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Highly accessible aqueous synthesis of well-dispersed dendrimer type platinum nanoparticles and their catalytic applications

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Nano Research 2019年第5期12卷 1083-1092页

作者： Adrian Fernandez-Lodeiro Jamila Djafari David Lopez-Tejedor Carlos Perez-Rizquez Benito Rodriguez-Gonzalez jose luis capelo jose M.Palomo Carlos Lodeiro Javier Fernandez-Lodeiro BIOSCOPE Group LAQV@REQUIMTEChemistry DepartmentFaculty of Science and TechnologyUniversity NOVA of LisbonCaparica CampusCaparica 2829-516Portugal PROTEOMASS Scientific Society Rua dos InventoresMadan ParqueCaparica CampusCaparica 2829-516Portugal Department of Biocatalysis Institute of Catalysis(CSIC)MadridSpainMarie Curie 2CantoblancoUAM CampusMadrid 28049Spain Scientific and Technological Research Assistance Center(CACTI) University of VigoLagoas-MarcosendeVigo 36310Spain

The application of novel methodologies to the synthesis of nanomaterials is still a challenge in many different technological and scientific *** efficient and reproducible synthetic methodologies,that produce fewer residues and reduce the cost of raw materials must be *** the present work,we have explored the attractive possibility to apply the cheap iron (Ⅱ) sulphate salt in the reduction process of the K2PtCl4 to produce colloids *** synthesis took places in water and was assisted by sodium citrate (SC) using polyvinylpyrrolidone (PVP) as a *** adjustment of this novelty process allows obtaining well-dispersed and sub-20 nm dendrimer-type platinum nanoparticles (Pt D-NPs).The nano-dendrimers produced have been characterized using dynamic light scattering (DLS),transmission electron microscopy (TEM),high-resolution TEM (HR-TEM),XRD spectroscopy,inductive couple plasma (ICP) analysis,Fourier transform infrared (FT-IR) and ultraviolet-visible (UV-vis) *** conformational results derived from the size and shape will be *** application of the Pt D-NPs has been explored in the reduction of p-nitrophenol (p-NP) to p-aminophenol (p-AP) in aqueous media at room temperature obtained TOF value of 253 min^-***,our Pt D-NPs were tested as artificial metalloenzyme showing catechol oxidase activity for oxidation of L-DOPA.

关键词： platinum dendrimer NPs catalytic application green synthesis cateohol oxidase-like activity

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado jose M.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon luis H.Pagan Rivera Jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

CFD modelling:The most useful tool for developing mesoscale urban canopy parameterizations

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Building Simulation 2021年第3期14卷 407-419页

作者： Riccardo Buccolieri jose luis Santiago Alberto Martilli Dipartimento di Scienze e Tecnologie Biologiche edAmbientali University ofSalentoS.P.6 Lecce-MonteroniLecce 73700Italy Environment Department Research Center for EnergyEnvironment and Technology(CIEMAT)Madrid 28040Spain

1 Introduction The fact that most of the world’s population lives in cities(UN-Habitat 2016)has increased interest in urban *** models,such as the Weather Research and Forecasting(WRF)model(***/weather-research-and-forecasting-model),are used to reproduce the meteorology and climatology over cities and around them,where the complex interactions between the atmosphere and urban surfaces(buildings,vegetation,urban obstacles,etc.)induce strong heterogeneity in the flow properties within the urban canopy layer(UCL)(Di Sabatino et al.2013;Lateb et al.2016;Tominaga and Stathopoulos 2016).

关键词： meteorology urban forecasting

Invasive-invaded system of non-Lipschitz porous medium equations with advection

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International Journal of Biomathematics 2021年第7期14卷 299-327页

作者： jose luis Diaz Palencia Escuela Politecnica Superior Universidad Francisco de Vitoria Ctra.Pozuelo-Majadahonda Km 1 80028223Pozuelo de AlarconMadrid

This work provides analytical results towards applications in the field of invasive-invaded systems modeled with nonlinear diffusion and with *** results focus on showing regularity,existence and uniqueness of weak solutions using the condition of a nonlinear slightly positive parabolic operator and the reaction-absorption monotone *** coupling in the reaction-absorption terms,that characterizes the species interaction,impedes the formulation of a global comparison principle that is shown to exist ***,this work provides analytical solutions obtained as selfsimilar minimal and maximal profiles.A propagating diffusive front is shown to exist until the invaded specie notes the existence of the *** the desertion of the invaded st arts,the diffusive front vanishes globally and the nonlinear diffusion concentrates only on the propagating tail which exhibits finite ***,the invaded specie is shown to exhibit an exponential decay along a characteristic *** exponential decay is not trivial in the nonlinear diffusion case and confirms that the invasive continues to feed on the invaded during the desertion.

关键词： Nonlinearity reaction absorption coupled system diffusion porous media

Structural performance assessment of GFRP elastic gridshells by machine learning interpretability methods

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Frontiers of Structural and Civil Engineering 2022年第10期16卷 1249-1266页

作者： Soheila KOOKALANI Bin CHENG jose luis Chavez TORRES Department of Civil Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Civil Engineering Technical University of LojaLoja 110102Ecuador

The prediction of structural performance plays a significant role in damage assessment of glass fiber reinforcement polymer(GFRP)elastic gridshell *** learning(ML)approaches are implemented in this study,to predict maximum stress and displacement of GFRP elastic gridshell *** ML algorithms,including linear regression(LR),ridge regression(RR),support vector regression(SVR),K-nearest neighbors(KNN),decision tree(DT),random forest(RF),adaptive boosting(AdaBoost),extreme gradient boosting(XGBoost),category boosting(CatBoost),and light gradient boosting machine(LightGBM),are implemented in this *** features of structural performance considered in this study are the maximum stress as f1(x)and the maximum displacement to self-weight ratio as f2(x).A comparative study is conducted and the Catboost model presents the highest prediction ***,interpretable ML approaches,including shapely additive explanations(SHAP),partial dependence plot(PDP),and accumulated local effects(ALE),are applied to explain the *** is employed to describe the importance of each variable to structural performance both locally and *** results of sensitivity analysis(SA),feature importance of the CatBoost model and SHAP approach indicate the same parameters as the most significant variables for f1(x)and f2(x).

关键词： machine learning gridshell structure regression sensitivity analysis interpretability methods

Magnetofection as a new tool to study microglia biology

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Neural Regeneration Research 2019年第5期14卷 767-768页

作者： jose luis Venero Miguel Angel Burguillos Instituto de Biomedicina de Sevilla (IBiS)/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla and Departamento de Bioquímica y Biología Molecular Facultad de Farmacia Universidad de Sevilla Department of Biochemistry University of Cambridge

Microglia are the resident macrophages of the brain,originally described by Pio del Rio-Hortega(a student of Santiago Ramon y Cajal)in a series of studies in *** those pioneering studies,many others have followed to describe microglia as complex and multitasking cells with many diverse roles under physiological(*** key role in synapse pruning during development)or diseased *** exist as sentinels or surveyors of the environment that surround neurons,becoming reactive upon a wide array of stimuli and consequently developing an appropriate inflammatory *** fact,a neuroinflammatory response driven by microglia is found in virtually every disease process that occurs within the central nervous ***,a better understanding of the mechanisms governing the microglia response is the key to improving the outcome of neurodegenerative conditions.

关键词： Magnetofection new tool study microglia biology

Novel nanocomposites based on a strawberry-like gold-coated magnetite （Fe@Au） for protein separation in multiple myeloma serum samples

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Nano Research 2015年第4期8卷 1189-1198页

作者： jose E. Araujo Carlos Lodeiro jose L. capelo Benito Rodrfguez-Gonzalez Alcindo A. dos Santos~ Hugo M. Santos Javier Ferna.ndez-Lodeiro BIOSCOPE Research Group UCIBIO-REQUIMTE Department of Chemistry Faculty of Science and Technology University NOVA of Lisbon 2829-516 Caparica Portugal PROTEOMASS Scientific Society Madan Parque Rua dos Inventores 2825-182 Caparica Portuga Scientific and Technological Research Assistance Centre (CACTI) University of Vigo Vigo Spain Instituto de Quimica Universidade de Sao Paulo Av. Prof. Lineu Prestes 748 CxP 26077 Sao Paulo 05508-000 Brazil

A new process to produce magnetite partially coated with strawberry-like gold nanoparticles in aqueous media is reported. The fast response to magnetic fields and optical properties of gold nanoparticle-based colloidal systems are the two main advantages of this new Fe@Au nanomaterial. These advantages allow for the use of this new colloidal nanomaterial for various purposes in proteomics and biomedicine, as proteins can bind to the surface, and the surface can also be funcfionalized. As proof-of-concept, the new Fe@Au nanoparticles have been assessed in biomarker discovery as a tool for pre-concentration and separation of proteins from complex proteomes. To this end, sera from healthy people were compared with sera from patients diagnosed with multiple myeloma. The application of this new Fe@Au nanomaterial combined with mass spectrometry has allowed for the identification of 53 proteins, and it has also shown that the heat shock protein HSP75 and the plasma protease C1 inhibitor are potential biomarkers for diagnostics and control of multilvle mveloma vro^ression.

关键词： nanoproteomics strawberry-nanopartides multifunctional hybridnanoparticles biomarkers multiple myeloma

Machine Learning-Based Radio Access Technology Selection in the Internet of Moving Things

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China Communications 2021年第7期18卷 13-24页

作者： Ramon Sanchez-Iborra luis Bernal-Escobedo jose Santa Dept.Engineering and Applied Techniques University Centre of Defence at the Spanish Air Force Academy30729 San JavierSpain Dept.Information and Communication Engineering University of Murcia30100 MurciaSpain Dept.of Electronics Computing Technology and ProjectsTechnical University of Cartagena30202 CartagenaSpain

The Internet of Moving Things(IoMT)takes a step further with respect to traditional static IoT *** this line,the integration of new eco-friendly mobility devices such as scooters or bicycles within the Cooperative-Intelligent Transportation Systems(C-ITS)and smart city ecosystems is crucial to provide novel *** this end,a range of communication technologies is available,such as cellular,vehicular WiFi or Low-Power Wide-Area Network(LPWAN);however,none of them can fully cover energy consumption and Quality of Service(QoS)***,we propose a Decision Support System(DSS),based on supervised Machine Learning(ML)classification,for selecting the most adequate transmission interface to send a certain message in a multi-Radio Access Technology(RAT)set *** ML algorithms have been explored taking into account computing and energy constraints of IoMT enddevices and traffic ***,a real implementation of a decision tree-based DSS for micro-controller units is presented and *** attained results demonstrate the validity of the proposal,saving energy in communication tasks as well as satisfying QoS requirements of certain urgent *** footprint of the real implementation on an Arduino Uno is 444 bytes and it can be executed in around 50µs.

关键词： internet of moving things multi-RAT CITS classification personal mobility

What Isat Stake in Comparing the Literatures?

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Journal of Foreign Languages and Cultures 2023年第1期7卷 53-64页

作者： jose luis Jobim Fluminense Federal University

This paper will present and discuss a few questions raised in David Damrosch's Comparing the Literatures:Literary Studies in a Global Age,a book that,divided into chapters based on some selected keywords,develops rele... 详细信息

关键词： comparative literature translation world literature trasnational literary experience linguistic imperialism