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PANDAS PARTICIPAN EN HOCKEY Y CANAN

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China & The World Cultural Exchange 2022年第2期88卷 F0004-F0004页

作者： jose eduardo cadena ortiz 不详

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Analysis of the Effects of Botulinum Toxin Type A to Promote the Survival of Transverse Rectus Abdominis Myocutaneous Flaps in an Animal Model

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Journal of Biosciences and Medicines 2020年第10期8卷 63-73页

作者： Erika Otilia Haro García Edna M. Aizpuru Jorge eduardo Gutierrez Salgado Maria Irene Rivera Salgado jose Telich Vidal Olin Carrasco ortiz Department of Plastic and Reconstructive Surgery at Hospital Angeles del Pedregal Mexico City Mexico Department of Plastic and Reconstructive Surgery at PEMEX Hospital Facultad Mexicana de Medicina Universidad la Salle Mexico City Mexico Facultad Medicina UNAM Mexico City Mexico Department of Pathology in Pemex Hospital Mexico City Mexico Facultad Mexicana de Medicina Universidad la Salle Mexico City Mexico

The transverse rectus abdominis myocutaneous (TRAM) flap is one of the techniques for breast reconstruction surgery and other defects. Assuring the vascular input is the main factor that it should be ensured for the survival of the fap. Objective: The article presented is an experimental study, with the objective of evaluating the effect of the vasculature on the myocutaneous flaps of the abdominal rectum with botulinum toxin type A (TBoA) thay may improve the survival of the tissue by promoting the blood perfusion in distal parts of the flap and diminish the risk of necrosis. Material and methods: A total of 30 Wistar male rats, dissect pedicled right TRAM flap in all rats, divided into three groups: Group 1 was applied in saline solution 0.9%;Group 2 was applied in pre surgically TBoA (1 week before lifting the flap);Group 3, will apply TBOA Trans surgical. Results: Histological analysis showed: increased vascularity in group 2 TBoA compared with the saline solution with P < 0.05 statistically significant. In terms of fibrosis, inflammation and granulation tissue, there was no statistically significant difference at p = 0.6. Muscle atrophy was higher in the group of TBoA in the saline group p < 0.05. It was concluded that botulinum toxin type A prevents vasoconstriction of the vessel and promotes vasodilation subsequently lifting the muscle flap, no complications were observed in the groups with TBoA so it can be considered a safe substace and can be used for further studies.

关键词： Botulinum Toxin Tranverse Rectus Abdominis Myocutaneos Flap Vasodilatation Survival

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Specific Immunotherapy in Advanced Cervical-Uterine Cancer Using Humanized Monoclonal Antibody Nimotuzumab and CIMAvax-EGF<sup>®</sup>Therapeutic Vaccine

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Journal of Cancer Therapy 2021年第3期12卷 146-156页

作者： Raiza Ruiz-Lorente Sayly Alfonso eduardo Santiesteban Yamilka Sánchez Kirenia Camacho Erasmo Mendoza Carmen Elena Viada Ramón ortiz Ihosvannys Carreño Mayelin Troche Meylan Cepeda Ana Rosa Vals Leticia Cabrera Annia Gorte Delmis Batista Milagros Domenech Yanela Santiesteban Yuliannis Santiesteban Daymys Estevez Jessica García-Viamontes Conrado Ramos Mico Mayra Ramos-Suzarte González Coro Hospital La Habana Cuba Celestino Hernández Robau Hospital Villa Clara Cuba jose Ramón Lopez Tabranes Hospital Matanzas Cuba III Congreso Hospital Pinar del Río Cuba Faustino Perez Hospital Matanzas Cuba Center of Molecular Immunology Havana Cuba

Cervical uterine cancer represents the fourth most common malignant neoplasm worldwide in the female sex in terms of incidence, principally from epithelial origen. The high expression of EGFR in this tumor leads to the search for therapeutic alternatives. An Expanded Access Clinical Program was carried out in parallel groups, randomized, multicenter and prospective study, to evaluate the survival of patients with advanced cervical carcinoma, without therapeutic alternative, who would be treated with the therapeutic vaccine CIMAvax-EGF®, the humanized mAb nimotuzumab or the combination of both products, which targeted EGF and EGFR respectively. The patients were included between 2008 and 2010 with a more than five years follow-up. The results show that the serious adverse events related to the experimental treatments were 0.9%;1.1% and 2.6% and a medi

关键词： CIMAvax-EGF® Nimotuzumab Survival Safety Advanced Cervical Cancer

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