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Influence of olive oil and its components on mesenchymal stem cell biology

World Journal of Stem Cells 2019年第12期11卷 1045-1064页

作者： Antonio Casado-Díaz Gabriel Dorado jose manuel Quesada-Gómez CIBER de Fragilidad y Envejecimiento Saludable(CIBERFES) Instituto Maimónides de Investigación Biomédica de Córdoba(IMIBIC)Hospital Universitario Reina SofíaCórdoba 14004Spain Departement Bioquímica y Biología Molecular Campus Rabanales C6-1-E17Campus de Excelencia Internacional Agroalimentario(ceiA3)Universidad de CórdobaCIBERFESCórdoba 14071Spain Unidad de Gestión Clínica de Endocrinología y Nutrición CIBER de Fragilidad y Envejecimiento Saludable(CIBERFES)Instituto Maimónides de Investigación Biomédica de Córdoba(IMIBIC)Hospital Universitario Reina SofíaCórdoba 14004Spain

Extra virgin olive oil is characterized by its high content of unsaturated fatty acid residues in triglycerides,mainly oleic acid,and the presence of bioactive and antioxidant *** consumption is associated with lower risk of suffering chronic diseases and unwanted processes linked to aging,due to the antioxidant capacity and capability of its components to modulate cellular signaling *** of olive oil can alter the physiology of mesenchymal stem cells(MSCs).This may explain part of the healthy effects of olive oil consumption,such as prevention of unwanted aging *** date,there are no specific studies on the action of olive oil on MSCs,but effects of many components of such food on cell viability and differentiation have been *** objective of this article is to review existing literature on how different compounds of extra virgin olive oil,including residues of fatty acids,vitamins,squalene,triterpenes,pigments and phenols,affect MSC maintenance and differentiation,in order to provide a better understanding of the healthy effects of this ***,most studies have shown a positive effect of these compounds on *** collective findings support the hypothesis that at least part of the beneficial effects of extra virgin olive oil consumption on health may be mediated by its effects on MSCs.

关键词： Olive oil Mesenchymal stem cells Cellular differentiation Aging Cellular niche Mediterranean diet

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The first meteorological observations at a tropical high elevation site:Antisana,1846

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Journal of Mountain Science 2016年第6期13卷 1047-1055页

作者： Aria Ma M.FARRONA Fernando DOMINGUEZ-CASTRO Ma cruz GALLEGO jose M.VAQUERO Departamento de Fisica Facultad de CienciasUniversidad de ExtremaduraBadajoz 06071Spain Instituto de Fisica de Cantabria(UC-CSIC) Santander 39005Spain Departamento de Ingenieria Civily Ambiental Escuela Politecnica NacionalQuito 170112Ecuador Instituto Nacional de Meteorologiae Hidrologia Quito 170135Ecuador instituto universitario de investigación del agua cambio climático y sostenibilidad (iacys) universidad de extremaduraBadajoz 06071，Spain departamento de física centro universitario de mérida universidad de extremaduraMerida 06800Spain

Antisana is a stratovolcano with an associated glacier located in the Ecuadorian Andes. Dr Aguirre made meteorological readings every day, at every hour from sunrise to sunset, from December 1845 to December 1846, at Antisana using a meteorological station at 4060 mamsl （meters above mean sea level）. Unfortunately, only the monthly average data have been preserved. These meteorological data are here studied and compared with the closest modern stations for monthly values of temperature, rainfall, and pressure. According to these comparisons, the year 1846 was rainy and cold in comparison with the current climate. Moreover, these observations have been useful to help resolve a debate about a possible E1Nifio event in 1846 with the high precipitation in Antisana and Quito in 1846 discarding the occurrence of an E1 Nifio event. The probable occurrence of a La Nifia event is discussed. These data are the earliest known systematic instrumental meteorological observations taken at above 4000 mamsl.

关键词： Early instrumental records Glacier Pastclimate conditions

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Novel therapeutic strategies targeting mitochondria as a gateway in neurodegeneration

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Neural Regeneration Research 2023年第5期18卷 991-995页

作者： Diogo Trigo jose Joao Vitoria Odete A.B.da cruz e Silva Neuroscience and Signalling Laboratory Institute of Biomedicine(iBiMED)Department of Medical SciencesUniversity of AveiroAveiroPortugal

In recent years, multiple disciplines have focused on mitochondrial biology and contributed to understanding its relevance towards adult-onset neurodegenerative disorders. These are complex dynamic organelles that have a variety of functions in ensuring cellular health and homeostasis. The plethora of mitochondrial functionalities confers them an intrinsic susceptibility to internal and external stressors(such as mutation accumulation or environmental toxins), particularly so in long-lived postmitotic cells such as neurons. Thus, it is reasonable to postulate an involvement of mitochondria in aging-associated neurological disorders, notably neurodegenerative pathologies including Alzheimer’s disease and Parkinson’s disease. On the other hand, biological effects resulting from neurodegeneration can in turn affect mitochondrial health and function, promoting a feedback loop further contributing to the progression of neuronal dysfunction and cellular death. This review examines state-of-the-art knowledge, focus on current research exploring mitochondrial health as a contributing factor to neuroregeneration, and the development of therapeutic approaches aimed at restoring mitochondrial homeostasis in a pathological setting.

关键词： Alzheimer’s disease axon energy homeostasis glymphatic system mitochondria mitostasis neurodegeneration neuroregeneration Parkinson’s disease therapeutical strategies

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Role of artificial intelligence in cardiology

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World Journal of Cardiology 2023年第4期15卷 116-118页

作者： Rafael Vidal-Perez jose manuel Vazquez-Rodriguez Servicio de Cardiología Unidad de Imagen y Función CardíacaComplexo Hospitalario Universitario A Coruña Centro de Investigación Biomédica en Red-Instituto de Salud Carlos ⅢA Coruña 15006A CoruñaSpain Servicio de Cardiología Complexo Hospitalario Universitario A CoruñaA Coruña 15006A CoruñaSpain

Artificial intelligence(AI)is the process of having a computational program that can perform tasks of human intelligence by mimicking human thought *** is a rapidly evolving transdisciplinary field which integrates many elements to develop algorithms that aim to simulate human intuition,decision-making,and object *** overarching aims of AI in cardiovascular medicine are threefold:To optimize patient care,improve efficiency,and improve clinical *** cardiology,there has been a growth in the potential sources of new patient data,as well as advances in investigations and therapies,which position the field well to uniquely benefit from *** this editorial,we highlight some of the main research priorities currently and where the next steps are heading us.

关键词： Artificial intelligence Machine learning Deep learning Electrocardiography Cardiac imaging

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Grain yield losses in yellow-rusted durum wheat estimated using digital and conventional parameters under field conditions

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The Crop Journal 2015年第3期3卷 200-210页

作者： Omar Vergara-diaz Shawn C.Kefauver Abdelhalim Elazab Maria Teresa Nieto-Taladriz jose Luis Araus Unit of Plant Physiology Department of Plant BiologyFaculty of BiologyUniversity of BarcelonaDiagonal 64508028 BarcelonaSpain National Institute for Agricultural and Food Research and Technology(INIA) Ctra de la Coruna 7.528040Madrid Spain

The biotrophic fungus Puccinia striiformis f. sp. tritici is the causal agent of the yellow rust in wheat. Between the years 2010–2013 a new strain of this pathogen(Warrior/Ambition),against which the present cultivated wheat varieties have no resistance, appeared and spread rapidly. It threatens cereal production in most of Europe. The search for sources of resistance to this strain is proposed as the most efficient and safe solution to ensure high grain production. This will be helped by the development of high performance and low cost techniques for field phenotyping. In this study we analyzed vegetation indices in the Red,Green, Blue(RGB) images of crop canopies under field conditions. We evaluated their accuracy in predicting grain yield and assessing disease severity in comparison to other field measurements including the Normalized Difference Vegetation Index(NDVI), leaf chlorophyll content, stomatal conductance, and canopy temperature. We also discuss yield components and agronomic parameters in relation to grain yield and disease ***-based indices proved to be accurate predictors of grain yield and grain yield losses associated with yellow rust(R2= 0.581 and R2= 0.536, respectively), far surpassing the predictive ability of NDVI(R2= 0.118 and R2= 0.128, respectively). In comparison to potential yield, we found the presence of disease to be correlated with reductions in the number of grains per spike, grains per square meter, kernel weight and harvest index. Grain yield losses in the presence of yellow rust were also greater in later heading varieties. The combination of RGB-based indices and days to heading together explained 70.9% of the variability in grain yield and 62.7% of the yield losses.

关键词： Wheat yellow rust Field phenotyping NDVI Phenology,Puccinia striiformis RGB-based indices Triticum durum

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Liquid biopsy approach to pancreatic cancer

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World Journal of Gastrointestinal Oncology 2021年第10期13卷 1263-1287页

作者： Sonia Perales Carolina Torres Cristina Jimenez-Luna jose Prados Joaquina Martinez-Galan jose manuel Sanchez-Manas Octavio Caba Department of Biochemistry and Molecular Biology I Faculty of SciencesUniversity of GranadaGranada 18071Spain Department of Biochemistry and Molecular Biology III and Immunology Faculty of SciencesUniversity of GranadaGranada 18071Spain Institute of Biopathology and Regenerative Medicine(IBIMER) Center of Biomedical Research(CIBM)University of GranadaGranada 18100Spain Department of Medical Oncology Hospital Universitario Virgen de las NievesGranada 18011Spain School for International Postgraduate Studies University of GranadaGranada 18071Spain

Pancreatic cancer(PC)continues to pose a major clinical *** has been little improvement in patient survival over the past few decades,and it is projected to become the second leading cause of cancer mortality by *** dismal 5-year survival rate of less than 10%after the diagnosis is attributable to the lack of early symptoms,the absence of specific biomarkers for an early diagnosis,and the inadequacy of available *** patients are diagnosed when the disease has already metastasized and cannot be *** interception is vital,actively intervening in the malignization process before the development of a full-blown advanced *** early diagnosis of PC has a dramatic impact on the survival of patients,and improved techniques are urgently needed to detect and evaluate this disease at an early *** is difficult to obtain tissue biopsies from the pancreas due to its anatomical position;however,liquid biopsies are readily available and can provide useful information for the diagnosis,prognosis,stratification,and follow-up of patients with PC and for the design of individually tailored *** aim of this review was to provide an update of the latest advances in knowledge on the application of carbohydrates,proteins,cell-free nucleic acids,circulating tumor cells,metabo-lome compounds,exosomes,and platelets in blood as potential biomarkers for PC,focusing on their clinical relevance and potential for improving patient outcomes.

关键词： Pancreatic cancer Biomarkers Liquid biopsy Clinical management Cancer interception Cancer monitoring

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From"planning in section"to"semiduplex":The New Humanism and the alternate-corridor technique

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Frontiers of Architectural Research 2020年第3期9卷 485-497页

作者： Alejandro Perez-Duarte Fernandez jose manuel Falcon Meraz School of Architecture and Design Instituto Tecnologico y de Estudios Superiores de Occidente45604TlaquepaqueJaliscoMexico

Most of the pretending innovative modern housing projects show a common element that can be perceived when looking at the cross-section,evidencing the use of alternate corridors,which was recognized as a projective technique under Wells Coates expression"Planning in Section".Contrasting virtues concerning the resulting space were observed at different historical *** late 19th Century used it to create *** modern architecture used it to increase efficiency,where flexibility was ***,during the’60s,the alternative corridor technique started to be used to attend social issues,popularizing the split-level term,and echoing 19th Century privacy *** like Smithson’s"doorstep"and Candilis"semi-duplex"section reveal their ***-differentiated areas(public/intimate/col-lective)and socially controlled areas were obtained in domestic interiors with a few steps,creating singular spaces where children can play while being monitored by ***-duplex geometry showed new adaptability to different profiles:a small kitchenless apartment for a bachelor could be inserted aside from a larger two-level family *** paper shows an overview of this projective technique by contrasting different housing *** similar split-level geometries seem to have been coming back recently,questions about it are necessary.

关键词： Alternate corridor split-level housing Privacy duplex

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Pupil apodization for increasing data storage density

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Chinese Optics Letters 2009年第8期7卷 720-723页

作者： Vidal F.Canales Pedro J.Valle jose E.Oti manuel P.Cagigal Department of Física Aplicada University of CantabriaLos Castros S/NSantander 39005Spain AOTEK S.COOP. Bo San Andrés 19Arrasate-Mondragón 20500Spain

We introduce a technique for increasing density in optical data storage systems. This technique is based on the use of a superresolving filter at the pupil of a confocal readout system. The main characteristic of this confocal readout system is that the light beam traverses twice through the pupil filter. We describe how to analyze the system performance for general filters, but we focus the study on filters with no focus displacement. Although the storage density attainable depends on the filter characteristics, we show that the storage density can be easily duplicated.

关键词： Pupil apodization for increasing data storage density PSF data

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Multitemporal landslide inventory analysis of an intertropical mountain in west-central Mexico——Basis for hazard management

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Journal of Mountain Science 2022年第6期19卷 1650-1669页

作者： Alejandro Cesar VALDES CARRERA manuel E.MENDOZA Teodoro CARLÓN ALLENDE jose Luis MACIAS Centro de Investigaciones en Geografia Ambiental Universidad Nacional Autonoma de MexicoMorelia 58190Mexico Consejo Nacional de Ciencia y Tecnologia-Instituto de Geofisica-Unidad Michoacan Universidad Nacional Autonoma de MexicoMorelia 58190Mexico Instituto de Geofisica-Unidad Michoacan Universidad Nacional Autonoma de MexicoMorelia 58190Mexico

Landslides in intertropical mountainous areas of Mexico are a natural hazard that could potentially generate a disaster. Despite this, many areas lack landslide inventories, making it difficult to monitor and efficiently manage the associated risks for local populations. For this reason, the aim of this research was to undertake a multitemporal landslide inventory and analyze its conditioning factors in the Pico de Tancítaro stratovolcano, which, in recent decades, has presented several high-risk geomorphological events with disastrous consequences for nearby localities. The spatial distribution of landslides and its conditioning factors were mapped at a 1:50,000 scale for the 1995-2020 period, through visual interpretation of orthophotos and satellite images(Landsat, SPOT, and SENTINEL). The conditioning factors that link the most to landslides were Quaternary andesite and basaltic andesite rocks;volcanic cones, mountain river valleys, and very steep to steep slopes(30° to >45°), oriented to the South, North, and East;Andosols and Leptosols;and the oyamel fir and mixed forests. 505 landslide events classified into slides and flows that occurred in 1995, 2004, 2010, and 2015 were identified. New scars generated by the reactivation of landslide processes were also observed. The landslides in the study area were triggered by torrential rains caused by hurricanes and tropical storms;such as hurricanes Alex and Patricia. The inventory and analysis of conditioning factors highlighted the distribution and dynamics of slides and flows in the study area. In addition, the most important factors for studies of landslide susceptibility, hazards, and risks in the Pico de Tancítaro stratovolcano were identified, contributing to the management of geomorphological risks in intertropical mountain areas.

关键词： Geomorphology Mass wasting Natural hazards Pico de Tancítaro stratovolcano Risk management

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Formal verification of safety protocol in train control system

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Science China(Technological Sciences) 2011年第11期54卷 3078-3090页

作者： ZHANG Yan TANG Tao LI KePing MERA jose manuel ZHU Li ZHAO Lin XU TianHua State Key Laboratory of Rail Traffic Control and Safety Beijing Jiaotong University Beijing 100044 China Railway Technologies Research Centre Universidad Politecnica de Madrid Madrid 228006 Spain

In order to satisfy the safety-critical requirements,the train control system(TCS) often employs a layered safety communication protocol to provide reliable ***,both description and verification of the safety protocols may be formidable due to the system *** this paper,interface automata(IA) are used to describe the safety service interface behaviors of safety communication protocol.A formal verification method is proposed to describe the safety communication protocols using IA and translate IA model into PROMELA model so that the protocols can be verified by the model checker SPIN.A case study of using this method to describe and verify a safety communication protocol is *** verification results illustrate that the proposed method is effective to describe the safety protocols and verify deadlocks,livelocks and several mandatory consistency properties.A prototype of safety protocols is also developed based on the presented formally verifying method.

关键词： train control system safety communication protocol interface automata verification

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