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Examining the“revisability”benefit of hip resurfacing arthroplasty

World Journal of Orthopedics 2024年第6期15卷 554-559页

作者： jose george Adam J Taylor Thomas P Schmalzried Department of Orthopedics Harbor UCLA Medical CenterTorranceCA 90509United States

BACKGROUND Hip resurfacing arthroplasty(HRA)is an alternative to total hip arthroplasty(THA)that is typically reserved for young active patients because it preserves ***,the benefits of HRA only hold true if conversion THA after failed HRA provides acceptable *** To compare patient reported outcomes for conversion THA after HRA failure to primary *** A retrospective review of 36 patients(37 hips)that underwent conversion THA for failed HRA between October 2006 and May 2019 by a single surgeon was *** reported outcomes[modified Harris Hip Score(mHHS),University of California Los Angeles(UCLA)activity score]were obtained via an email-based responder-anonymous *** were compared to normative data of a primary THA cohort with similar *** analysis was performed comparing outcomes of conversion THA for adverse local tissue reaction(ALTR)vs all other causes for *** The study group had a lower mHHS than the control group(81.7±13.8 vs 90.2±11.6,P<0.01);however,both groups had similar UCLA activity levels(7.5±2.3 vs 7.2±1.6,P=0.51).Patients that underwent conversion for non-ATLR causes had similar mHHS(85.2±11.5 vs 90.2±11.6,P=0.11)and higher UCLA activity levels(8.5±1.8 vs 7.2±1.6,P<0.01)compared to the control *** that underwent conversion for ATLR had worse mHHS(77.1±14.5 vs 90.2±11.6,P<0.01)and UCLA activity levels(6.1±2.3 vs 7.2±1.6,P=0.05)when compared to the control *** Patient outcomes equivalent to primary THA can be achieved following HRA conversion to ***,inferior outcomes were demonstrated for ALTR-related HRA *** selection and perhaps further studies examining alternative HRA bearing surfaces should be considered.

关键词： Total hip arthroplasty Hip resurfacing arthroplasty Conversion total hip arthroplasty Adverse local tissue reaction Patient reported outcome measures

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CONSTANS alters the circadian clock in Arabidopsis thaliana

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Molecular Plant 2024年第8期17卷 1204-1220页

作者： Pedro de los Reyes Gloria Serrano-Bueno Francisco J.Romero-Campero He Gao jose M.Romero Federico Valverde Plant Development Group-Institute for Plant Biochemistry and Photosynthesis Consejo Superior de Investigaciones CientificasUniversidad de SevillaSevilleSpain Department of Computer Science and Artificial Intelligence Universidad de SevillaSevilleSpain Department of Plant Developmental Biology Max Planck Institute for Plant Breeding ResearchCologneGermany Department of Plant Biochemistry and Molecular Biology Universidad de SevillaSevilleSpain

Plants are sessile organisms that have acquired highly plastic developmental strategies to adapt to the *** these processes,the floral transition is essential to ensure reproductive success and is finelyregulated by several internal andexternal genetic *** photoperiodic pathway,which controls plant response to day length,is one of the most important pathways controlling *** Arabidopsis photoperiodic flowering,CONSTANS(CO)is the central gene activating the expression of the florigen FLOWERING LOCUS T(FT)in the leaves at the end of a long *** circadian clock strongly regulates Co ***,to date,no evidence has been reported regarding a feedbackloop from the photoperiod pathway back to the circadian *** transcriptional networks,we have identified relevant network motifs regulating the interplay between the circadian clock and the photoperiod *** expression,chromatin immunoprecipitation experiments,and phenotypic analysis allowed us to elucidate the role of Co over the circadian *** with altered cO expression showed a different internal clock period,measured by daily leaf rhythmic *** showed that co upregulates the expression of key genes related to the circadian clock,such as CCA1,LHY,PRR5,and Gl,at the end of a long day by bindingto specific sites on their ***,a high numberof PRR5-repressed target genes are upregulated by CO,and this could explain the phase transition promoted by *** CO-PRR5 complex interacts with the bZiP transcriptionfactor HY5andhelps to localize the complex in the promoters of clock *** together,our results indicate that there may be a feedback loop in which co communicates back to the circadian clock,providing seasonal information to the circadian system.

关键词： CONSTANS circadian clock photoperiod

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Using dung beetles to evaluate the effects of urbanization on Atlantic Forest biodiversity

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Insect Science 2013年第3期20卷 393-406页

作者： Vanesca Korasaki jose Lopes george Gardner Brown Julio Louzada Departamento de Agronomia Departamento de Biologia Animal e Vegetal Universidade Estadual de Londrina Londrina-PR Empresa Brasileira de Pesquisa Agropecu~ria Embrapa Florestas Colombo-PR Departamento de Biologia Setor de Ecologia Universidade Federal de Lavras Lavras Minas Gerais Brazil

We used dung beetles to evaluate the impact of urbanization on insect biodi- versity in three Atlantic Forest fragments in Londrina, Parana, Brazil. This study provides the first empirical evidence of the impact of urbanization on richness, abundance, compo- sition and guild structure of dung beetle communities from the Brazilian Atlantic Forest. We evaluated the community aspects （abundance, richness, composition and food guilds） of dung beetles in fragments with different degrees of immersion in the urban matrix using pitfall traps with four alternative baits （rotten meat, rotten fish, pig dung and decaying ba- nana）. A total of 1 719 individuals were collected, belonging to 29 species from 11 genera and six Scarabaeinae tribes. The most urban-immersed fragment showed a higher species dominance and the beetle community captured on dung presented the greatest evenness. The beetle communities were distinct with respect to the fragments and feeding habits. Except for the dung beetle assemblage in the most urbanized forest fragment, all others exhibited contrasting differences in species composition attracted to each bait type. Our results clearly show that the degree of urbanization affects Atlantic Forest dung beetle communities and that the preservation of forest fragments inside the cities, even small ones, can provide refuges for Scarabaeinae.

关键词： bioindicator coprophagous beetles food preference fragmentation habitat loss urban matrix

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c-Met signaling in the development of tumorigenesis and chemoresistance: Potential applications in pancreatic cancer

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World Journal of Gastroenterology 2014年第26期20卷 8458-8470页

作者： Daniel Delitto Eva Vertes-george Steven J Hughes Kevin E Behrns jose G Trevino Department of Surgery University of Florida-Gainesville Department of Pathology University of Florida-Gainesville

Pancreatic ductal adenocarcinoma is the 4th leading cause of cancer deaths in the United States. The majority of patients are candidates only for palliative chemotherapy, which has proven largely ineffective in halting tumor progression. One proposed mechanism of chemoresistance involves signaling via the mesenchymal-epithelial transition factor protein (MET), a previously established pathway critical to cell proliferation and migration. Here, we review the literature to characterize the role of MET in the development of tumorigenesis, metastasis and chemoresistance, highlighting the potential of MET as a therapeutic target in pancreatic cancer. In this review, we characterize the role of c-Met in the development of tumorigenesis, metastasis and chemoresistance, highlighting the potential of c-Met as a therapeutic target in pancreatic cancer.

关键词： Pancreatic adenocarcinoma c-Met Chemoresistance Receptor tyrosine kinase

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Omentum facilitates liver regeneration

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World Journal of Gastroenterology 2009年第9期15卷 1057-1064页

作者： Ashok K Singh Nishit Pancholi Jilpa Patel Natalia O Litbarg Krishnamurthy P Gudehithlu Perianna Sethupathi Mark Kraus george Dunea jose AL Arruda Department of Medicine Stroger Hospital of Cook CountyChicago IL 60612United States Hektoen Institute of Medicine Chicago IL 60612United States Loyola-Hines Medical Center Maywood IL 60612United States University of Illinois at Chicago and the Chicago VAMC Chicago IL 60612United States

AIM:To investigate the mechanism of liver regeneration induced by fusing the omentum to a small traumatic injury created in the liver. We studied three groups of rats. In one group the rats were omentectomized; in another group the omentum was left in situ and was not activated,and in the third group the omentum was activated by polydextran particles. METHODS:We pre-activated the omentum by injecting polydextran particles and then made a small wedge wound in the rat liver to allow the omentum to fuse to the wound. We monitored the regeneration of the liver by determining the ratio of liver weight/body weight,by histological evaluation (including immune staining for cytokeratin-19,an oval cell marker),and by testing for developmental gene activation using reverse transcription polymerase chain reaction (RT-PCR). RESULTS:There was no liver regeneration in the omentectomized rats,nor was there significant regeneration when the omentum was not activated,even though in this instance the omentum had fusedwith the liver. In contrast,the liver in the rats with the activated omentum expanded to a size 50% greater than the original,and there was histologically an interlying tissue between the wounded liver and the activated omentum in which bile ducts,containing cytokeratin-19 positive oval cells,extended from the wound edge. In this interlying tissue,oval cells were abundant and appeared to proliferate to form new liver tissue. In rats pre-treated with drugs that inhibited hepatocyte growth,liver proliferation was ongoing,indicating that regeneration of the liver was the result of oval cell expansion. CONCLUSION:Activated omentum facilitates liver regeneration following injury by a mechanism that depends largely on oval cell proliferation.

关键词： Cytokeratin Foreign body Growth factors Oval cell Progenitor cells

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The Ecological Classification of Coastal Wet Longleaf Pine (Pinus palustris) of Florida from Reference Conditions

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American Journal of Plant Sciences 2012年第9期3卷 1205-1218页

作者： george L. McCaskill Shibu jose Center for Agroforestry School of Natural Resources University of Missouri Columbia USA Forest Inventory & Analysis Northern Research Station USDA Forest Service Newtown Square USA

Tropical storms, fire, and urbanization have produced a heavily fragmented forested landscape along Florida’s Gulf coast. The longleaf pine forest, one of the most threatened ecosystems in the US, makes up a major part of this fragmented landscape. These three disturbance regimes have produced a mosaic of differently-aged pine patches of single or two cohort structures along this coastline. The major focus of our study was to determine reference ecosystem conditions by assessing the soil biochemical properties, overstory stand structure, and understory plant species richness along a patch-derived 110-year chronosequence in order to accurately evaluate on-going longleaf pine restoration projects. This ecological dataset was also used to classify each reference patch as mesic flatwoods, wet flatwoods, or wet savanna. All of the reference locations were found to have similar soil types with no significant differences in their soil biogeochemistry. Mean diameter-at-breast height (DBH), tree height, and patch basal area increased as mean patch age increased. Stand growth reached a plateau around 80-90 years. Shrub cover was significantly higher in the matureaged patches (86-110 years) than in the young (6-10 years) or mid-aged (17-52 years) patches, despite prescribed fire. Plant species diversity as indicated by the Shannon-Wiener index decreased with patch age. Soil biogeochemical properties, forest structure, and understory species composition were effective for ecologically classifying our pine patches as 55 % mesic flatwoods, 20% wet flatwoods, and 25% wet savanna. Florida’s Gulf coastal wet longleaf pine flatwoods attain a structural and plant species equilibrium between 80-90 years.

关键词： Forest Structure Species Richness Restoration Pine Patches Shannon-Wiener Soil Biogeochemistry

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Effects of Silver Nanoparticles on the Activities of Soil Enzymes Involved in Carbon and Nutrient Cycling

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Pedosphere 2018年第2期28卷 209-214页

作者： Frieda EIVAZI Zahra AFRASIABI Elizabeth jose Department of Agriculture and Environmental Sciences Lincoln University Department of Environmental Studies Soka University Department of Physiology and Cell Biology The Ohio State University

Soils are continuously exposed to large amounts of engineered nanoparticles, especially silver nanoparticles (AgNPs), which can affect the activity, stability, and specificity of microbial enzymes. Therefore, the measurement of specific enzyme activity can be used to identify major changes in soil environments. Accordingly, the aim of the present study was to investigate the effects of AgNPs on soil enzymes that play critical roles in mineralizing carbon and nutrients in soil. Soil samples (silt loam and sandy loam) were collected from the surface layer (0–15 cm) of a field at the george Washington Carver Farm, Lincoln University of Missouri, USA. The soils were then treated with AgNP solutions at 0, 1 600, or 3 200 μg Ag kg^(-1) dry soil, using either 10- or 50-nm AgNPs and a randomized complete block design, with three replicates per treatment. The AgNP-treated soil samples were homogenized and incubated for one month, and soil acid phosphatase, β-glucosaminidase, β-glucosidase, and arylsulfatase activities were measured after one hour, one week, and one month of incubation. The activities of all four enzymes were reduced by AgNP treatment after one hour and one ***, AgNP size had no effect. After one month of incubation, the AgNP treatments had mixed effects, which suggests that soil enzymes are only affected on a short-term basis. Further studies are required to determine the mechanisms by which AgNPs reduce soil enzyme activity.

关键词： engineered nanoparticles nanotechnology nanoparticle concentration nanoparticle size soil environment

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Visual exploration of movement and event data with interactive time masks

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Visual Informatics 2017年第1期1卷 25-39页

作者： Natalia Andrienko Gennady Andrienko Elena Camossi Christophe Claramunt jose Manuel Cordero Garcia Georg Fuchs Melita Hadzagic Anne-Laure Jousselme Cyril Ray David Scarlatti george Vouros Fraunhofer Institute IAIS Sankt AugustinGermany City University London LondonUK NATO Science and Technology Organization Centre for Maritime Research and ExperimentationItaly Naval Academy Research Institute France CRIDA-Reference Center for Research Development and Innovation in ATMMadridSpain Boeing Research&Technology Europe Spain Department of Digital System University of PiraeusGreece

We introduce the concept of time mask,which is a type of temporal filter suitable for selection of multiple disjoint time intervals in which some query conditions *** a filter can be applied to time-referenced objects,such as events and trajectories,for selecting those objects or segments of trajectories that fit in one of the selected time *** selected subsets of objects or segments are dynamically summarized in various ways,and the summaries are represented visually on maps and/or other displays to enable *** time mask filtering can be especially helpful in analysis of disparate data(e.g.,event records,positions of moving objects,and time series of measurements),which may come from different *** detect relationships between such data,the analyst may set query conditions on the basis of one dataset and investigate the subsets of objects and values in the other datasets that co-occurred in time with these *** describe the desired features of an interactive tool for time mask filtering and present a possible implementation of such a *** example of analysing two real world data collections related to aviation and maritime traffic,we show the way of using time masks in combination with other types of filters and demonstrate the utility of the time mask filtering.

关键词： Data visualization Interactive visualization Interaction technique

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Status of CCS Technology in Japan and Brazil： A Comparative Analysis

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Journal of Environmental Science and Engineering(B) 2013年第3期2卷 155-176页

作者： george Augusto Batista Camara jose Ce1io Andrade jose Puppim de Oliveira Paulo Sergio Rocha Federal University of Bahia Salvador CEP 40.210-630 Brazil UNU-IAS (United Nations University-Institute of Advanced Studies) Yokohama 220-8502 Japan UNIFACS (University Salvador) Laureate International Universities Salvador CEP 41.950-275 Brazil

This article presents a comparative analysis of the technology status of CCS （carbon capture and storage） in Japan and Brazil. Japan＇s GHG （greenhouse Gas） emissions are declining while Brazil＇s are increasing. Among ESTs （environmentally sound technologies） the potential of GHG mitigation of CCS has gained prominence. The research identifies the main activities and positions of the actors involved in CCS technology implementation in Japan and Brazil, and contrasts and compares reasons for the large-scale use of the CCS technologies in the two countries. This analysis is based on a literature review and a field survey done to collect primary data via visits to organizations and experts. This data was enhanced by an analysis of patent deposits in the area of CCS in the two countries in last 20 years. As regards the legal framework for climate change, and for CCS in particular, while responses to the main international decisions can be found in Japan, in Brazil this is not the case. In Japan the public sector has an effective participation together with private sector and civil society. In Brazil CCS activities are conducted by the private sector which is in turn putting pressure on civil society in particular academia. Currently, Japan is focusing on CCS capture technologies, while Brazil is focusing on CCS storage technologies. In summary, the CCS framework is being more efficiently carried out in Japan than in Brazil.

关键词： CCS technology environmentally sound technologies climate change Japan and Brazil.

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Learning to synthesize:robust phase retrieval at low photon counts

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Light(Science & Applications) 2020年第1期9卷 1657-1672页

作者： Mo Deng Shuai Li Alexandre Goy Iksung Kang george Barbastathis Department of Electrical Engineering and Computer Science Massachusetts Institute of TechnologyCambridgeMA 02139USA Sensebrain Technology Limited LLC 2550 N 1st StreetSuite 300San JoseCA 95131USA Omnisens SA Riond Bosson 31110 MorgesVDSwitzerland Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA Singapore-MIT Alliance for Research and Technology(SMART)Centre Singapore 117543Singapore

The quality of inverse problem solutions obtained through deep learning is limited by the nature of the priors learned from examples presented during the training *** in the case of quantitative phase retrieval,spatial frequencies that are underrepresented in the training database,most often at the high band,tend to be suppressed in the *** hoc solutions have been proposed,such as pre-amplifying the high spatial frequencies in the examples;however,while that strategy improves the resolution,it also leads to high-frequency artefacts,as well as low-frequency distortions in the ***,we present a new approach that learns separately how to handle the two frequency bands,low and high,and learns how to synthesize these two bands into full-band *** show that this“learning to synthesize”(LS)method yields phase reconstructions of high spatial resolution and without artefacts and that it is resilient to high-noise conditions,e.g.,in the case of very low photon *** addition to the problem of quantitative phase retrieval,the LS method is applicable,in principle,to any inverse problem where the forward operator treats different frequency bands unevenly,i.e.,is ill-posed.

关键词： synthesize bands phase

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