vaccination and frequent cattle handling in corrals are stressors, the response is not strong enough to cause immunosuppression in cattle.

关键词： Cattle Stress Stressor Cortisol Rabies Vaccination Antibody

Association of Serum Antioxidant Enzymes and Nervous Tissue Markers in Hypertensive Patients

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World Journal of Cardiovascular Diseases 2014年第4期4卷 160-168页

作者： Marisol Pena-sanchez Sergio Gonzalez-Garcia Gretel Riveron-Forment Otman Fernandez-Concepcion Olivia Martinez-Bonne Gisselle Lemus-Molina Isabel Fernandez-Almirall Maria de la Caridad Menendez-Sainz Alina Gonzalez-Quevedo Janis TEells Institute of Neurology and Neurosurgery HavanaCuba National Genetic Center HavanaCuba College of Health Sciences University of Wisconsin-MilwaukeeMilwaukeeUSA

Background and Purpose: Hypertension has serious effects on cerebral blood vessels. Oxidative stress seems to be implicated in blood pressure elevation, through increased reactive oxygen species and/or decreased antioxidant capacity. Recently blood markers indicating damage to the central nervous system were reported to be increased in hypertensive patients. However, it is unknown whether antioxidant capacity is related to these changes. This study was designed to explore if the concentration of blood markers for nervous tissue damage was associated to antioxidant capacity in hypertensive patients. Methods: Twenty hypertensive patients and 23 healthy controls were studied. They were paired by age, sex, ethnicity, or risk factors. Serum neuron specific enolase (NSE) and S100 calcium binding protein B (S100B) were measured as nervous tissue damage markers, as well as the activity of antioxidant enzymes (catalase, glutathione peroxidase, glutathione reductase and gamma-glutamyltransferase). Results: Serum neuronal specific enolase (NSE) and S100 calcium binding protein B (S100B) concentrations determined by immunoassay were significantly increased in patients vs. controls. The activities of antioxidant enzymes measured by spectrophotometry showed that plasmatic catalase and erythrocytic glutathione peroxidase were significantly increased in patients, but erythocytic catalase was decreased. Gamma-glutamyltransferase activity was significantly correlated with S100B in hypertensive patients, while erythrocytic catalase activity was decreased in subjects with higher NSE levels. Conclusion: This preliminary investigation suggested that antioxidant status might be modulated through changes in antioxidant enzymatic activity in hypertensive patients. The association of some of these changes with peripheral markers of damage to the central nervous system could indicate that the increased levels of these proteins in hypertension are partly related to oxidative stress.

关键词： Hypertension Gamma-glutamyltransferase Catalase Neuron Specific Enolase S100 Calcium Binding Protein B