检索结果-南通市图书馆

Tenofovir vs lamivudine plus adefovir in chronic hepatitis B:TENOSIMP-B study

World Journal of Gastroenterology 2017年第41期23卷 7459-7469页

作者： manuel Rodríguez Juan manuel Pascasio Enrique Fraga Javier Fuentes Martín Prieto Gloria Sánchez-Antolín jose Luis Calleja Esther Molina María Luisa García-Buey María Angeles Blanco Javier Salmerón María Lucía Bonet jose Antonio Pons jose manuel González Miguel Angel Casado Francisco Jorquera 无 Division of Gastroenterology and Hepatology.Hospital Universitario Central de Asturias Unit for the Clinical Management of Digestive Diseases IBISHospital Universitario Virgen del Rocío Liver Transplantation and Hepatology Unit Gastroenterology ServiceHospital Universitario Reina Sofía Digestive Medicine Service Hospital Universitario Miguel Servet Hepatology Unit Digestive Medicine ServiceHospital Universitari i Politècnic La Fe Hepatology Unit Hospital Universitario Rio Hortega Liver Unit Hospital Universitario Puerta de Hierro de MajadahondaUniversidad Autónoma de Madrid Digestive Medicine Service Hospital Clínico de Santiago de Compostela Liver Unit Hospital Universitario de La Princesa Digestive Medicine Service Hospital General Universitario Gregorio Maranon Digestive Medicine Unit Complejo Hospitalario de Granada Digestive Medicine Service Hospital Universitario Son Espases Hepatology Unit IMIB Hospital Universitario Virgen de la Arrixaca Digestive Medicine Service Hospital Clínico Universitario de Valladolid Pharmacoeconomics and Outcomes Research Iberia Division of Gastroenterology and Hepatology Complejo Asistencial Universitario de León the TENOSIMP-B Research Group

AIM To demonstrate the non-inferiority(15% non-inferiority limit) of monotherapy with tenofovir disoproxil fumarate(TDF) vs the combination of lamivudine(LAM) plus adefovir dipivoxil(ADV) in the maintenance of virologic response in patients with chronic hepatitis B(CHB) and prior failure with *** This study was a Phase IV prospective, randomized, open, controlled study with 2 parallel groups(TDF and LAM+ADV) of adult patients with hepatitis B e antigen(HBe Ag)-negative CHB, prior failure with LAM, on treatment with LAM+ADV for at least 6 mo, without prior resistance to ADV and with an undetectable viral load at the start of the study, in 14 Spanish hospitals. The follow-up time for each patient was 48 wk after randomization, with quarterly visits in which the viral load, biochemical and serological parameters, adverse effects, adherence to treatment and consumption of hospital resources were *** Forty-six patients were evaluated [median age: 55.4 years(30.2-75.2); 84.8% male], including 22 patients with TDF and 24 with LAM+ADV. During study development, hepatitis B virus DNA(HBV-DNA) remained undetectable, all patients remained HBe Ag negative, and hepatitis B surface antigen(HBs Ag) positive. Alanine aminotransferase(ALT) values at the end of the study were similar in the 2 groups(25.1± 7.65, TDF vs 24.22 ± 8.38, LAM+ADV, P = 0.646). No significant changes were observed in creatinine or serum phosphorus values in either group. No significant differences between the 2 groups were noted in the identification of adverse effects(AEs)(53.8%, TDF vs 37.5%, LAM+ADV, P = 0.170), and none of the AEs which occurred were serious. Treatment adherence was 95.5% and 83.3% in the TDF and the LAM+ADV groups, respectively(P = 0.488). The costs associated with hospital resource consumption were significantly lower with the TDF treatment than the LAM+ADV treatment(€4943 ± 1059 vs €5811 ± 1538, respectively, P < 0.001).CONCLUSION TDF monotherapy proved to be safe

关键词： Tenofovir Lamivudine+Adefovir Efficacy Safety Adherence Costs Hepatitis B

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A model for defect formation in materials exposed to radiation

引用

Matter and Radiation at Extremes 2021年第1期6卷 64-72页

作者： Sergio Davis Felipe gonzalez-Cataldo Gonzalo Gutierrez Gonzalo Avaria Biswajit Bora Jalaj Jain jose Moreno Cristian Pavez Leopoldo Soto Comision Chilena de Energıa Nuclear Casilla 188-DSantiagoChile Departamento de Fısica Facultad de Ciencias ExactasUniversidad Andres BelloSazie 2212piso 7Santiago 8370136Chile Department of Earth and Planetary Science University of CaliforniaBerkeleyCalifornia 94720USA Grupo de Nanomateriales Departamento de FısicaFacultad de CienciasUniversidad de ChileCasilla 653SantiagoChile

A simple model for the stochastic evolution of defects in a material under irradiation is *** the master-equation formalism,we derive an expression for the average number of defects in terms of the power flux and the exposure *** model reproduces the qualitative behavior of self-healing due to defect recombination,reaching a steady-state concentration of defects that depends on the power flux of the incident radiation and the material temperature,while also suggesting a particular time scale on which the incident energy is most efficient for producing defects,in good agreement with experimental *** this model,we discuss the integral damage factor,a descriptor that combines the power flux and the square of the irradiation *** recent years,the scientific community involved in plasma-facing materials for nuclear fusion reactors has used this parameter to measure the equivalent material damage produced in experiments of various types with different types of radiation and wide ranges of power flux and irradiation *** integral damage factor is useful in practice but lacks formal theoretical *** this simple model,we find that it is directly proportional to the maximum concentration of defects.

关键词： defect qualitative formal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impact of the adherence to medical treatment on the main urinary metabolic disorders in patients with kidney stones

引用

Asian Journal of Urology 2021年第3期8卷 275-279页

作者： Braulio Omar Manzo jose David Cabrera Esteban Emiliani Hector manuel Sanchez Brian Howard Eisner jose Ernesto Torres Urology Department Hospital Regional de Alta Especialidad del BajioBlvd.Milenio#130Col.San Carlos la RonchaLeonGuanajuatoMexico Urology Department Fundacion PuigvertUniversidad Autonoma de BarcelonaBarcelonaSpain Urology Department Massachusetts General HospitalHarvard Medical SchoolBostonUSA

Objective:To assess the effect of the adherence to medical treatment on urinary parameters in the 24-h metabolic study of patients with kidney ***:A retrospective,longitudinal,descriptive,and observational study was carried out by reviewing the hospital electronic medical record from 2014 to *** adherence to drug treatment was measured 6 months after its initiation,and the numerical values of the metabolic studies were *** tests were performed to compare the difference before and after ***:Ninety patients were evaluated,with 73.3% of *** 180-day overall adherence rate was 61.2% in patients treated with a single drug and 85.4% in patients treated with multiple *** is a statistically significant increase in citrate levels in patients with good adherence in comparison with non-adherent patients(p=0.031 vs.p=0.528).Conclusions:Medical treatment and dietary measures in patients with kidney stones have an initial impact at 6 months on the values of the main urinary metabolic alterations that predispose to calculi formation;the most significant is seen in those patients with adherence to medical treatment for hypocitraturia.

关键词： Kidney stones Renal stones Metabolic disorders Medical treatment Citrate Oxalate Lithiasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Modelling fuel loads of understorey vegetation and forest floor components in pine stands in NW Spain

引用

Forest Ecosystems 2022年第6期9卷 775-789页

作者： jose A.Vega Stefano Arellano-Perez Juan Gabriel Alvarez-gonzalez Cristina Fernandez Enrique Jimenez Pedro Cuinas jose María Fernandez-Alonso Daniel J.Vega-Nieva Fernando Castedo-Dorado Cecilia Alonso-Rego Teresa Fontúrbel Ana Daría Ruiz-gonzalez Centro de Investigacion Forestal de Lourizan PO Box 12736080PontevedraSpain Unidad de Gestion Ambiental y Forestal Sostenible(UXAFORES) Departamento de Ingeniería AgroforestalEscuela Politecnica Superior de IngenieríaUniversidad de Santiago de CompostelaCampus Universitario s/n27002LugoSpain Facultad de Ciencias Forestales Universidad Juarez del Estado de DurangoRío Papaloapan y Blvd.Durango s/nCol.Valle del Sur34120DurangoMexico Departamento de Ingeniería y Ciencias Agrarias Universidad de LeonCampus de Ponferrada24401PonferradaSpain

In this study,310 destructively sampled plots were used to develop two equation systems for the three main pine species in NW Spain(***;*** and ***):one for estimating loads of understorey fuel components by size and condition(live and dead)and another one for forest floor *** systems of equations were simultaneously fitted for estimating fuel loads using overstorey,understorey and forest floor variables as *** systems of equations included both the effect of pine species and the effect of understorey compositions dominated by ferns-brambles or by woody species,due to their obvious structural and physiological *** general,the goodness-of-fit statistics indicated that the estimates were reasonably robust and accurate for all of the fuel *** best results were obtained for total understorey vegetation,total forest floor and raw humus fuel loads,with more than 76%of the observed variability explained,whereas the poorest results were obtained for coarse fuel loads of understory vegetation with a 53%of observed variability *** reduce the overall costs associated with the field inventories necessary for operational use of the models,the additive systems were fitted again using only overstorey variables as potential *** relationships for fine(<6 mm)and total understorey vegetation and total forest floor fuel loads were obtained,indicating the complexity of the forest overstorey-understorey and overstorey-forest floor ***,these models explained around 52%of the observed ***,equations estimating the total understorey vegetation and the total forest floor fuel loads based only on canopy cover were *** models explained only 26%-32%of the observed variability;however,their main advantage is that although understorey vegetation in forested landscapes is largely invisible to remote sensing,canopy cover can be estimated with moderate accuracy,allowin

关键词： Area-based approach Additive equation systems Live and dead fine fuel Pinus pinaster Pinus radiata Pinus sylvestris

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Organic coating of 1-2-nm-size silicon nanoparticles： Effect on particle properties

引用

Nano Research 2015年第6期8卷 2047-2062页

作者： Cristian R. Lillo Juan J. Romero manuel Llansola Portoles Reinaldo Pis Diez Paula Caregnato Monica C. gonzalez Instituto de Investigaciones Fisicoquimicas Teoricas y Aplicadas (INIFTA) CCT-La Plata-CONICET Facultad de Ciencias Universidad National de La Plata cc 16 Suc. 4 1900 La Plata Argentina CEQUINOR CCT-La Plata-CONICET Facultad de Ciencias Exactas Universidad Nacional de La Plata cc 9621900 La Plata Argentina Department of Chemistry and Biochemistry Center for Bioenergy and Photosynthesis Arizona State University Tempe Arizona USA

Photoluminescent silicon nanoparticles 1-2 nm in size were synthesized by a wet chemical procedure and derivatized with propylamine （NH2SiNP）. Surface NH2 groups were used as linkers for additional poly（ethylene glycol）（PEG） and folic acid （Fo） attachment （PEG-NHSiNP and Fo-NHSiNP, respectively） to enable efficient targeting of the particles to tumors and inflammatory sites. The particles were characterized by transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, ζ potential, dynamic light scattering, and time-resolved anisotropy. The photophysical properties and photosensitizing capacity of the particles and their interaction with proteins was dependent on the nature of the attached molecules. While PEG attachment did not alter the photophysical behavior of NH2SiNP, the attachment of Fo diminished particle photoluminescence. Particles retained the capacity for 1O2 generation; however, efficient 1O2 quenching by the attached surface groups may be a drawback when using these particles as 1O2photosensitizers. In addition, Fo attachment provided particles with the capacity to generate the superoxide anion radical （O2-）. The particles were able to bind tryptophan residues of bovine serum albumin （BSA） within quenching distances. NH2SiNP and PEG-NHSLNP ground state complexes with BSA showed binding constants of （3.1 ± 0.3） × 10^4 and （1.3 ±0.4） × 10^3 M-1, respectively. The lower value observed for PEG-NHSiNP complexes indicates that surface PEGylation leads to a reduction in protein adsorption, which is required to prevent opsonization. An increase in particle luminescence upon BSA binding was attributed to the hydrophobic environment generated by the protein. NH2SiNP-BSA complexes were also capable of resonance energy transfer.

关键词： propylamine folic acid poly(ethylene glycol) photoluminescence protein-binding singlet oxygen

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

What is the most effective exercise protocol to improve cardiovascular fitness in overweight and obese subjects？

引用

Journal of Sport and Health Science 2017年第4期6卷 454-461页

作者： Eliane Aparecida Castro Ana Belen Peinado Pedro jose Benito MercedeS Galindo Marcela gonzalez-Gross Rocio Cupeiro Department of Health and Human Performance Faculty of Physical Activity and Sport Sciences Universidad Polit~cnica de Madrid Madrid 28040 Spain LFE Research Group Universidad PolitOcnica de Madrid Madrid 28040 Spain Faculty of Physical Activity and Sport Sciences Universidad Politecnica de Madrid Madrid 28040 Spain ImFINE Research Group Universidad PolitOcnica de Madrid Madrid 28040 Spain

Background: Increased peak oxygen consumption(VO2 peak) can reduce cardiovascular risks associated with obesity. Our aim was to analyze the effect of a weight loss program on cardiovascular fitness in overweight(W) and obese(O) ***: One hundred and sixty-seven subjects(77 males and 90 females), aged 18–50 years, performed a modified Bruce protocol before(pre)and after(post) a weight loss program of 24 weeks. This program combined physical training(strength, S; endurance, E; combined strength + endurance, SE; or physical activity recommendation, PA) 3 times per week, with a 25%–30% caloric restriction ***: VO2 peak improved in overweight and obese males(pre and post values in L/min, respectively; W = 3.2 ± 0.6 vs. 3.7 ± 0.5, p < 0.001;O = 3.6 ± 0.6 vs. 3.8 ± 0.6, p = 0.013) as well as in overweight females(2.0 ± 0.3 vs. 2.3 ± 0.4, p < 0.001). VO2 peak in the first ventilatory threshold(VT1) increased for all 4 interventions in males(p < 0.05), except for S in the obese group(1.6 ± 0.2 vs. 1.7 ± 0.3, p = 0.141). In females, it increased in E(0.9 ± 0.2 vs. 1.4 ± 0.3, p < 0.001), SE(0.9 ± 0.2 vs. 1.2 ± 0.4, p = 0.003), and PA(0.9 ± 0.1 vs. 1.2 ± 0.2, p = 0.006) in overweight groups. Time-to-exhaustion improved in all subjects except for females in PA group(15.7 ± 0.3 min vs. 15.9 ± 0.3 min, p = 0.495).Conclusion: Our results suggest that all methods, including the recommendation of physical activity, can improve cardiovascular fitness in overweight subjects and obese males.

关键词： Combined training Endurance training Obesity Oxygen consumption Physical activity Strength training Ventilatory threshold

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Myth and Origins： Men Want to Know

引用

Journal of Literature and Art Studies 2015年第10期5卷 930-945页

作者： jose manuel Losada Universite Complutense Madrid Spain

Starting with a personal definition of ＂myth＂, this paper seeks to substantiate the claim that every myth is essentially etiological, in the sense that myths somehow express a cosmogony or an eschatology, whether particular or universal. In order to do that, this study reassesses Classical and Judeo-Christian mythologies to revisit and contrast the narratives of origin--of the cosmos, of the gods and of men--found in ancient polytheism and in Judeo-Christian monotheism. Taking into consideration how these general and particular cosmogonies convey a specific understanding of the passage of time, this article does not merely recount the cosmogonies, theogonies, and anthropogonies found in the Bible and in the works of authors from Classical Antiquity, but it also incorporates a critical commentary on pieces of art and literature that have reinterpreted such mythical tales in more recent times The result of the research is the disclosure of a sort of universal etiology that may be found in mythology which, as argued, explains the origins of the world, of the gods, and of men so as to satisfy humankind＇s ambition to unveil the mysteries of the cosmos. Myth thus functions in these cases as a vehicle that makes it possible for man to return the fullness of a primordial age, abandoning the fleeting time that entraps him and entering a time still absolute

关键词： mythology myth criticism cosmogony theogony anthropogony Bible Genesis Gonzalo Torrente

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Some Thoughts on the Portuguese Colonial City and Architecture in Post-Colonial Times

引用

Sociology Study 2014年第10期4卷 881-890页

作者： jose manuel Fernandes jose manuel Fernandes Rua Joao Teixeira Simoes 19 1. esq.2780-254 Oeiras Portugal

The research on the architecture and urbanism of the former Portuguese Africa allows us to consider and to establish the real intrinsic value, typological and morphological diversity, and the lengthy duration of the legacy of this architectural/urban heritage. Portuguese colonization in Africa produced more recently, mostly in the period 1950-1975, some vast and great material values, of which seven or eight main cities, including the vast contents of their modern architecture, are striking examples. We can evaluate the most positive aspects with future impact represented by this Portuguese architects＇ practice （cultural ethics, use of modern technology, and service to society） and the architectonic work produced during that era. Although these cities and its architecture were created within a late colonial context of indisputable discrimination, they have prevailed despite wars and circumstantial abandonment. Now they represent a consistent material basis for the modernization and/or revitalization of urban life in these countries. Architects that are at present working and intervening in these countries should understand this ambivalence and complementary nature between the ex-colonial ＂concrete city＂ and the ＂informal city＂ pre- and post-colonial, so that their performance is socially and culturally informed, correct, and positive.

关键词： Portuguese colonial modern architecture post-colonial

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Deep brain stimulation for obsessive-compulsive disorder:A systematic review of worldwide experience after 20 years

引用

World Journal of Psychiatry 2021年第9期11卷 659-680页

作者： Lorea Mar-Barrutia Eva Real Cinto Segalas Sara Bertolin jose manuel Menchon Pino Alonso OCD Clinical and Research Unit Department of PsychiatryHospital de BellvitgeBarcelona 08907Spain Bellvitge Biomedical Research Institute-IDIBELL Barcelona 08907Spain CIBERSAM(Centro de Investigaci on en Red de Salud Mental) Carlos Ⅲ Health InstituteMadrid 28029Spain Department of Clinical Sciences Faculty of MedicineUniversity of BarcelonaBarcelona 08907Spain

BACKGROUND Twenty years after its first use in a patient with obsessive-compulsive disorder(OCD),the results confirm that deep brain stimulation(DBS)is a promising therapy for patients with severe and resistant forms of the ***,many unknowns remain,including the optimal anatomical targets,the best stimulation parameters,the long-term(LT)effects of the therapy,and the clinical or biological factors associated with *** systematic review of the articles published to date on DBS for OCD assesses the short and LT efficacy of the therapy and seeks to identify predictors of *** To summarize the existing knowledge on the efficacy and tolerability of DBS in treatment-resistant *** A comprehensive search was conducted in the PubMed,Cochrane,Scopus,and *** databases from inception to December 31,2020,using the following strategy:“(Obsessive-compulsive disorder OR OCD)AND(deep brain stimulation OR DBS).”Clinical trials and observational studies published in English and evaluating the effectiveness of DBS for OCD in humans were included and screened for relevant information using a standardized collection *** inclusion criteria were as follows:a main diagnosis of OCD,DBS conducted for therapeutic purposes and variation in symptoms of OCD measured by the Yale-Brown Obsessive-Compulsive scale(Y-BOCS)as primary *** were analyzed with descriptive *** Forty articles identified by the search strategy met the eligibility *** a follow-up threshold of 36 mo,29 studies(with 230 patients)provided information on short-term(ST)response to DBS in,while 11(with 155 patients)reported results on LT *** follow-up period was 18.5±8.0 mo for the ST studies and 63.7±20.7 mo for the LT ***,the percentage of reduction in Y-BOCS scores was similar in ST(47.4%)and LT responses(47.2%)to DBS,but more patients in the LT reports met the criteria for response(defined as a reduction in

关键词： Deep brain stimulation Obsessive-compulsive disorder Predictors of response Side effects Short-term Long-term

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An elastin-like recombinamer-based bioactive hydrogel embedded with mesenchymal stromal cells as an injectable scaffold for osteochondral repair

引用

Regenerative Biomaterials 2019年第6期6卷 335-347页

作者： Filippo Cipriani Blanca Arino Palao Israel gonzalez de Torre Aurelio Vega Castrillo Hector jose Aguado hernandez Matilde Alonso Rodrigo Angel jose Alvarez Barcia Ana Sanchez Veronica Garcıa Diaz Monica Lopez Pena jose Carlos Rodriguez-Cabello Technical Proteins Nanobiotechnology S.L. Paseo Belen 9AValladolid 47011Spain Departamento de traumatologıa Hospital Clınico de ValladolidAv.Ramon y Cajal 3Valladolid 47003Spain Bioforge University of Valladolid CIBER-BBNPaseo de Belen 19Valladolid 47011Spain SIBA-UVA:servicio investigacion y bienestar animal University of ValladolidC/Plaza de Santa Cruz 8Valladolid 47002Spain Instituto de Biologıa y Genetica Molecular(IBGM) Universidad de Valladolid y CSICCalle Sanz y Fores 3Valladolid 47003Spain Facultad de veterinaria Campus UniversitarioAvda.Carballo Calero s/nLugo 27002Spain

The aim of this study was to evaluate injectable,in situ cross-linkable elastin-like recombinamers(ELRs)for osteochondral *** the ELR-based hydrogel alone and the ELR-based hydrogel embedded with rabbit mesenchymal stromal cells(rMSCs)were tested for the regeneration of critical subchondral defects in 10 New Zealand ***,cylindrical osteochondral defects were filled with an aqueous solution of ELRs and the animals sacrificed at 4months for histological and gross evaluation of features of biomaterial performance,including integration,cellular infiltration,surrounding matrix quality and the new matrix in the *** both approaches helped cartilage regeneration,the results suggest that the specific composition of the rMSC-containing hydrogel permitted adequate bone regeneration,whereas the ELR-based hydrogel alone led to an excellent regeneration of hyaline *** conclusion,the ELR cross-linker solution can be easily delivered and forms a stable well-integrated hydrogel that supports infiltration and de novo matrix synthesis.

关键词： biopolymer animal test cartilage bone

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：