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ESCRT-I Component VPS23A Sustains Salt Tolerance by Strengthening the SOS module in Arabidopsis

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molecular Plant 2020年第8期13卷 1134-1148页

作者： Lijuan Lou Feifei Yu miaomiao Tian Guangchao Liu Yaorong Wu Yujiao Wu Ran Xia jose m.pardo Yan Guo Qi Xie State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyThe Innovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101 P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193P.R.China Instituto de Bioquimica Vegetal y Fotosintesis Consejo Superior de Investigaciones Cientificas and Universidad de SevillaSevilla 41092Spain

The Salt-Overly-Sensitive(SOS)signaling module,comprising the sodium-transport protein SOS1 and the regulatory proteins SOS2 and SOS3,is well known as the central salt excretion system,which helps protect plants against salt *** we report that VPS23A,a component of the ESCRT(endosomal sorting complex required for transport),plays an essential role in the function of the SOS module in conferring plant salt ***23A enhances the interaction of SOS2 and *** the presence of salt stress,VPS23A positively regulates the redistribution of SOS2 to the plasma membrane,which then activates the antiporter activity of SOS1 to reduce Na+accumulation in plant *** evidence demonstrated that plant salt tolerance achieved by the overexpression of SOS2 and SOS3 dependeds on *** together,our results revealed that VPS23A is a crucial regulator of the SOS module and affects the localization of SOS2 to the cell ***,the strong salt tolerance of Arabidopsis seedlings conferred by the engineered membrane-bound SOS2 revealed the significance of SOS2 sorting to the cell membrane in achieving its function,providing a potential strategy for crop salt tolerance engineering.

关键词： SOS pathway ESCRTs VPS23a salt cell membrane

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-mercado Aranza I.Torrado-Tapias Iris K.Salgado jose m.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

Analyzing the multilevel structure of the European airport network

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Chinese Journal of Aeronautics 2017年第2期30卷 554-560页

作者： Oriol Lordan jose m.Sallan Department of management Universitat Politecnica de Catalunya-BarcelonaTech Terrassa 08222 Spain

The multilayered structure of the European airport network（EAN）,composed of connections and flights between European cities,is analyzed through the k-core decomposition of the connections *** decomposition allows to identify the core,bridge and periphery layers of the *** core layer includes the best-connected cities,which include important business air traffic *** periphery layer includes cities with lesser connections,which serve low populated areas where air travel is an economic *** remaining cities form the bridge of the EAN,including important leisure travel origins and *** multilayered structure of the EAN affects network robustness,as the EAN is more robust to isolation of nodes of the core,than to the isolation of a combination of core and bridge nodes.

关键词： Air transport networks Complex networks k-core decomposition Network multilevel structure Robustness

Twists and Gromov Hyperbolicity of Riemann Surfaces

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Acta mathematica Sinica,English Series 2011年第1期27卷 29-44页

作者： Katsuhiko mATSUZAKI jose m. RODRIGUEZ Department of mathematics School of Education Waseda University Shinjuku Tokyo 169-8050 Japan Departamento de matemdticas Universidad Carlos IH de Madrid Avenida de la Universidad 30 28911 Legangs Madrid Spain

The main aim of this paper is to study whether the Gromov hyperbolicity is preserved under some transformations on Riemann surfaces （with their Poincare metrics）. We prove that quasiconformal maps between Riemann surfaces preserve hyperbolicity; however, we also show that arbitrary twists along simple closed geodesics do not preserve it, in general.

关键词： Quasiconformal maps Riemann surfaces Gromov hyperbolicity

Effect of successive sprays on liquid distribution in fluidized beds

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Particuology 2021年第1期19卷 17-24页

作者： Cedric Briens Liliana pardo Reyes Franco Berruti Jennifer mcmillan Institute for Chemicals and Fuels from Alternative Resources Western University22312 Wonderland Rd.IldertonONN0M 2A0Canada Edmonton Research Centre Syncrude Canada Ltd942117th AveEdmontonABT6N 1H4 Canada

In processes such as Fluid Coking^(™),agglomerate formation should be minimized since it reduces the yield of valuable products,and degrades operability because of the fouling of *** experimental model,consisting of an aqueous solution of gum arabic with a dye,has been successfully developed to simulate the formation of agglomerates in the Fluid Coking^(™)process,where bitumen is sprayed into a fluidized bed of coke particles The particles wetted by a spray could be predicted by assuming that all the particles in the wake of bubbles formed from the tip of the spray jet have been wetted by the injected *** transfer of liquid from particles wetted with the spray to dry bed particles was relatively ineffective,as the number of wet particles increased by only 50%.With successive liquid injections,the proportion of the liquid trapped in agglomerates increases in latter injections:large agglomerates from earlier injections accumulate above the grid and are carried by gas bubbles into the spray jet cavity,where they seed fresh agglomerates.

关键词： Fluidized bed Liquid injection Agglomerate formation Fluid Coker

Cellular senescence: is the problem a solution for muscle repair?

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Cellular & molecular Immunology 2023年第5期20卷 429-431页

作者： jose m.Izquierdo Centro de Biologia molecular Severo Ochoa Consejo Superior de Investigaciones CientificasUniversidad Autonoma de Madrid(CSIC/UAM)C/Nicolas Cabrera 1Campus de Cantoblanco28049 MadridSpain

In their recent article in Nature,moiseeva et *** that senescent cells are integral components of the skeletal muscle regenerative niche,showing that they repress regeneration in response to different types of injuries in young mice and that this regeneration is even more profound in aged *** observations point to selective links between the conservation of cell identity traits and two universal senescence hallmarks(i.e.,inflammation and matrix remodeling/fibrosis)across cell types,regeneration times,and aging statuses.

关键词： showing injuries regeneration

A versatile microfluidic device for multiple ex vivo/ in vitro tissue assays unrestrained from tissue topography

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microsystems & Nanoengineering 2020年第1期6卷 806-819页

作者： jose m.de Hoyos-Vega Alan m.Gonzalez-Suarez jose L.Garcia-Cordero Unidad monterrey Centro de Investigacion y de Estudios Avanzados del IPNVia del conocimiento 201Parque PIITApodacaNL 66628Mexico

Precision-cut tissue slices are an important in vitro system to study organ function because they preserve most of the native cellular microenvironments of organs,including complex intercellular ***,during sample manipulation or slicing,some of the natural surface topology and structure of these tissues is lost or ***,we introduce a microfluidic platform to perform multiple assays on the surface of a tissue section,unhindered by surface *** device consists of a valve on one side and eight open microchannels located on the opposite side,with the tissue section sandwiched between these two *** the valve is actuated,eight independent microfluidic channels are formed over a tissue *** strategy prevents cross-contamination when performing assays and enables *** irregular tissues such as an aorta,we conducted multiple in vitro and ex vivo assays on tissue sections,including short-term culturing,a drug toxicity assay,a fluorescence immunohistochemistry staining assay,and an immune cell assay,in which we observed the interaction of neutrophils with lipopolysaccharide(LPS)-stimulated *** microfluidic platform can be employed in other disciplines,such as tissue physiology and pathophysiology,morphogenesis,drug toxicity and efficiency,metabolism studies,and diagnostics,enabling the conduction of several assays with a single biopsy sample.

关键词： metabolism topography versatile

Implicit Continuous User Authentication for mobile Devices based on Deep Reinforcement Learning

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Computer Systems Science & Engineering 2023年第2期44卷 1357-1372页

作者： Christy James jose m.S.Rajasree Government Engineering College Idukki685603India APJ Abdul Kalam Technological University Thiruvananthapuram695016India

The predominant method for smart phone accessing is conﬁned to methods directing the authentication by means of Point-of-Entry that heavily depend on physiological biometrics like,ﬁngerprint or *** continuous authentication initiating to be loftier to conventional authentication mechanisms by continuously conﬁrming users’identities on continuing basis and mark the instant at which an illegitimate hacker grasps dominance of the ***,divergent issues remain *** research aims to investigate the power of Deep Reinforcement Learning technique to implicit continuous authentication for mobile devices using a method called,Gaussian Weighted Cauchy Kriging-based Continuous Czekanowski’s(GWCK-CC).First,a Gaussian Weighted Non-local mean Filter Preprocessing model is applied for reducing the noise pre-sent in the raw input face *** Kriging Regression function is employed to reduce the ***,Continuous Czekanowski’s Clas-siﬁcation is utilized for proﬁcient classiﬁcation between the genuine user and *** this way,the proposed GWCK-CC method achieves accurate authen-tication with minimum error rate and *** assessment of the pro-posed GWCK-CC method and existing methods are carried out with different factors by using UmDAA-02 Face *** results conﬁrm that the proposed GWCK-CC method enhances authentication accuracy,by 9%,reduces the authen-tication time,and error rate by 44%,and 43%as compared to the existing methods.

关键词： Deep reinforcement learning gaussian weighted non-local meanﬁlter cauchy kriging regression continuous czekanowski’s implicit continuous authentication mobile devices

morphodynamics of sandy beaches under the influence of storm sequences:Current research status and future needs

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Water Science and Engineering 2019年第3期12卷 221-234页

作者： Sonja Eichentopf Harshinie Karunarathna jose m.Alsina Department of Civil and Environmental Engineering Imperial College London South Kensington Campus London SW7 2AZ UK College of Engineering Swansea University Bay Campus Swansea SA1 8EN UK Laboratori d'Enginyeria marítima Universitat Politecnica de Catalunya Barcelona 08034 Spain

This paper reviews and discusses the current research status, trends, and future needs in the field of beach morphodynamics under the influence of storm *** paper reviews how the three main research methods, field investigations, numerical modelling, and physical modelling, have been used to study beach morphodynamics during storm *** quantitative definitions of storm sequences at different sites are presented and *** is shown that the definition of storm sequences is site-specific and requires knowledge of the storm climate, beach characteristics, and the temporal scale of beach ***, the paper brings together currently available approaches aimed at describing the effect of storm sequences on beach erosion in a general *** importance of storm chronology and the effects of an extreme storm within a sequence of storms are *** that, the more poorly studied aspect of beach recovery in between storms within a sequence is *** indicators for defining beach recovery, namely the shoreline location, sediment volumes, and the beach state, are identified and ***, important research needs, including the need for detailed physical modelling, are identified.

关键词： Storm sequences Beach morphodynamics Beach erosion Extreme storms Return period Beach recovery