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Congenitally Corrected Transposition of the Great Arteries: Conduction Anomalies: A Case Report

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World Journal of Cardiovascular Diseases 2021年第9期11卷 439-444页

作者： jose Antonio Luna-Alvarez-Amezquita Javier Ivan Armenta-Moreno Joaquin Berarducci Jorge luis Bermudez-Gonzalez jose luis siller-nava Edson Alberto Escandón-Villalobos Nilda Espinola-Zavaleta Roberto Cano-Zarate Juan Ignacio Straface Department of Nuclear Cardiology National Institute of Cardiology Ignacio Chavez Mexico City Mexico Department of Echocardiography ABC Medical Center I.A.P. Mexico City Mexico Department of Magnetic Resonance National Institute of Cardiology Ignacio Chavez Mexico City Mexico

Introduction: Congenitally corrected transposition of the great arteries (CCTGA) is a rare heart disease that encompasses an atrioventricular and ventriculoarterial discordance and accounts for less than 1 percent of congenital heart diseases. Objective: To present an atypical case of a man with complex congenital heart disease and conduction anomalies. Case Presentation: This is a case of a 34-year-old patient who came to the hospital with 1 week of dyspnea on exertion and episodes of lipothymia. The patient was referred to our hospital after an electrocardiogram from his primary care with evidence of blocked atrial fibrillation. During the initial evaluation blocked atrial fibrillation was confirmed with a rescue ventricular rate of 38 bpm. A magnetic resonance confirmed the presence of the atrioventricular and ventriculoarterial discordance, the aorta had a left anterior position, perimembranous ventricular septal defect with a right to left shunt, biventricular systolic dysfunction, moderate tricuspid, and mitral regurgitation, interventricular septal intramyocardial and biatrial fibrosis, left atrial dilation, and dilation of the pulmonary artery. After pacemaker placement, the patient has an improvement in his clinical symptoms and quality of life. Conclusions: Cardiac arrhythmias are CCTGA’s leading cause of death, mostly ventricular tachycardia, and atrial fibrillation. Right bundle branch block is a previously unreported and potentially very rare presentati

关键词： Congenital Heart Disease Congenitally Corrected Transposition of the Great Arteries Cardiac Magnetic Resonance Echocardiography Arrhythmia

Interferon Regulatory Factor 5 and Renin-Angiotensin-Aldosterone System Polymorphisms in Coronary Artery Disease: An Overview of Experimental and Clinical Studies

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World Journal of Cardiovascular Diseases 2021年第7期11卷 332-341页

作者： Jorge luis Bermudez-Gonzalez Rodrigo Dagio-Cuellar Cristina Villarreal-Guerrero Ana Gilabert-Garcia luis Angel Ferral-Barbabosa Joaquin Berarducci jose luis siller-nava jose Antonio Luna-Alvarez-Amezquita Javier Iván Armenta-Moreno Nilda Espínola-Zavaleta Erick Alexanderson-Rosas Juan Ignacio Straface National Institute of Cardiology Ignacio Chavez Mexico City Mexico Medicine Faculty of National Autonomous University of Mexico Mexico City Mexico

Heart diseases are the main cause of mortality in Mexico, being coronary heart disease the most frequent in the country. Its high prevalence makes important the study of the pathophysiology and the search for prognostic factors. Different genes and polymorphisms promote atherogenesis and coronary artery disease, they affect inflammatory and vascular pathological processes. Interferon regulatory factor 5 (IRF5) is associated with coronary heart disease, it promotes chronic inflammation and cytokines release;it could trigger immune reactions and its activating receptors express in the vascular endothelium. Besides, polymorphisms in the renin-angiotensin-aldosterone system (RAAS) are implied with coronary disease, they are found in angiotensinogen (AGT), angiotensin II type 1 receptor (AT1R), angiotensin II type 2 receptor (AT2R), and angiotensin-converting enzyme (ACE) genes. These genetic polymorphisms are associated with a prothrombotic state, endothelial dysfunction, and immune activation. Multiple experimental studies showed that chronic activation of RAAS and chronic expression of IRF5 generates an environment prone to the development of atherosclerosis, and autoimmune and cardiovascular diseases. Studying these specific genes and their relationship with coronary heart disease will allow a better understanding of the pathological process and possibly the quest for new treatments.

关键词： Interferon Regulatory Factor 5 (IRF5) Angiotensin-Converting Enzyme (ACE) Angiotensinogen (AGT) Angiotensin II Type 1 Receptor (AT1R) Angiotensin II Type 2 Receptor (AT2R) Polymorphisms

Cerebral dopamine neurotrophic factor transfection in dopamine neurons using neurotensin-polyplex nanoparticles reverses 6-hydroxydopamine-induced nigrostriatal neurodegeneration

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Neural Regeneration Research 2022年第4期17卷 854-866页

作者： Manuel A.Fernandez-Parrilla David Reyes-Corona Yazmin M.Flores-Martinez Rasajna Nadella Michael J.Bannon Lourdes Escobedo Minerva Maldonado-Berny Jaime Santoyo-Salazar luis O.Soto-Rojas Claudia Luna-Herrera jose Ayala-Davila Juan A.Gonzalez-Barrios Gonzalo Flores Maria E.Gutierrez-Castillo Armando JEspadas-Alvarez Irma A.Martínez-Dávila Porfirio nava Daniel Martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa Institucional de Biomedicina Molecular Escuela Nacional de Medicina y HomeopatíaInstituto Politécnico NacionalCiudad de MéxicoMéxico Department of Biosciences IIIT-SrikakulamRajiv Gandhi University of Knowledge Technologies(RGUKT)Andhra PradeshIndia Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de MéxicoTlalnepantla de BazEdo.de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasCiudad de MéxicoMéxico Laboratorio de Medicina Genómica Hospital Regional“1°de Octubre”ISSSTECiudad de MéxicoMéxico Laboratorio de Neuropsiquiatría Instituto de FisiologíaBenemérita Universidad Autónoma de PueblaPueblaPueblaMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Programa de Nanociencias y nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Overexpression of neurotrophic factors in nigral dopamine neurons is a promising approach to reverse neurodegeneration of the nigrostriatal dopamine system,a hallmark in Parkinson's *** human cerebral dopamine neurotrophic factor(h CDNF)has recently emerged as a strong candidate for Parkinson's disease *** study shows that h CDNF expression in dopamine neurons using the neurotensinpolyplex nanoparticle system reverses 6-hydroxydopamine-induced morphological,biochemical,and behavioral *** independent electron microscopy techniques showed that the neurotensin-polyplex nanoparticles containing the h CDNF gene,ranging in size from 20 to 150 nm,enabled the expression of a secretable h CDNF in *** injection in the substantia nigra compacta on day 21 after the 6-hydroxydopamine lesion resulted in detectable h CDNF in dopamine neurons,whose levels remained constant throughout the study in the substantia nigra compacta and *** with the lesioned group,tyrosine hydroxylase-positive(TH^(+))nigral cell population and TH+fiber density rose in the substantia nigra compacta and striatum after h CDNF *** increase inβIII-tubulin and growth-associated protein 43 phospho-S41(GAP43 p)followed TH^(+)cell recovery,as well as dopamine and its catabolite *** reversal(80%)of drugactivated circling behavior and full recovery of spontaneous motor and non-motor behavior were ***-derived neurotrophic factor recovery in dopamine neurons that also occurred suggests its participation in the neurotrophic *** findings support the potential of nanoparticle-mediated h CDNF gene delivery to develop a disease-modifying treatment against Parkinson's *** Institutional Animal Care and Use Committee of Centro de Investigación y de Estudios Avanzados approved our experimental procedures for animal use(authorization No.162-15)on June 9,2019.

关键词： axonal growth brain-derived neurotrophic factor gene delivery nanoparticles neuritogenesis neuronal cytoskeleton neuroregeneration neurorestoration neurotrophic therapy Parkinson's disease reinnervation substantia nigra

Diagnosis of breast cancer by analysis of sialic acid concentrations in human saliva by surface-enhanced Raman spectroscopy of silver nanoparticles

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Nano Research 2017年第11期10卷 3662-3670页

作者： Aida Hernandez-Arteaga jose de Jeses Zermeno nava Eleazar Samuel Kolosovas-Machuca J. Jesus Velazquez-Salazar Ekaterina Vinogradova Miguel jose-Yacaman Hugo Ricardo navarro-Contreras Coordinacion para la Innovacion y Aplicacion de la Ciencia y la Tecnologia(CIACYT) Universidad Autonoma de San Luis Potosi(A)lvaro Obregon 64 San Luis Potosi S.L.P.78000 Mexico Division de Gineco-Obstetricia Hospital Central Dr.Ignacio Morones Prieto Ave.Venustiano Carranza 2395 Zona Universitaria San Luis Potosi S.L.P.78290 Mexico Department of Physics and Astronomy University of Texas at San Antonio San Antonio TX 78249 USA

Breast cancer is the most common type of malignant tumor among women and their second leading cause of cancer-related *** most common method for screening and diagnosis is ***,two main problems have been ***,the dose of radiation received during the test prevents the method from the use on women who are 〈 40 years ***,there can be mammogram failure owing to the lack of tumor contrast with the fibrous ***,there is a need for screening methods that will help to identify high-risk *** developed a biological marker test that can help to identify *** levels of sialic acid （SA） in saliva are known to correlated with breast *** this study,we evaluated the feasibility of Raman spectroscopy as a method for quantification of SA in saliva,using citrate-reduced silver nanoparticles （cit-Ag-NPs） as a surface-enhanced Raman spectroscopy （SERS） *** of SA was accomplished by measuring its intensity in saliva and comparing it with a calibration curve of SA *** mean SA concentration in saliva was found to be significantly higher among 100 breast cancer patients （18.3 ＆#177; 9.4 mg＆#183;dL-1;mean ＆#177; SD） than among 106 healthy controls （3.5 ＆#177; 1.0 mg＆#183;dL-1）.The SERS test showed sensitivity of 94% and specificity 98% for detection of patients with breast cancer,assuming that SA concentration 〉 7 mg＆#183;dL-1 is a cutoff for positive test *** findings prove the usefulness of this SERS technique as a simple,convenient,and highly sensitive method of quantitative analysis of SA in *** simplicity of this nanotechnological test may help to substantially reduce the mortality among patients with breast cancer by providing women with a simple,noninvasive screening test that can be applied regardless of age or density of breast tissue.

关键词： breast cancer surface-enhanced Raman spectroscopy (SERS) Raman nanoparticles sialic acid

A High-Resolution Modeling Strategy to Assess Impacts of Climate Change for Mesoamerica and the Caribbean

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American Journal of Climate Change 2016年第2期5卷 202-228页

作者： Robert Oglesby Clinton Rowe Alfred Grunwaldt Ines Ferreira Franklyn Ruiz Jayaka Campbell luis Alvarado Francisco Argenal Berta Olmedo Alejandro del Castillo Pilar Lopez Edwards Matos Yosef nava Carlos Perez Joel Perez Department of Earth and Atmospheric Sciences University of Nebraska Lincoln NE USA Climate Change and Sustainability Division Inter-American Development Bank Washington DC USA Instituto de Hidrología Meteorología y Estudios Ambientales de Colombia Bogota Colombia University of the West Indies Kingston Jamaica Instituto Meteorológico Nacional Costa Rica San Jose Costa Rica Servicio Meteorológico Nacional de Honduras Dirección General de Aeronáutica Civil Tegucigalpa Honduras Empresa de Transmisión Eléctrica Paname?a Ciudad de Panamá Panamá Water Center for the Humid Tropics of Latin America and the Caribbean (CATHALAC) Ciudad de Panamá Panamá Unidad de Análisis Meteorológico Empresa de Transmisión Eléctrica Paname?a Ciudad de Panamá Panamá Instituto Nacional de Ecología y Cambio Climático Mexico City Mexico National Weather Service MARN San Salvador El Salvador

Mesoamerica and the Caribbean are low-latitude regions at risk for the effects of climate change. Global climate models provide large-scale assessment of climate drivers, but, at a horizontal resolution of 100 km, cannot resolve the effects of topography and land use as they impact the local temperature and precipitation that are keys to climate impacts. We developed a robust dynamical downscaling strategy that used the WRF regional climate model to downscale at 4 - 12 km resolution GCM results. Model verification demonstrates the need for such resolution of topography in order to properly simulate temperatures. Precipitation is more difficult to evaluate, being highly variable in time and space. Overall, a 36 km resolution is inadequate;12 km appears reasonable, especially in regions of low topography, but the 4 km resolution provides the best match with observations. This represents a tradeoff between model resolution and the computational effort needed to make simulations. A key goal is to provide climate change specialists in each country with the information they need to evaluate possible future climate change impacts.

关键词： Regional Climate Models Dynamical Downscaling Strategy Mesoamerica and Caribbean Climate Change