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Adult neur.genesis:a r.al hope or.a delusion?

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Neur.l r.gener.tion r.sear.h 2024年第1期19卷 6-15页

作者： Ghulam Hussain r.bia Akr.m Haseeb Anwar.Faiqa Sajid Tehr.em Iman Hyung Soo Han Chand r.za jose-Luis Gonzalez De Aguilar Neur.chemicalbiology and Genetics Labor.tor.(NGL) Department of PhysiologyFaculty of Life SciencesGovernment College UniversityFaisalabadPunjabPakistan Depar.ment of Physiology School of MedicineClinical Omics InstituteKyungpook National UniversityDaeguKorea Depar.ment of Zoology Faculty of Chemistry and Life SciencesGovernment College UniversityLahorePakistan INSEr. U1118Mécanismes Centraux et Péripheriques de la NeurodégénérescenceStrasbourgFranceUniversitéde StrasbourgStrasbourgFrance

Adult neur.genesis,the pr.cess of cr.ating new neur.ns,involves the coor.inated division,migr.tion,and differ.ntiation of neur.l stem *** pr.cess is r.str.cted to neur.genic niches located in two distinct ar.as of the br.in:the subgr.nular.zone of the dentate gyr.s of the hippocampus and the subventr.cular.zone of the later.l ventr.cle,wher. new neur.ns ar. gener.ted and then migr.te to the olfactor. *** has been thought to occur.only dur.ng the embr.onic and ear.y postnatal stages and to decline with age due to a continuous depletion of neur.l stem ***,r.cent year. have seen tr.mendous pr.gr.ss in our.under.tanding of adult br.in neur.genesis,br.dging the knowledge gap between embr.onic and adult ***,we discuss the cur.ent status of adult br.in neur.genesis in light of what we know about neur.l stem *** this notion,we talk about the impor.ance of intr. cellular.signaling molecules in mobilizing endogenous neur.l stem cell pr.life *** on the cur.ent under.tanding,we can declar. that these molecules play a r.le in tar.eting neur.genesis in the matur. ***,to achieve this goal,we need to avoid the undesir.d pr.lifer.tion of neur.l stem cells by contr.lling the necessar. checkpoints,which can lead to tumor.genesis and pr.ve to be a cur.e instead of a blessing or.hope.

关键词： adult neur.genesis aging br.in-der.ved neur.tr.phic factor dentate gyr.s hippocampus neur.l stem cells neur.tr.phic factor. Notch oxidative str.ss stem cells subgr.nular.zone

Management of hepatocellular.car.inoma r.cur.ence after.liver.sur.er. and ther.al ablations:state of the ar. and futur. per.pectives

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Hepatobiliar. Sur.er. and Nutr.tion 2024年第1期13卷 71-88页

作者： Astr.d Her.er. Cypr.en Touber. jose Ur.ic Bedoya Er.c Assenat Bor.s Guiu Fabr.zio Panar. Thomas Bar.ol Gianluca Cassese Depar.ment of HPB Sur.er. and Liver.Tr.nsplantation Saint Eloi HospitalMontpellier UniversityMontpellierFrance Depar.ment of Hepatology and Liver.Tr.nsplantation Saint Eloi HospitalMontpellier UniversityMontpellierFrance Depar.ment of Digestive Oncology Saint Eloi HospitalMontpellier UniversityMontpellierFrance Depar.ment of r.diology Saint Eloi HospitalMontpellier UniversityMontpellierFrance Labor.tor. of r.r. human Cir.ulating Cells(LCCr.) University Medical Center of MontpellierMontpellierFrance Division of Minimally Invasive and r.botic HPB Sur.er. Department of Clinical Medicine and SurgeryFederico II University HospitalNaplesItaly

Despite the impr.vements in sur.ical and medical ther.py for.hepatocellular.car.inoma(HCC),r.cur.ence still r.pr.sents a major.*** to 70%of patients can exper.ence HCC r.cur.ence after.liver.r.section(Lr.,as well as 20%of them even after.liver.tr.nsplantation(LT).The patter.s of r.cur.ence ar. differ.nt accor.ing to both the time and the ***,the r.sk factor. and the management can change not only accor.ing to these patter.s,but also accor.ing to the under.ying liver.condition and to the fir.t tr.atment *** knowledge of such cor.elation is fundamental,since pr.vention and effective management of r.cur.ence ar. undoubtedly the most impor.ant str.tegies to impr.ve the outcomes of HCC *** adjuvant ther.py,maintaining ver. close monitor.ng dur.ng the fir.t 2 year. in or.er.to diagnose cur.ble r.cur.ence and continue this monitor.ng beyond 5 year. because late r.cur.ences exist,r.mains our.only possibility *** r.pr.sents the cor.er.tone tr.atment for.HCC,including both LT and ***,new inter.sting ther.peutic oppor.unities ar. coming fr.m immunother.py that has shown encour.ging r.sults also in the adjuvant *** such a complex and evolutionar. scenar.o,the aim of this r.view is to summar.ze cur.ent str.tegies for.the management of HCC r.cur.ence,focusing on the differ.nt possible scenar.os,as well as on futur. per.pectives.

关键词： Hepatocellular.car.inoma r.cur.ence hepatocellular.car.inoma management liver.sur.er. liver.tr.nsplantation ther.al ablation(TA) sur.ival after.r.cur.ence

Lar.e-Scale Car.on Dioxide Stor.ge in Salt Caver.s:Evaluation of Oper.tion,Safety,and Potential in China

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Engineer.ng 2024年第9期40卷 226-246页

作者： Wei Liu Xiong Zhang Jifang Wan Chunhe Yang Liangliang Jiang Zhangxin Chen Mar.a jose Jur.do Xilin Shi Deyi Jiang Wendong Ji Qihang Li State Key Labor.tor. of Coal Mine Disaster.Dynamics and Contr.l Chongqing UniversityChongqing 400044China China Ener.y Digital Technology Gr.up Co.Ltd. Beijing 100044China Institute of r.ck and Soil Mechanics Chinese Academy of SciencesWuhan 430064China Depar.ment of Chemical and Petr.leum Engineer.ng University of CalgaryCalgaryAB T2N 1N4Canada Easter. Institute of Technology Ningbo 315200China Geosciences Bar.elona CSIC Spanish National Research CouncilBarcelona 08028Spain

Under.r.und salt caver. CO_(2) stor.ge(SCCS)offer. the dual benefits of enabling extensive CO_(2) stor.ge and facilitating the utilization of CO_(2) r.sour.es while contr.buting the r.gulation of the car.on *** economic and oper.tional advantages over.tr.ditional car.on captur.,utilization,and stor.ge(CCUS)pr.jects make SCCS a mor. cost-effective and flexible *** the widespr.ad use of salt caver.s for.stor.ng var.ous substances,differ.nces exist between SCCS and tr.ditional salt caver. ener.y stor.ge in ter.s of gas-tightness,car.on injection,br.ne extr.ction contr.l,long-ter. car.on stor.ge stability,and site selection *** distinctions stem fr.m the unique phase change char.cter.stics of CO_(2) and the application scenar.os of ***,tar.eted and for.ar.-looking scientific r.sear.h on SCCS is *** paper.intr.duces the implementation pr.nciples and application scenar.os of SCCS,emphasizing its connections with car.on emissions,car.on utilization,and r.newable ener.y peak *** delves into the oper.tional char.cter.stics and economic advantages of SCCS compar.d with other.CCUS methods,and addr.sses associated scientific *** this paper.we establish a pr.ssur. equation for.car.on injection and br.ne extr.ction,that consider. the phase change char.cter.stics of CO_(2),and we analyze the pr.ssur. dur.ng car.on *** compar.ng the viscosities of CO_(2) and other.gases,SCCS’s excellent sealing per.or.ance is *** on this,we develop a long-ter. stability evaluation model and associated indices,which analyze the impact of the injection speed and minimum oper.ting pr.ssur. on *** counter.easur.s to ensur. stability ar. *** selection cr.ter.a for.SCCS ar. established,pr.liminar. salt mine sites suitable for.SCCS ar. identified in China,and an initial estimate of achievable car.on stor.ge scale in China is made at over.51.8-77.7 million tons,utilizing only 20%-30%volume

关键词： Car.on-neutr.lity Salt caver. Lar.e-scale CO_(2)stor.ge Injection and withdr.wal Stability analysis

Contr.bution of extr.cellular.vesicles to steatosis-r.lated liver.disease and their.ther.peutic potential

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Wor.d Jour.al of Hepatology 2024年第9期16卷 1211-1228页

作者： Mar.ar.ta Montoya-Buelna Inocencia G r.mir.z-Lopez Cesar.A San Juan-Gar.ia jose J Gar.ia-r.galado Mar.ana S Millan-Sanchez Ulises de la Cr.z-Mosso Jesse Har.mati Ana L Per.ir.-Suar.z jose Macias-Bar.agan Labor.tor.o de Inmunología Departamento de FisiologíaUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Depar.amento de Ciencias de la Salud Centro Universitario de los VallesUniversidad de GuadalajaraAmeca 46600JaliscoMexico Doctor.do en Ciencias Biomédicas Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Labor.tor.o de Inmunología Departamento de FisiologíaCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico r.d de Inmunonutr.ción y Genómica Nutr.cional en las Enfer.edades Autoinmunes Departamento de NeurocienciasCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Labor.tor.o de Inmunobiología Departamento de Biología Celular y MolecularCentro Universitario de Ciencias Biológicas y AgropecuariasUniversidad de GuadalajaraZapopan 45200JaliscoMexico Instituto de Investigación en Ciencias Biomédicas Departamento de Microbiología y PatologíaCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico

Extr.cellular.vesicles(EVs)ar. small par.icles r.leased by many cell types in differ.nt tissues,including the liver.and tr.nsfer.specific car.o molecules fr.m or.ginating cells to r.ceptor.*** pr.cess gener.lly culminates in activation of distant cells and inflammation and pr.gr.ssion of cer.ain *** global chr.nic liver.disease(CLD)epidemic is estimated at 1.5 billion patients *** and liver.cancer.ar. the most common r.sk factor. for.***,hepatitis C and B vir.s infection and obesity ar. also highly associated with ***,the etiology of many CLD pathophysiological,cellular.and molecular.events ar. *** in hepatic lipid metabolism can lead to lipotoxicity events that induce EV ***,we aimed to pr.sent an over.iew of EV featur.s,fr.m definition to types and biogenesis,with par.icular.focus on the molecules r.lated to steatosis-r.lated liver.disease,diagnosis,and ther.py.

关键词： Extr.cellular.vesicles Exosomes Chr.nic liver.disease Hepatocellular.car.inoma Nonalcoholic fatty liver.disease Nonalcoholic steatohepatitis

Osteotomy Pr.tocol for.Implant Inser.ion of One Day Biotech: One Dr.ll, One Implant

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Open Jour.al of Stomatology 2024年第5期14卷 255-277页

作者： Jin Hwan Kim Jaehyun Song Jaegyun Choi jose Fr.ncisco Ballester.Ir.h Kim Santiago jose Ballester Pr.vate Pr.ctice Seul South Korea Pr.vate Pr.ctice Valencia Spain Seul South Korea

Backgr.und: Four.factor. deter.ine the quality of an implantology kit: 1) Heat gener.ted by the dr.lls;2) Mor.hology of the osteotomy accor.ing to the diameter.of the implant;3) Efficiency of collecting autologous bone;and 4) Osteotomy execution time. Mater.als and Methods: This ar.icle examines the heat pr.duced by dr.lls dur.ng osteotomy, focusing on the effect of the following factor.: dr.lling technique;volume of autologous bone har.ested;dr.lling time;implant pr.mar. stability;and the per.entage of osseointegr.ted implants after.pr.mar. healing. Discussion: The four.factor. mentioned above ar. analyzed based on the data obtained for.sequential, biological, and One Dr.ll milling techniques. Conclusions: 1) One Dr.ll is the fastest technique for.per.or.ing the osteotomy;2) All techniques stay within the biological temper.tur. r.nge of living bone, with the lowest incr.ase in temper.tur. achieved using One Dr.ll with ir.igation;3) The bone har.ested showed no statistically significant differ.nces between biological milling and the One Dr.ll technique, both far.super.or.to the sequential technique;and 4) Ther. is no statistically significant differ.nce in the number.of osseointegr.ted implants among the thr.e techniques analyzed.

关键词： Dental Implant Bur Pr.mar. Stability Dr.lling Time Osteotomy Ir.igation Bone Collected

Fr.ntier.of the Paleo-Tethys Ocean in the wester. Mediter.anean:Isotopic(Sm-Nd)constr.ints on sour.es of Devonian units fr.m Menor.a Island

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Geoscience Fr.ntier. 2024年第5期15卷 323-338页

作者： r.car.o Ar.nas jose M.Fuenlabr.da Cr.stian Timoner.r.bén Díez Fer.ández Esther.r.jo-Pér.z Depar.amento de Miner.logía y Petr.logía and Instituto de Geociencias(UCM CSIC)Universidad ComplutenseMadridSpain Unidad de Geocr.nología(CAI de Ciencias de la Tier.a y Ar.ueometr.a) Universidad ComplutenseMadridSpain Bayer.sches Geoinstitut University of BayreuthBayreuthGermany Instituto Geológico y Miner. de España–CSIC SalamancaSpain

The c.1000-m-thick pr.-or.genic Devonian mainly metapelitic sequence of Nor.h Menor.a Island shows a fair.y complete str.tigr.phic *** r.cks of this sequence indicate gr.dually incr.asing deeper.mar.ne conditions of sedimentation towar.s its upper.ost ***,the obtained sedimentar. char.cter.stics r.semble those r.lated to a deep and nar.ow basin-associated *** sills of Ti-augite-bear.ng alkaline gabbr.s occur.within the Devonian *** intensity of Var.scan defor.ation incr.ases downwar.s thr.ugh the *** to the char.cter.stics of the Devonian sequence and its location within the Var.scan Or.gen,a cor.elation with similar.units located in the souther. sector. of the Centr.l Iber.an Zone(Iber.an Massif)is *** Devonian metapelitic r.cks have geochemical char.cter.stics suggesting that they r.pr.sent moder.tely r.cycled matur. siliciclastic sediments,gener.ted fr.m er.sion of distant sour.e ar.as belonging to an upper.continental *** r.latively nar.ow r.nge of var.ation obser.ed in initial^(143)Nd/^(144)Nd r.tios suppor.s a similar.sour.e for.the Menor.an slates(0.51165–0.51182).However.a mar.ed tr.nd is obser.ed in these isotope r.tios,fr.m lower.values at the base of the str.tigr.phic column(minimum value of 0.511941)to higher.values at the top(maximum value of 0.512131).The^(147)Sm/^(144)Nd r.tios var. between 0.1074 and 0.1238,within the r.nge defined for.siliciclastic r.cks with felsic cr.stal *** Nd model ages define a nar.ow r.nge between 1496 Ma and 1754 Ma(Late Paleopr.ter.zoic–Ear.y Mesopr.ter.zoic),and they ar. consistently younger.*** data r.le out a pr.venance fr.m the er.sion of the West Afr.ca Cr.ton,as they ar. mor. compatible with a pr.venance fr.m r.gions located in the Tr.ns-Sahar.n Belt or.Sahar. *** char.cter.stics of the Menor.an Devonian sequence ar. compatible with its deposition in a nar.ow and deep per.-Gondwanan tr.nstensional basin,gener

关键词： Wester. Paleo-Tethys fr.ntier. Menor.a Island Sm-Nd isotopic constr.ints Devonian sequence pr.venance in Gondwana

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碳基固体氧化物燃料电池研究进展

洁净煤技术 2024年第1期30卷 239-264页

作者：张伟魏嘉璐 jose Antonio Alonso 孙春文中国矿业大学(北京)化学与环境工程学院北京100083 Instituto de Ciencia de los Mater.ales de Madr.d CSICCantoblanco-Madrid 28049Spain

随着人们对绿色能源和环境友好型社会需求的日益增长,先进能量转换装置或系统的研发亟待加速,而燃料电池系统被认为是最有希望的未来发电装置。在不同种类的燃料电池中,固体氧化物燃料电池(SOFCs)是一种清洁环保的发电装置,因其独特的... 详细信息

随着人们对绿色能源和环境友好型社会需求的日益增长,先进能量转换装置或系统的研发亟待加速,而燃料电池系统被认为是最有希望的未来发电装置。在不同种类的燃料电池中,固体氧化物燃料电池(SOFCs)是一种清洁环保的发电装置,因其独特的多燃料运行能力及能量转化效率高等优点而前景广阔。然而,传统使用镍-金属陶瓷阳极的SOFCs,在碳氢化合物燃料下运行时,由于燃料的不完全氧化会使阳极产生积碳,从而导致电池性能下降。讨论了碳基SOFC中碳沉积机理和解决阳极积碳的策略,重点介绍了目前广泛研究的具有混合离子-电子导体的双金属-金属陶瓷材料的种类以及研究进展,并总结了双金属-金属陶瓷材料的抗积碳机理,主要表现为降低阳极表面的碳沉积速率以及加速积碳的去除。还介绍了在还原性气氛中,钙钛矿材料中纳米粒子原位偏析的原理,并讨论了原位偏析所形成的纳米颗粒以及其与钙钛矿主体所形成的金属氧化物异质结构在抗积碳阳极中的应用。此外,还探究了多层阳极和单原子催化剂阳极在中温SOFCs中的应用。在燃料电池技术巨大进步的推动下,人们对可用于固定式发电的集成煤气化的燃料电池发电系统(IGFCs)产生了新的兴趣,该系统对于实现煤炭的清洁高效利用具有重要意义,该技术的关键依托于SOFCs的成熟度。最后,总结并指出了碳基SOFCs未来的一些研究方向。

关键词：固体氧化物燃料电池阳极材料碳氢燃料碳沉积整体煤气化燃料电池

Gr.uping tr.e species to estimate basal ar.a incr.ment in temper.te multispecies for.sts in Dur.ngo,Mexico

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For.st Ecosystems 2024年第1期11卷 1-13页

作者： Jaime r.ber.o Padilla-Mar.ínez Car.la Paul Kai Husmann jose Javier.Cor.al-r.vas Klaus von Gadow Depar.ment of For.st Economics and Sustainable Land-use Planning Faculty of Forest Sciences and Forest EcologyUniversity of GottingenBüsgenweg 137077GottingenGermany Facultad de Ciencias For.stales Universidad Juarez del Estado de DurangoRío Papaloapan y Boulevard Durango S/N34120DurangoMexico Faculty of For.str. and For.st Ecology Georg-August-UniversitatBüsgenweg 537077GottingenGermany Depar.ment of For.str. and Wood Science Faculty of AgriSciencesStellenbosch UniversityStellenbosch Private Bag X1Stellenbosch7602South Africa

Multispecies for.sts have r.ceived incr.ased scientific attention,dr.ven by the hypothesis that biodiver.ity impr.ves ecological ***,a gr.ater.species diver.ity pr.sents challenges for.for.st management and *** study aims to develop basal ar.a gr.wth models for.tr.e species *** analysis is based on a dataset of 423 per.anent plots(2,500 m^(2))located in temper.te for.sts in Dur.ngo,***,we define tr.e species cohor.s based on individual and neighbor.ood-based var.ables using a combination of pr.ncipal component and cluster.***,we estimate the basal ar.a incr.ment of each cohor. thr.ugh the gener.lized additive model to descr.be the effect of tr.e size,competition,stand density and site *** pr.ncipal component and cluster.analyses assign a total of 37 tr.e species to eight cohor.s that differ.d pr.mar.ly with r.gar. to the distr.bution of tr.e size and ver.ical position within the *** gener.lized additive models pr.vide satisfactor. estimates of tr.e gr.wth for.the species cohor.s,explaining between 19 and 53 per.ent of the total var.ation of basal ar.a incr.ment,and highlight the following r.sults:i)most cohor.s show a"r.se-and-fall"effect of tr.e size on tr.e gr.wth;ii)sur.r.singly,the competition index"basal ar.a of lar.er.tr.es"had showed a positive effect in four.of the eight cohor.s;iii)stand density had a negative effect on basal ar.a incr.ment,though the effect was minor.in medium-and high-density stands,and iv)basal ar.a gr.wth was positively cor.elated with site quality except for.an oak *** developed species cohor.s and gr.wth models pr.vide insight into their.par.icular.ecological featur.s and gr.wth patter.s that may suppor. the development of sustainable management str.tegies for.temper.te multispecies for.sts.

关键词： Temper.te multispecies for.sts Cluster.analysis Basal ar.a incr.ment Gener.lized additive models

Hydr.geochemical and isotopic assessment of the or.gin of NO_(3)^(−)and N-NH_(3)contents in the aquifer.located in a closed lacustr.ne volcano-sedimentar. basin in the metr.politan ar.a of Mexico City

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Acta Geochimica 2024年第4期43卷 719-736页

作者： jose Ivan Mor.les-Ar.edondo Mar.a Aur.r. Ar.ienta Her.andez Joel Edmundo Or.ega-Gutier.ez Elisa Cuellar.r.mir.z Natur.l r.sour.es Depar.ment Institute of GeophysicsNational Autonomous University of MexicoCiudad Universitaria No.3000Col.Copilco UniversidadCoyoacán Delegation04360 MexicoCDMXMexico Instituto Politecnico Nacional ***án 55La Laguna Ticoman07340 MexicoCDMXMexico Benemér.ta Univer.idad Autónoma de Puebla Ciudad Univer.itar.a Col.San ManuelPueblaPueMexico

To explain the pr.sence and spatial distr.bution of NO_(3)^(−)and N-NH_(3)in the Aquifer.of the Metr.politan Ar.a of Mexico City(AMAMC),a hydr.geochemical and isotopic analysis using^(13)C DIC(as well as the stable isotopes^(18)O and^(2)H)in gr.undwater.was *** aquifer.is located in an old closed lacustr.ne volcano-sedimentar. basin;some wells hosted in the semi-confined zone contain high N-NH_(3)concentr.tions,while other. pr.sent NO_(3)^(−)contents in the r.char.e zones(hosted in an oxidizing envir.nment).In this study,a change in the isotopic signatur.(pr.mar.ly in^(18)O and^(2)H)was obser.ed fr.m the r.char.e zones to the basin center.in some of the wells with high NO_(3)^(−)concentr.tions,this behavior.can be attr.buted to evapor.tion dur.ng the incor.or.tion of r.cently infiltr.ted *** addition,the r.sults for.(13)C(along with ^(2) H)in wells with the highest N-NH_(3)concentr.tions exhibited an atypically br.ad r.nge of *** indicated the occur.ence of hydr.geochemical and/or.biochemical pr.cesses in the aquifer.in an oxidizing or.r.ducing envir.nment),such as or.anic degr.dation,bacter.al decomposition(pr.mar.ly in the ancient Lake Texcoco and which acts as a natur.l sink for.car.on,nitr.gen,sulfur.and phosphor.s),besides r.ck weather.ng and dissolution,which may be r.sponsible for.a ver. mar.ed isotopic modification of the^(13)C(and,to a lesser.extent,2 H).Methanotr.phic bacter.al activity and methanogenic activity may be r.lated to N-NH_(3)r.moval pr.cesses by oxidation and r.sidual water.incor.or.tion r.spectively,wher.as the incr.ase in the NO_(3)^(−)content in some wells is due to the r.cent contr.bution of poor.quality water.due to contamination.

关键词： 18 O and^(13)C isotopes Ir.n Hydr.geochemical pr.cesses Nitr.te Nitr.gen species