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Prevalence and risk factors of acute-on-chronic liver failure in a single center from Argentina

World Journal of Hepatology 2016年第34期8卷 1529-1534页

作者： Cristian Dominguez Eugenia Romero Jorgelina Graciano jose luis fernandez luis Viola Division of Gastroenterology Sanatorio Guemes Centro Integral de Gastroenterología

AIMTo study the prevalence, characteristics, risk factors and mortality at 28 d of acute-on-chronic liver failure (ACLF). METHODSA total of 100 cirrhotic patients admitted to our hospital for more than one day were included during the period between June 2013 and December 2015. We used the European Association for the Study of the Liver-Chronic Liver Failure-Consortium diagnostic criteria for ACLF, considering it as the acute decompensation of cirrhosis associated with the presence of one or more organ failure. For the diagnosis of organic failure the Chronic Liver Failure-Sequential Organ Failure Assessment score was used. Our population was divided into patients with and without ACLF. Clinical characteristics, presence of precipitating events, potential risk factors for developing ACLF and causes of mortality were analyzed. Mortality at 28 d was evaluated. RESULTSTwenty-nine patients (29%) developed ACLF criteria. Alcoholism, detected in 58 patients (58%), was the major etiological agent of cirrhosis. Bacterial infections were recognized as a precipitating event in 41.3% of cases and gastrointestinal bleeding in 27.5%. No precipitating event was identifiable in 27.5% of patients with ACLF. Comparing patients with and without ACLF, statistically significant risk factors were: Child Pugh score 10.2 ± 2.1 vs 8.4 ± 1.6 (P ˂ 0.0001), MELD score 20.7 ± 8.5 vs 12.3 ± 4 (P ˂ 0.0001), presence of ascites 27 (93%) vs 43 (60.5%) (P = 0.001), leukocytosis 15300 ± 8033 per cubic millimeter vs 10770 ± 5601 per cubic millimeter (P ˂ 0.0001), and high plasma levels of C reactive protein values 50.9 ± 46.4 mg/L vs 28.6 ± 23.4 mg/L (P ˂ 0.0019). Mortality rate was 62% (18 patients) vs 5.6% (4 patients), respectively (P CONCLUSIONWe observed that the ACLF is a frequent entity in this group of patients and has a significantly higher mortality rate.

关键词： Acute-on-chronic liver failure Acute liver decompensation Cirrhosis Ascites Mortality

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5Ws of Green and Sustainable Software

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Tsinghua Science and Technology 2020年第3期25卷 401-414页

作者： Coral Calero Javier Mancebo Felix Garcia Maria Angeles Moraga jose Alberto Garcia Berna jose luis fernandez-Aleman Ambrosio Toval the Institute of Technology and Information Systems University of Castilla-La ManchaCiudad Real 13071Spain. the Department of Informatics and Systems University of MurciaMurcia 30003Spain

Green and Sustainable Software has emerged as a new and highly active area in the software *** several years of research and work,we believe that it is now necessary to obtain a general snapshot of how the research in this area is *** do so,we have applied the 5 Ws(why,when,who,where,and what),a formula for getting the complete story on a *** have therefore carried out a study,using 542 publications related to Green and Sustainable Software research;these were recovered using *** results obtained allow us to conclude that it is important to identify key elements of the research to allow researchers be fully aware of the state of the research on Green and Sustainable Software(why);the study uses papers published between 2000 and the beginning of November 2018(when);the most prolific authors are mainly from Europe,although the USA is the most active country,Green and Sustainable Software being a very interactive area with a good number of multinational publications(who);the top five keywords related to sustainable aspects are Green Software,Green IT,Software Sustainability,Energy Consumption,and Energy Efficiency(what);finally,as regards the places authors prefer to publish in,there is almost a complete balance between conferences and journals,with a trend towards an increase in the number of publications(where).

关键词： Green Software Sustainable Software Software Engineering Software Sustainability Energy Efficiency Energy Utilization

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Risk factors and classifications of hilar cholangiocarcinoma

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World Journal of Gastrointestinal Oncology 2013年第7期5卷 132-138页

作者： Miguel Angel Suarez-Munoz jose luis fernandez-Aguilar Belinda Sanchez-Perez jose Antonio Perez-Daga Beatriz Garcia-Albiach Ysabel Pulido-Roa Naiara Marin-Camero Julio Santoyo-Santoyo General Digestive and Transplantation Surgery Service HPB and Liver Transplant UnitUniversity Hospital Carlos Haya29010 MalagaSpain

Cholangiocarcinoma is the second most common primary malignant tumor of the *** cholangiocarcinoma or Klatskin tumor represents more than 50% of all biliary tract cholangiocarcinomas.A wide range of risk factors have been identified among patients with Perihilar cholangiocarcinoma including advanced age,male gender,primary sclerosing cholangitis,choledochal cysts,cholelithiasis,cholecystitis,parasitic infection(Opisthorchis viverrini and Clonorchis sinensis),inflammatory bowel disease,alcoholic cirrhosis,nonalcoholic cirrhosis,chronic pancreatitis and metabolic *** classifications have been used to describe the pathologic and radiologic appearance of *** three systems most commonly used to evaluate Perihilar cholangiocarcinoma are the Bismuth-Corlette(BC) system,the Memorial Sloan-Kettering Cancer Center and the TNM *** BC classification provides preoperative assessment of local *** Memorial Sloan-Kettering cancer center proposes a staging system according to three factors related to local tumor extent:the location and extent of bile duct involvement,the presence or absence of portal venous invasion,and the presence or absence of hepatic lobar *** TNM classification,besides the usual descriptors,tumor,node and metastases,provides additional information concerning the possibility for the residual tumor(R) and the histological grade(G).Recently,in 2011,a new consensus classification for the Perihilar cholangiocarcinoma had been *** consensus was organised by the European Hepato-PancreatoBiliary Association which identified the need for a new staging system for this type of *** classification includes information concerning biliary or vascular(portal or arterial) involvement,lymph node status or metastases,but also other essential aspects related to the surgical risk,such as remnant hepatic volume or the possibility of underlying disease.

关键词： Hilar cholangiocarcinoma Klatskin tumor Perihilar cholangiocarcinoma Bile duct cancer

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Unraveling the interaction between soil microbiomes and their potential for restoring polluted soils

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Frontiers of Environmental Science & Engineering 2024年第8期18卷 149-151页

作者： Carlos O.Lomeli-Ortega Mingming Sun jose luis Balcazar Catalan Institute for Water Research(ICRA-CERCA) Girona 17003Spain University of Girona Girona 17004Spain Soil Ecology Laboratory College of Resources and Environmental SciencesNanjing Agricultural UniversityNanjing 210095China

Soils are not exempt from anthropogenic pollution,which can eventually cause disturbance of the microbial communities and areas without any kind of *** soil microbiota,bacteria play an important role in pollutant degradation,enabling them to thrive in contaminated *** this,several techniques have been used to increase the number of pollutantdegrading bacteria in situ or for subsequent ***,bacteriophages exhibit a high tolerance to pollutants and enhance bacterial metabolic activity through phage-encoded auxiliary metabolic genes(AMGs),thereby augmenting their skills for nutrient assimilation,resistance to phage infection,antibiotic resistance,heavy metal resistance,and degradation of pesticides and xenobiotics,among *** phage-encoded AMGs have been described during the last few years,but their diversity,distribution,and function have not been extensively explored,warranting further ***,we highlight soil microbiome interactions,especially bacterium and phage interactions to understand this unexplored world with a high potential for restoring polluted soils.

关键词： Auxiliary metabolic genes Microbiome Pollutants Soils Viruses

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Insights into the origin of precipitation moisture for tropical cyclones during rapid intensification process

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Tropical Cyclone Research and Review 2024年第2期13卷 72-87页

作者： Albenis Perez-Alarcon jose C.fernandez-Alvarez Ricardo M.Trigo Raquel Nieto luis Gimeno Centro de Investigacion Mari~na Universidade de VigoEnvironmental Physics Laboratory(EPhysLab)Campus As Lagoas s/nOurenseSpain Departamento de Meteorología Instituto Superior de Tecnologías y Ciencias AplicadasUniversidad de La HabanaLa HabanaCuba Instituto Dom Luiz(IDL) Facultade de Ci^enciasUniversidade de LisboaLisboaPortugal Departamento de Meteorologia Universidade Federal do Rio de JaneiroRio de JaneiroBrazil

In this study,we identiﬁed the moisture sources for the precipitation associated with tropical cyclones(TCs)during the rapid intensiﬁcation(RI)process from 1980 to 2018 by applying a Lagrangian moisture source diagnostic *** detected sixteen regions on a global scale for RI events distributed as follows:four in the North Atlantic(NATL),two in the Central and East Paciﬁc Ocean(NEPAC),the North Indian Ocean(NIO)and South Indian Ocean(SIO),and three in the South Paciﬁc Ocean(SPO)and the Western North Paciﬁc Ocean(WNP).The moisture uptake(MU)mostly was from the regions where TCs underwent *** Western NATL,tropical NATL,Caribbean Sea,the Gulf of Mexico and the Central America and Mexico landmass supported~85.4%of the precipitating moisture in the NATL,while the latter source and the eastern North Paciﬁc Ocean provided the higher amount of moisture in NEPAC(~84.3%).The Arabian Sea,the Bay of Bengal and the Indian Peninsula were the major moisture sources in NIO,contributing approximately 81.3%.The eastern and western parts of the Indian Ocean supplied most of the atmospheric humidity in SIO(~83.8%).The combined contributions(~87.9%)from the western and central SPO and the Coral Sea were notably higher in ***,TCs in the WNP basin mostly received moisture from the western North Paciﬁc Ocean,the Philippine Sea and the China Sea,accounting for 80.1%.The remaining moisture support in each basin came from the summed contributions of the remote ***,RI TCs gained more moisture up to 2500 km from the cyclone centre than those slow intensiﬁcation(SI)and the total MU was approximately three times higher during RI than ***,the patterns of the MU differences respond to the typical pathways of moisture transport in each basin.

关键词： Tropical cyclones Rapid intensiﬁcation Moisture sources Precipitation Lagrangian moisture tracking

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Sexual dimorphism in the antitumor immune responses elicited by the combination of fasting and chemotherapy

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Cancer Communications 2024年第4期44卷 508-513页

作者： Andrés Pastor-Fernández Manuel Montero Gómez de las Heras jose Ignacio Escrig-Larena Marta Barradas Cristina Pantoja Adrian Plaza jose luis Lopez-Aceituno Esther Durán Alejo Efeyan Maria Mittelbrunn Lola Martinez Pablo jose fernandez-Marcos Metabolic Syndrome Group(BIOPROMET) Madrid Institute for Advanced Studies(IMDEA)FoodE28049MadridSpain Molecular Biology Center Severo Ochoa(CBMSO) Spanish National Research Council(CSIC)Madrid Autonoma University(UAM)MadridSpain Department of Basic Medical Sciences Institute of Applied Molecular MedicineSchool of MedicineUniversity Studies Center(CEU)-San Pablo UniversityMadridSpain Metabolism and Cell Signaling Laboratory Spanish National Cancer Research Centre(CNIO) MadridSpain 5Flow Cytometry UnitBiotechnology ProgrammeSpanish National Cancer Research Centre(CNIO)MadridSpain

Fasting reduces chemotherapy toxicity[1],enhances immunogenic tumor cell death[2,3]and increases CD8^(+)T cell infiltration in tumors,particularly when combined with chemotherapy[2,3]or immunotherapy[4].More-over,fast... 详细信息

关键词： chemotherapy fasting immune

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Bacteriophages assisted bacteria to facilitate soil multifunctionality under organochlorine pesticide contamination

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Science China Technological Sciences 2024年第10期67卷 3116-3128页

作者： ZHAO DuoKai CHAO HuiZhen BALCAZAR jose luis WU ShiMao ZHENG XiaoXuan WU YunLing YUAN ShuJian SUN MingMing HU Feng Soil Ecology Lab Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization and Jiangsu Key Laboratory for Solid Organic Waste UtilizationNanjing Agriculture University J.F.Blumenbach Institute of Zoology and Anthropology University of G?ttingen Catalan Institute for Water Research (ICRA) University of Girona College of Environmental and Resource Sciences Zhejiang University

As the most abundant living entities in the environment, viruses have been well recognized as crucial members in sustaining biogeochemical cycling. However, the significance of viruses in soil ecosystem multifunctionality remains under-explored. In this study, we used metagenomics and meta-viromics analysis to investigate the role of soil viruses in soil ecosystem functions under heavy, light, and no organochlorine pesticides(OCPs) contamination. In the three types of soil samples collected, lightcontaminated soils supported the highest level of multifunctionality, followed by heavy-contaminated soils and clean ***, our results revealed a positive correlation between bacterial community evenness and multifunctionality index(p <0.05). Dominant bacterial species with biodegradation and stress resistance advantages exhibited higher abundance in OCPaffected soils, potentially playing a core functional supporting role. Furthermore, our results indicated that the species richness and diversity of bacteriophages were positively correlated with multifunctionality(p < 0.05) in OCP-affected soils. Bacteriophages in OCP-affected soils regulate host metabolism and enhance soil ecosystem multifunctionality by infecting functional bacterial hosts and encoding AMGs related to soil element cycling. Our findings emphasize the potential effect of phages on ecosystem multifunctionality in contaminated soil, suggesting that phages may serve as contributors to soil ecology beyond bacteria and other microorganisms. Therefore, in polluted or constrained soils, further research could potentially translate phage communities and related ecological processes into artificial methods for application in soil pollution remediation or ecological restoration.

关键词： soil ecosystem multifunctionality viruses auxiliary metabolic genes organochlorine pesticides contamination

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Exploring research on ecotechnology through artificial intelligence and bibliometric maps

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Environmental Science and Ecotechnology 2024年第5期21卷 405-412页

作者： Ricardo Ruiz-Sanchez Ricardo Arencibia-Jorge Julia Tagüena jose luis Jimenez-Andrade Humberto Carrillo-Calvet Unidad Profesional Interdisciplinaria de Ingeniería Palenque(UPIIP) Instituto Politecnico NacionalPalenqueChiapasCP 29960Mexico Complexity Sciences Center National Autonomous University of MexicoCircuito Centro Cultural s/nCoyoacan04510Mexico CityMexico Institute of Renewable Energies(IER) National Autonomous University of MexicoPriv.Xochicalco s/nCol.CentroTemixcoMorelosCP 62580Mexico Faculty of Sciences National Autonomous University of MexicoCircuito Centro Cultural s/nCoyoacan04510Mexico CityMexico

Ecotechnology,quintessential for crafting sustainable socio-environmental strategies,remains tantalizingly *** analysis,steered by the nuances of machine learning and augmented by bibliometric insights,delineates the expansive terrain of this domain,elucidates pivotal research themes and conundrums,and discerns the vanguard nations in this ***,we deftly connect our discoveries to the United Nations'2030 Sustainable Development Goals,thereby accentuating the profound societal ramifications of ecotechnology.

关键词： Ecotechnologies Bibliometrics Sustainable development goals Network analysis SOM neural networks

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Adult neurogenesis:a real hope or a delusion?

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Neural Regeneration Research 2024年第1期19卷 6-15页

作者： Ghulam Hussain Rabia Akram Haseeb Anwar Faiqa Sajid Tehreem Iman Hyung Soo Han Chand Raza jose-luis Gonzalez De Aguilar Neurochemicalbiology and Genetics Laboratory(NGL) Department of PhysiologyFaculty of Life SciencesGovernment College UniversityFaisalabadPunjabPakistan Department of Physiology School of MedicineClinical Omics InstituteKyungpook National UniversityDaeguKorea Department of Zoology Faculty of Chemistry and Life SciencesGovernment College UniversityLahorePakistan INSERM U1118Mécanismes Centraux et Péripheriques de la NeurodégénérescenceStrasbourgFranceUniversitéde StrasbourgStrasbourgFrance

Adult neurogenesis,the process of creating new neurons,involves the coordinated division,migration,and differentiation of neural stem *** process is restricted to neurogenic niches located in two distinct areas of the brain:the subgranular zone of the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricle,where new neurons are generated and then migrate to the olfactory *** has been thought to occur only during the embryonic and early postnatal stages and to decline with age due to a continuous depletion of neural stem ***,recent years have seen tremendous progress in our understanding of adult brain neurogenesis,bridging the knowledge gap between embryonic and adult ***,we discuss the current status of adult brain neurogenesis in light of what we know about neural stem *** this notion,we talk about the importance of intra cellular signaling molecules in mobilizing endogenous neural stem cell prolife *** on the current understanding,we can declare that these molecules play a role in targeting neurogenesis in the mature ***,to achieve this goal,we need to avoid the undesired proliferation of neural stem cells by controlling the necessary checkpoints,which can lead to tumorigenesis and prove to be a curse instead of a blessing or hope.

关键词： adult neurogenesis aging brain-derived neurotrophic factor dentate gyrus hippocampus neural stem cells neurotrophic factors Notch oxidative stress stem cells subgranular zone

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High-repetition-rate source of nanosecond duration kA-current pulses driven by relativistic laser pulses

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High Power Laser Science and Engineering 2024年第3期12卷 106-115页

作者： Michael Ehret Jakub Cikhardt Philip Wykeham Bradford Iuliana-Mariana Vladisavlevici Tomas Burian Diego de luis jose luis Henares Rubén Hernández Martín Jon Imanol Apiñaniz Roberto Lera JoséAntonio Pérez-Hernández João Jorge Santos Giancarlo Gatti Centro de Láseres Pulsados(CLPU) VillamayorSpain Czech Technical University in Prague Faculty of Electrical EngineeringPragueCzech Republic Univ.Bordeaux-CNRS-CEA Centre Lasers Intenses et Applications(CELIA)UMR 5107TalenceFrance Department of Radiation and Chemical Physics FZU-Institute of Physics of the Czech Academy of SciencesPragueCzech Republic

We report the first high-repetition-rate generation and simultaneous characterization of nanosecond-scale return currents of kA-magnitude issued by the polarization of a target irradiated with a PW-class high-repetition-rate titanium:sapphire laser system at relativistic *** present experimental results obtained with the VEGA-3 laser at intensities from5×10^(18)to 1.3×10^(20)W cm^(-2).A non-invasive inductive return-current monitor is adopted to measure the derivative of return currents of the order of kA ns-1and analysis methodology is developed to derive return *** compare the current for copper,aluminium and Kapton targets at different laser *** data show the stable production of current peaks and clear prospects for the tailoring of the pulse shape,which is promising for future applications in highenergy-density science,for example,electromagnetic interference stress tests,high-voltage pulse response measurements and charged particle beam *** compare the target discharge of the order of hundreds of nC with theoretical predictions and a good agreement is found.

关键词： current pulses electromagnetic pulse application high-power laser relativistic laser plasma

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