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Long-Term Follow-Up of 82 Cavernous Sinus Meningiomas Treated with Radiosurgery

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Journal of Cancer Therapy 2014年第11期5卷 1005-1011页

作者： Mari Pascual Gallego jose Samblas jose Carlos Bustos jose Angel Gutierrez diaz Marisa Gonzalez Kita Sallabanda[1 1Departament of Neurosurgery Hospital Clínico San Carlos Universidad Complutense de Madrid Madrid Espana Departament of Neurosurgery Hospital Clínico San Carlos Universidad Complutense de Madrid Madrid Espana Neuro-Oncology Unit Hospital San Francisco de Asís—Grupo IMO Madrid Espana

The cases of 82 patients with cavernous sinus meningioma (CSM) treated with Stereotactic Radiosurgery (SRS) at our institution from 1992 to 2005 were retrospectively reviewed. The mean follow-up time was 8.38 years. Patients’?age ranged between 16 and 78 years (mean 51). There were 35 patients who had been operated before, and two of them had been treated with fractionated radiotherapy. Twenty-three from 35 patients were surgically intervened?(65.7%)?and?presented post-surgical morbidity. Only in 3 cases the surgery was considered complete. The patients were referred for SRS treatment due to having tumour remains or a tumour growth. The mean volume of the tumour was 17.96 (+/?13.67) cm3.?All the patients had been treated with a Linear Accelerator (LINAC) using a high precision positioning and radiation system (SRS 2000) University of Florida. The clinical progress of the patients was assessed using preand post-SRS radiological imaging, post-surgical and pre-post-SRS morbidity and mortality. Tumour volume decreased significantly with RS in 61 of 82 patients (74.4%). The tumour volume remained stable 12 patients (14.6%) and only in 9 patients (11%) was there tumour growth after SRS. Of these, 5 required surgical intervention, and 7 of the 82 underwent SRS or another fractionated stereotactic radiotherapy after the RS. Morbidity due to the SRS was only seen in 14 out of the 82 patients treated with SRS, five of them recovered completely. SRS is a high precise and effective treatment with low morbidity, becoming more and more the option of choices?in the treatment of cavernous sinus meningioma.

关键词： Cavernous Sinus Meningioma Radiosurgery LINAC

Synthesis of Tantalum Hydride Using Mechanical Milling and Its Characterization by XRD,SEM,and TGA

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Advances in Nanoparticles 2014年第4期3卷 159-166页

作者： jose luis Iturbe-Garcia Beatriz Eugenia Lopez-Munoz Chemistry Department National Institute of Nuclear ResearchesOcoyoacacMexico

In this paper, we report the results obtained from different phases of metal hydrides. The synthesis and characterization of tantalum hydrides were obtained “in situ” during mechanical milling. Elemental Ta with purity of 99.8% was used in this investigation to obtain the hydrides. A highenergy ball milling technique was utilized to prepare hydrogenated phases. Ta hydrides and oxides were formed as function of milling process time. Milling times of 5, 10 and 20 hours were programmed, and the ball-to-powder weight ratio was 10:1. The material was first characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD). Before and after hydrogenation process the material was also analyzed by TGA. X-ray diffraction analysis demonstrated that only tantalum hydrides (Ta2H and TaH0.5) were obtained after 20 h of milling. We will discuss the effect of the ball-milling process about formation “in situ” of nanometric tantalum hydrides with methanol as a hydrogen source.

关键词： Nanometric Ta Hydrides Mechanical Milling Methanol Dissociation XRD TGA SEM

A Holistic Model for the Development of Entrepreneurial Competencies of the Entrepreneur XXI： The Tree Model

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Chinese Business Review 2012年第3期11卷 309-321页

作者： jose luis Soares Ferreira Cristina Maria Pinto Albuquerque Tree Institute Lisbon Portugal University of Coimbra Coimbra Portugal

In the present article it will be critically questioned the traditional entrepreneurship education approaches based on a narrow conception of competency, and their values. Assuming the perspective that to be an entrepreneur is basically an attitude towards life and the world, there proposed holistic, constructivist and experiential processes and strategies for entrepreneurship education. The ＂entrepreneur XXI＂, must be able to undertake a social function of change, so, an economical and social development more human, ethical and intelligent. Under this assumption, the ＂Tree Model for the Development of Entrepreneurial Competencies＂, that will be discussed globally in the second part of this article, suggests a dynamic and experiential approach ofentrepreneurship education based on the qualification of people＇s behaviour, self-esteem, competencies and experiences; a profile of key behavioural and performance competencies （root）, experimental pedagogical procedures （trunk） and real results within group projects （fruits）. This model has been developed during the last decade （2001-2011）, using a multidisciplinary research-action procedure, within business, education （at different teaching levels） and social project environments.

关键词： entrepreneurship education competency tree model entrepreneur XXI

Revamping Newtonian Gravity

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International Journal of Geosciences 2014年第7期5卷 684-689页

作者： Donald H.Eckhardt jose luis Garrido Pestana Canterbury NHUSA Departamento de Fsica Universidad de JaenCampus Las LagunillasJaenSpain

The nineteenth century’s quest for the missing matter (Vulcan) ended with the publication of Einstein’s General Theory of Relativity. We contend that the current quest for the missing matter is parallel in its perseverance and in its ultimate futility. After setting the search for dark matter in its historic perspective, we critique extant dark matter models and offer alternative explanations—derived from a Lorentz-invariant Lagrangian—that will, at the very least, sow seeds of doubt about the existence of dark matter.

关键词： Gravitons Dark Matter Dark Energy

Modifications of L-Glutamine and L-Leucine Transport in Proliferating Lymphocytes

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Journal of Biosciences and Medicines 2015年第3期3卷 104-109页

作者： Francisco Sanchez jose luis Gil Macarena Perán Department of Biochemistry Molecular Biology and Immunology University of Málaga Málaga Spain Department of Health Sciences University of Jaén Jaén Spain

Lymphocytes respond to mitogens that stimulate proliferation by increasing theirs metabolic activity. In this study we investigate L-Glutamine and L-Leucine uptake as markers of cell response to Concavalina A (ConcaA) stimulation, using a high-resolution flow technique. We found that lymphocytes induced to blast transformation enhanced rate and efficiency of amino acid uptake during cell proliferation. Considering that increases in transport is the first quantifiable response of cells during malignant transformation, amino acid uptake could also be useful as an early marker of malignancy.

关键词： Cell Membrane Transport Lymphocytes L-Glutamine L-Leucine Malignancy Biomarkers

A New Path to Create Solutions for Quantum Annealing Problems

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Journal of Quantum Information Science 2021年第3期11卷 112-123页

作者： jose luis Hevia Ezequiel Murina Guido Peterssen Mario Piattini aQuantum: Alhambra IT Madrid Spain aQuantum/University of Castilla-La Mancha Ciudad Real Spain

Quantum computing has already become a technology to be used by large companies in finance, distribution, health care, chemistry, etc. Among the different approaches, quantum annealing is one of the most promising in the short term. However, software development platforms do not offer user-friendly interfaces for the definition of annealing problems. In this paper we present a solution to this problem: QPath®’s Annealer Compositor that facilitates the definition and execution of annealing algorithms in either quantum annealing or digital annealing computers. An example based on a nurse work schedule is used for illustrating this special interface.

关键词： Quantum Software Quantum Annealing QPath Annealer Compositor

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高含硫量锂硫电池用一维碳基材料

高含硫量锂硫电池用一维碳基材料

作者： Flores Mamani jose luis 浙江大学

学位级别：硕士

锂硫电池技术的高理论容量（1672 mA h g-1）比目前应用于锂离子电池的过渡金属氧化物阴极高出6倍,这使得它在运输与储能系统方面具有强大的吸引力,除此以外,锂硫电池还能提供较高的理论能量密度（2567 W h kg-1）。然而,每一项技术都... 详细信息

锂硫电池技术的高理论容量（1672 mA h g-1）比目前应用于锂离子电池的过渡金属氧化物阴极高出6倍,这使得它在运输与储能系统方面具有强大的吸引力,除此以外,锂硫电池还能提供较高的理论能量密度（2567 W h kg-1）。然而,每一项技术都有其缺陷,对于锂硫电池来说也是如此。尽管锂硫电池有着明显优势和良好的前景,目前仍存在一些问题阻碍了其实际应用,如硫的绝缘性能、硫变成硫化锂时的大体积膨胀、固体电解质界面的不均匀形成和树枝状物的形成等,这些问题在高含硫量的阴极上表现得更为明显,但运用传统浆液涂层工艺来制备硫磺阴极却可能无法达到预期的高能量密度,依靠集电体、粘合剂、导电碳等非活性材料来制备硫磺阴极会降低锂硫电池的整体能量密度,因此,急切需要找到制备硫磺阴极的替代方法。本项工作提出了三种实用和直接的方法来克服上述问题,它们分别在第三、第四和第五章中作详细介绍。第一种方法是在不同的含硫量下,通过简单的真空过滤,仅用碳纳米管作为粘合剂、电流收集器和导电剂来设计和制备含硫阴极。对于硫含量为50-70%的阴极来说,临界硫含量约为7 mg cm-2。而研究发现,仅使用MWCNTs会受到临界硫含量的限制,当高于该值时,阴极的厚度会增加,电阻相应增加,电压下降导致较低平台处的电压分布显示出强烈的钝化。在此条件下制备的阴极显示出1400 mA h g-1（约9.8 mA h cm-2）的良好放电能力,使得其在基于电极总质量的条件下具备约1900 W h kg-1的高能量密度。在第二种方法中,开发了一种三维无粘结剂电极。这种简单的合成方法在稳定的3D活性碳纤维毡（S-MWCNTs/ACFF）上毡合和吸附硫沉积的多壁碳纳米管。此外,在设计的电极中还产生了杂化效应。毡合的碳纳米管膜起硫基质的作用,而吸附/浸渍在碳纤维表面的碳纳米管则如同一个中间层,起着多硫化物捕捉器和硫沉淀主体的作用。与此同时,在碳纤维上形成平行的中孔提高了电极的电化学性能,改变了电极的整体电子转移路径,与独立式碳纳米管（S-MWCNTs）电极相比,这种电子转移路径使电极获得了较低的电荷转移电阻。电化学结果表明,硫负载量为7 mg cm-2的独立式S-MWCNTs电极的初始放电容量仅为790 mA h g-1,并且在108圈循环后失效,与其相比,硫负载量为8 mg cm-2的S-MWCNTs/ACFF电极的初始放电容量则为1197 mA hg-1,300圈循环后保持500 mA h g-1的可逆容量,硫利用率和可循环性都得到了显著的提高,这是因为锂在锂阳极上沉积得更好,并且多硫化锂约束得到了改善。结果表明,通过形成分级孔来设计具有双电子转移路径的硫电极,可以延长锂硫电池的循环寿命,避免阴极负载硫量大的锂硫电池在充电过程中出现“猝死”现象。在第三种方法中,在活性碳纤维毡（ACFF）上化学沉积MnO2制成双功能中间层后,将其插入重硫阴极（＞10 mg cm-2）和电池隔膜之间。得益于其分层的微/中尺度孔隙结构特征和MnO2的多硫化物保持能力,一个使用MnO2@ACFF中间层的电池（含有一个15 mg cm-2的阴极）在2 mA cm-2下进行350圈评估循环后显示出1072 mA h g-1的高可逆容量和430 mA h g-1的高容量保持率。此外,两个使用MnO2@ACFF中间层的电池（含有一个20 mg cm-2的阴极和一个30 mg cm-2的阴极）在0.1 C下进行100圈评估循环后显示出初始容量分别为1133和1051,最终容量分别为736和446 mA h g-1。这种电化学性能和简单的制备证明,MnO2基ACFF中间层可以有效地减缓多硫化物在重硫阴极中的扩散,从而延长锂硫电池的寿命。

关键词：锂硫电池多壁碳纳米管活性碳纤维毡高含硫量硫阴极分级孔隙二氧化锰中间层

Mullim-墨西哥传统菜Mole创业研究

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Mullim-墨西哥传统菜Mole创业研究

作者： jose luis Garcia Vazquez 上海外国语大学

学位级别：硕士

本论文旨在研究在墨西哥创建一家生产销售墨西哥传统食品Mole的品牌企业的可行性。Mole是一种墨西哥传统酱汁,将以Mullim为商标以表达产品的丰富的历史文化传统。本研究将探讨企业构想的可行性,以及在墨西哥市场和国际市场成功的可能性... 详细信息

本论文旨在研究在墨西哥创建一家生产销售墨西哥传统食品Mole的品牌企业的可行性。Mole是一种墨西哥传统酱汁,将以Mullim为商标以表达产品的丰富的历史文化传统。本研究将探讨企业构想的可行性,以及在墨西哥市场和国际市场成功的可能性。本研究在蓝海战略、价值链分析、波特五力模型以及PEST模型的基础上构建企业的总体战略。当前墨西哥超市中销售的Mole虽然廉价但质量平平,为数不多的优质Mole通常没有品牌影响力。计划成立的公司将采用家族企业为基础的小型私营公司形式。除了采用具有文化传统内涵的Mullim为品牌外,公司还将通过产品的包装形式强调其文化品位。本研究涵盖公司和品牌创立所需的所有元素,包括品牌建设、公司架构、产品开发和生产、零售渠道,以及公司在市场中发展所需的管理手册和运营流程。本研究还采用严格的财务标准对企业各环节财务可行性进行了分析验证。Mullim将在本研究的基础上首先在墨西哥城开展业务,待条件成熟后将在墨西哥其他地区以及国际市场拓展市场。本研究的创新之处在于通过现代管理理念将一种传统食品提升为拥有丰富文化内涵和国际市场潜力的高端商品。本研究不仅能为公司实际运营打下基础,还可以为类似商业计划提供借鉴参考作用。

关键词：战略创业计划墨西哥市场 Mole Mullim

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基于格的电子投票系统原型设计

基于格的电子投票系统原型设计

作者： NARANJO VILLOTA jose luis 西南交通大学

学位级别：硕士

随着硬件和软件的增强,经典计算机甚至量子计算都变得越来越强大。这给现有的电子投票系统的安全性带来严重隐患。本文件设计了一个电子投票系统。该系统提供针对基于量子计算机攻击的安全性,并优化了现有解决方案。本方案的优点在于使... 详细信息

随着硬件和软件的增强,经典计算机甚至量子计算都变得越来越强大。这给现有的电子投票系统的安全性带来严重隐患。本文件设计了一个电子投票系统。该系统提供针对基于量子计算机攻击的安全性,并优化了现有解决方案。本方案的优点在于使用一种极其困难的数学问题来解决系统的强安全,这种方法被称为学习错误(LWE),即使使用量子计算机也已证明难以解决。本文的投票系统基于Brakerski,Gentry和Vaikuntanathan提出的名为BGV的同态加密系统。该系统提供了一个密码系统,它基于R-LWE问题的安全性(原始LWE问题的变化),并提供一定程度的同态运算能力,具有足够的能力来实施投票系统。利用Wu等人开发的基于格的数字签名算法(DSA),协议提供一些用于选民的其他加密安全服务。本论文利用同态加密库(HELib)开发了原型系统,实现BGV密码系统。使用IDE ***提供与库兼容的开发平台,同时可以用于开发图形用户界面应用程序。上述原型可在GitHub存储库免费获得:https://***/joseluisnaranjo/HEVotingSystem。

关键词： LWE 同态加密 BGV DSA 格子