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Clinical Efficacy of Inhaled Nitric Oxide in Preventing the Progression of Moderate to Severe COVID-19 and Its Correlation to Viral Clearance:Results of a Pilot Study

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Infectious Microbes & Diseases 2022年第1期4卷 26-33页

作者： Merlin Moni Thushara Madathil Dipu T.Sathyapalan Veena Menon Georg Gutjahr Fabia Edathadathil Deepthi Sureshkumar Preetha Prasanna Soumya jose Roshni Jerome Ajai Krishnan Indulekha C.l.Pillai Geetha Kumar Bipin Nair Victor Nizet Aveek Jayant Department of Medicine Division of Infectious DiseasesAmrita Institute of Medical ScienceAmrita Vishwa VidyapeethamKochiKeralaIndia Department of Cardiac Anaesthesiology Amrita Institute of Medical ScienceAmrita Vishwa VidyapeethamKochiKeralaIndia Clinical Virology laboratory Amrita Institute of Medical SciencesAmrita Vishwa VidyapeethamKochiKeralaIndia Center for Research in Analytics and Technologies for Education(CREATE) Amrita Vishwa VidyapeethamAmritapuriKollamKeralaIndia Department of Infection Control and Epidemiology Amrita Institute of Medical ScienceAmrita Vishwa VidyapeethamKochiKeralaIndia School of Medicine Amrita Institute of Medical ScienceAmrita Vishwa VidyapeethamKochiKeralaIndia School of Biotechnology Amrita Vishwa VidyapeethamAmritapuriKollamKeralaIndia Skaggs School of Pharmacy and Pharmaceutical Sciences University of CaliforniaSan DiegoLa JollaCaliforniaUSA Department of Pediatrics University of CaliforniaSan DiegoLa JollaCaliforniaUSA

Hypoxic patients with coronavirus disease 2019(COVID-19)are at high risk of adverse *** nitric oxide(iNO)has shown anti-viral and immunomodulatory effects in ***,in vivo evidence of efficacy in hypoxic COVID-19 is *** open label feasibility study was conducted at a single referral center in South India and evaluated the effectiveness of repurposed iNO in improving clinical outcomes in COVID-19 and its correlation with viral *** recruited hypoxemic COVID-19 patients and allocated them into treatment(iNO)and control groups(1:1).Viral clearance on day 5 favored the treatment group(100%vs 72%,Pl clearance as adjudged by normalized longitudinal cycle threshold(Ct)values was positively impacted in the treatment *** proportion of patients who attained clinical improvement,defined as a≥2-point change on the World Health Organization ordinal scale,was higher in the iNO cohort(n=11,79%)as compared to the control group(n=4,36%)(odds ratio 6.42,95%confidence interval 1.09–37.73,P=0.032).The proportion of patients progressing to mechanical ventilation in the control group(4/11)was significantly higher than in the treatment group(0/14).The all-cause 28-day mortality was significantly different among the study arms,with 36%(4/11)of the patients dying in the control group while none died in the treatment *** numbers needed to treat to prevent an additional poor outcome of death was estimated to be *** study demonstrates the putative role of repurposed iNO in hypoxemic COVID-19 patients and calls for extended validation.

关键词： nitric oxide COVID-19 antiviral activity WHO ordinal scale

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Comparison of different statistical approaches to evaluate morphometric sperm subpopulations in men

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Asian Journal of Andrology 2016年第6期18卷 819-823页

作者： Jesus l Yaniz Sandra Vicente-Fiel Caries Soler Pilar Recreo Teresa Carretero Araceli Bono jose M Berne Pilar Santolaria TECNOGAM research group Environmental Sciences Institute (IUCA) Department of Animal Production and Food Sciences Higher Polytechnic School University of Zaragoza Ctra. Cuarte S/N 22071 Huesca Spain Department of Functional Biology and Physical Anthropology University of Valencia 46100 Burjassot Valencia Spain R+D Department Proiser R+D Scientific Park University of Valencia 46980 Paterna Valencia Spain TECNOGAM research group Environmental Sciences Institute (IUCA) Departament of Human Anatomy and Histology Faculty of Health and Sport Sciences of Huesca Plaza Universidad 3 22002 Huesca Spain TECNOGAM research group Environmental Sciences Institute (IUCA) Hospital General San Jorge de Huesca Area de Urologla Av. Martfnez de Velasco 36 22004 Huesca Spain

This study was designed to characterize morphometric sperm subpopulations in normozoospermic men by using different statistical methods and examining their suitability to classify correctly different sperm nuclear morphologies present in human ejaculates. Ejaculates from 21 normozoospermic men were collected for the study. After semen collection and analysis, samples were prepared for morphometric determination. At least 200 spermatozoa per sample were assessed for sperm morphometry by computer-assisted sperm morphometry analysis （CASA-Morph） using fluorescence. Clustering and discriminant procedures were performed to identify sperm subpopulations from the morphometric data obtained. Clustering procedures resulted in the classification of spermatozoa into three morphometric subpopulations （large-round 30.4%, small-round 46.6%, and large-elongated 22.9%）. In the second analysis, using discriminant methods, the classification was made independently of size and shape. Three morphological categories according to nuclear size （small 〈10.90 μm^2, intermediate 10.91-13.07 μm^2, and large 〉13.07 μm^2） and four categories were defined on 400 canonical cells （100 × 4） from 10 men according to sperm nuclear shape （oval, pyriform, round, and elongated）. Thereafter, the resulting classification functions were used to categorize 4200 spermatozoa from 21 men. Differences in the class distribution were observed among men from both clustering and discriminant procedures. It was concluded that the combination of CASA-Morph fluorescence-based technology with multivariate cluster or discriminant analyses provides new information on the description of different morphometric sperm subpopulations in normal individuals, and that important variations in the distribution of morphometric sperm subpopulations may exist between men, with possible functional implications.

关键词： computer-assisted sperm morphometry analysis man sperm subpopulations

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Multi-objective parametrization of interatomic potentials for large deformation pathways and fracture of two-dimensional materials

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npj Computational Materials 2021年第1期7卷 1042-1052页

作者： Xu Zhang Hoang Nguyen Jeffrey T.Paci Subramanian K.R.S.Sankaranarayanan jose l.Mendoza-Cortes Horacio D.Espinosa Theoretical and Applied Mechanics Program Northwestern UniversityEvanstonILUSA Department of Chemistry University of VictoriaVictoriaBCCanada Center for Nanoscale Materials Argonne National LaboratoryLemontILUSA Department of Chemical Engineering&Materials Science Michigan State UniversityEast LansingMIUSA Department of Mechanical Engineering Northwestern UniversityEvanstonILUSA

This investigation presents a generally applicable framework for parameterizing interatomic potentials to accurately capture large deformation *** incorporates a multi-objective genetic algorithm,training and screening property sets,and correlation and principal component *** framework enables iterative definition of properties in the training and screening sets,guided by correlation relationships between properties,aiming to achieve optimal parametrizations for properties of ***,the performance of increasingly complex potentials,Buckingham,Stillinger-Weber,Tersoff,and modified reactive empirical bond-order potentials are *** MoSe_(2)as a case study,we demonstrate good reproducibility of training/screening properties and superior *** MoSe_(2),the best performance is achieved using the Tersoff potential,which is ascribed to its apparent higher flexibility embedded in its functional *** results should facilitate the selection and parametrization of interatomic potentials for exploring mechanical and phononic properties of a large library of two-dimensional and bulk materials.

关键词： materials apparent enable

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Single-Photon Interaction with Beam Splitters

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Optics and Photonics Journal 2018年第2期8卷 20-28页

作者： jose l. Parra Courtesy Postdoctoral Associate Florida International University Miami FL USA

The production of maxima and minima by the superposition of two or more light signals provides fundamental support for the wave nature of light. This result is based on the study of wave interference phenomena which remains the only approach to explain the production of those maxima and minima. In a system that is prepared to work with only one photon at a time, any detector can signal only one or zero. In 1986, a rigorously controlled experiment was designed by Grangier, G. Roger, and A. Aspect, [Europhys lett. 1(4), p. 173, 1986] that guaranteed a single-photon beam. The explanation of the experimental results implied the interference of the wave function of a single-photon with itself. Thus, the explanation of interference that is accepted for an ensemble of photons was assumed to be valid for a single photon. In this study, we prepare a Mach-Zehnder interferometer using the same type of beam splitters used by Grangier et al. to test the assumption mentioned above. Our results allow us to explain the results of Grangier et al. because of the interaction between light and the beam splitters. Our results also verify that their wave interpretation of the results is not valid. Here, we present the essential findings of the extensive experimental evidence that supports our ideas.

关键词： Interference Beam Splitter Mach-Zehnder Interferometer

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Observations of the Sun’s Dragging Forces

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Journal of Applied Mathematics and Physics 2020年第4期8卷 643-651页

作者： jose l. Parra Physics Department Florida International University Miami USA

The classical theory of gravity, developed by Isaac Newton, predicts that the gravitational force between two masses is always colinear with the direction defined by the center of mass of both bodies. Some work done in the last 60 years has shown experimental evidence that the reality may be somehow more complex. That complexity was confirmed by the author of this paper and he goes farther announcing that the Sun is emitting particles with 44 m spatial periodicity that creates isotropic gravitational effects. Those effects are identical to the ones produced by dragging forces according to the General Theory of Relativity under the Kerr’s Metric. The purpose of this paper is to introduce experimental evidence confirming the author’s predictions that the Moon can modify the dragging force coming from the Sun’s core.

关键词： Gravity Universal Gravitational Constant Diffraction Interference Dragging Forces

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Corpuscular Point of View to Explain light’s Properties

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Optics and Photonics Journal 2018年第5期8卷 135-145页

作者： jose l. Parra Courtesy Postdoctoral Associate Florida International University Miami FL USA

This letter introduces a simple model to explain the Diffraction and Interference of light. It was created using only a corpuscular point of view. The mean concept of the model introduced in this paper is that light has two independent states of polarization that oscillate with equal frequencies but with a π/2 difference of phase. This model allows the author to determine the intensity of light at any point after it exceeds no edge or any number of them.

关键词： Diffraction Interference Photons Mach-Zehnder Interferometer

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Toward a Common Ground for Gravity and Optics

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Journal of Applied Mathematics and Physics 2018年第9期6卷 1896-1906页

作者： jose l. Parra Department of Physics Florida International University Miami FL USA

A long enough period of observation of the Sun’s gravitational dragging effects by using a modified Cavendish’s balance output of experimental evidence shows new patterns. Those patterns can be explained assuming that the Sun has a torus with rotation, precession, and nutation. This purpose of this paper is to introduce the frequencies of all those movements. The torus’s rotational period can be used to explain the Sun’s magnetic pole reversal. Utilizing a modified Cavendish’s balance showed an output of dragging forces stronger than the attraction between the gravitational masses. This tool afforded this research a new experimental possibility to a more precise determination of the Universal Gravitational Constant Big G. Moreover, the dragging forces directly affect any volume of mass, which includes the atmosphere. This paper shows a correlation between the Sun’s dragging peaks and density of the air squared. The aforementioned correlation and the inverse cubic relation with the distance to the Sun are common for the dragging and tide forces providing the possibility that tidal forces are also a gravitational dragging consequence. The last 2017 total Solar eclipse created a new temporal reaction on the modified Cavendish’s balance. That temporal pattern looks as the spatial pattern created by an opaque disk. This similarity allows the researcher to calculate that the dragging forces are transmitted by photons with spatial periodicity of value λ = 6.1 km.

关键词： Spinning Black Holes Kerr’s Metric General Relativity Torsion Measurements Gravitational Constant G Rotation Precession Solar Cycles

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The Implications of the Sun’s Dragging Effect on Gravitational Experiments

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International Journal of Astronomy and Astrophysics 2017年第3期7卷 174-184页

作者： jose l. Parra Department of Physics Florida International University Miami FL USA

Experimental determinations of Newton’s gravitational constant, Big G, have increased, in number and precision, during the last 30 years. There is, however, a persistent discrepancy between various authors. After examining some literature proposing that the differences in Big G might be a function of the length of the day along the years, this paper proposes an alternative hypothesis in which the periodicity of said variation is a function of the relative periodicity of the Sun-Earth distance. The hypothesis introduced here becomes a direct application of the Kerr Metric that describes a massive rotating star. The Kerr solution for the equations of the General Theory of Relativity of Albert Einstein fits well with this relative periodicity and adequately predicts the arrangement of the ex-perimental G values reported by sixteen different laboratories. Also, the author explains how the Sun disturbs gravity on the surface of the Earth.

关键词： Spinning Black Holes Kerr’s Metric General Relativity Torsion Measurements Gravitational Constant G Precession

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Big data in healthcare:Conceptual network structure,key challenges and opportunities

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数字通信与网络:英文版 2023年第4期9卷 856-868页

作者： leonardo B.Furstenaua Pedro leivas Michele Kremer Sott Michael S.Dohan jose Ricardo lopez-Robles Manuel J.Cobo Nicola luigi Bragazzi Kim-Kwang Raymond Choo Post-Graduate Program in Industrial Engineering Federal University of Rio Grande Do SulPorto Alegre90035-190Brazil University of Santa Cruz Do Sul Av.Independencia 2293Santa Cruz Do SulRSBrazil Business School Unisinos UniversityAv.Dr.Nilo Peçanha 160091330-002Porto AlegreBrazil Faculty of Business Administration Lakehead UniversityThunder BayOntarioCanada Autonomous University of Zacatecas Av.Ramon Lopez Velarde Col.CentroZacatecas98000Mexico Department of Computer Science and Artificial Intelligence Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain York University ON M3J 1P3Canada Department of Information Systems and Cyber Security University of Texas at San AntonioSan AntonioTX78249USA

Big data is a concept that deals with large or complex data sets by using data analysis tools(e.g.,data mining,machine learning)to analyze information extracted from several sources *** data has attracted wide attention from academia,for example,in supporting patients and health professionals by improving the accuracy of decision-making,diagnosis and disease *** research aimed to perform a Bibliometric Performance and Network Analysis(BPNA)supported by a Scoping Review(SR)to depict the strategic themes,thematic evolution structure,main challenges and opportunities related to the concept of big data applied in the healthcare *** this goal in mind,4857 documents from the Web of Science covering the period between 2009 to June 2020 were analyzed with the support of SciMAT *** bibliometric performance showed the number of publications and citations over time,scientific productivity and the geographic distribution of publications and research *** strategic diagram yielded 20 clusters and their relative importance in terms of centrality and *** thematic evolution structure presented the most important themes and how it changes over ***,we presented the main challenges and future opportunities of big data in healthcare.

关键词： Big data Healthcare digitalization Bibliometric Strategic intelligence Co-word analysis SciMAT

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Serum biomarkers and risk of hepatocellular carcinoma recurrence after liver transplantation

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World Journal of Hepatology 2019年第1期11卷 50-63页

作者： Maria J Citores jose l lucena Sara de la Fuente Valentin Cuervas-Mons Department of Internal Medicine Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana liver Transplantation Unit Hospital Universitario Puerta de Hierro-Majadahonda Department of Surgery Hospital Universitario Puerta de Hierro-Majadahonda Valentin Cuervas-Mons Department of Internal Medicine HospitalUniversitario Puerta de Hierro-Majadahonda Department of Medicine Universidad Autónoma de Madrid

liver transplantation(lT) is the only potentially curative treatment for selected patients with cirrhosis and hepatocellular carcinoma(HCC) who are not candidates for resection. When the Milan criteria are strictly applied, 75% to85%of 3-to 4-year actuarial survival rates are achieved, but up to 20% of the patients experience HCC recurrence after transplantation. The Milan criteria are based on the preoperative tumor macromorphology, tumor size and number on computed tomography or magnetic resonance imaging that neither correlate well with posttransplant histological study of the liver explant nor accurately predict HCC recurrence after lT, since they do not include objective measures of tumor biology. Preoperative biological markers, including alpha-fetoprotein, desgamma-carboxiprothrombin or neutrophil-to-lymphocyte ratio and platelet-tolymphocyte ratio, can predict the risk for HCC recurrence after *** biomarkers have been proposed as surrogate markers of tumor differentiation and vascular invasion, with varied risk magnitudes depending on the defined cutoffs. Different studies have shown that the combination of one or several biomarkers integrated into prognostic models predict the risk of HCC recurrence after lT more accurately than Milan criteria alone. In this review, we focus on the potential utility of these serum biological markers to improve the performance of Milan criteria to identify patients at high risk of tumoral Published online: January 27, 2019 recurrence after *** transplantation(lT) is the only potentially curative treatment for selected patients with cirrhosis and hepatocellular carcinoma(HCC) who are not candidates for resection. When the Milan criteria are strictly applied, 75% to85%of 3-to 4-year actuarial survival rates are achieved, but up to 20% of the patients experience HCC recurrence after transplantation. The Milan criteria are based on the preoperative tumor macromorphology, tumor size and number on computed t

关键词： Hepatocellular carcinoma liver transplantation Recurrence Selection criteria Prognostic score Biomarker Alpha-fetoprotein Systemic inflammatory marker

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