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An elastin-like recombinamer-based bioactive hydrogel embedded with mesenchymal stromal cells as an injectable scaffold for osteochondral repair

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Regenerative Biomaterials 2019年第6期6卷 335-347页

作者： Filippo Cipriani Blanca Arino Palao Israel Gonzalez de Torre Aurelio Vega Castrillo Hector jose Aguado Hernandez Matilde Alonso Rodrigo Angel jose Alvarez Barcia Ana Sanchez Veronica Garcıa Diaz Monica Lopez Pena jose carlos rodriguez-cabello Technical Proteins Nanobiotechnology S.L. Paseo Belen 9AValladolid 47011Spain Departamento de traumatologıa Hospital Clınico de ValladolidAv.Ramon y Cajal 3Valladolid 47003Spain Bioforge University of Valladolid CIBER-BBNPaseo de Belen 19Valladolid 47011Spain SIBA-UVA:servicio investigacion y bienestar animal University of ValladolidC/Plaza de Santa Cruz 8Valladolid 47002Spain Instituto de Biologıa y Genetica Molecular(IBGM) Universidad de Valladolid y CSICCalle Sanz y Fores 3Valladolid 47003Spain Facultad de veterinaria Campus UniversitarioAvda.Carballo Calero s/nLugo 27002Spain

The aim of this study was to evaluate injectable,in situ cross-linkable elastin-like recombinamers(ELRs)for osteochondral *** the ELR-based hydrogel alone and the ELR-based hydrogel embedded with rabbit mesenchymal stromal cells(rMSCs)were tested for the regeneration of critical subchondral defects in 10 New Zealand ***,cylindrical osteochondral defects were filled with an aqueous solution of ELRs and the animals sacrificed at 4months for histological and gross evaluation of features of biomaterial performance,including integration,cellular infiltration,surrounding matrix quality and the new matrix in the *** both approaches helped cartilage regeneration,the results suggest that the specific composition of the rMSC-containing hydrogel permitted adequate bone regeneration,whereas the ELR-based hydrogel alone led to an excellent regeneration of hyaline *** conclusion,the ELR cross-linker solution can be easily delivered and forms a stable well-integrated hydrogel that supports infiltration and de novo matrix synthesis.

关键词： biopolymer animal test cartilage bone

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Warm Forged Medium Carbon V Steel

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Journal of Iron and Steel Research International 2011年第S1期18卷 822-826页

作者： carlos Garcia-Mateo Beatriz Lopez jose Maria rodriguez-Ibabe MATERALIA Research Group.Department of Physical Metallurgy Centro Nacional de Investigaciones Metalúrgicas (CENIM-CSIC)Avda.Gregorio del Amo 8.E-28040MadridSpain CEIT and TECNUM (University of Navarra) Po Manuel de Lardizabal 15San SebastianE-20018Basque ContrySpain

Nowadays there is a continuous demand,particularly from the automotive industry,for cheaper,lighter and more reliable *** is not surprising then that steel research has been focused during the last decades in new qualities and *** paper is dealing with the use of vanadium microalloyed steels on one of those new processes,warm *** its low precipitation temperature and its recognised ability to strengthen steel microstructures via austenite grain growth control,precipitation hardening and interference of the static recrystallization process,vanadium in microalloyed steels seem to be an appropriate candidate for warm forging.

关键词： warm forging vanadium microalloyed steels

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Highly accessible aqueous synthesis of well-dispersed dendrimer type platinum nanoparticles and their catalytic applications

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Nano Research 2019年第5期12卷 1083-1092页

作者： Adrian Fernandez-Lodeiro Jamila Djafari David Lopez-Tejedor carlos Perez-Rizquez Benito rodriguez-Gonzalez jose Luis Capelo jose M.Palomo carlos Lodeiro Javier Fernandez-Lodeiro BIOSCOPE Group LAQV@REQUIMTEChemistry DepartmentFaculty of Science and TechnologyUniversity NOVA of LisbonCaparica CampusCaparica 2829-516Portugal PROTEOMASS Scientific Society Rua dos InventoresMadan ParqueCaparica CampusCaparica 2829-516Portugal Department of Biocatalysis Institute of Catalysis(CSIC)MadridSpainMarie Curie 2CantoblancoUAM CampusMadrid 28049Spain Scientific and Technological Research Assistance Center(CACTI) University of VigoLagoas-MarcosendeVigo 36310Spain

The application of novel methodologies to the synthesis of nanomaterials is still a challenge in many different technological and scientific *** efficient and reproducible synthetic methodologies,that produce fewer residues and reduce the cost of raw materials must be *** the present work,we have explored the attractive possibility to apply the cheap iron (Ⅱ) sulphate salt in the reduction process of the K2PtCl4 to produce colloids *** synthesis took places in water and was assisted by sodium citrate (SC) using polyvinylpyrrolidone (PVP) as a *** adjustment of this novelty process allows obtaining well-dispersed and sub-20 nm dendrimer-type platinum nanoparticles (Pt D-NPs).The nano-dendrimers produced have been characterized using dynamic light scattering (DLS),transmission electron microscopy (TEM),high-resolution TEM (HR-TEM),XRD spectroscopy,inductive couple plasma (ICP) analysis,Fourier transform infrared (FT-IR) and ultraviolet-visible (UV-vis) *** conformational results derived from the size and shape will be *** application of the Pt D-NPs has been explored in the reduction of p-nitrophenol (p-NP) to p-aminophenol (p-AP) in aqueous media at room temperature obtained TOF value of 253 min^-***,our Pt D-NPs were tested as artificial metalloenzyme showing catechol oxidase activity for oxidation of L-DOPA.

关键词： platinum dendrimer NPs catalytic application green synthesis cateohol oxidase-like activity

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T follicular helper expansion and humoral-mediated rejection are independent of the HVEM/BTLA pathway

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Cellular & Molecular Immunology 2017年第6期14卷 497-510页

作者： jose-Ignacio rodriguez-Barbosa carlos Fernandez-Renedo Ana Maria Bravo Moral Leo Biihler Maria-Luisa del Rio Transplantation Immunobiology Section Institute of Biomedicine University of Leon and Castilla and Leon Regional Transplantation Coordination Leon University Hospital Leon Spain Department of Veterinary Clinical Sciences University of Santiago de Compostela Veterinary Faculty Lugo Spain Visceral and Transplantation Surgery Department of Surgery University Hospitals of Geneva and Faculty of Medicine Geneva Switzerland

The molecular pathways contributing to humoral-mediated allograft rejection are poorly defined. In this study, we assessed the role of the herpesvirus entry mediator/B- and T-lymphocyte attenuator （HVEM/BTLA） signalling pathway in the context of antibody-mediated allograft rejection. An experimental setting was designed to elucidate whether the blockade of HVEM/BTLA interactions could modulate de novo induction of host antidonor-specific antibodies during the course of graft rejection. To test this hypothesis, fully allogeneic major histocompatibility complex-mismatched skin grafts were transplanted onto the right flank of recipient mice that were treated with isotype control, anti-CD40L or modulatory antibodies of the HVEM/BTLA signalling pathway. The frequencies of CD4 T follicular helper （Tfh） cells （B220-, CD4＋ CXCR5＋ PD-lhigh）, extrafollicular helper cells （B220-, CD4＋ CXCR5- PD-1＋ and PD-1-） and germinal centre （GC） B cells （B220＋Fas＋ GL7＋） were analysed by flow cytometry in draining and non-draining lymph nodes at day 10 post transplantation during the acute phase of graft rejection. The host antidonor isotype-specific humoral immune response was also assessed. Whereas blockade of the CD40/CD40L pathway was highly effective in preventing the allogeneic humoral immune response, antibody-mediated blockade of the HVEM/BTLA-interacting pathway affected neither the expansion of Tfh cells nor the expansion of GC B cells. Consequently, the course of the host antidonor antibody-mediated response proceeded normally, without detectable evidence of impaired development. In summary, these data indicate that HVEM/BTLA interactions are dispensable for the formation of de novo host antidonor isotype-specific antibodies in transplantation.

关键词： BTLA (CD272) humoral immunity HVEM (TNFRSF14, CD270) T follicular helper cells transplantation

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Twists and Gromov Hyperbolicity of Riemann Surfaces

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Acta Mathematica Sinica,English Series 2011年第1期27卷 29-44页

作者： Katsuhiko MATSUZAKI jose M. rodriguez Department of Mathematics School of Education Waseda University Shinjuku Tokyo 169-8050 Japan Departamento de Matemdticas Universidad Carlos IH de Madrid Avenida de la Universidad 30 28911 Legangs Madrid Spain

The main aim of this paper is to study whether the Gromov hyperbolicity is preserved under some transformations on Riemann surfaces （with their Poincare metrics）. We prove that quasiconformal maps between Riemann surfaces preserve hyperbolicity; however, we also show that arbitrary twists along simple closed geodesics do not preserve it, in general.

关键词： Quasiconformal maps Riemann surfaces Gromov hyperbolicity

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On a Classical Theorem on the Diameter and Minimum Degree of a Graph

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Acta Mathematica Sinica,English Series 2017年第11期33卷 1477-1503页

作者： Veronica HERNANDEZ Domingo PESTANA jose M. rodriguez Universidad carlosⅢde Madrid Avenida de la Universidad3028911 LeganesSpain

In this work, we obtain good upper bounds for the diameter of any graph in terms of its minimum degree and its order, improving a classical theorem due to Erdos, Pach, Pollack and Tuza. We use these bounds in order to study hyperbolic graphs （in the Gromov sense）. To compute the hyperbolicity constant is an almost intractable problem, thus it is natural to try to bound it in terms of some parameters of the graph. Let H（n, δ0） be the set of graphs G with n vertices and minimum degree 50, and J（n, Δ） be the set of graphs G with n vertices and maximum degree A. We study the four following extremal problems on graphs： a（n,δ0） = min{δ（G）｜ G ∈H（n, δ0）}, b（n, δ0） =- max{δ（G）｜ e ∈H（n, δ0）}, α（n, Δ） = min{δ（G） [ G ∈ J（n, Δ）} and β（n,Δ） = max{δ（G） ] G∈Π（n,Δ）}. In particular, we obtain bounds for b（n, δ0） and we compute the precise value of a（n, δ0）, α（n, Δ） and w（n, Δ） for all values of n, r0 and A, respectively.

关键词： Extremal problems on graphs diameter minimum degree maximum degree Gromov hyperbolicity hyperbolicity constant finite graphs

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Alliance Free and Alliance Cover Sets

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Acta Mathematica Sinica,English Series 2011年第3期27卷 497-504页

作者： Juan Alberto rodriguez-VELAZQUEZ jose Maria SIGARRETA Ismael GONZALEZ YERO Sergio BERMUDO Departament d'Enginyeria Informdtica i Matematiques Universitat Rovira i Virgili Av. Paisos Catalans 26 43007 Tarragona Spain Faculty of Mathematics Autonomous University of Guerrero Carlos E. Adame 5 Col. La Garita Acapuleo Guerrero Mexico Departament d'Enginyeria Informatica i Matematiques Universitat Rovira i Virgili Av. Pai'sos Catalans 26 43007 Tarragona Spain Department of Economy Quantitative Methods and Economic History Pablo de Olavide University Carretera de Utrera Kin. 1 41013 Sevilla Spain

A defensive （offensive） k-alliance in F = （V, E） is a set S C V such that every v in S （in the boundary of S） has at least k more neighbors in S than it has in V ／ S. A set X C_ V is defensive （offensive） k-alliance free, if for all defensive （offensive） k-alliance S, S／ X ≠ 0, i.e., X does not contain any defensive （offensive） k-alliance as a subset. A set Y C V is a defensive （offensive） k-alliance cover, if for all defensive （offensive） k-alliance S, S ∩ Y ≠ 0, i.e., Y contains at least one vertex from each defensive （offensive） k-alliance of F. In this paper we show several mathematical properties of defensive （offensive） k-alliance free sets and defensive （offensive） k-alliance cover sets, including tight bounds on their cardinality.

关键词： Defensive alliance offensive alliance alliance free set alliance cover set

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Partitioning a Graph into Defensive k-Alliances

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Acta Mathematica Sinica,English Series 2011年第1期27卷 73-82页

作者： Ismael G.YERO Sergio BERMUDO Juan A.rodriguez-VELAZQUEZ jose M.SIGARRETA Department of Computer Engineering and Mathematics Rovira i Virgili UniversityAv.Pai'sos Catalans 2643007 TarragonaSpain Department of Economy Quantitative Methods and Economic HistoryPablo de Olavide UniversityCarretera de Utrera Kin.141013-SevillaSpain Department of Computer Engineering and Mathematics Rovira i Virgili UniversityAv.Paisos Catalans 2643007 TarragonaSpain Faculty of Mathematics Autonomous University of GuerreroCarlos E.Adame 5Co1.La GaritaAcapulcoGuerreroMexico

A defensive k-alliance in a graph is a set S of vertices with the property that every vertex in S has at least k more neighbors in S than it has outside of S. A defensive k-alliance S is called global if it forms a dominating Set. In this paper we study the problem of partitioning the vertex set of a graph into （global） defensive k-alliances. The （global） defensive k-alliance partition number of a graph Г = （V, E）, ψkgd（F）） ψkd（F）, is defined to be the maximum number of sets in a partition of V such that each set is a （global） defensive k-alliance. We obtain tight bounds on ψkd（F） and ψkgd（F） in terms of several parameters of the graph including the order, size, maximum and minimum degree, the algebraic connectivity and the isoperimetric number. Moreover, we study the close relationships that exist among partitions of F1 × F2 into （global） defensive （kl ＋ k2）-alliances and partitions of Fi into （global） defensive ki-alliances, i ∈ {1, 2}.

关键词： Defensive alliances dominating sets domination isoperimetric number

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Use of a lyophilized bovine pericardium graft to repair tunical defect in patients with Peyronie＇s disease： experience in a clinical setting

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Asian Journal of Andrology 2017年第3期19卷 316-320页

作者： Javier Romero Otero Borja Garcia Gomez jose Medina Polo carlos Pascual Mateoe Silvia Garcia Barreras Eduard Garcia Cruz Javier de la Riva de la Vifia Alfredo rodriguez Antolin 12 de Octubre University Hospital Department of Urology Madrid Spain Monteprincipe University Hospital Department of Urology Madrid Spain Clinic Hospital Department of Urology Barcelona Spain

Many different materials are available for grafting during surgery for Peyronie＇s disease （PD）. To study the outcomes associated with the use of a lyophilized bovine pericardium graft （Peri-Guard） to repair tunical defects in patients with PD, descriptive study of 43 patients with disabling penile curvature was performed. Curvature was measured before and after the intervention using a standardized procedure. Surgical technique was plaque excision and grafting of the tunical defect carried out by a single surgeon. A lyophilized bovine pericardium patch was used for grafting. We measured the change in penile curvature and length, the ability to perform successful sexual intercourse without further pharmacological or surgical treatment, and the satisfaction with treatment. Follow-up data were available for a total of 41 patients. Median age was 50 years （IQR 48-52）; mean follow-up time was 14 ± 6 months. Complete penile straightening was achieved in 33 patients （80.5%） and five patients （12.2%） had curvature under 20. Three months after surgery and stretching therapy, mean （s.d.） flaccid penile length increased from 11.2 ± 2.8 cm to 12.1 ± 2.9 cm （P = 0.062）. Seventy-five percentage of patients reported being able to achieve successful intercourse without further treatment. Eighty-five percentage of patients reported to be satisfied with the treatment. There was no evidence of tissue rejection or infection, and only four patients suffered an adverse event. Plaque excision and grafting of the tunical defect with lyophilized bovine pericardium seems to be a safe and effective treatment for patients with PD.

关键词： penile curvature pericardium patch Peyronie's disease surgical treatment

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Role of artificial intelligence in cardiology

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World Journal of Cardiology 2023年第4期15卷 116-118页

作者： Rafael Vidal-Perez jose Manuel Vazquez-rodriguez Servicio de Cardiología Unidad de Imagen y Función CardíacaComplexo Hospitalario Universitario A Coruña Centro de Investigación Biomédica en Red-Instituto de Salud Carlos ⅢA Coruña 15006A CoruñaSpain Servicio de Cardiología Complexo Hospitalario Universitario A CoruñaA Coruña 15006A CoruñaSpain

Artificial intelligence(AI)is the process of having a computational program that can perform tasks of human intelligence by mimicking human thought *** is a rapidly evolving transdisciplinary field which integrates many elements to develop algorithms that aim to simulate human intuition,decision-making,and object *** overarching aims of AI in cardiovascular medicine are threefold:To optimize patient care,improve efficiency,and improve clinical *** cardiology,there has been a growth in the potential sources of new patient data,as well as advances in investigations and therapies,which position the field well to uniquely benefit from *** this editorial,we highlight some of the main research priorities currently and where the next steps are heading us.

关键词： Artificial intelligence Machine learning Deep learning Electrocardiography Cardiac imaging

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