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Asian Journal of Andrology 2024年第1期26卷 67-70页

作者： Marcello Henrique Araujo Da Silva Gabriela Faria Buys-Goncalves joao Henrique Duque Reis Estrada Francisco jose Barcellos Sampaio Diogo Benchimol de Souza Urogenital Research Unit Rio de Janeiro State UniversityRio de Janeiro 20551-030RJBrazil

The objective of this study was to investigate whether treatment with Tribulus terrestris(Tt)has any impact on the testicular morphology and function in a rodent *** male rats were divided into a control group and a group receiving 100 mg kg^(-1) body weight of Tt *** 4o days of experiment,the animals were submitted to euthanasia;epididymal tail spermatozoa were collected;and spermatozoa concentration,motility,and viability were *** addition,testicles were collected and processed for histomorphometrical *** were compared using the Student's t-test and considered significant when P<*** concentration,motility,and viability showed no difference between the ***,testicular weight and volume,seminiferous tubule diameter,tunica propria surface density,seminiferous epithelium surface density,and intertubular compartment surface density were statistically similar between the ***,seminiferous epithelium height and tubular lumen surface density were augmented in animals treated with *** with Tt does not cause a major impact on testicular morphology,promoting only subtle *** difference on spermatozoa parameters was observed.

关键词： morphometry testicle Tribulus terrestris

The Drought of Amazonia in 2023-2024

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American Journal of Climate Change 2024年第3期13卷 567-597页

作者： jose A. Marengo Ana P. Cunha Jhan-Carlo Espinoza Rong Fu Jochen Schöngart Juan C. Jimenez Mabel C. Costa joao M. Ribeiro Sly Wongchuig Siyu Zhao National Center for Monitoring and Early Warning of Natural Disasters/CEMADEN São José dos Campos Brazil UNESP/CEMADEN São José dos Campos Brazil Graduate School of International Studies Korea University Seoul South Korea Institut des Géosciences de l’Environnement (IGE) Institut de Recherche pour le Dévelopement (IRD) Saint Martin d’Heres France Instituto de Investigación sobre la Enseñanza de las Matemáticas (IREM PUCP) Pontificia Universidad Católica del Perú Lima Peru Department of Atmospheric and Oceanic Sciences University of California Los Angeles Los Angeles CA USA Departament of Environmental Dynamics Instituto Nacional de Pesquisas da Amazônia (INPA) Manaus Brazil Global Change Unit (GCU) of the Image Processing Laboratory (IPL) Universitat de València Estudi General (UVEG) Paterna Spain Laboratoire d’Etudes en Géophysique et Océanographie Spatiales (LEGOS) Université de Toulouse CNES/CNRS/IRD/UT3 Toulouse France

The Amazon basin has experienced an extreme drought that started in the austral summer of 2022-23 and extends into 2024. This drought started earlier than other previous droughts. Although some rain fell during the austral summer, totals remained below average. Higher temperatures during austral winter and spring 2023, which affected most of Central South America, then aggravated drought conditions. This coincided with an intense El Niño and abnormally warm tropical North Atlantic Ocean temperatures since mid-2023. Decreased rainfall across the Amazon basin, negative anomalies in evapotranspiration (derived from latent heat) and soil moisture indicators, as well as increased temperatures during the dry-to-wet transition season, September-October-November (SON) 2023, combined to delay the onset of the wet season in the hydrological year 2023-24 by nearly two months and caused it to be uncharacteristically weak. SON 2023 registered a precipitation deficit of the order of 50 to 100 mm/month, and temperatures +3˚C higher than usual in Amazonia, leading to reduced evapotranspiration and soil moisture indicators. These processes, in turn, determined an exceptionally late onset and a lengthening of the dry season, affecting the 2023-2024 hydrological year. These changes were aggravated by a heat wave from June to December 2023. Drought-heat compound events and their consequences are the most critical natural threats to society. River levels reached record lows, or dried up completely, affecting Amazonian ecosystems. Increased risk of wildfires is another concern exacerbated by these conditions.

关键词： El Niño SST in the Tropical Atlantic Amazon Drought River Levels Heatwave Dry Season Length

Allophane as a Nanotechnological Additive in Masonry Materials to Increase Resistance and Waterproofing

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Advances in Materials Physics and Chemistry 2024年第8期14卷 196-212页

作者： Edward H. Jiménez joao Rivera Juan H. Villalba Paola E. Vera Marlon Cuenca Belén Granja Javier Fuentes Sandra Gavilanes Daniel Hidalgo Fernando Garcia jose Bermudez Washington Ruiz Alexis Martial Debut Facultad de Ingeniera Qumica Universidad Central del Ecuador Quito Ecuador Facultad de Arquitectura y Urbanismo Universidad Central del Ecuador Quito Ecuador Nanomaterials Characterization Laboratory Universidad de las Fuerzas Armadas ESPE Sangolqu Ecuador

The constant need for high-strength materials in the construction industry promotes the research of additives that improve the properties of masonry materials. The use of allophane as an additive in concrete and mortar mixtures was implemented to improve their strength and waterproofing, respectively, using compression and water absorption tests according to their corresponding standards (ASTM C1231, ASTM D2938, and ASTM C1585). The samples were evaluated at different concentrations and curing ages. In addition, different sand/cement ratios were considered for the mortar. The results revealed that there was a 9.4% increase in compressive strength in concrete and a 23.7% reduction in water absorption in mortar for the 5:1 ratio. These changes would be the result of the interaction of the nanoporous additive in the atomic crystal structure of the material demonstrating the nanotechnological nature of allophane.

关键词： Allophane Nano Additive Strength Impermeability Concrete Mortar

MULTIOBJECTIVE ROUTING IN MULTISERVICE MPLS NETWORKS WITH TRAFFIC SPLITTING-A NETWORK FLOW APPROACH

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Journal of Systems Science and Systems Engineering 2015年第4期24卷 389-432页

作者： Rita Girao-Silva jose Craveirinha joao Climaco M.Eugenia Captivo Department of Electrical and Computer Engineering University of Coimbra Polo ⅡPinhal de Marrocos P-3030-290 Coimbra Portugal Institute of Computers and Systems Engineering of Coimbra(INESC-Coimbra)R.Antero de Quental 199 P-3000-033 Coimbra Portugal Centro de Investigacao Operacional Faculdade de CienciasUniversidade de Lisboa Campo GrandeBloco C6Piso 4 P-1749-016 Lisboa Portugal

A multiobjective routing model for Multiprotocol Label Switching networks with multiple service types and traffic splitting is presented in this paper. The routing problem is formulated as a multiobjective mixed-integer program, where the considered objectives are the minimization of the bandwidth routing cost and the minimization of the load cost in the network links with a constraint on the maximal splitting of traffic trunks. Two different exact methods are developed for solving the formulated problem, one based on the classical constraint method and another based on a modified constraint method. A very extensive experimental study, with results on network performance measures in various reference test networks and in randomly generated networks, is also presented and its results are discussed.

关键词： Routing models multiobjective optimization telecommunication networks network flowapproach traffic splitting

Ammonia Sensing System Based on Wavelength Modulation Spectroscopy

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Photonic Sensors 2015年第2期5卷 109-115页

作者： Duarte VIVEIROS joao FERREIRA Susana O. SILVA Joana RIBEIRO Deolinda FLORES jose L. SANTOS Orlando FRAZAO jose M. BAPTISTA INESC Porto Rua do Campo Alegre 687 4169-007 Porto Portugal Geology Center of the University of Porto and Department of Geosciences Environment and Spatial Plannings Facultyof Science at University of Porto Rua do Campo Alegre 687 4169-007 Porto Portugal Department of Physics and Astronomy Faculty of Science at University of Porto Rua do Campo Alegre 687 4169-007 Porto Portugal Competence Center of Exact Sciences and Engineering University of Madeira Campus da Penteada 9000-390 Funchal Portugal

A sensing system in the near infrared region has been developed for ammonia sensing based on the wavelength modulation spectroscopy （WMS） principle. The WMS is a rather sensitive technique for detecting atomic/molecular species, presenting the advantage that it can be used in the near-infrared region by using the optical telecommunications technology. In this technique, the laser wavelength and intensity were modulated by applying a sine wave signal through the injection current, which allowed the shift of the detection bandwidth to higher frequencies where laser intensity noise was typically lower. Two multi-pass cells based on free space light propagation with 160 cm and 16 cm of optical path length were used, allowing the redundancy operation and technology validation. This system used a diode laser with an emission wavelength at 1512.21nm, where NH3 has a strong absorption line. The control of the NH3 gas sensing system, as well as acquisition, processing and data presentation was performed.

关键词： Ammonia sensing fiber optic system near infrared region wavelength modulation spectroscopy,environment

Novel therapeutic strategies targeting mitochondria as a gateway in neurodegeneration

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Neural Regeneration Research 2023年第5期18卷 991-995页

作者： Diogo Trigo jose joao vitor.a Odete A.B.da Cruz e Silva Neuroscience and Signalling Laboratory Institute of Biomedicine(iBiMED)Department of Medical SciencesUniversity of AveiroAveiroPortugal

In recent years, multiple disciplines have focused on mitochondrial biology and contributed to understanding its relevance towards adult-onset neurodegenerative disorders. These are complex dynamic organelles that have a variety of functions in ensuring cellular health and homeostasis. The plethora of mitochondrial functionalities confers them an intrinsic susceptibility to internal and external stressors(such as mutation accumulation or environmental toxins), particularly so in long-lived postmitotic cells such as neurons. Thus, it is reasonable to postulate an involvement of mitochondria in aging-associated neurological disorders, notably neurodegenerative pathologies including Alzheimer’s disease and Parkinson’s disease. On the other hand, biological effects resulting from neurodegeneration can in turn affect mitochondrial health and function, promoting a feedback loop further contributing to the progression of neuronal dysfunction and cellular death. This review examines state-of-the-art knowledge, focus on current research exploring mitochondrial health as a contributing factor to neuroregeneration, and the development of therapeutic approaches aimed at restoring mitochondrial homeostasis in a pathological setting.

关键词： Alzheimer’s disease axon energy homeostasis glymphatic system mitochondria mitostasis neurodegeneration neuroregeneration Parkinson’s disease therapeutical strategies

Investigation of Galactic open cluster remnants： the case of NGC 7193

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Research in Astronomy and Astrophysics 2017年第1期17卷 31-54页

作者： Mateus de Souza Angelo joao Francisco Coelho dos Santos Jr Wagner jose Barbosa Corradi Francisco Ferreira de Souza Maia Andres Eduardo Piatti Departamento de Fisica ICEx Universidade Federal de Minas Gerais Av. Antonio Carlos 6627 31270-901 Belo Horizonte MG Brazil Observatorio Astronomico Universidad Nacional de Cordoba Laprida 854 5000 Cordoba Argentina Consejo Nacional de Investigaciones Cientificas y Tecnicas Av. Rivadavia 1917 C1033AAJ Buenos AiresArgentina

Galactic open clusters （OCs） that survive the early gas-expulsion phase are gradually de- stroyed over time by the action of disruptive dynamical processes. Their final evolutionary stages are characterized by a poorly populated concentration of stars called an open cluster remnant （OCR）. This study is devoted to assessing the real physical nature of the OCR candidate NGC 7193. GMOS/Gemini spectroscopy of 53 stars in the inner target region were obtained to derive radial velocities and at- mospheric parameters. We also employed photometric and proper motion data. The analysis method consists of the following steps：（i） analysis of the statistical resemblance between the cluster and a set of field samples with respect to the sequences defined in color-magnitude diagrams （CMDs）; （ii） a 5-dimensional iterative exclusion routine was employed to identify outliers from kinematical and posi- tional data; （iii） isochrone fitting to thes× （J - Ks） CMD of the remaining stars and the dispersion of spectral types along empirical sequences in the （J - H） × （H - Ks） diagram were checked. A group of stars was identified for which the mean heliocentric distance is compatible with that obtained via isochrone fitting and whose metallicities are compatible with each other. Fifteen of the member stars observed spectroscopically were identified together with another 19 probable members. Our results indi- cate that NGC 7193 is a genuine OCR, of a once very populous OC, for which the following parameters were derived： d = 501±46 pc, t = 2.5±1.2 Gyr, （[Fe/H]） = -0.17±0.23 and E（B-V） = 0.05±0.05. Its luminosity and mass functions show depletion of low mass stars, confirming the OCR is in a dynam- ically evolved state.

关键词： open cluster remnants - Galactic open clusters

Smoothing GNSS Time Series with Asymmetric Simple Moving Averages

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Journal of Civil Engineering and Architecture 2012年第6期6卷 745-750页

作者： jose Nuno Lima joao Casaca National Laboratory of Civil Engineering Lisbon Portugal

There is an increasing trend to apply GNSS continuous observation of short baselines to the monitoring of engineering works, such as bridges and dams, for their structural analysis and safety control. In the case of large dams, one important application of the GNSS continuous observation is thc establishment of early warning systems that demand accurate, frequently updated information and where the analysis of the baseline time series, in order to separate signal from noise is mandatory. The paper presents a study on the performance of linear filters of the asymmetric moving average type to smooth baseline time series. The transfer function of the filter is adopted as a smoothing criterion to choose an adequate order for the moving average, in face of the spectral density function of the baseline time series. Onc series of measurements of a short test baseline （325 m）, materialized in the campus of the National Laboratory for Civil Engineering, is used as an example of the proposed strategy.

关键词： GNSS moving averages spectral density.

KIR and a specific HLA-C gene are associated with susceptibility and resistance to hepatitis B virus infection in a Brazilian population

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Cellular & Molecular Immunology 2014年第6期11卷 609-612页

作者： Patricia Araujo Giovana Goncalves Flavia Latini Orlando Ferreira Luis Cristovao Porto jose Augusto Barreto Manoel joao Castelo Girao Ricardo Sobhie Diaz Colsan - Associacao Beneficente de Coleta de Sangue Sao Paulo SP Brazil Department of Gynecology Federal University ofao Paulo (UNIFESP) Sao Paulo SP Brazil Molecular Virology Laboratory Biology Institute Federal University of Rio de Janeiro (UERJ) Rio de Janeiro R J Brazil Histocompatibility and Cryopreservation Laboratory Federal University of Rio de Janeiro (UERJ) Rio de Janeiro R J Brazil Retrovirology Laboratory Federal University of Sao Paulo (UNIFESP) Sao Paulo SP Brazil

BRIEF REPORT The activity of natural killer （NK） cells is partially regulated by killer cell immunoglobulin-like receptors （KIRs） interacting with human leukocyte antigen C （HLA-C） ligands.1 The ligands of sever... 详细信息

关键词： infection Brazilian population

Adenoma incidence decreases u nder the efect of polypectomy

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World Journal of Gastroenterology 2012年第11期18卷 1243-1248页

作者： Isadora Rosa Paulo Fidalgo jose Soares Susana Vinga Carla Oliveira joao P Silva Susana M Ferro Paula Chaves Antonio G Oliveira Carlos N Leitao Gastroenterology Department Instituto Portu-gues de Oncologia de Lisboa Francisco Gentil EPE 1099-023Lisboa Portugal Faculdade de Ciencias da Safldeda Universidade da Beira Interior 6200-506 Covilha Portugal jose Soares Gastroenterology Department Hospital de SantoAntonio EPE 4099-001 Porto Portugal Instituto de Engenharia de Sistemas e Com-putadores: Investigacao e Desenvolvimento 1000-029 LisboaPortugal Hospital de Santo Antonio EPE 4099-001Porto Portugal Pathology Department Instituto Portugues deOncologia de Lisboa Francisco Gentil EPE 1099-023 LisboaPortugal Biostatistics Department Faculdade deCiencias M6dicas 1169-056 Lisboa Portugal

MM： To investigate whether, under the influence of pol ypectomy, the incidence of adenoma decreases with age.METHODS： Consecutive patients with colonic adenomas identified at index colonoscopy were retrospectively selected if they had undergone three or more complete colonoscopies, at least 24 mo apart. Patients who had any first-degree relative with colorectal cancer were excluded. Data regarding number of adenomas at each colonoscopy, their location, size and histological classification were recorded. The monthly incidence density of adenomas after the index examination was estimated for the study population, by using the person-years method. Baseline adenomas were excluded from incidence calculations but their characteristics were correlated with recurrence at follow-up, using the X^42 test.RESULTS： One hundred and fifty-six patients were included （109 male, mean age at index colonoscopy 56.8 ± 10.3 years）, with follow-up that ranged from 48 to 232 mo. No significant correlations were observed between the number, the presence of villous component, or the size of adenomas at index colonoscopy and the presence of adenomas at subsequent colonoscopies （P = 0.49, 0.12 and 0.78, respectively）. The incidence of colonic adenomas was observed to decay from 1.4% person-months at the beginning of the study to values close to 0%, at 12 years after index colonoscopy.CONCLUSION： Our results suggest the sporadic formation of adenomas occurs within a discrete period and that, when these adenomas are removed, all neoplasia-prone clones may be extinguished.

关键词： Colorectal cancer Colorectal adenoma In-cidence Age Polypectomy