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Adjuvant Therapy on Cancer of the Lower Rectum. Evaluation of the Effects of Preoperative Radiotherapy on the Prognosis of Patients with Cancer of the Lower Rectum

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Journal of Cancer Therapy 2012年第6期3卷 912-919页

作者： jose alfredo reis neto jose alfredo reis Junior Odorino Kagohara Joaquim Simoes neto Sergio OBanci Luciane HOliveira Surgery Catholic University of CampinasCampinasBrazil Surgery Clinica Reis NetoCatholic University CampinasCampinasBrazil Coloproctology Clinica Reis NetoCatholic University CampinasCampinasBrazil.

Aims: The prognosis on treatment of the cancer of the rectum has not changed in the last fifty years. Survival rates of 50 to 55% seems immutable in several published series. The main cause for those results is the high incidence of recurrence, either local or widespread. Local recurrence is directly related to the number of undifferentiated cells and to the grade of wall invasion. Widespread recurrence depends specifically on the lymphatic and vascular spreading. So any kind of treatment that would diminish the number of undifferentiated cells and the size or the tumor wall penetration would certainly decrease the local recurrence rate, lengthening the interval free from cancer and, perhaps, modifying the long term survival rate. Between 1978 and 2009, a total of 538 patients with adenocarcinoma of the lower rectum (from the pectinate line to 10 cm above) were treated by preoperative radiotherapy. Methodology: The same protocol was used in all the patients – 400 cGy, 200 cGy/day, during 4 consecutive weeks (anterior and posterior pelvic fields) by means of a Linear Megavoltage Accelerator (25 MeV). Surgery was performed 2 months after completion of the radiotherapy. Results: Statistical analysis of the whole group showed that preoperative radiotherapy does decrease frequency of undifferentiated cells. Moreover, the incidence of local recurrence diminished after irradiation by 3.4%. Preoperative radiotherapy reduces tumor volume (ERUS) and wall invasion, as well as the mortality rate due to local recurrence (2.4%) and alters long-term survival rate (80.1%). Conclusion: Preoperative radiotherapy is really effective in reducing the number of undifferentiated cells and in diminishing the tumor volume and the carcinomatous infiltration of the rectal wall.

关键词： Rectal Cancer Cancer of the Lower Rectum Irradiation Preoperative Radiotherapy Local Recurrence Mortality Survival

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Neoadjuvant Radiotherapy in Stage I Cancer of the Lower Rectum

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Journal of Cancer Therapy 2014年第6期5卷 560-564页

作者： Antonio jose Tiburcio Alves Junior Gustavo Alejandro Gutierrez Espinoza Luciane Hiane Oliveira Sergio Oliva Banci Joaquim Simoes neto Odorino Hideyoshi Kagohara jose alfredo reis Junior jose alfredo reis neto Coloproctology Department Clínica Reis Neto Campinas Brazil Coloproctology Department Clinica Reis Neto Catholic University Campinas Campinas Brazil Surgery Department Catholic University of Campinas Campinas Brazil Surgery Department Clinica Reis Neto Catholic University Campinas Campinas Brazil

Introduction: The mortality rate in cancer of the lower rectum is related to the incidence of local recurrence, in the first 5 years. For stage I tumors, local excision has being increasingly used, but recent studies showed a higher incidence rate of local recurrence. Therefore, preoperative radiotherapy should be considered even for these tumors, as an attempt to prevent recurrence and provide cure. Objective: To show the effectiveness of neoadjuvant radiotherapy in stage I cancer of the lower rectum of a cohort population. Materials and Method: A cohort study in a prospective database was made with a total of 75 patients considered as stage I cancer of the lower rectum. Preoperative long course of 4500 cG radiotherapy was performed in this selected group of patients and followed up for a minimum period of five years. Results: Stage I/TI group had 27 patients. All of them presented complete response to the treatment and did not need to be submitted to surgery. Five years follow up with no recurrence. The stage I/TII group had 48 patients. After neoadjuvant radiotherapy, 8 patients had to be submitted to surgery for persistent tumor. All were submitted to full total local excision (FTLE), but anatomopathological examination showed no residual cancer. Conclusion: Preoperative long course of 4500 cG irradiation, not only reduced the local recurrence and mortality rate in lower rectal cancer, but also reduced indication for surgery in patients with stage I cancer of the lower rectum.

关键词： Rectal Cancer Cancer of the Lower Rectum Irradiation Preoperative Radiotherapy Local Recurrence Mortality Survival

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Occupational Performance of Women with Chronic Pelvic Pain and the Potential of Coping as an Unassisted Intervention

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International Journal of Clinical Medicine 2018年第9期9卷 737-749页

作者： Omero Benedicto Poli-neto Raquel Verceze Bortolieiro Júlio Cesar Rosa-e-Silva Francisco jose Candido-dos-reis Antonio Alberto Nogueira Department of Gynecology and Obstetrics Ribeirao Preto Medical SchoolUniversity of Sao PauloRibeirao PretoSPBrazil

Objective: To assess the satisfaction and occupational performance of women with chronic pelvic pain and to discuss unassisted intervention strategies by the occupational therapist for the care of these patients. Methods: A case-control study was conducted on 75 women with chronic pelvic pain and 75 apparently healthy women. The study was approved by the Research Ethics Committee of the institution and all subjects gave written informed consent to participate. Pain intensity was determined using a visual analogue scale and each patient was submitted to psycho-metric assessment using the Patient Health Questionnaire, the Self-Reporting Questionnaire of Psychiatric Screening and the Tampa Scale of Kinesiophofobia in their Brazilian version. The main outcomes regarding occupational performance and satisfaction were evaluated using the Canadian Measure of Occupational Performance. Results: The performance and satisfaction scores of women with chronic pelvic pain were significantly lower than those of healthy women. The presence of pain and kinesophobia was directly and independently correlated with low performance and satisfaction scores regardless of ethnicity, marital status, schooling, or psychometric scores. Conclusion: women with chronic pelvic pain present significant impairment of satisfaction and occupational performance. Coping is a potential unassisted intervention strategy to be applied to this population by occupational therapists.

关键词： Coping Occupational Therapy Performance Resilience Satisfaction

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Failure in Fuel Injector Nozzles Used in Diesel Engines

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Journal of Mechanics Engineering and Automation 2015年第4期5卷 237-240页

作者： jose Costa de Macedo neto Marina Anunciacao Brito de Oliveira Eduardo Rafael Barreda del Campo Ricardo Wilson Aguiar Da Cruz Nayra reis do Nascimento Joao Evangelista neto Department of Materials Engineering School of Engineering Amazonas State University Manaus 69065-020 Brazil Department of Mechanical Engineering School of Engineering Amazonas State University Manaus 69065-020 Brazil Department of Materials Engineering and Bioprocess Faculty of Chemical Engineering University of Campinas Sao Paulo13083-852 Brazil Department of Electrical Engineering Faculty of Technology University Federal of Amazonas Manaus 69077-000 Brazil

This paper aims to conduct a study of the problems associated with the wear of the needles and fuel injection nozzles utilized in diesel engines. The wear found on the needles is mainly associated to impurities in the fuel oil and microcavitation occurred due to high pressure in the phase of the air compression for combustion of the combustible fluid. These pressures associated with the temperature and the fluid velocity results in the occurrence of vaporization, which releases shock waves that cause damage to the affected surface. The impurities solid particles from the fuel oil cause problems inside the nozzles as obstruction of the holes and wear on the needle tip and nozzle seat surface. These failures affect in the atomization of the fuel, since the deterioration of the internal passages of the nozzles interferes in the spray formation and in the end passage of the fluid. For the execution of this study it will be used digital microscopic analysis in specimens that suffered damage, in order to investigate the effects of fuel property, and the temperature conditions and pressure in the formation of the wear on the needles and injector nozzle.

关键词： Fuel injector nozzle injector needles wear.

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Gastric Bypass with Long Pouch and Transit Bipartition for Endoscopic Access to the Remaining Stomach

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Surgical Science 2022年第8期13卷 353-366页

作者： Paulo reis Esselin de Melo Marcella Giovana Gava-Brandolis Thonya Cruz Braga Danilo Fossalussa Minari Ricardo Augusto Martins Bueno da Costa jose Geraldo Moraes Sampaio neto Louise Flores Silva José Humberto Cardoso Resende Hospital Estadual Alberto Rassi Surgical Skills Coordinator Goi&#226nia Brazil UNIFAN Research Coordinator Aparecida de Goi&#226nia Brazil

Introduction: obesity has a complex and multifactorial etiology, difficult treatment and increasing incidence rates in recent decades. The treatment involves clinical and pharmacological approaches and, in case of lack of results, surgical interventions. Roux-en-Y gastric bypass (RYGB) is one of these surgical interventions in which the stomach is divided, creating a small pouch, and the remaining portion of the stomach become excluded and left without endoscopic access. Objective: to evaluate the results of modified RYGB with long pouch and endoscopic access to the remaining stomach. Materials and Methods: prospective clinical trial with sample selected among patients seen at the Alberto Rassi General State Hospital of Goiânia (HGG) and indicated for bariatric and metabolic surgery confirmed by the medical and multidisciplinary team. The study was conducted from January 2020 to August 2021. Clinical history and laboratory test results of the selected patients were collected through consultations with the medical and multidisciplinary team. Results: twelve participants were included in the study. Of these, 11 (91.7%) were women and the mean age was 46.3 years. The weight before surgery was 112.17 kg (92.00 - 150.00) and the Body Mass Index (BMI) was 44.89 (35.06 - 74.39). After 18 months of surgery, the mean weight was 80.77 kg (±11.92) and the mean BMI was 29.46 (±11.00), showing a significant reduction in both (p = 0.003 and p = 0.002, respectively). All patients underwent endoscopic evaluation of the pouch, remaining stomach and duodenum at 12 months postoperatively. The mean percentage of lost excess weight loss was 68.21%. Conclusion: We conclude that the proposed changes in RYGB (GBLP + GIB – Roux-en-Y gastric bypass with long pouch and gastrointestinal bipartition) did not compromise weight loss or control of type 2 diabetes and other comorbidities and proved to be a safe and effective alternative without gastroduodenal exclusion, enabling a better postop

关键词： Obesity Bariatric Surgery Metabolic Surgery Roux-En-Y Gastric Bypass

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A Descriptive Research With Family Farmers＇ Beneficiaries and Non-beneficiaries of the PRONAF in the Municipality of Itapuranga, State of Goias, Brazil

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Sociology Study 2013年第4期3卷 289-299页

作者： Waltuir Batista Machado Luiz Manoel de Moraes Camargo Almeida Odilon jose de Oliveira neto Faculty of alfredo Nasser Brazil Federal University of Goias Brazil Federal University of Uberliandia Brazil

This article is a part of a descriptive survey which aims to characterize, classify, and compare the household production in the Municipality of Itapuranga, State of Goias, Brazil, considering the access to the National Program for Strengthening Family Agriculture （PRONAF） and its respective differentiation between beneficiary and non-beneficiary groups by the program. It applied the technique of group comparison analysis and frequency inquiry, taking into consideration several variables. Information about the origin, distribution and total income, food safety, land property, production diversification, expenditures and participation in social organizations were collected. The sample consisted of 70 producers, the calculation sample was defined by determined value at the confidence level of 90% whereas the sampling error of 7%. The results allowed describing, classifying, characterizing, and comparing the socio-economic and productive profile of farmers from that area and their access to PRONAF.

关键词： Agricultural funding family agriculture food safety PRONAF public policy

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Integration of Fogo Player and SAGE (Scalable Adaptive Graphics Environment) for 8K UHD Video Exhibition

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Journal of Computer and Communications 2014年第12期2卷 50-55页

作者： Jane de Almeida Guido Lemos de Souza Filho Carlos Eduardo Coelho Freire Batista Lucenildo Lins de Aquino Junior jose Ivan Vilarouca Filho Manoel Silva neto Cicero Inacio da Silva Leandro Ciuffo Iara Machado Clayton reis da Silva Laboratory of Cinematic Arts and Visualization (LabCine) Mackenzie Presbyterian University S&atildeo Paulo Brazil Laboratory of Digital Video Applications (LAVID) Federal University of Paraíba (UFPB) Jo&atildeo Pessoa Brazil Telehealth Program Federal University of S&atildeo Paulo (UNIFESP) S&atildeo Paulo Brazil The National Education and Research Network (RNP) Rio de Janeiro Brazil

After 4K, 8K UHD resolution can be considered the new challenge for film, visualization and television. Due to the dimension of 8K image, the remote micro and macro images are considered appropriate for visualization with scientific and educational purposes. This article describes the implementation of the 8K video plug-in to play UHD videos into the SAGE, a collaborative environment for the advancement of scientific research and education developed by EVL (Electronic Visualization Laboratory), upgrading its current resolution for video playing. It also presents the challenges of producing 8K content, the development of the code and introduces the features to view 8K ultra high definition videos in multiple tiles through the use of low cost computer clusters. The SAGE 8K video plug-in implementation was made possible because of the previous development of the Fogo Player, a system to run 4K and 8K content. The results were successfully presented at the CineGrid International Workshop 2013 in San Diego.

关键词： 8K Ultra High Definition Fogo Player Visualization SAGE UHD CineGrid

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Gastric Bypass with Long Pouch and Transit Bipartition for Endoscopic Access to the Remaining Stomach

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Surgical Science（外科学） 2022年第8期

作者： paulo reis esselin de melo marcella giovana gava-brandolis thonya cruz braga danilo fossalussa minari ricardo augusto martins bueno da costa jose geraldo moraes sampaio neto louise flores silva josé humberto cardoso resende

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FungalTraits:a user-friendly traits database of fungi and fungus-like stramenopiles

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Fungal Diversity 2020年第2期105卷 I0001-I0016页

作者： Sergei Põlme Kessy Abarenkov RHenrik Nilsson Björn D.Lindahl Karina Engelbrecht Clemmensen Havard Kauserud Nhu Nguyen Rasmus Kjøller Scott T.Bates Petr Baldrian Tobias Guldberg Frøslev Kristjan Adojaan alfredo Vizzini Ave Suija Donald Pfister Hans-Otto Baral Helle Järv Hugo Madrid Jenni Nordén Jian-Kui Liu Julia Pawlowska Kadri Põldmaa Kadri Pärtel Kadri Runnel Karen Hansen Karl-Henrik Larsson Kevin David Hyde Marcelo Sandoval-Denis Matthew E.Smith Merje Toome-Heller Nalin N.Wijayawardene Nelson Menolli Jr Nicole K.Reynolds Rein Drenkhan Sajeewa S.N.Maharachchikumbura Tatiana B.Gibertoni Thomas Læssøe William Davis Yuri Tokarev Adriana Corrales Adriene Mayra Soares Ahto Agan Alexandre reis Machado Andrés Argüelles-Moyao Andrew Detheridge Angelina de Meiras-Ottoni Annemieke Verbeken Arun Kumar Dutta Bao-Kai Cui C.K.Pradeep César Marín Daniel Stanton Daniyal Gohar Dhanushka N.Wanasinghe Eveli Otsing Farzad Aslani Gareth W.Griffith Thorsten H.Lumbsch Hans-Peter Grossart Hossein Masigol Ina Timling Inga Hiiesalu Jane Oja John Y.Kupagme József Geml Julieta Alvarez-Manjarrez Kai Ilves Kaire Loit Kalev Adamson Kazuhide Nara Kati Küngas Keilor Rojas-Jimenez Krišs Bitenieks Laszlo Irinyi LászlóGNagy Liina Soonvald Li-Wei Zhou Lysett Wagner M.Catherine Aime MaarjaÖpik María Isabel Mujica Martin Metsoja Martin Ryberg Martti Vasar Masao Murata Matthew PNelsen Michelle Cleary Milan C.Samarakoon Mingkwan Doilom Mohammad Bahram Niloufar Hagh-Doust Olesya Dulya Peter Johnston Petr Kohout Qian Chen Qing Tian Rajasree Nandi Rasekh Amiri Rekhani Hansika Perera Renata dos Santos Chikowski Renato L.Mendes-Alvarenga Roberto Garibay-Orijel Robin Gielen Rungtiwa Phookamsak Ruvishika S.Jayawardena Saleh Rahimlou Samantha C.Karunarathna Saowaluck Tibpromma Shawn P.Brown Siim-Kaarel Sepp Sunil Mundra Zhu-Hua Luo Tanay Bose Tanel Vahter Tarquin Netherway Teng Yang Tom May Torda Varga Wei Li Victor Rafael Matos Coimbra Virton Rodrigo Targino de Oliveira Vitor Xavier de Lima Vladimir S.Mikryukov Yongzhong Lu Yosuke Matsuda Yumiko Miyamoto Urm Institute of Ecology and Earth Sciences University of Tartu14A Ravila50411 TartuEstonia Natural History Museum University of Tartu46 Vanemuise Str51003 TartuEstonia Gothenburg Global Biodiversity Centre Box 46140530 GothenburgSweden Department of Biological and Environmental Sciences University of GothenburgGothenburgSweden Department of Soil and Environment Swedish University of Agricultural SciencesBox 701475007 UppsalaSweden Department of Forest Mycology and Plant Pathology Swedish University of Agricultural SciencesBox 702675007 UppsalaSweden Section for Genetics and Evolutionary Biology(EvoGene) Department of BiosciencesUniversity of OsloP.O.Box 1066BlindernNO-0316 OsloNorway University of Hawaiʻi at Mānoa 3190 Maile WaySt.John 102HonoluluHIUSA Department of Biology University of CopenhagenUniversitetsparken 152100 CopenhagenØDenmark Purdue University Northwest WestvilleIN 46391USA Institute of Microbiology Czech Academy of SciencesVidenska 108314220 Praha 4Czech Republic GLOBE Institute University of CopenhagenØster Farimagsgade 5KH7.2.321353 CopenhagenDenmark Dipartimento di Scienze della Vita e Biologia dei Sistemi Universitàdi TorinoViale Mattioli 2510125 TorinoItaly Department of Organismic and Evolutionary Biology and Farlow Library and Herbarium Harvard University22 Divinity AveCambridgeMA 02138USA Blaihofstr.42 72074 TübingenGermany SYNLAB Estonia Veerenni 53aTallinn 11313Estonia Escuela de Tecnología Médica Universidad Santo TomásLos Carreras 753OsornoChile Centro de Genómica y Bioinformática Universidad MayorCamino La Pirámide 5750HuechurabaSantiagoChile Norwegian Institute for Nature Research(NINA) Sognsveien 680855 OsloNorway School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Evolutionary Biology Faculty of BiologyBiological and Chemical Research CentreUniversity of Warsawul.Zwirki i Wigury 10102-089 WarsawPoland Department of Botany Swedish Museum of

The cryptic lifestyle of most fungi necessitates molecular identification of the guild in environmental *** the past decades,rapid development and affordability of molecular tools have tremendously improved insights of the fungal diversity in all ecosystems and ***,in spite of the progress of molecular methods,knowledge about functional properties of the fungal taxa is vague and interpretation of environmental studies in an ecologically meaningful manner remains *** order to facilitate functional assignments and ecological interpretation of environmental studies we introduce a user friendly traits and character database FungalTraits operating at genus and species hypothesis *** the information from previous efforts such as FUNGuild and FunFun together with involvement of expert knowledge,we reannotated 10,210 and 151 fungal and Stramenopila genera,*** resulted in a stand-alone spreadsheet dataset covering 17 lifestyle related traits of fungal and Stramenopila genera,designed for rapid functional assignments of environmental *** order to assign the trait states to fungal species hypotheses,the scientific community of experts manually categorised and assigned available trait information to 697,413 fungal ITS *** the basis of those sequences we were able to summarise trait and host information into 92,623 fungal species hypotheses at 1%dissimilarity threshold.

关键词： Fungal traits Trophic modes Function Guild Bioinformatics High-throughput sequencing Community ecology

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