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Diagnosis and management of bacterial infections in decompensated cirrhosis

World Journal of Hepatology 2013年第1期5卷 16-25页

作者： Maria Pleguezuelo jose Manuel Benitez Juan Jurado jose luis Montero Manuel De la Mata Liver Research Unit Reina Sofia University HospitalAvda Menendez Pidal s/n14004 CordobaSpain

Bacterial infections are one of the most frequent complications in cirrhosis and result in high mortality *** with cirrhosis have altered and impaired immunity,which favours bacterial *** of infections are more frequent in patients with decompensated cirrhosis than those with compensated liver *** most common and life-threatening infection in cirrhosis is spontaneous bacterial peritonitis followed by urinary tract infections,pneumonia,endocarditis and skin and soft-tissue *** with decompensated cirrhosis have increased risk of developing sepsis,multiple organ failure and *** factors associated with the development of infections are severe liver failure,variceal bleeding,low ascitic protein level and prior episodes of spontaneous bacterial peritonitis (SBP).The prognosis of these patients is closely related to a prompt and accurate *** appropriate treatment decreases the mortality *** strategies are the mainstay of the management of these *** antibiotics should be started immediately following the diagnosis of SBP and the first-line antibiotic treatment is third-generation ***,the efficacy of currently recommended empirical antibiotic therapy is very low in nosocomial infections including SBP,compared to community-acquired *** may be associated with the emergence of infections caused by Enterococcus faecium and extended-spectrum β-lactamaseproducing Enterobacteriaceae,which are resistant to the first line antimicrobial agents used for *** emergence of resistant bacteria,underlines the need to restrict the use of prophylactic antibiotics to patients with the greatest risk of *** infections should be treated with wide spectrum *** studies of early diagnosis,prevention and treatment are needed to improve the outcomes in patients with decompensated cirrhosis.

关键词： Cirrhosis Infections Spontaneous bacterial peritonitis Ascites Antibiotics

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An elastin-like recombinamer-based bioactive hydrogel embedded with mesenchymal stromal cells as an injectable scaffold for osteochondral repair

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Regenerative Biomaterials 2019年第6期6卷 335-347页

作者： Filippo Cipriani Blanca Arino Palao Israel Gonzalez de Torre Aurelio Vega Castrillo Hector jose Aguado Hernandez Matilde Alonso rodrigo Angel jose Alvarez Barcia Ana Sanchez Veronica Garcıa Diaz Monica Lopez Pena jose Carlos Rodriguez-Cabello Technical Proteins Nanobiotechnology S.L. Paseo Belen 9AValladolid 47011Spain Departamento de traumatologıa Hospital Clınico de ValladolidAv.Ramon y Cajal 3Valladolid 47003Spain Bioforge University of Valladolid CIBER-BBNPaseo de Belen 19Valladolid 47011Spain SIBA-UVA:servicio investigacion y bienestar animal University of ValladolidC/Plaza de Santa Cruz 8Valladolid 47002Spain Instituto de Biologıa y Genetica Molecular(IBGM) Universidad de Valladolid y CSICCalle Sanz y Fores 3Valladolid 47003Spain Facultad de veterinaria Campus UniversitarioAvda.Carballo Calero s/nLugo 27002Spain

The aim of this study was to evaluate injectable,in situ cross-linkable elastin-like recombinamers(ELRs)for osteochondral *** the ELR-based hydrogel alone and the ELR-based hydrogel embedded with rabbit mesenchymal stromal cells(rMSCs)were tested for the regeneration of critical subchondral defects in 10 New Zealand ***,cylindrical osteochondral defects were filled with an aqueous solution of ELRs and the animals sacrificed at 4months for histological and gross evaluation of features of biomaterial performance,including integration,cellular infiltration,surrounding matrix quality and the new matrix in the *** both approaches helped cartilage regeneration,the results suggest that the specific composition of the rMSC-containing hydrogel permitted adequate bone regeneration,whereas the ELR-based hydrogel alone led to an excellent regeneration of hyaline *** conclusion,the ELR cross-linker solution can be easily delivered and forms a stable well-integrated hydrogel that supports infiltration and de novo matrix synthesis.

关键词： biopolymer animal test cartilage bone

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TML:a language to specify aerial robotic missions for the framework Aerostack

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International Journal of Intelligent Computing and Cybernetics 2017年第4期10卷 491-512页

作者： Martin Molina Ramon A.Suarez-Fernandez Carlos Sampedro jose luis Sanchez-Lopez Pascual Campoy Department of Artificial Intelligence Technical University of Madrid(UPM)MadridSpain Centre for Automation and Robotics Technical University of MadridMadridSpain

Purpose–The purpose of this paper is to describe the specification language TML for adaptive mission plans that the authors designed and implemented for the open-source framework Aerostack for aerial ***/methodology/approach–The TML language combines a task-based hierarchical approach together with a more flexible representation,rule-based reactive planning,to facilitate *** approach includes additional notions that abstract programming *** authors built an interpreter integrated in the software framework *** interpreter was validated with flight experiments for multi-robot missions in dynamic ***–The experiments proved that the TML language is easy to use and expressive enough to formulate adaptive missions in dynamic *** experiments also showed that the TML interpreter is efficient to execute multi-robot aerial missions and reusable for different *** TML interpreter is able to verify the mission plan before its execution,which increases robustness and safety,avoiding the execution of certain plans that are not ***/value–One of the main contributions of this work is the availability of a reliable solution to specify aerial mission plans,integrated in an active open-source project with periodic *** the best knowledge of the authors,there are not solutions similar to this in other active open-source *** additional contributions,TML uses an original combination of representations for adaptive mission plans(*** trees with original abstract notions and rule-based reactive planning)together with the demonstration of its adequacy for aerial robotics.

关键词： Adaptive mission plans Aerial robotic systems Autonomous aerial systems Mission plan specification

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Depth of closure:New calculation method based on sediment data

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International Journal of Sediment Research 2018年第2期33卷 198-207页

作者： luis Aragonés jose Ignacio Pagán Isabel López José C.Serra Department of civil engineering University of Alicante Department of transportation ETSI Caminos Polytechnic University of Valencia

Obtaining depth of closure(DoC) in an accurate manner is a fundamental issue for coastal engineering,since good results for coastal structures and beach nourishment depend mainly on DoC. Currently, there are two methods for obtaining the DoC, mathematical formulations and profile surveys. However, these methods can incur important errors if one does not take into account the characteristics and morphology of the area, or if one does not have a sufficiently long time series. In this work the DoC is obtained from the break in the trend of the sediment with the depth, that is, in general with the increase of the depth a decrease in the size of the sediment takes place. However, at one point this tendency changes and the size increases, and then decreases again. When comparing the point where the minimum sediment size occurs before the increase, it is observed that the error incurred is small compared to other methods. If the Standard Deviation of Depth Change(SDDC) method is considered as the most accurate method, the error incurred by the proposed method is less than 7%. In addition, it can be seen that the dispersion of the sediment method always occurs outside the zone of bar movement. Whereas in the methods of profiles survey(using 2 cm precision profiles), sometimes the DoC is obtained within the active zone of bar movement. In addition, where the relative minimum of the median sediment size is found, and the sizes of 0.063 and 0.125 mm predominate in the composition of the sample. Therefore, this new method allows the precise location of the DoC to be obtained in a fast and simple way. Furthermore, this method has the advantage that it is not affected by the modifications that may be experienced by both the study area and the cross-shore beach profile.

关键词： Depth of Closure Median sediment size Profile surveys Profile change GIS

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Cretaceous Antarctic plesiosaurs:stratigraphy,systematics and paleobiogeography

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Advances in Polar Science 2019年第3期30卷 210-227页

作者： jose Patricio O’GORMAN rodrigo OTERO Marcelo REGUERO Zulma GASPARINI División Paleontología Vertebrados Museo de La PlataUniversidad Nacional de La PlataPaseo del Bosque s/n.B1900FWALa PlataArgentina Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) ArgentinaGodoy Cruz 2290C1425FQBCABAArgentina Red Paleontológica U-Chile Laboratorio de Ontogenia y FilogeniaDepartamento de BiologíaFacultad de CienciasUniversidad de ChileLas Palmeras 3425SantiagoChile Instituto Antártico Argentino 25 de Mayo 1143B1650HMKSan MartínBuenos AiresArgentina

The last twenty million years(Maastrichtian–Santonian)of Southern Hemisphere plesiosaur history is especially well recorded in the Weddellian Province(Patagonia;Western Antarctica and New Zealand).The oldest Late Cretaceous plesiosaurs,two specimens referred to Polycotylidae indet.,come from the Santonian levels of the Santa Marta Formation,while the oldest elasmosaurids come from the lower Campanian of the same *** the lower Maastrichtian of the Snow Hill Island Formation the non-aristonectine elasmosaurid Vegasaurus molyi is recorded together with other non-diagnosable elasmosaurid specimens,but no aristonectines are *** appears in the Antarctic record in the upper Maastrichtian of the López de Bertodano Formation and are represented by Morturneria and *** specimens from the upper Campanian previously referred to Aristonectinae *** referred to Elasmosauridae indet.,shortening the temporal record of Aristonectinae in *** aristonectines appears in the Antarctic record in the upper Maastrichtian of the López de Bertodano Formation and are represented by Morturneria and *** Antarctic Cretaceous elasmosaurids show a paleobiogeographic connection with South America and New Zealand(Weddellian Province).This connection is indicated by the shared presence of the Aristonectinae Kaiwhekea katiki(New Zealand)and Aristonectes(Argentina and Chile).Recent phylogenetic analysis recovered the aristonectines within the Weddellonectia clade,which includes the aristonectines and the non-aristonectines Vegasaurus molyi(Isla Vega,Antarctica);Kawanectes lafquenianum(Argentina);Morenosaurus stocki and Aphrosaurus furlongi(California).Among the Weddellonectia,the aristonectines show a relatively large body size and extremely derived features and probably occupied a trophic niche that differed from the trophic niche of other *** way of contrast Kawanectes lafquenianum is an extremely small body-

关键词： Elasmosauridae Aristonectinae Polycotylidae Santa Marta Formation Snow Hill Island Formation López de Bertodano Formation Weddellonectia

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Effects of Recreational Soccer on Health Outcomes:A Narrative Review

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Journal of Science in Sport and Exercise 2019年第2期1卷 142-150页

作者： Israel Castillo-Bellot jose Mora-Gonzalez luis Fradua Francisco B.Ortega luis Gracia-Marco Department of Physical Education and Sport Faculty of Sport SciencesUniversity of GranadaGranadaSpain PROmoting FITness and Health Through Physical Activity(PROFITH)Research Group Department of Physical Education and SportFaculty of Sport SciencesUniversity of GranadaGranadaSpain

Soccer is a very popular team sport that involves a variety of physical actions,such as sprints,accelerations,sudden decelera-tions,and jumps,among *** has placed recreational soccer in a good position as a strategy to increase physical activity levels and promote health across the *** this regard,recreational(non-competitive)soccer promotes social interaction and has the potential to increase long-term adherence to physical activity,even in those without prior experience in this *** this narrative review,we address the effects of recreational soccer on various health outcomes across the lifespan(i.e.,from childhood to the elderly years)in both *** addition,the beneficial effects of recreational soccer for people with prevalent pathologies,such as hypertension,type II diabetes mellitus,and cancer,are discussed.

关键词： Physical fitness Physical activity Hypertension Diabetes Cancer Football

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Association between the CYBA and NOX4 genes of NADPH oxidase and its relationship with metabolic syndrome in non-alcoholic fatty liver disease in Brazilian population

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Hepatobiliary & Pancreatic Diseases International 2018年第4期17卷 330-335页

作者： Fabiola Rabelo jose Tadeu Stefano Ana Mercedes Cavaleiro rodrigo Vieira Costa Lima Daniel Ferraz de Campos Mazo Flair jose Carrilho Maria Lúcia Correa-Giannellac Claudia P.Oliveiraa Departamento de Gastroenterologia Faculdade de Medicina FMUSPUniversidade de Sao PauloSao PauloSPBrazil Hospital das Clinicas HCFMUSP Departamento de GastroenterologiaLIM07Faculdade de MedicinaUniversidade de Sao PauloSao PauloSPBrazil Laboratório de Carboidratos e Radioimunensaio LIM18Hospital das Clinicas HCFMUSP(LIM07)Faculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Programa de Pos-Graduacao em Medicina Universidade Nove de Julho(UNINOVE)Sao PauloBrazil

Background: Oxidative stress has been implicated in the progression of severe forms of non-alcoholic fatty liver disease(NAFLD). NADPH oxidase produces reactive oxygen species. In the present study, we investigated for the first time two single nucleotide polymorphisms(SNPs) in the regulatory region of genes encoding NADPH oxidase 4(NOX4) and p22 phox(CYBA) in ***: A total of 207 biopsy-proven NAFLD patients [simple steatosis(n = 27); nonalcoholic steatohepatitis(NASH)(n = 180)] were evaluated. Genomic DNA was extracted from peripheral blood cells, and polymorphisms in CYBA(unregistered) and NOX4(rs3017887) were determined by direct sequencing of ***: Associations of CYBA-675 T/A with high-density lipoprotein(HDL)(TT vs TA vs AA; P < 0.01) and triglycerides(TGL)(TT vs XA; P < 0.01) were observed only in NASH patients. For polymorphisms in the NOX4 gene, NOX4(rs3017887) CA + AA genotypes was significant associated with alanine aminotransferase(ALT)(CA + AA vs CC; P = 0.02). However, there was no association of SNPs in the CYBA and NOX4 genes encoding the NADPH oxidase system proteins and the presence of NASH. Regarding the clinical results, it was observed that the most advanced degrees of fibrosis occurred in patients diagnosed with type 2 diabetes mellitus(66.9% vs 37.5%, P < 0.01) and those who were more obese(32.2 vs 29.0 kg/m2,P < 0.01). In addition, serum glucose and insulin levels increased significantly in the presence of ***: There were associations between the presence of the allele A in the NOX4 SNP and a higher concentration of ALT in the NAFLD population; between the presence of the AA genotype in the polymorphism of the CYBA-675 T/A CYBA gene and a higher level of TGL and lower HDL in NASH patients. The presence of metabolic syndrome was associated with advanced degrees of fibrosis in NAFLD patients.

关键词： Non-alcoholic fatty liver disease Nonalcoholic steatohepatitis Genetic polymorphism Metabolic syndrome

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Seasonal Effect of Sunlight on COVID-19 among Countries with and without Lock-Downs

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Open Journal of Epidemiology 2021年第3期11卷 303-325页

作者： jose-luis Sagripanti US Department of Defense (RETIRED) Annapolis Maryland USA

Objective: The main aim of the study was to determine whether COVID-19 epidemiological data reported by countries in different hemispheres correlated with the seasons of the year. Since stay-at-home orders could be a main factor affecting the time individuals spent outdoors, the progression of COVID-19 in countries that mandated the most stringent lock-downs and stay-at-home orders was compared to countries in the same hemisphere that did not order their citizens to remain at home. Methods: Infections attributed to COVID-19 per million inhabitants, deaths per infections × 100, and deaths per million inhabitants from different countries were analyzed utilizing national reports registered in the Johns’ Hopkins database together with the most recent world population data. The null hypothesis (no difference between countries with and without lock-downs) was tested (two tailed test, p Results: The shift of highest infection rates from countries in the northern-towards countries in the southern-hemisphere during early 2020 and the reverse in December of the same year correlates with the seasonal variation in the flux of germicidal sunlight. Mortality rate for the same virus among different countries did not show a seasonal component. COVID-19 infection mortality rate was considerably lower in developing countries of South America (11 of the largest countries) than in several (at least 8) developed European countries. Discussion: COVID-19 resulted in higher infections during winter than in summer. The finding of a seasonal component, correlating the progression of the pandemic with local solar flux, demonstrates that infectious virus in the environment plays a role in the pandemic since direct person-to-person transmission would afford little time for solar inactivation. Similar epidemiological data amongst “locked” and “unlocked” countries demonstrates that

关键词： SARS-CoV-2 COVID-19 Coronaviruses Global Health Environmental Health Quarantine Lock-Down Epidemic Pandemic Virus Inactivation Solar Radiation Seasonal Progression COVID-19 Photobiology

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Prevalence of occult hepatitis B virus infection

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World Journal of Gastroenterology 2011年第12期17卷 1538-1542页

作者： Maria luisa Gutiérrez-García Conrado M Fernandez-Rodriguez jose luis Lledo-Navarro Ingrid Buhigas-Garcia Service of Gastroenterology Hospital Universitario Fundación AlcorcónAv Budapest-128922 AlcorcónMadridSpain

Occult hepatitis B virus(HBV) infection(OBI) is characterized by the persistence of HBV DNA in the liver tissue in individuals negative for the HBV surface *** prevalence of OBI is quite variable depending on the level of endemic disease in different parts of the world,the different assays utilized in the studies,and the different populations *** studies have been carried out on OBI prevalence in different areas of the world and categories of *** studies show that OBI prevalence seems to be higher among subjects at high risk for HBV infection and with liver disease than among individuals at low risk of infection and without liver disease.

关键词： Occult hepatitis B virus infection Hepatitis B virus DNA Anti-HBc Hepatitis B virus seronegative Hepatitis C Crytogenetic hepatitis Dialysis Human immunodeficiency virus Blood donors

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HLA B27 as Predisposition Factor to Suffer Age Related Macular Degeneration

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Cellular & Molecular Immunology 2009年第4期6卷 303-307页

作者： Enrique Villegas Becerril Rafael Gonzalez Fernandez luis Perula Torres Manuel Santos Lacomba jose Maria Gallardo Galera Hospital Universitario Reina Sofia Cordoba Spain Faculty of Medicine University of Cordoba Spain Hospital Universitario Reina Sofia C/Conchita Cintron n 4 Atico 2 CP 14011

To research whether specific alleles HLA class Ⅰ （HLA-A and HLA-B） and class Ⅱ （HLA-DR） are risk factors for the development of exudative type of Age Related Macular Degeneration（ARMD）, HLA antigens are expressed both in normal and affected eyes with ARMD. We designed a prospective case-controlled study. We recruited 75 patients with choroidal neovascuiarization predominantly classic or occult, secondary to ARMD, and treated with photodynamic therapy. Two hundred and fifty patients over 55 years old, without ophthalmologic pathology who went to hospital for an analytical routine check were used as control. The analysis of the data shows a significant difference between two groups. Allele HLA-B27 correlated positively with ARMD （p 〈 0.0113）. However, we didn＇t find alleles negatively associated. Thus HLA-B27 is an allele predisposed to suffer ARMD.

关键词： HLA alleles ARMD HLA B27 patient with ARMD

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